Article
Oncology
Henrike Barbara Zech, Joanna Berger, Wael Yassin Mansour, Lena Nordquist, Clara Marie von Bargen, Lara Bussmann, Agnes Oetting, Sabrina Christiansen, Nikolaus Moeckelmann, Arne Boettcher, Chia-Jung Busch, Cordula Petersen, Christian Betz, Kai Rothkamm, Malte Kriegs, Sabrina Koecher, Thorsten Rieckmann
Summary: HPV-positive OPSCC shows enhanced immunogenicity and defective DNA repair, leading to increased radiosensitivity, but further research is needed for validation.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Rex H. Lee, Ritu Roy, Hua Li, Aaron Hechmer, Tian Ran Zhu, Adila Izgutdina, Adam B. Olshen, Daniel E. Johnson, Jennifer R. Grandis
Summary: Currently, there are no clinical strategies utilizing tumor gene expression to inform therapeutic selection for patients with head and neck squamous cell carcinoma (HNSCC). Patient-derived xenografts (PDXs) are translationally relevant preclinical models for human tumors; however, the overall transcriptomic concordance of HNSCC PDXs with primary human HNSCC, especially in HPV+ disease, is understudied. This study characterized 64 HNSCC PDXs at the transcriptomic level and found that PDXs can recapitulate HNSCC molecular subtypes and provide a resource for the discovery of predictive biomarkers for treatment selection in HNSCC.
Article
Oncology
Elham Nafea Alsahafi, Selvam Thavaraj, Nazanin Sarvestani, Ofra Novoplansky, Moshe Elkabets, Bushra Ayaz, Mahvash Tavassoli
Summary: High-risk Human Papillomavirus (HPV) infection is now recognized as an independent risk factor in head and neck squamous cell carcinoma (HNSCC). Despite the favorable prognosis of HPV-induced HNSCC, treatment modalities and toxic side effects remain similar to HPV-negative tumors. Overexpression of Epidermal Growth Factor Receptor (EGFR) in HNSCC correlates with radiotherapy resistance, while the EGFR inhibitor Cetuximab shows varying responses between HNSCC subtypes.
Article
Oncology
Nan Zuo, Lin Ma, Tianyang Liu, Weitao Hu, Yupeng Luo, He Meng, Qiushi Ren, Yongqiang Deng, Lanlan Wei, Qi Liu
Summary: HPV-positive head and neck squamous cell carcinoma (HNSCC) has a better prognosis and greater cisplatin sensitivity compared to their HPV-negative counterparts. Understanding the molecular mechanisms underlying HPV-induced cisplatin sensitivity is crucial for improving the prognosis of HPV-negative HNSCC. This study revealed a deficiency in the Fanconi anemia (FA) pathway and reduced XPF expression in HPV-positive HNSCC cells. Inhibiting XPF increased the activity of the alternative end-joining (alt-EJ) pathway in HPV-negative HNSCC, leading to enhanced cisplatin sensitivity. Combining FA and alt-EJ inhibition may be a strategy to treat HPV-negative HNSCC.
Article
Oncology
Kun Cao, Yuanyuan Chen, Songyun Zhao, Yijuan Huang, Tingting Liu, Hu Liu, Bailong Li, Jianguo Cui, Jianming Cai, Chong Bai, Yanyong Yang, Fu Gao
Summary: This study revealed the significant role of Sirt3 in radioresistance of NSCLC, with knockdown of Sirt3 increasing cellular sensitivity to radiation while overexpression promoting resistance. Additionally, Sirt3 was found to play a critical role in the activation of the ATM-Chk2 pathway.
Review
Oncology
Nabil F. F. Saba, Saagar Pamulapati, Bhamini Patel, Mayur Mody, Primoz Strojan, Robert Takes, Antti A. A. Maekitie, Oded Cohen, Pia Pace-Asciak, Jan B. B. Vermorken, Carol Bradford, Arlene Forastiere, Yong Teng, Andreas Wieland, Alfio Ferlito
Summary: Head and neck cancer (HNC) is a common malignancy, with oropharyngeal squamous cell carcinoma (OPSCC) being the majority of cases. The incidence of HPV-related OPSCC, caused by human papillomavirus (HPV), is increasing rapidly. Immunotherapy has shown promise in managing recurrent and metastatic HNC, leading to interest in its application for HPV-related OPSCC. This review focuses on the immune characteristics and potential for immunotherapy in this virus-driven cancer.
Article
Oncology
Wenfeng Gou, Xiaojun Yu, Shaohua Wu, Hongying Wu, Huajie Chang, Leyuan Chen, Huiqiang Wei, Changfen Bi, Hongxin Ning, Yingliang Wu, Wenbin Hou, Daiying Zuo, Yiliang Li
Summary: This study investigated the impact of AND-1 on the radiosensitivity of non-small cell lung cancer (NSCLC) and found that AND-1 inhibition significantly increased the radiosensitivity of NSCLC cells, likely by regulating the cell cycle and enhancing DNA damage.
Article
Oncology
Simona Citro, Claudia Miccolo, Alessandro Medda, Lavinia Ghiani, Marta Tagliabue, Mohssen Ansarin, Susanna Chiocca
Summary: This study demonstrates that human papillomavirus (HPV) stabilizes SMAD4 to promote the expression of DNA damage repair (DDR) proteins, which may facilitate viral replication and increase the sensitivity of early-stage head and neck cancer (HNC) to treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Ting Jiang, Jinfeng Chen, Zhenzhen Wang, Xiaofei Wang, Jun Ma, Fei Zhao, Chen Huang, Yanke Chen
Summary: In this study, the functional roles and target genes of miR-4796 and miR-1287 in breast cancer cells in response to radiation were investigated. It was found that miR-4796 can enhance radiation-induced cell death by targeting multiple DNA damage response and repair components, and repress NHEJ and HR DNA repair pathways. miR-4796 can act as an effective radiation sensitising agent.
Article
Oncology
Sabrina Koecher, Henrike Barbara Zech, Leonie Krug, Fruzsina Gatzemeier, Sabrina Christiansen, Felix Meyer, Ruth Rietow, Nina Struve, Wael Yassin Mansour, Malte Kriegs, Cordula Petersen, Christian Betz, Kai Rothkamm, Thorsten Rieckmann
Summary: This study reveals that human papillomavirus-positive squamous cell carcinoma of the head and neck (HPV+ HNSCC) cells exhibit enhanced radiation sensitivity and impaired DNA repair. However, contrary to previous studies, this research did not confirm the existence of differences and found that ATM inhibition has minimal effects on HPV+ cells.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Siyao Deng, Tijana Vlatkovic, Moying Li, Tianzuo Zhan, Marlon R. Veldwijk, Carsten Herskind
Summary: This review focuses on the role of DNA damage response and repair pathways in radiotherapy, and the potential for enhancing the sensitivity of colorectal cancer to radiotherapy by targeting cell-cycle checkpoint proteins.
Review
Oncology
Benjamin R. Roman, Abraham Aragones
Summary: Globally, 4.5% of cancers are caused by HPV, with HPV oropharyngeal cancer now surpassing cervical cancer in the United States. The highest burden of oropharyngeal cancer is seen in middle-aged and older White men. HPV vaccination offers promise in changing disease epidemiology, but current vaccination rates are too low to effectively reduce disease transmission.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Susanne Flach, Karen Howarth, Sophie Hackinger, Christodoulos Pipinikas, Pete Ellis, Kirsten McLay, Giovanni Marsico, Tim Forshew, Christoph Walz, Christoph A. Reichel, Olivier Gires, Martin Canis, Philipp Baumeister
Summary: This study demonstrates the potential of ctDNA as a biomarker for detecting minimal residual disease and recurrence in HNSCC and shows the feasibility of personalized ctDNA assays for disease detection prior to clinical recurrence.
BRITISH JOURNAL OF CANCER
(2022)
Editorial Material
Oncology
Joanne Soo, Michael C. Jin, Beth M. Beadle, F. Christopher Holsinger, Andrey Finegersh
Summary: This study reveals that measuring the genetic components of human papillomavirus-related throat cancer after surgery can help predict the effectiveness of treatment.
Article
Oncology
Brandon Labarge, Max Hennessy, Lijun Zhang, David Goldrich, Scott Chartrand, Carson Purnell, Sage Wright, David Goldenberg, James R. Broach
Summary: HPV integration in head and neck cancer correlates with extensive pangenomic structural variation, which may have prognostic implications.
MOLECULAR CANCER RESEARCH
(2022)
Article
Otorhinolaryngology
Konrad Stuermer, Tanja Winter, Lisa Nachtsheim, Jens Peter Klussmann, Jan Christoffer Luers
Summary: In cochlear implantation, different surgical steps are required for optimal round window membrane visibility in adults and children, with the procedure being more challenging in children.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Otorhinolaryngology
Maria Grosheva, Jens Peter Klussmann, Dirk Beutner, Michael Formanek, Claudia Lill, Rainer Laskawi, Johannes Zenk, Carina Pick, Birgit Erlacher, Julian Bemmer, Jovanna Thielker, Monika Jering, Ralf Tostmann, Orlando Guntinas-Lichius
Summary: This trial aims to analyze the impact of closed wound drains on postoperative complications following parotid surgery, with nine participating hospitals and ongoing patient enrollment.
LARYNGO-RHINO-OTOLOGIE
(2021)
Article
Medicine, General & Internal
Leopold Lecheler, Freia Paulke, Lena Sonnow, Ulrich Limper, David Schwarz, Stefanie Jansen, Jens Peter Klussmann, Jens Tank, Jens Jordan
Summary: A recent study by the European Space Agency found that mastoid effusions are common during strict head down tilt bed rest, and artificial gravity does not prevent their formation. This model can be used to study mechanisms and potential countermeasures for space flight-associated mastoid effusions.
AMERICAN JOURNAL OF MEDICINE
(2021)
Review
Otorhinolaryngology
Edward Odell, Hans Edmund Eckel, Ricard Simo, Miquel Quer, Vinidh Paleri, Jens Peter Klussmann, Marc Remacle, Elisabeth Sjogren, Cesare Piazza
Summary: The relationship between the degree of dysplasia and the risk of malignant transformation is not clear, tobacco and alcohol consumption are important factors in the development of laryngeal dysplasia, and traditional cancer molecular pathways do not apply to laryngeal dysplasia.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Otorhinolaryngology
Antonia Nolte, Moritz Meyer, Jan-Christoffer Luers, Dirk Fuerstenberg, Jens Peter Klussmann, Ruth Lang-Roth, Stefanie Jansen
Summary: The study examined the impact of pressure changes on cochlear implanted patients during simulated flights and dives. Results showed that the implants were generally able to withstand pressure changes without significant issues, although some patients experienced slight discomfort. Further studies are needed to provide adequate guidance for CI patients regarding diving and flying.
LARYNGO-RHINO-OTOLOGIE
(2022)
Article
Oncology
Philipp H. Zimmermann, Marijn Stuut, Nora Wuerdemann, Kathrin Moellenhoff, Malte Suchan, Hans Eckel, Philipp Wolber, Shachi J. Sharma, Fabian Kaemmerer, Christine Langer, Claus Wittekindt, Steffen Wagner, Bernd Kremer, Ernst Jan M. Speel, Jens P. Klussmann
Summary: Oropharyngeal squamous cell carcinoma (OPSCC) is a common malignancy of the upper aerodigestive tract with no proven superior treatment modality between upfront surgery and primary chemoradiation. This study compared overall survival rates in both cohorts and found no significant difference, emphasizing the importance of treatment recommendations based on side-effect profiles. Further research on functional outcomes is necessary for improving quality of life in OPSCC patients.
Article
Oncology
Johannes Doescher, Moritz Meyer, Christoph Arolt, Alexander Quaas, Jens Peter Klussmann, Philipp Wolber, Agnes Bankfalvi, Hans-Ulrich Schildhaus, Tobias Bastian, Stephan Lang, Simon Laban, Patrick J. Schuler, Cornelia Brunner, Thomas K. Hoffmann, Stephanie E. Weissinger
Summary: Adenoid cystic carcinoma (ACC) is a rare tumor with late occurring metastases and recurrences. The lack of effective treatment in the palliative situation and unsuccessful trials on immunotherapeutic drugs show the need for prognostic markers and understanding the reasons for the lack of response to immunotherapy. The study found that ACC is not recognized by infiltrating immune cells, suggesting the need for other methods to induce recognition of ACC by the immune system. The low immunogenicity of ACC and the abundance of lymphocytes have no influence on prognosis, explaining the observed lack of response towards immunotherapy.
Article
Medicine, General & Internal
Helen Abing, Carina Pick, Tabea Steffens, Jenny Shachi Sharma, Jens Peter Klussmann, Maria Grosheva
Summary: This study evaluated the reanimation of the smile using gracilis muscle transplant with masseteric nerve reinnervation in five patients with long-standing peripheral facial palsy. Results showed that the surgery was feasible and led to rapid and reliable reinnervation of the lower face muscles, resulting in a spontaneous smile within 10 months.
Article
Biochemistry & Molecular Biology
Marcel Mayer, Lisa Nachtsheim, Franziska Hoffmann, Ferdinand von Eggeling, Orlando Guntinas-Lichius, Johanna Prinz, Jens Peter Klussmann, Alexander Quaas, Christoph Arolt, Philipp Wolber
Summary: This study found that CD138 is expressed in different types of salivary gland carcinomas and lymph node metastases, indicating that CD138 may be a potential target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Christiane Dings, Peter Meiser, Frank Holzer, Michael Flegel, Dominik Selzer, Eszter Nagy, Ralph Moesges, Jens Peter Klussmann, Thorsten Lehr
Summary: The intranasal administration of azelastine has been found to accelerate the decline in viral load and symptom severity in COVID-19 patients. Older patients experience a slower decline in viral load, and male patients have higher peak viral loads than females.
Article
Biochemistry & Molecular Biology
Christoph Watermann, Malin Tordis Meyer, Steffen Wagner, Claus Wittekindt, Jens Peter Klussmann, Sueleyman Erguen, Eveline Baumgart-Vogt, Srikanth Karnati
Summary: The presence and composition of peroxisomes in different cell types of the human parotid gland were investigated in this study. Through various techniques, including biochemistry and microscopy, we found that peroxisomes are present in all cells of the parotid gland, with a higher abundance in striated duct cells compared to acinar cells. The study also revealed the presence of antioxidative enzymes, such as catalase, suggesting their role in protecting against oxidative stress in the parotid gland.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Steffen Wagner, Christine Langer, Nora Wuerdemann, Susanne Reiser, Helen Abing, Joern Pons-Kuehnemann, Elena-Sophie Prigge, Magnus von Knebel Doeberitz, Stefan Gattenloehner, Tim Waterboer, Lea Schroeder, Christoph Arens, Jens Peter Klussmann, Claus Wittekindt
Summary: Human papillomavirus (HPV) association is a crucial predictor of survival in head and neck squamous cell carcinomas (HNSCC). However, its role in cancer of unknown origin in this region (CUPHNSCC) is not well understood. This study aimed to identify prognostic markers in CUPHNSCC, and the results showed that p16 alone, along with performance status (ECOG), can be used for risk stratification. Further studies may reveal additional factors for risk classification in CUPHNSCC cases with special profiles.
Review
Medicine, General & Internal
Georg Schlachtenberger, Fabian Doerr, Hruy Menghesha, Patrick Lauinger, Philipp Wolber, Anton Sabashnikov, Aron-Frederik Popov, Sascha Macherey-Meyer, Gerardus Bennink, Jens P. Klussmann, Thorsten Wahlers, Khosro Hekmat, Mathias B. Heldwein
Summary: This work reviews recent studies of pulmonary metastatic head and neck cancer (HNC) patients and the outcomes after pulmonary metastasectomy (PM). The study found that PM is a reliable treatment of choice for patients with isolated pulmonary metastases.
MEDICINA-LITHUANIA
(2022)
Article
Pathology
Philipp Wolber, Lisa Nachtsheim, Franziska Hoffmann, Jens Peter Klussmann, Moritz Meyer, Ferdinand von Eggeling, Orlando Guntinas-Lichius, Alexander Quaas, Christoph Arolt
Summary: This study found that various types of salivary gland carcinomas (SGCs) express Trop-2 at different levels, suggesting its potential as a therapeutic target for further clinical studies. Trop-2 may represent a promising avenue for the treatment of advanced SGCs, for which there are currently limited systemic treatment options.
HEAD & NECK PATHOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Moritz Friedo Meyer, Philipp Wolber, Christoph Arolt, Maximilian Wessel, Alexander Quaas, Stephan Lang, Jens Peter Klussmann, Robert Semrau, Dirk Beutner
Summary: Compared to primary parotid cancers, patients with cutaneous squamous cell carcinoma metastases to the parotid gland present with significantly higher age and worse survival outcomes.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2021)
