Article
Neurosciences
Brunno Rocha Levone, John F. Cryan, Olivia F. O'Leary
Summary: Studies have shown that different sub-regions of the hippocampus play distinct roles in stress responses, with the intermediate hippocampus playing a predominant role in stress-induced social avoidance, and the ventral sub-region having a predominant role in active coping behaviors and antidepressant-like behavior.
Article
Biochemistry & Molecular Biology
Mi Kyoung Seo, Jung An Lee, Sehoon Jeong, Dae-Hyun Seog, Jung Goo Lee, Sung Woo Park
Summary: In an animal model of chronic unpredictable stress-induced depression, chronic treatment with the mGlu2/3 receptor antagonist LY341495 showed antidepressant effects possibly through the activation of hippocampal mTORC1 signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gerardo Bernabe Ramirez-Rodriguez, Nelly Maritza Vega-Rivera, David Meneses-San Juan, Leonardo Ortiz-Lopez, Erika Montserrat Estrada-Camarena, Monica Flores-Ramos
Summary: The study found that fluoxetine, environmental enrichment, and their combination had significant effects on depressive-associated behavior, with fluoxetine reversing anhedonia and the environmental enrichment improving the coat deterioration and anhedonia. Additionally, the combination of fluoxetine and environmental enrichment showed more significant effects than fluoxetine alone on certain events of the neurogenic process, indicating that environmental enrichment enhances the benefits of pharmacological treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jose Erik Alvarez-Contino, Estela Diaz-Sanchez, Marina Mirchandani-Duque, Jose Andres Sanchez-Perez, Miguel A. Barbancho, Alexander Lopez-Salas, Natalia Garcia-Casares, Kjell Fuxe, Dasiel O. Borroto-Escuela, Manuel Narvaez
Summary: This study found that intranasal infusion of GALR2 and Y1R agonists promotes neuroblast proliferation and induces the expression of the neurotrophic factor BDNF in the ventral hippocampus, resulting in antidepressant effects. These effects may be mediated by increased formation of Y1R-GALR2 heteroreceptor complexes. These findings may provide a new approach for the development of novel therapies for major depressive disorder.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Plant Sciences
Han-Zhang Wang, Wu-Long Luo, Ning-Xi Zeng, Hui-Zhen Li, Ling Li, Can Yan, Li-Li Wu
Summary: The Chinese herbal formula JiaWeiSiNiSan (JWSNS) was found to increase stress resilience and prevent stress damage by regulating proteins in cerebrospinal fluid (CSF) based on proteomics and bioinformatics analysis. This study provides a scientific basis for further research on Chinese formulas for preventing mental illness.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Fatma Z. Sakhri, Naoki Adachi, Sakina Zerizer, Yusuke Ohashi, Hideshi Ikemoto, Mana Tsukada, Zahia Kabouche, Tadashi Hisamitsu, Masataka Sunagawa
Summary: This study demonstrates the antidepressant effect of Cydonia oblonga fruit extract by enhancing hippocampal neurogenesis in a rat model of depression. The extract successfully suppressed physiological and behavioral markers of chronic stress, prevented structural abnormalities in the hippocampus, and improved mood function in normal rats.
PHYTOTHERAPY RESEARCH
(2021)
Article
Neurosciences
Yu-han Xie, Chun-ni Zhou, Xin Liang, Jing Tang, Chun-mao Yang, Yan-min Luo, Feng-lei Chao, Lin Jiang, Jin Wang, Ying-qiang Qi, Pei-lin Zhu, Yue Li, Kai Xiao, Yong Tang
Summary: Chronic stress can decrease the number of synapses in the hippocampus, while treatment with anti-Lingo-1 antibody can prevent this decline and improve spatial learning and memory abilities in stressed rats. The antibody also helps protect synapses and enhance the expression of postsynaptic density protein-95 (PSD-95) in specific regions of the hippocampus.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Integrative & Complementary Medicine
Pit Shan Chong, Chi Him Poon, Jaydeep Roy, Ka Chun Tsui, Sze Yuen Lew, Michael Weng Lok Phang, Rachael Julia Yuenyinn Tan, Poh Guat Cheng, Man-Lung Fung, Kah Hui Wong, Lee Wei Lim
Summary: Hericium erinaceus exerts antidepressant effects by promoting neurogenesis and reducing neuroinflammation through enhancing the BDNF-TrkB-CREB signaling pathway. The neurogenesis blocker temozolomide completely eliminates the antidepressant-like effects of HE, and HE induces anti-neuroinflammatory effects by decreasing astrocyte activation in the hippocampus.
Article
Neurosciences
Ye Li, Cuiqin Fan, Rui Gao, Tian Lan, Wenjing Wang, Shu Yan Yu
Summary: The study reveals that altered levels of miR-211-5p in the hippocampal DG area have a significant impact on neurogenesis, apoptosis, and depression-like behaviors in rats. Specifically, up-regulation of miR-211-5p can alleviate depression-like behaviors, reduce neuronal apoptosis, and promote neuronal regeneration; while down-regulation of miR-211-5p can induce depression-like behaviors, increase neuronal apoptosis, and decrease neuronal regeneration.
Review
Biochemistry & Molecular Biology
Timothy J. Schoenfeld, Chance Swanson
Summary: Physical exercise has wide-ranging benefits to cognitive functioning and mental state, with effects resembling enhancements to hippocampal functioning. Beta-endorphins released during exercise are a potential candidate for moderating increases in neurogenesis and related behavioral benefits. Further exploration of beta-endorphin as a key mediator of hippocampal neurogenesis could provide insights into how exercise promotes adult neurogenesis and overall brain health.
Article
Neurosciences
Can Sun, Jian Fu, Zhenzhen Qu, Lijing Jia, Dongxiao Li, Junli Zhen, Weiping Wang
Summary: The study found that chronic intermittent hypobaric hypoxia treatment can rescue cognitive deficits in epileptic rats by activating the Wnt/β-catenin pathway, providing a potential therapeutic approach for epilepsy-induced cognitive impairments.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Shu Yang, Li Yi, Xiaodi Xia, Xiaolu Chen, Xiao Hou, Longjie Zhang, Fang Yang, Jiaxin Liao, Zhijie Han, Yixiao Fu
Summary: This study used a rat model to investigate transcriptome changes in the amygdala-hippocampal neural network under chronic unpredictable mild stress (CUMS), and identified depression-related modules. Differential gene expression and enrichment analyses revealed candidate genes associated with neuronal myelination in the amygdala and synaptic transmission in the hippocampus. Furthermore, central genes were identified in both the amygdala and hippocampus modules through module hub gene statistics, differential gene expression, and protein-protein interaction networks.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Behavioral Sciences
Toshinori Yoshioka, Daisuke Yamada, Riho Kobayashi, Eri Segi-Nishida, Akiyoshi Saitoh
Summary: Adult hippocampal neurogenesis is closely related to depressive disorders, and psychological stress can decrease cell survival rate in the hippocampus of mice, influencing the validity of emotional stress in animal models of depression.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Edith Araceli Cabrera-Munoz, Gerardo Bernabe Ramirez-Rodriguez, Lizeth Diaz-Yanez, Veronica Reyes-Galindo, David Meneses-San Juan, Nelly Maritza Vega-Rivera
Summary: Melatonin, synthesized by the pineal gland, has neuroprotective and neurodevelopmental effects. It acts as an antidepressant by regulating the generation of new neurons. In this study, melatonin was shown to prevent the harmful effects of temozolomide, a chemotherapeutic drug, on depression-like behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Barbara Planchez, Natalia Lagunas, Anne-Marie Le Guisquet, Marc Legrand, Alexandre Surget, Rene Hen, Catherine Belzung
Summary: Studies have shown that increasing adult hippocampal neurogenesis can promote stress resilience and prevent the development of stress-induced depressive-like symptoms.