Article
Medicine, General & Internal
Georgiana Serban, Flaviu Tamas, Rodica Balasa, Doina Manu, Corina Tamas, Adrian Balasa
Summary: This retrospective study assessed the impact of clinical and imaging features on the survival of 75 patients with glioblastoma multiforme (GBM). The results showed that tumor size, pre- and postoperative KPSI had a significant impact on survival rate.
Article
Biotechnology & Applied Microbiology
Farzana Kabir, Mohd Nazmul Hasan Apu
Summary: Glioblastoma (GBM) is a malignant and intractable central nervous system tumor. It is important to search for new markers associated with GBM pathogenesis. In this study, microarray datasets were integrated and analyzed, and differentially expressed genes (DEGs) in GBM tissue samples were identified. Functional analysis showed that upregulated genes related to extracellular matrix (ECM) were associated with the invasive nature of GBM, while downregulated DEGs were related to neuronal processes and structures. Additionally, crucial pathways and hub genes were identified, and high expression of FN1 was found to be associated with poor prognosis.
Article
Behavioral Sciences
Jia-Qi Chen, Nuo Zhang, Zhi-Lin Su, Hui-Guo Qiu, Xin-Guo Zhuang, Zhi-hua Tao
Summary: This study aimed to uncover the potential mechanism of glioblastoma multiforme (GBM) in the tumor microenvironment and provide candidate biomarkers for GBM prognosis. Through analysis of immune associated genes and clinical traits, three crucial genes were identified, which showed good prognostic efficacy for GBM.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2022)
Article
Oncology
Pan Xie, Han Yan, Ying Gao, Xi Li, Dong-Bo Zhou, Zhao-Qian Liu
Summary: In this study, we established an m6A-related lncRNA risk model to predict the prognosis of glioblastoma multiforme (GBM) patients. The model showed good accuracy and effectiveness in predicting and assessing the survival of GBM patients, and it can function independently of other clinical characteristics. We also identified immune regulation pathways and anticancer drug sensitivity related to the risk model.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, General & Internal
Francisco Revilla-Pacheco, Pamela Rodriguez-Salgado, Monica Barrera-Ramirez, Maria Paula Morales-Ruiz, Mauro Loyo-Varela, Johnatan Rubalcava-Ortega, Tenoch Herrada-Pineda
Summary: The study revealed a weak but statistically significant association between the extent of surgical resection and overall survival in patients with glioblastoma multiforme. However, the evidence level for this association is low and cannot establish a cause-and-effect relationship between these variables.
Article
Oncology
Xiaozong Duan, Bo Yang, Chengbin Zhao, Boran Tie, Lei Cao, Yuyuan Gao
Summary: In recent years, studies have shown that preoperative inflammatory response, coagulation function, and nutritional status are associated with the development and prognosis of malignant tumors. This study aimed to investigate the relationship between preoperative hematological markers and the prognosis of glioblastoma multiforme (GBM) patients. Through retrospective analysis of 281 GBM patients, it was found that high levels of certain hematological markers were associated with shorter overall survival. A random forest model including these markers showed potential in predicting the 3-year survival status of GBM patients after treatment.
Article
Immunology
Wenqing Gao, Yuanyuan Li, Teng Zhang, Jianglong Lu, Jiasong Pan, Qi Qi, Siqi Dong, Xiangjun Chen, Zhipeng Su, Jixi Li
Summary: This study reveals that chemokines, including CCL2, CCL8, CCL18, CCL28, CXCL1, CXCL5, and CXCL13, are highly expressed in glioblastoma and are associated with immune cell infiltration regulation and worse patient outcomes. Among them, CCL18 is identified as a critical driver of GBM malignant behaviors.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Oncology
Dongdong Xiao, Jingnan Wu, Hongyang Zhao, Xiaobing Jiang, Chuansheng Nie
Summary: This study evaluated the impact of RPP25 on the occurrence and prognosis of glioblastoma multiforme (GBM) using comprehensive bioinformatics analysis. The results showed that RPP25 was commonly highly expressed in multiple cancers but lowly expressed in GBM, and high RPP25 expression was significantly associated with poor prognosis in GBM patients and had predictive value for survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shuhua Zheng, Wensi Tao
Summary: The study identified a simple three-gene transcriptome signature that can connect GBM's overall prognosis with gene expression, while also correlating perfusion imaging features with SOCS3 expression levels. SOCS3 expression levels are considered a potential selection marker for patients who may benefit from early initiation of angiogenesis inhibitors.
Article
Computer Science, Artificial Intelligence
Ran Su, Xiaoying Liu, Qiangguo Jin, Xiaofeng Liu, Leyi Wei
Summary: A predictive model named DeepRA was developed to accurately predict the molecular subtype and patient overall survival of GBM using deep imaging features and machine learning technologies. Experiments showed that DeepRA outperformed traditional hand-crafted methods and regular convolutional neural networks.
KNOWLEDGE-BASED SYSTEMS
(2021)
Article
Oncology
Nicholas F. Brown, Diego Ottaviani, John Tazare, John Gregson, Neil Kitchen, Sebastian Brandner, Naomi Fersht, Paul Mulholland
Summary: The study examined the survival of 490 real-world patients with glioblastoma and identified factors such as age, surgery, post-surgical treatment, and MGMT promotor methylation as predictors of longer survival. The average survival of patients was 9 months.
Article
Multidisciplinary Sciences
Yuanning Zheng, Francisco Carrillo-Perez, Marija Pizurica, Dieter Henrik Heiland, Olivier Gevaert
Summary: In this study, two deep learning models were used to predict the transcriptional subtypes and prognosis of glioblastoma (GBM) cells from histology images. The results showed consistent associations between spatial cellular organization and patient prognosis. The study also confirmed that transcriptional heterogeneity and cell-state plasticity are key factors in the development of therapeutic resistance in GBM.
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Changjun Rao, Jinghao Jin, Jianglong Lu, Chengde Wang, Zerui Wu, Zhangzhang Zhu, Ming Tu, Zhipeng Su, Qun Li
Summary: This study constructed a risk score based on preoperative peripheral blood tests and conventional MRI to predict the prognosis of GBM patients. The developed nomogram model exhibited appropriate predictive power, and vascular endothelial growth factor A (VEGFA) was identified as the key peripheral blood test-related gene associated with poor prognosis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Jinghua Wang, Xinqi Qiu, Jiayu Huang, Zewei Zhuo, Hao Chen, Ruijie Zeng, Huihuan Wu, Kehang Guo, Qi Yang, Huiling Ye, Wei Huang, Yujun Luo
Summary: This study constructed a mitophagy-related risk model to predict the prognosis of glioblastoma multiforme (GBM). The risk model was validated in two independent cohorts and identified as an independent factor for predicting overall survival. In addition, the risk model was closely associated with regulation of immune infiltration and tumor microenvironment.
Article
Genetics & Heredity
Rongchuan Zhao, Xiaohan Sa, Nan Ouyang, Hong Zhang, Jiao Yang, Jinlin Pan, Jinhui Gu, Yuanshuai Zhou
Summary: The analysis identified common prognostic LncRNAs among different cancers, providing insights into cancer pathogenesis and potential novel drug targets in specific cancers like GBM.
FRONTIERS IN GENETICS
(2021)
Letter
Pathology
Alexandros Iliadis, Thomas Zaraboukas, Panagiotis Selviaridis, Athanasios Chatzisotiriou
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
(2017)
Article
Oncology
Georgios Iliadis, Vassiliki Kotoula, Athanasios Chatzisotiriou, Despina Televantou, Anastasia G. Eleftheraki, Sofia Lambaki, Despina Misailidou, Panagiotis Selviaridis, George Fountzilas
Review
Clinical Neurology
Abraham Tsitlakidis, Nicolas Foroglou, Christos A. Venetis, Ioannis Patsalas, Athanasios Hatzisotiriou, Panagiotis Selviaridis
JOURNAL OF NEUROSURGERY
(2010)
Article
Orthopedics
Konstantinos Ditsios, Achilleas Boutsiadis, Dorothea Kapoukranidou, Athanasios Chatzisotiriou, Ioannis Kalpidis, Maria Albani, Anastasios Christodoulou
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2014)
Article
Clinical Neurology
Ioannis P. Kalpidis, Dorothea Kapoukranidou, Nicolas Charalambakis, Athanasios Chatzisotiriou, Maria Albani
Review
Clinical Neurology
Konstantinos I. Avgerinos, Athanasios Chatzisotiriou, Anna-Bettina Haidich, Apostolos Tsapas, Vasileios-Arsenios Lioutas
Article
Biochemistry & Molecular Biology
Evangelia Kesidou, Christina Bitsina, Athanasios Chatzisotiriou, Paschalis Theotokis, Evgenia Dandi, Despina A. Tata, Evangelia Spandou
Summary: Research found that administering N-acetylcysteine (NAC) can significantly alleviate sensorimotor deficits caused by neonatal hypoxic ischemic (HI) brain injury and maintain this effect into adulthood. Furthermore, NAC can reduce the severity of brain damage and decrease the short-term expression of inducible nitric oxide synthase (iNOS).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Patrick Fransen, Niels Hansen-Algbnstaedt, Athanasos Chatzisotiriou, David Cesar Gonzalez Noriega, Vincent Pointillart
ACTA ORTHOPAEDICA BELGICA
(2018)
Article
Clinical Neurology
Panagiotis Selviaridis, Basihos Zountsas, Athanasios Chatzisotiriou, Thomas Zaraboukas, Adnan Gerdemeli
CLINICAL NEUROLOGY AND NEUROSURGERY
(2007)
Article
Medicine, Research & Experimental
D Kapoukranidou, N Gougoulias, A Hatzisotiriou, D Fardi, M Albani, I Kalpidis
MEDICAL SCIENCE MONITOR
(2005)
Article
Developmental Biology
AS Chatzisotiriou, D Kapoukranidou, NE Gougoulias, M Albani
DEVELOPMENTAL BRAIN RESEARCH
(2005)
Article
Orthopedics
N Gougoulias, A Hatzisotiriou, D Kapoukranidou, M Albani
BMC MUSCULOSKELETAL DISORDERS
(2004)
Article
Medicine, General & Internal
P. Selviaridis, N. Foroglou, A. Tsitlakidis, A. Hatzisotiriou, I Magras, I Patsalas
Article
Medicine, General & Internal
A. Kritis, D. Kapoukranidou, B. Michailidou, A. Hatzisotiriou, M. Albani