Article
Oncology
John A. Vargo, Vitali Moiseenko, Jimm Grimm, Jimmy Caudell, David A. Clump, Ellen Yorke, Jinyu Xue, Yevgeniy Vinogradskiy, Eduardo G. Moros, Panayiotis Mavroidis, Sheena Jain, Issam El Naqa, Lawrence B. Marks, Dwight E. Heron
Summary: This study systematically reviewed the available literature on tumor control probability with SBRT in head and neck cancer patients, finding a dose-response relationship suggesting better local control and possibly improved overall survival with doses of 35 to 45 Gy (in 5 fractions) compared with <30 Gy. It is suggested that SBRT doses equivalent to 5-fraction doses of 40 to 50 Gy are used for retreatment.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Sachin R. Jhawar, Marcelo Bonomi, Paul M. Harari
Summary: The Oncology Grand Rounds series aims to help readers apply the results of key studies in clinical practice, using case presentations, literature reviews, and treatment recommendations to enhance understanding of the latest developments in oncology.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Mehdi Bouhaddou, Rex H. Lee, Hua Li, Neil E. Bhola, Rachel A. O'Keefe, Mohammad Naser, Tian Ran Zhu, Kelechi Nwachuku, Umamaheswar Duvvuri, Adam B. Olshen, Ritu Roy, Aaron Hechmer, Jennifer Bolen, Stephen B. Keysar, Antonio Jimeno, Gordon B. Mills, Scott Vandenberg, Danielle L. Swaney, Daniel E. Johnson, Nevan J. Krogan, Jennifer R. Grandis
Summary: Unbiased hierarchical clustering analysis identified predictive biomarkers for response to cetuximab therapy in patients with head and neck squamous cell carcinoma, while a minimalist biomarker signature consisting of 8 proteins was validated for accurate prediction of cetuximab response.
Article
Oncology
Amanda E. Yung, Gareth Crouch, Alexander H. R. Varey, Serigne Lo, Michael S. Elliott, Jenny Lee, Robert Rawson, Ruta Gupta, Angela M. Hong, Jonathan R. Clark, Sydney Ch'ng
Summary: More than 60% of patients treated surgically for pT3/4 HNcSCC were alive and free of disease at 5 years posttreatment. High-risk features such as margin involvement and having had previous treatment (radiotherapy/surgery) should be used to guide adjuvant therapy.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Lucas Maahs, Ahmed I. Ghanem, Radhika Gutta, Amy Tang, Swarn Arya, Zaid Al Saheli, Haythem Ali, Steven Chang, Samantha Tam, Vivian Wu, Farzan Siddiqui, Jawad Sheqwara
Summary: Contrary to previous studies, cetuximab is not associated with lower rates of anemia after radiotherapy for nonmetastatic head and neck squamous cell carcinoma patients compared to radiotherapy alone. Further prospective studies are needed to elucidate the effect of cetuximab on radiotherapy-induced anemia.
Article
Oncology
Mihaly Cserepes, Gyorgyi A. Nelhubel, Monika Meilinger-Dobra, Adrienn Herczeg, Dora Turk, Zita Hegedus, Laura Svajda, Erzsebet Raso, Andrea Ladanyi, Kristof Gyorgy Csiko, Istvan Kenessey, Arpad Szoor, Gyorgy Vereb, Eva Remenar, Jozsef Tovari
Summary: In this study, the effects of EGFRvIII and EGFR R521K variants on cetuximab efficacy were investigated. The results showed that the frequency of the EGFRvIII allele in head and neck squamous cell carcinoma patients is less than 1%, indicating that it does not lead to common resistance. EGFR R521K, present in 42% of the patients, was found to reduce cell sensitivity in vitro and in vivo experiments, but this preclinical difference did not correlate with patients' progression-free or overall survival.
Article
Oncology
Treewut Rassamegevanon, Louis Feindt, Lydia Koi, Johannes Mueller, Robert Freudenberg, Steffen Loeck, Wiebke Sihver, Enes Cevik, Ariane Christel Kuehn, Claere von Neubeck, Annett Linge, Hans-Juergen Pietzsch, Joerg Kotzerke, Michael Baumann, Mechthild Krause, Antje Dietrich
Summary: The combination treatment of molecular targeted therapy and external radiotherapy shows promise in improving local tumor control in a HNSCC xenograft model. This study investigates the underlying molecular responses, revealing an increase in DNA double strand breaks and upregulation of genes involved in cell cycle arrest and programmed cell death in tumors treated with the combination therapy.
Article
Multidisciplinary Sciences
Zhiyong Wang, Yusuke Goto, Michael M. Allevato, Victoria H. Wu, Robert Saddawi-Konefka, Mara Gilardi, Diego Alvarado, Bryan S. Yung, Aoife O'Farrell, Alfredo A. Molinolo, Umamaheswar Duvvuri, Jennifer R. Grandis, Joseph A. Califano, Ezra E. W. Cohen, J. Silvio Gutkind
Summary: The study suggests that HER3 inhibition can enhance the response to PD-1 blockade in HNSCC patients and may provide a multimodal precision immunotherapeutic approach for treating PIK3CA wild-type HNSCC.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Matthew C. Ward, Shlomo A. Koyfman, Richard L. Bakst, Danielle N. Margalit, Beth M. Beadle, Jonathan J. Beitler, Steven Shih-Wei Chang, Jay S. Cooper, Thomas J. Galloway, John A. Ridge, Jared R. Robbins, Assuntina G. Sacco, C. Jillian Tsai, Sue S. Yom, Farzan Siddiqui
Summary: The retreatment of previously irradiated recurring or second primary head and neck cancers is a complex task with few guidelines to support practice. Through literature search and voting, a consensus on treatment options has been reached.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Pierluigi Bonomo, Isacco Desideri, Monica Mangoni, Calogero Saieva, Mauro Loi, Carlotta Becherini, Cecilia Cerbai, Michele Ganovelli, Viola Salvestrini, Giulia Stocchi, Margherita Zani, Annarita Palomba, Lorenzo Livi
Summary: This study reported on the anti-tumor activity and tolerability of Durvalumab in combination with Cetuximab and radiation for high-risk head and neck squamous cell carcinoma. Optimal drug exposure and high progression-free survival rates were observed.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Otorhinolaryngology
Mark C. Korpics, William Tyler Turchan, Matthew Koshy, Michael T. Spiotto
Summary: Compared to chemoradiotherapy or radiotherapy alone, cetuximab-based bioradiotherapy is associated with decreased overall survival for patients with HNSCC, suggesting minimal benefit of bioradiotherapy in this population.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Julie E. Bauman, Nabil F. Saba, Denise Roe, Jessica R. Bauman, John Kaczmar, Aarti Bhatia, Jameel Muzaffar, Ricklie Julian, Steven Wang, Shethal Bearelly, Audrey Baker, Conor Steuer, Anshu Giri, Barbara Burtness, Sara Centuori, Carlos Caulin, Robert Klein, Kathylynn Saboda, Stefanie Obara, Christine H. Chung
Summary: This study evaluated the efficacy of combining ficlatuzumab and cetuximab in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC). The results showed that the combination therapy had a significant improvement in progression-free survival compared to monotherapy, and cMet overexpression associated with HPV-negative disease was associated with reduced risk of progression.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Vijay Maruti Patil, Vanita Noronha, Nandini Menon, Ajay Singh, Sarbani Ghosh-Laskar, Ashwini Budrukkar, Atanu Bhattacharjee, Monali Swain, Vijayalakshmi Mathrudev, Kavita Nawale, Arun Balaji, Zoya Peelay, Mitali Alone, Shruti Pathak, Abhishek Mahajan, Suman Kumar, Nilendu Purandare, Archi Agarwal, Ameya Puranik, Shantanu Pendse, Monica Reddy Yallala, Harsh Sahu, Venkatesh Kapu, Sayak Dey, Jatin Choudhary, Madala Ravi Krishna, Alok Shetty, Naveen Karuvandan, Rahul Ravind, Rahul Rai, Kunal Jobanputra, Pankaj Chaturvedi, Prathamesh S. Pai, Devendra Chaukar, Sudhir Nair, Shivakumar Thiagarajan, Kumar Prabhash
Summary: This study investigated the efficacy of docetaxel as a radiosensitizer in cisplatin-ineligible patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC) undergoing chemoradiation. The results showed that the addition of docetaxel to radiation improved 2-year disease-free survival (DFS) and overall survival (OS) compared to radiation alone.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tai-Lin Huang, Hui-Ching Chuang, Ming-Hsien Tsai, Chih-Yen Chien, Yan-Ye Su, Yu-Tsai Lin, Chao-Hui Yang, Chi-Chih Lai, Shau-Hsuan Li, Fu-Min Fang
Summary: This study aimed to explore the treatment outcomes and prognostic factors for patients with previously irradiated but unresectable recurrent head and neck squamous cell carcinoma (rHNSCC) treated by stereotactic body radiotherapy (SBRT) plus cetuximab at a single institute in Taiwan. The results showed that the treatment response rate and survival rates were relatively low in this treatment approach, but the re-irradiation interval was found to be a significant prognostic factor for treatment response.
BIOMEDICAL JOURNAL
(2022)
Article
Oncology
Vijay Maruti Patil, Vanita Noronha, Nandini Menon, Rahul Rai, Atanu Bhattacharjee, Ajay Singh, Kavita Nawale, Shweta Jogdhankar, Rupali Tambe, Sachin Dhumal, Riddhi Sawant, Mitali Alone, Devanshi Karla, Zoya Peelay, Shruti Pathak, Arun Balaji, Suman Kumar, Nilendu Purandare, Archi Agarwal, Ameya Puranik, Abhishek Mahajan, Amit Janu, Gunjesh Kumar Singh, Neha Mittal, Subhash Yadav, Shripad Banavali, Kumar Prabhash
Summary: This study found that only 1%-3% of patients in low- and middle-income countries have access to the approved regimens for treating advanced head and neck squamous cell carcinoma due to cost issues. Previous research has shown that metronomic chemotherapy can improve survival. The study aimed to assess whether the addition of low-dose nivolumab to triple metronomic chemotherapy improved overall survival.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Jens von der Gruen, Ria Winkelmann, Iris Burck, Daniel Martin, Franz Roedel, Peter Johannes Wild, Katrin Bankov, Andreas Weigert, Ivan-Maximiliano Kur, Christian Brandts, Natalie Filmann, Christian Issing, Philipp Thoenissen, Anna Maria Tanneberger, Claus Roedel, Shahram Ghanaati, Panagiotis Balermpas
Summary: This study investigated the efficacy of neoadjuvant chemoradiotherapy (nCRT) in locally advanced oral cavity cancer (LA-OCC) patients. The results showed that nCRT followed by radical surgery is feasible and has high response rates. Additionally, changes in diffusion-weighted magnetic resonance imaging (DW-MRI) signal intensities and immunohistochemistry can serve as predictive biomarkers for treatment response and prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Roman Ludwig, Jean-Marc Hoffmann, Bertrand Pouymayou, Gregoire Morand, Martina Broglie Dappen, Matthias Guckenberger, Vincent Gregoire, Panagiotis Balermpas, Jan Unkelbach
Summary: The dataset provides detailed information on lymph node involvement in patients with oropharyngeal squamous cell carcinoma. It can be used to build quantitative models for predicting lymphatic metastasis and personalize the clinical target volume definition and neck dissection range in radiation therapy and surgical treatment.
Article
Otorhinolaryngology
Cosima E. Riemenschnitter, Gregoire B. Morand, Charlotte S. Schouten, Niels J. Rupp, Panagiotis Balermpas, Thomas Gander, Martina A. Broglie Daeppen
Summary: This study found that deep invading tumors with small tumor diameters in oral squamous cell carcinoma were restaged when using depth of invasion (DOI) for pathological tumor classification. The use of DOI as a staging factor can better determine the need for adjuvant radiotherapy and is associated with overall survival.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Sebastian M. Christ, Philip Heesen, Urs J. Muehlematter, Kaspar Pohl, Gabriel William Thiel, Jonas Willmann, Maiwand Ahmadsei, Tiuri E. Kroese, Michael Mayinger, Panagiotis Balermpas, Andreas Wicki, Nicolaus Andratschke, Martin Huellner, Matthias Guckenberger
Summary: This study aimed to analyze the recognition of and treatment recommendations for oligometastatic patients by multidisciplinary tumor boards (MDTs) in order to better understand current treatment patterns. The results showed that more than half of oligometastatic cases were discussed in MDTs, and the majority received a recommendation including the addition of local therapy. This highlights the importance of multidisciplinary decision-making and the need for standardization in MDT discussions.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Bouchra Tawk, Katrin Rein, Christian Schwager, Maximilian Knoll, Ute Wirkner, Juliane Hoerner-Rieber, Jakob Liermann, Ina Kurth, Panagiotis Balermpas, Claus Roedel, Annett Linge, Steffen Loeck, Fabian Lohaus, Ingeborg Tinhofer, Mechtild Krause, Martin Stuschke, Anca Ligia Grosu, Daniel Zips, Stephanie E. Combs, Claus Belka, Albrecht Stenzinger, Christel Herold-Mende, Michael Baumann, Peter Schirmacher, Jurgen Debus, Amir Abdollahi
Summary: This study suggests that the DNA methylation landscape of tumor cells may indicate epigenetic changes caused by chronic tumor hypoxia. The researchers developed a tumor hypoxia classifier (Hypoxia-M) based on DNA methylation profiles, which showed independent prognostic effects in patients with head and neck squamous cell carcinoma (HNSCC). These findings underscore the importance of DNA methylation-based classifiers as biomarkers of tumor hypoxia.
CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, General & Internal
Alexander Ruehle, Sebastian Marschner, Marlen Haderlein, Alexander Fabian, Maria Weymann, Max Behrens, Carolin Senger, Daniel R. Dickstein, Johannes Kraft, Jens von der Gruen, Eric Chen, Todd Aquino-Michaels, Justus Domschikowski, Amanda Bickel, Alev Altay-Langguth, Goda Kalinauskaite, Victor Lewitzki, Konstantinos Ferentinos, Constantinos Zamboglou, Soeren Schnellhardt, Erik Haehl, Simon K. B. Spohn, Eleni Gkika, Daniela Zoeller, Matthias Guckenberger, Volker Budach, Claus Belka, Richard Bakst, Arnulf Mayer, Heinz Schmidberger, Anca-Ligia Grosu, Panagiotis Balermpas, Carmen Stromberger, Nils H. Nicolay
Summary: This study aimed to investigate whether the addition of chemotherapy or cetuximab to radiotherapy improves survival in older adults with HNSCC. The results showed that chemoradiation, but not cetuximab-based bioradiotherapy, was associated with longer overall survival compared to radiotherapy alone. Additionally, the addition of chemotherapy also prolonged progression-free survival. Rating: 8/10.
Article
Oncology
Mireille Conrad, Riccardo Dal Bello, Janita E. van Timmeren, Nicolaus Andratschke, Lotte Wilke, Matthias Guckenberger, Stephanie Tanadini-Lang, Panagiotis Balermpas
Summary: This study compares the effect of MR-guided radiotherapy and conventional radiotherapy on the surface dose of head and neck cancer patients, and finds that using MR-linac can effectively cover superficial tissue and reduce side effects.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Sebastian Starke, Alex Zwanenburg, Karoline Leger, Fabian Lohaus, Annett Linge, Goda Kalinauskaite, Inge Tinhofer, Nika Guberina, Maja Guberina, Panagiotis Balermpas, Jens von der Gruen, Ute Ganswindt, Claus Belka, Jan C. Peeken, Stephanie E. Combs, Simon Boeke, Daniel Zips, Christian Richter, Esther G. C. Troost, Mechthild Krause, Michael Baumann, Steffen Loeck
Summary: Using deep neural networks and multitask learning strategies to improve predictive performance of outcome tasks in head and neck cancer.
Article
Oncology
Maiwand Ahmadsei, Kai Thaler, Elena Gasser, Bertrand Pouymayou, Riccardo Dal Bello, Sebastian M. Christ, Jonas Willmann, Boldizsar Kovacs, Panagiotis Balermpas, Stephanie Tanadini-Lang, Ardan M. Saguner, Michael Mayinger, Nicolaus Andratschke, Matthias Guckenberger
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Maiwand Ahmadsei, Sebastian M. Christ, Tiuri E. Kroese, Anja Kuhnis, Jonas Willmann, Panagiotis Balermpas, Nicolaus Andratschke, Stephanie Tanadini-Lang, Matthias Guckenberger
Summary: This study analyzed the safety and efficacy profile of radiotherapy in patients treated with multiple repeat courses of irradiation. The results showed that multiple courses of repeat radiotherapy maintain a favorable therapeutic ratio of high response combined with reasonable safety profile. Increasing numbers of radiotherapy courses, type 1 reirradiation, and poor overall health status were associated with worse treatment responses.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Pathology
Aline Golliez, Gregoire B. Morand, Martina A. Broglie, Panagiotis Balermpas, Niels J. Rupp
Summary: This study aimed to evaluate histopathological parameters in salvage neck dissection (ND) specimens from 75 patients with head and neck squamous cell carcinoma (HNSCC). The presence/amount of viable tumor cells was found to be the only parameter correlated with worse clinical outcome. Other parameters did not show a distinctive correlation with prognosis. It is important to note that (swirled) keratin debris alone should not be considered as viable tumor cells (ypN0).
HEAD & NECK PATHOLOGY
(2023)
Article
Oncology
Jonas Willmann, L. Appelt, Panagiotis Balermpas, G. Baumert, Dirk de Ruysscher, Morten Hoyer, Coen Hurkmans, Orit Kaidar-Person, Icro Meattini, Maximilian Niyazi, Philip Poortmans, Nick Reynaert, Stephanie Tandini-Lang, Yvette van der Linden, Carsten Nieder, Nicolaus Andratschke
Summary: This study investigated the patterns of care for re-irradiation internationally and found significant heterogeneity across anatomical regions, highlighting the need for high-quality evidence from prospective studies to guide treatment decisions and establish safe cumulative dose constraints.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Jens von der Grun, Maiwand Ahmadsei, Isabel Breyer, Christian Britschgi, Daniel Eberli, Thomas Hermanns, Joanna Mangana, Henrik Petrowsky, Egle Ramelyte, Patrick Roth, Gabriel Schar, Isabelle Opitz, Michael Weller, Andreas Wicki, Isabell Witzel, Panagiotis Balermpas, Matthias Guckenberger
Summary: Despite the disruption caused by the COVID-19 pandemic, clinical trial activities and patient recruitment at CCCZ remained high, with no significant differences observed compared to the pre-pandemic year.
Review
Oncology
Nicolaus Andratschke, Jonas Willmann, Ane L. Appelt, Najlaa Alyamani, Panagiotis Balermpas, Brigitta G. Baumert, Coen Hurkmans, Morten Hoyer, Johannes A. Langendijk, Orit Kaidar-Person, Yvette van der Linden, Icro Meattini, Maximilian Niyazi, Nick Reynaert, Dirk De Ruysscher, Stephanie Tanadini-Lang, Peter Hoskin, Philip Poortmans, Carsten Nieder
Summary: Re-irradiation can be used as a means of achieving durable local control for cancer patients with limited treatment options. However, there is a lack of prospective evidence and understanding of the radiobiology. This consensus aims to assist decision making and standardize classification and reporting of re-irradiation.
Article
Oncology
Sebastian M. Christ, Michael Denner, Nicolaus Andratschke, Panagiotis Balermpas, Brigitte Hilty, Stephanie Tanadini-Lang, Lotte Wilke, Sophie Perryck, Matthias Guckenberger
Summary: During the first year of the COVID-19 pandemic, weekly online surveys were conducted to monitor stress levels and health concerns among employees in a radiation oncology department. The surveys were found to be feasible and valuable in identifying profession and workplace specific stress patterns and guiding tailored interventions.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2022)