Review
Oncology
Ji-Young Kim, Sebastian Zschaeck, Juergen Debus, Fabian Weykamp
Summary: The role of combined moderate hyperthermia and re-irradiation, except for locoregionally recurrent breast cancer, has not been established. This review highlights the need for more clinical trials to generate higher levels of clinical evidence for combined re-irradiation and hyperthermia.
Article
Oncology
Jeeshan Jiffry, Thongthai Thavornwatanayong, Devika Rao, Elisha J. Fogel, Durvanand Saytoo, Rishika Nahata, Hillary Guzik, Imran Chaudhary, Titto Augustine, Sanjay Goel, Radhashree Maitra
Summary: The study revealed that Pelareorep can enhance its propagation and oncolytic effect in colorectal cancer cells by regulating autophagy-related genes and proteins.
CLINICAL CANCER RESEARCH
(2021)
Article
Biochemical Research Methods
Seyed Mohammad Amini, Elham Mohammadi, Shaghayegh Askarian-Amiri, Yaser Azizi, Ali Shakeri-Zadeh, Ali Neshastehriz
Summary: The study suggests that using plant compounds with therapeutic potential such as apigenin to synthesize gold nanoparticles can improve their applications in photothermal therapy. These synthesized gold nanoparticles exhibit good stability in the biological environment and show no significant toxic effects when applied. Additionally, through photothermal therapy, these gold nanoparticles can induce apoptosis in cells, achieving better results compared to commonly used gold nanoparticles.
IET NANOBIOTECHNOLOGY
(2021)
Article
Biophysics
Mounika Choppadandi, Khyati Parmar, K. Srinivasa Rao, K. H. Rao, Aditya Singh, Hemant Kumar, Aditya Teja Guduru, Amit Shard, Govinda Kapusetti
Summary: In this study, cobalt-zinc nanoferrites (MNPs) with a tunable heating profile were loaded with Doxorubicin (DOX) through surface conjugation technique. The MNPs exhibited superparamagnetism and enhanced saturation magnetization, and could maintain a therapeutic temperature for an indefinite amount of time. In vitro experiments showed that DOX-Cs-MNPs caused substantial apoptosis in MCF-7 cells, suggesting their potential for clinical applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Environmental Sciences
Reza Malekzadeh, Tohid Mortezazadeh, Waleed K. Abdulsahib, Behnaz Babaye Abdollah, Michael R. Hamblin, Behzad Mansoori, Fahad Alsaikhan, Bo Zeng
Summary: Photothermal therapy (PTT) is a non-invasive method that utilizes near-infrared laser and plasmonic nanomaterials to convert light into heat, destroying malignant tissue. This review focuses on the use of nanoparticles (NPs) in PTT and their effects on cancer cells. The study shows that gold, silver, and iron NPs are commonly used in PTT, and their surface modification allows for selective delivery and controlled temperature increase. In addition, the presence of NPs during PTT promotes oxygen species generation, DNA and mitochondria damage, leading to cancer cell apoptosis. The advancements in chemical synthesis technology have enabled the preparation of NPs with various properties, allowing for more precise and specific multimodal cancer treatment.
ENVIRONMENTAL RESEARCH
(2023)
Article
Cell Biology
Gen Yang, Chunyang Lu, Zhusong Mei, Xiaoyi Sun, Jintao Han, Jing Qian, Yulan Liang, Zhuo Pan, Defeng Kong, Shirui Xu, Zhipeng Liu, Ying Gao, Guijun Qi, Yinren Shou, Shiyou Chen, Zhengxuan Cao, Ye Zhao, Chen Lin, Yanying Zhao, Yixing Geng, Wenjun Ma, Xueqing Yan
Summary: The study revealed that ultra-high dose rate FLASH-RT has killing effects on both cancer stem cells (CSC) and normal cancer cells, with CSC showing higher resistance compared to normal cancer cells. Additionally, CSC exhibited higher levels of lysosome and autophagy under FLASH irradiation, indicating potential mechanisms for their radio-resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kelly Xue Jing Jong, Elsa Haniffah Mejia Mohamed, Zaridatul Aini Ibrahim
Summary: This review discusses the role of TRAIL decoy receptors in modulating TRAIL-induced apoptosis in colorectal cancer. The current available in vitro, in vivo, and human studies suggest that decoy receptors might be associated with the reduced sensitivity towards TRAIL treatment, although there are discrepancies among different research groups.
Review
Chemistry, Multidisciplinary
Shaopeng Zhang, Hao Zhang, Peizhe Song, Daguang Wang, Yinghui Wang
Summary: Colorectal cancer is a highly malignant gastrointestinal tumor, and traditional chemotherapy and radiotherapy have limited efficacy. Nanomedicine-based therapeutic strategies have shown promise in recent years. This review focuses on the latest advances in nanomedicines for colorectal cancer treatment, including stimuli-responsive drug delivery systems and emerging therapies such as photothermal therapy, magnetothermal therapy, photodynamic therapy, sonodynamic therapy, and chemodynamic therapy. The challenges and future directions for the development of nanomedicines for clinical colorectal cancer treatment are also discussed.
CHEMICAL COMMUNICATIONS
(2023)
Article
Cell Biology
Emir Bozkurt, Heiko Dussmann, Manuela Salvucci, Brenton L. Cavanagh, Sandra Van Schaeybroeck, Daniel B. Longley, Seamus J. Martin, Jochen H. M. Prehn
Summary: The study reveals that TRAIL signaling not only activates apoptosis in colon cancer cells but also induces entosis through TRAIL receptors and the structural presence of caspase-8. The association of TRAIL signaling with cell-in-cell structures is significant in colorectal cancer, especially in the context of patient prognosis. Factors controlling entosis in tumors remain to be elucidated despite the evidence of entosis in cancers.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Marina Simon, Jesper Tranekjaer Jorgensen, Kamilla Norregaard, Jonas Rosager Henriksen, Gael Clergeaud, Thomas L. Andresen, Anders Elias Hansen, Andreas Kjaer
Summary: Traditional cancer treatments are often insufficient to achieve complete responses, so combination therapies are commonly used. Nanoparticle-based photothermal therapy (PTT) is a promising add-on treatment that uses localized hyperthermia to kill cancer cells. In this study, we evaluated the combination of gold nanoshell-based PTT and liposomal doxorubicin for colorectal cancer treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Oncology
Santu Sarkar, Nicole Levi
Summary: This study demonstrates the development of polymer-based nanoparticles that can generate heat and be used for fluorescence detection in treating oxaliplatin-resistant colorectal cancer cells. The nanoparticles were found to be internalized within the cells for heat generation, making the resistant cancer cells responsive to chemotherapy and inducing cell death within minutes. The results lay the groundwork for using photothermal polymer nanoparticles for cell ablation and enhancing chemotherapy in drug-resistant colorectal cancer cells.
Article
Cell Biology
Li-hao Zhao, Quan Li, Zhi-Jun Huang, Mi-Xue Sun, Jing-jing Lu, Xiao-hua Zhang, Gang Li, Fang Wu
Summary: NSD2 plays an oncogenic role in CRC by regulating H3K36me2 and the expression of multiple oncogenes, making it a promising therapeutic target.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Bryce McCarthy, Amit Cudykier, Ravi Singh, Nicole Levi-Polyachenko, Shay Soker
Summary: The study evaluated the ablative potential of CD44-targeted polymer nanoparticles using tumor organoid technology and found that these nanoparticles have limited transport in 3D, with HA-BSe NPs showing better anti-tumor effects.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Bryce McCarthy, Ravi Singh, Nicole Levi-Polyachenko
Summary: Metastatic colorectal cancer can be complicated by chemotherapy-resistant cell populations. Photothermal nanoparticles can provide focal heating to improve the response of CRC cells to oxaliplatin, by confining heating near individual cells. Reduction in cellular luciferase signal may allow single-cell-resolution recording of thermal dosimetry.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Chemistry, Multidisciplinary
Borja Herrero de la Parte, Mireia Irazola, Jorge Perez-Munoz, Irati Rodrigo, Sira Iturrizaga Correcher, Carmen Mar Medina, Kepa Castro, Nestor Etxebarria, Fernando Plazaola, Jose Angel Garcia, Ignacio Garcia-Alonso, Jose Javier Echevarria-Uraga
Summary: This study analyzed the effects of exposure to hyperthermia on rat liver tissue, finding that hyperthermia significantly increased hepatic enzyme levels and altered liver metabolism. However, these changes reverted to normal levels after 10 days.
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniel Lohmann, Marga Lang-Welzenbach, Lorenz Feldberger, Ellen Sommer, Stefan Buecken, Michael Lotter, Oliver J. Ott, Rainer Fietkau, Christoph Bert
Summary: Risk analysis is required by laws and regulations in Germany, impacting every department of a large clinic. The method introduced successfully improved the overall workflow of the radiation oncology department by efficiently and continuously identifying and addressing risks. It takes time and effort, but the interdisciplinary team's regular meetings have proven effective in managing risks.
ZEITSCHRIFT FUR MEDIZINISCHE PHYSIK
(2022)
Correction
Immunology
Anna-Jasmina Donaubauer, Ina Becker, Thomas Weissmann, Birgitta M. Froehlich, Luis E. Munoz, Thomas Gryc, Manuel Denzler, Oliver J. Ott, Rainer Fietkau, Udo S. Gaipl, Benjamin Frey
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Tim-Oliver Sauer, Oliver J. Ott, Godehard Lahmer, Rainer Fietkau, Christoph Bert
Summary: A markerless workflow for breast cancer patients has been introduced and evaluated retrospectively. The results show that this workflow can save time and dose while ensuring appropriate positioning accuracy.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Oncology
Adela Ademaj, Paraskevi D. Veltsista, Dietmar Marder, Roger A. Haelg, Emsad Puric, Thomas B. Brunner, Hans Crezee, Dorota Gabrys, Martine Franckena, Cihan Gani, Michael R. Horsman, Robert Krempien, Lars H. Lindner, Sergio Maluta, Markus Notter, Griseldis Petzold, Sultan Abdel-Rahman, Antonella Richetti, Andreas R. Thomsen, Pelagia Tsoutsou, Rainer Fietkau, Oliver J. Ott, Pirus Ghadjar, Oliver Riesterer
Summary: There is significant heterogeneity among European clinical centers in the practice of hyperthermia, including the indications treated and the recording of thermometric parameters. More evidence from clinical studies is needed to standardize hyperthermia practice.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Oncology
Oliver J. Ott, Udo S. Gaipl, Allison Lamrani, Rainer Fietkau
Summary: For decades, the antineoplastic potential of hyperthermia alone or in combination with radiotherapy and/or chemotherapy has been extensively researched in various tumor entities. This article summarizes the clinical evidence on the beneficial effects of additional hyperthermia in combination with intravesical Mitomycin C for superficial non-muscle-invasive bladder cancer, as well as deep regional microwave hyperthermia techniques used during external beam radiotherapy or chemoradiation for more advanced tumors. The presented data justifies further prospective trials on multimodality treatment for bladder preservation, including mild regional hyperthermia.
SEMINARS IN RADIATION ONCOLOGY
(2023)
Review
Oncology
Thomas Weissmann, Michael Rueckert, Florian Putz, Anna-Jasmina Donaubauer, Markus Hecht, Soren Schnellhardt, Philipp Schubert, Johannes Roesch, Daniel Hoefler, Oliver J. Ott, Marlen Haderlein, Sebastian Lettmaier, Rainer Fietkau, Benjamin Frey, Udo S. Gaipl, Lisa Deloch
Summary: Osteoarthritis is a common and economically relevant disease, especially in an ageing population. Despite numerous conventional treatment options, many patients are still refractory to treatment. Low-dose radiotherapy has shown potential in treating patients with inflammatory and degenerative diseases, but its effectiveness has not been proven in randomized trials. Further research is needed to investigate the underlying mechanisms and optimize patient stratification and treatment procedures.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Chemistry, Multidisciplinary
Lisa Zschiesche, Christina Janko, Bernhard Friedrich, Benjamin Frey, Julia Band, Stefan Lyer, Christoph Alexiou, Harald Unterweger
Summary: Dextran-coated superparamagnetic iron oxide nanoparticles (SPIONDex) of different sizes can be used as contrast agents in magnetic resonance imaging (MRI) without interfering with immune response.
Article
Cell Biology
Mareike F. Bauer, Laura S. Hildebrand, Marie-Charlotte Rosahl, Ramona Erber, Soren Schnellhardt, Maike Buettner-Herold, Florian Putz, Oliver J. Ott, Carolin C. Hack, Rainer Fietkau, Luitpold Distel
Summary: Cell-in-cell (CIC) structures in early hormone-sensitive breast cancer were studied. In vitro experiments showed that breast cancer cell lines had higher phagocytic capacity compared to primary human fibroblasts. Tissue analysis from 147 patients in a clinical trial revealed that CIC structures were associated with favorable local recurrence-free survival and disease-free survival, but unfavorable for metastasis-free survival. CIC had the highest prognostic value in young breast cancer patients.
Article
Cell Biology
Ilka Scheer, Ina Becker, Charlotte Schmitter, Sabine Semrau, Rainer Fietkau, Udo S. Gaipl, Benjamin Frey, Anna-Jasmina Donaubauer
Summary: The study investigates the reactivation of CMV during radiotherapy for brain tumors. It is found that patients with CMV reactivation have significantly higher levels of CD8+ T-EMRA cells. Additionally, the expression of CD27, CD28, and CD57 is associated with CMV infection status. The percentage of CD8+ T-EMRA cells may serve as a biomarker for predicting the risk of CMV reactivation during radiotherapy.
Article
Oncology
Oliver J. Ott, Wilhelm Stillkrieg, Ulrike Lambrecht, Claudia Schweizer, Allison Lamrani, Tim-Oliver Sauer, Vratislav Strnad, Christoph Bert, Carolin C. Hack, Rainer W. Fietkau, Matthias W. Beckmann
Summary: Compared to whole-breast irradiation, partial-breast irradiation reduces radiation doses to healthy tissues and should be recommended to suitable patients to minimize risks of secondary tumors and major cardiac events.
Article
Oncology
Thomas Weissmann, Sina Mansoorian, Matthias Stefan May, Sebastian Lettmaier, Daniel Hoefler, Lisa Deloch, Stefan Speer, Matthias Balk, Benjamin Frey, Udo S. Gaipl, Christoph Bert, Luitpold Valentin Distel, Franziska Walter, Claus Belka, Sabine Semrau, Heinrich Iro, Rainer Fietkau, Yixing Huang, Florian Putz
Summary: This study introduces two novel methods for automatically analyzing the distribution of nodal metastases in head and neck cancer patients. The deep learning method accurately assigns lymph node metastases to different levels, while the registration-based method allows for the analysis and visualization of the 3D probability distribution of metastases without predefined level boundaries.
Article
Health Care Sciences & Services
Wibke Mueller-Seubert, Patrick Ostermaier, Raymund E. Horch, Luitpold Distel, Benjamin Frey, Ramona Erber, Andreas Arkudas
Summary: Different irradiation regimens have different effects on random-pattern flaps. A higher total dose of postoperative irradiation may increase flap necrosis, and irradiation can increase the expression of VEGF and HIF-1α.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Meeting Abstract
Oncology
S. Hehlgans, A. -J. Donaubauer, I. Becker, B. Frey, O. J. Ott, T. Weissmann, C. Fournier, U. S. Gaipl, F. Roedel
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)
Meeting Abstract
Oncology
R. Khatun, M. Hader, M. Schmidt, C. Bert, M. Wadepohl, R. Fietkau, O. J. Ott, U. Gaipl, B. Frey
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)
Meeting Abstract
Oncology
A. Sengedorj, M. Hader, M. Rueckert, B. Frey, R. Fietkau, O. J. Ott, S. Scheidegger, S. M. Barba, U. S. Gaipl
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)