Article
Clinical Neurology
Takashi Tsuboi, Joshua K. Wong, Robert S. Eisinger, Lela Okromelidze, Mathew R. Burns, Adolfo Ramirez-Zamora, Leonardo Almeida, Aparna Wagle Shukla, Kelly D. Foote, Michael S. Okun, Sanjeet S. Grewal, Erik H. Middlebrooks
Summary: The optimal targets for deep brain stimulation in essential tremor and dystonic tremor remain unknown. This study suggests that DBS targeting the ventral intermediate nucleus/ventralis oralis posterior nucleus border and ventral intermediate nucleus region may be a reasonable treatment option for medication-refractory dystonic tremor and essential tremor patients. Our findings highlight the involvement of cerebello-thalamo-cortical and basal ganglia-thalamo-cortical networks in the pathophysiology of dystonic tremor.
Article
Clinical Neurology
Gabriela S. Gilmour, Davide Martino, Karen Hunka, Pia Lawrence, Zelma H. T. Kiss, Veronica Bruno
Summary: In this study, it was found that patients with ET-plus had similar tremor outcomes after VIM DBS compared to those with ET, without the development of new neurological issues. This suggests that patients with ET-plus can still be considered good candidates for VIM DBS treatment of tremor.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Johanna Philipson, Patric Blomstedt, Marwan Hariz, Marjan Jahanshahi
Summary: The study found that cZi targeting in the treatment of essential tremor using DBS did not have any major adverse effects on cognitive function, with only a slight decline in semantic verbal fluency. This indicates that cZi is a safe target from a cognitive perspective in the treatment of ET with DBS.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Julien Engelhardt, Emmanuel Cuny, Dominique Guehl, Pierre Burbaud, Nathalie Damon-Perriere, Camille Dallies-Labourdette, Juliette Thomas, Olivier Branchard, Louise-Amelie Schmitt, Narimane Gassa, Nejib Zemzemi
Summary: The study developed an inverse approach using machine learning regression to predict the position of leads for deep brain stimulation in essential tremor patients. Support vector regression (SVR) model showed the best performance in predicting the target and active contact position.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Stephanie Cernera, Jose D. Alcantara, Enrico Opri, Jackson N. Cagle, Robert S. Eisinger, Zachary Boogaart, Leena Pramanik, Madison Kelberman, Bhavana Patel, Kelly D. Foote, Michael S. Okun, Aysegul Gunduz
Summary: The study aimed to establish a physiology-driven responsive DBS system for personalized therapy in ET based on EMG signals. Results showed that EMG-driven rDBS provides clinically equivalent tremor suppression compared to traditional cDBS, while delivering less total electrical energy, leading to increased battery life of the INS.
Letter
Clinical Neurology
Paul Reker, Stefanie T. Jost, Petra Schiller, Alexandra Gronostay, Gereon R. Fink, Veerle Visser-Vandewalle, Keyoumars Ashkan, Alexandra Rizos, Pablo Martinez-Martin, Lena Strobel, Afsar Sattari, Lars Timmermann, Anna Sauerbier, K. Ray Chaudhuri, Elke Kalbe, Haidar S. Dafsari
Summary: Deep brain stimulation (DBS) is an effective treatment for essential tremor (ET). Gender differences have been observed in DBS for Parkinson's disease, and this systematic chart review also found gender differences in DBS treatment for ET. The main reason for this is the underrepresentation of women in referrals for surgical evaluation.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Nikolas R. Monteferrante, Brian G. Wilhelmi, Margaret Lambert, Francisco A. Ponce
Summary: Deep brain stimulation (DBS) is an established therapy for neurological movement disorders, but some patients may experience significant weight gain following DBS therapy. In a retrospective study, it was found that Parkinson's disease (PD) patients had significant weight gain at 3, 6, and 12 months post-DBS placement, with those undergoing STN DBS experiencing more weight gain than GPi DBS patients. Furthermore, PD patients with reduced LED after DBS surgery gained more weight compared to those with no change or increased LED levels.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Tariq Parker, Ashley L. B. Raghu, James J. FitzGerald, Alexander L. Green, Tipu Z. Aziz
Summary: Dual thalamo-pallidal stimulation demonstrates great flexibility and efficacy in managing complex movement disorders, but also has limitations.
JOURNAL OF NEUROSURGERY
(2021)
Article
Neurosciences
Cherry H. Yu, Daniel H. Lench, Christine Cooper, Nathan C. Rowland, Istvan Takacs, Gonzalo Revuelta
Summary: The study aimed to investigate the optimal stimulation sites and their overlap with white matter tracts in different subtypes of essential tremor (ET) and essential tremor plus syndrome (ET-plus). The results showed no significant differences in optimal stimulation site or white-matter tract overlap between ET, ET-plus, and ET-plus subgroups. This suggests that VIM DBS therapy is equally effective for ET and ET-plus patients.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Jurgen Germann, Brendan Santyr, Alexandre Boutet, Can Sarica, Clement T. Chow, Gavin J. B. Elias, Artur Vetkas, Andrew Yang, Mojgan Hodaie, Alfonso Fasano, Suneil K. Kalia, Michael L. Schwartz, Andres M. Lozano
Summary: Comparing the efficacy maps of DBS and MRgFUS suggests a potential alternative location for lesioning, more antero-superiorly. This may reduce complications, without sacrificing efficacy, and individualise targeting.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Alexandra Boogers, Jana Peeters, Tine Van Bogaert, Boateng Asamoah, Philippe De Vloo, Wim Vandenberghe, Bart Nuttin, Myles Mc Laughlin
Summary: This study aimed to investigate the effect of anodic and symmetric biphasic pulses on the therapeutic window in essential tremor patients. The results showed that anodic stimulation and symmetric biphasic stimulation could increase the therapeutic window in ET patients.
Article
Clinical Neurology
Josue M. Avecillas-Chasin, Christopher R. Honey, Manraj K. S. Heran, Marie T. Krueger
Summary: In patients with essential tremor whose tremor had progressed and no longer responded well to standard deep brain stimulation, directional deep brain stimulation (dDBS) provided better tremor control. The involvement of both the cerebellothalamic and pallidofugal pathways obtained with dDBS is associated with additional improvement over standard deep brain stimulation.
JOURNAL OF NEUROSURGERY
(2022)
Article
Neuroimaging
Erik H. Middlebrooks, Lela Okromelidze, Joshua K. Wong, Robert S. Eisinger, Mathew R. Burns, Ayushi Jain, Hsin-Pin Lin, Jun Yu, Enrico Opri, Andreas Horn, Lukas L. Goede, Kelly D. Foote, Michael S. Okun, Alfredo Quinones-Hinojosa, Ryan J. Uitti, Sanjeet S. Grewal, Takashi Tsuboi
Summary: This study found a correlation between structural connectivity and treatment outcomes in DBS for tremor patients, suggesting the potential for structural connectivity to predict contralateral tremor improvement. The predictive feature map showed the anatomical course of the DRTT, with all analyzed sweet spots overlapping this predictive tract.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
AnneMarie Brinda, Julia P. Slopsema, Rebecca D. Butler, Salman Ikramuddin, Thomas Beall, William Guo, Cong Chu, Remi Patriat, Henry Braun, Mojgan Goftari, Tara Palnitkar, Joshua Aman, Lauren Schrock, Scott E. Cooper, Joseph Matsumoto, Jerrold L. Vitek, Noam Harel, Matthew D. Johnson
Summary: By using ultra-high field MRI, researchers developed subject-specific pathway activation models for directional DBS leads. The study found that the efficacy and side effects of DBS therapy for Essential Tremor were associated with the activation of different pathways in the brain, and the degree of activation was significantly correlated with the suppression of tremor and the severity of side effects. Therefore, a model-based programming approach can achieve more selective activation of specific regions in the brain.
Review
Neurosciences
Tomasz M. Fraczek, Benjamin I. Ferleger, Timothy E. Brown, Margaret C. Thompson, Andrew J. Haddock, Brady C. Houston, Jeffrey G. Ojemann, Andrew L. Ko, Jeffrey A. Herron, Howard J. Chizeck
Summary: Deep Brain Stimulation (DBS) is an important tool for treating pharmacologically resistant neurological movement disorders, but the current open-loop design may limit its potential. The research demonstrated the feasibility of fully implanted, cortically driven aDBS as a treatment for pharmacologically resistant essential tremor. The use of feedback in adaptive DBS systems allows for a response to the patient's therapeutic needs, outperforming open-loop approaches in certain cases.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Oncology
Inbar Raber, Sarah Warack, Jaya Kanduri, Abby Pribish, Anuradha Godishala, Arielle Abovich, Anna Orbite, Sujithraj Dommaraju, Morgan Frazer, Mary Linton Peters, Aarti Asnani
Letter
Oncology
Inbar Raber, Mary Linton Peters, Aarti Asnani
Meeting Abstract
Oncology
James Michael Pauff, Kyriakos P. Papadopoulos, Filip Janku, Anita Ahmed Turk, Lipika Goyal, Rachna T. Shroff, Toshio Shimizu, Masafumi Ikeda, Nilofer Saba Azad, James M. Cleary, Mary Linton Bounetheau Peters, Mitesh J. Borad, Kurt A. Jaeckle, Sani Haider Kizilbash, Rebecca Tupper, Carrie E. Furin, Matthew P. Hanley, Elizabeth Goodwin Hill, Xu Xiaojian, James J. Harding
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Wenxin Xu, Andrew J. Piper-Vallillo, Poorva Bindal, Jonathan Wischhusen, Jaymin M. Patel, Daniel B. Costa, Mary Linton B. Peters
Summary: The clearance times of SARS-CoV-2 in cancer patients vary significantly depending on the criteria used, potentially leading to delays in cancer care and increased use of clearance testing.
Meeting Abstract
Oncology
J. Berlin, A. L. Coveler, K. K. Ciombor, F. Kazmi, J. Graham, M. L. Peters, J. W. Clark, M. Myers, A. De Gramont, T. R. J. Evans, S. Blagden
ANNALS OF ONCOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Stephanie L. Santoro, Mary Linton B. Peters
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Oncology
Joseph E. Grossman, Lakshmi Muthuswamy, Ling Huang, Dipikaa Akshinthala, Sofia Perea, Raul S. Gonzalez, Leo L. Tsai, Jonah Cohen, Bruno Bockorny, Andrea J. Bullock, Benjamin Schlechter, Mary Linton B. Peters, Catherine Conahan, Supraja Narasimhan, Christine Lim, Roger B. Davis, Robert Besaw, Mandeep S. Sawhney, Douglas Pleskow, Tyler M. Berzin, Martin Smith, Tara S. Kent, Mark Callery, Senthil K. Muthuswamy, Manuel Hidalgo
Summary: This pilot feasibility trial investigated the use of patient-derived organoids (PDOs) to guide personalized therapy for pancreatic ductal adenocarcinoma (PDAC). The study found that the drug sensitivity of PDOs can predict the clinical outcome of patients and is correlated with treatment responses.
CLINICAL CANCER RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Peter P. Mueller, Qiushi Chen, Turgay Ayer, Gizem S. Nemutlu, Ali Hajjar, Emily D. Bethea, Mary Linton B. Peters, Brian P. Lee, Naveed Z. Janjua, Fasiha Kanwal, Jagpreet Chhatwal
Summary: This study evaluated the cost-effectiveness of biannual surveillance for hepatocellular carcinoma (HCC) in patients cured of hepatitis C. The findings suggest that biannual surveillance is cost-effective until the age of 70 for patients with cirrhosis, and until the age of 60 for patients with stable advanced fibrosis.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Mary Linton B. Peters, Andrew Eckel, Anna Lietz, Claudia Seguin, Peter Mueller, Chin Hur, Pari Pandharipande
Summary: Genetic testing of first-degree relatives can inform targeted screening for pancreatic ductal adenocarcinoma, leading to potential gains in life expectancy.
Article
Medicine, General & Internal
Rodrigo Paredes de la Fuente, James W. Doolin, Mary Linton Peters
Summary: A previously healthy man in his 60s was diagnosed with a rare histological subtype of pancreatic cancer, adenosquamous carcinoma. Somatic mutation profiling revealed microsatellite instability and high tumor mutational burden. Combination therapy with gemcitabine, nab-paclitaxel, and pembrolizumab resulted in a sustained response, highlighting the importance of somatic testing for tailored therapy in pancreatic cancer.
Article
Oncology
Zachary M. Avigan, Rodrigo Paredes, Leora S. Boussi, Barbara D. Lam, Meghan E. Shea, Matthew J. Weinstock, Mary Linton B. Peters
Summary: COVID-19 clearance remains prolonged in oncology patients. Single-negative test clearance can reduce delays in care, but has a higher risk of recurrence. Clearance by a predefined waiting period is required to achieve a higher negative rate.
Meeting Abstract
Oncology
Lorena Ostios-Garcia, David Ramiro-Cortijo, Mary Linton Bounetheau Peters, Andrea J. Bullock
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Meeting Abstract
Oncology
Wenxin Xu, Andrew Piper-Vallillo, Poorva Bindal, Jonathan W. Wischhusen, Jaymin M. Patel, Daniel Botelho Costa, Mary Linton Bounetheau Peters
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Meeting Abstract
Oncology
Joseph Elan Grossman, Andrea J. Bullock, Susana Angarita, Bruno Bockorny, Farshid Dayyani, Molly Hurley, Kimberly McGregor, Eirini Pectasides, Mary Linton Bounetheau Peters, Venkataprasanth P. Reddy, Benjamin L. Schlechter, Mehrad Tavallai, Jessica A. Zerillo
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Meeting Abstract
Oncology
Leon Pappas, Stephanie Reyes, Aishwarya Lanka, Rachna T. Shroff, Tri Minh Le, Osama E. Rahma, Andrea Grace Bocobo, Mitesh J. Borad, Thomas DeLeon, Kabir Mody, Marc Thomas Roth, Mary Linton Bounetheau Peters, Laura Williams Goff, Kylie Boyhen, Christine VanCott, Nora Horick, Andrew X. Zhu, Milind M. Javle, Robin Kate Kelley, Lipika Goyal
JOURNAL OF CLINICAL ONCOLOGY
(2020)