期刊
STEROIDS
卷 78, 期 5, 页码 508-512出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2013.02.007
关键词
Bufalin; Bufalin 3-nitrogen-containing-ester; Structure-activity relationships; Cytotoxicity
资金
- National Natural Science Foundation of China [30925040, 81102329]
- Chinese National Science 82 Technology Major Project Key New Drug Creation and Manufacturing Program [2012ZX09301001-001, 2011ZX09307-002-03]
- Science Foundation of Shanghai [12XD14057]
A series of bufalin 3-nitrogen-containing-ester derivatives (2-6) were designed, synthesized, and evaluated for their proliferation inhibition activities against human cervical epithelial adenocarcinoma (HeLa) and non-small-cell lung cancer (A549) cell lines. The structure-activity relationships (SARs) of this new series were described in this paper. Cytotoxicity data revealed that C3 moiety had important influence on cytotoxic activity. On two cell lines, the bufalin-3-piperidinyl-4-carboxylate compound 2 (IC50 values on HeLa and A549 cell lines were 0.76 nM and 0.34 nM, respectively) displayed a significant cytotoxic potency compared to the parent compound bufalin. (C) 2013 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据