Article
Chemistry, Multidisciplinary
Dua Abuarqoub, Rand Zaza, Nazneen Aslam, Hanan Jafar, Suzan Zalloum, Renata Atoom, Abdalla Awidi
Summary: This study investigates the effect of Biodentine(TM) on odonto/osteogenic differentiation potential of hDPSCs in vitro. The results show that treatment with BD significantly increases the expression of odonto/osteogenic markers, upregulates genes related to the odonto/osteogenesis pathway, and enhances calcium deposits, suggesting BD as a promising candidate for regenerative medicine in dental tissue regeneration.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
So Mi Jeon, Je Sun Lim, Hyung-Ryong Kim, Jong-Ho Lee
Summary: The study demonstrates that aerobic glycolysis is induced during odontoblastic differentiation from human DPSCs, with upregulation of protein expression levels of PFKM and PFK2 mainly mediated by AKT activation. This increased PFK activity is essential for enhancing aerobic glycolysis, which plays a crucial role in odontoblastic differentiation of human DPSCs. These findings suggest that PFK activation-induced aerobic glycolysis accompanies and participates in the differentiation of human DPSCs into odontogenic lineage, potentially influencing dental pulp repair.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Anatomy & Morphology
Li Liu, Han Xie, Shouliang Zhao, Xiaofeng Huang
Summary: This study found that inhibition of GLUT1 can promote odontogenic differentiation of hDPSCs, which is regulated through the mTORC1-p70S6K pathway. These results provide a foundation for further application of hDPSCs in regenerative therapy.
Article
Cell Biology
Ning Wang, Xiao Han, Haoqing Yang, Dengsheng Xia, Zhipeng Fan
Summary: The study demonstrates that miR-6807-5p promotes odontogenic differentiation of dental pulp stem cells by silencing METTL7A, while METTL7A promotes odontogenic differentiation of dental pulp stem cells by binding with SNRNP200.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Na Li, Ming Yan, Yan Chen, Yanqiu Wang, Jintao Wu, Lin Fu, Jinhua Yu
Summary: IL-37 enhances the osteogenic and odontogenic differentiation ability of dental pulp stem cells (DPSCs) without affecting their proliferation, and also activates cell autophagy. Activation of autophagy promotes osteogenesis and odontogenesis of DPSCs, while inhibition of autophagy suppresses their differentiation.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Materials Science, Biomaterials
Xinxin Li, Zhaoxia Yu, Shihui Jiang, Xiaohua Dai, Guanhua Wang, Yue Wang, Zhimou Yang, Jie Gao, Huiru Zou
Summary: This study constructed amelogenin self-assembling peptide hydrogels and investigated their effects on the odontogenic differentiation of human dental pulp cells (HDPCs). The results showed that the D-gel exhibited the strongest enhancement effects and induced odontogenic differentiation through the MAPK-ERK1/2 and transforming growth factor/smad pathways. This study demonstrated the potential of amelogenin peptide hydrogel in dentine-pulp complex regeneration.
REGENERATIVE BIOMATERIALS
(2022)
Article
Cell Biology
Zilong Deng, Wenjuan Yan, Xingzhu Dai, Ming Chen, Qian Qu, Buling Wu, Wanghong Zhao
Summary: N-cadherin acts as a negative regulator by regulating beta-catenin activity during odontogenic differentiation of DPSCs, helping guide DPSC behavior through tuning these interactions, with implications for pulp regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Edward J. Calabrese, Evgenios Agathokleous, Gaurav Dhawan, Rachna Kapoor, Vittorio Calabrese
Summary: This study represents the first assessment of hormetic dose responses by human dental pulp stem cells, focusing on cell renewal and differentiation. The study found that hormetic dose responses are commonly observed in this model, involving a wide range of chemicals including pharmaceuticals, dietary supplements/extracts from medicinal plants, and endogenous agents. The study evaluated the mechanistic foundations, study design considerations, and therapeutic implications of the hormetic dose responses in hDPSCs.
AGEING RESEARCH REVIEWS
(2022)
Article
Medicine, Research & Experimental
Xiaoling Wei, Jiayang Li, Hui Liu, Chenguang Niu, Dong Chen
Summary: Regenerative endodontics is gaining attention as an alternative approach to regenerate dental pulp-like tissues. Stem cells and their microenvironment play a crucial role in pulp regeneration. A compound called salidroside has been found to have various protective effects, but its ability to regulate the osteogenic/odontogenic differentiation of human dental pulp stem cells (hDPSCs) is still unclear.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Health Care Sciences & Services
Melissa D. Mercado-Rubio, Erick Perez-Argueta, Alejandro Zepeda-Pedreguera, Fernando J. Aguilar-Ayala, Ricardo Penaloza-Cuevas, Angela Ku-Gonzalez, Rafael A. Rojas-Herrera, Beatriz A. Rodas-Junco, Geovanny I. Nic-Can
Summary: Dental tissue-derived mesenchymal stem cells exhibit differences in adipogenic capacity, with dental follicle stem cells and periodontal ligament stem cells showing higher lipid accumulation and expression of adipogenic markers compared to dental pulp stem cells. These findings contribute to our understanding of adipogenic commitment and developmental origins among dental tissue-derived MSCs.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biology
Nerea Garcia-Urkia, Jon Luzuriaga, Veronica Uribe-Etxebarria, Igor Irastorza, Francisco Javier Fernandez-San-Argimiro, Beatriz Olalde, Nerea Briz, Fernando Unda, Gaskon Ibarretxe, Iratxe Madarieta, Jose Ramon Pineda
Summary: Obesity has a negative impact on human lifespan and is a significant public health issue worldwide. However, the development of in vitro 3D adipose tissue models is limited and expensive. In this study, we designed and produced 3D solid foams using a mixture of collagen and decellularized adipose tissue to mimic the in vivo adipose microenvironment. We demonstrated that these foams are compatible with dental pulp stem cell culture and can support adipocyte differentiation.
Article
Cell Biology
Chai Foong Lai, Juliet Shen, Anamaria Balic, Pierfrancesco Pagella, Martin E. Schwab, Thimios A. Mitsiadis
Summary: The study identified the widespread distribution of Nogo-A in human teeth, and clarified its significant regulatory role in the development of dental pulp stem cells, indicating its potential application in clinics.
Article
Dentistry, Oral Surgery & Medicine
Chatvadee Kornsuthisopon, Kevin A. Tompkins, Thanaphum Osathanon
Summary: This study investigated the effects of Tideglusib on the proliferation, apoptosis, migration, and odonto/osteogenic differentiation of human dental pulp stem cells (hDPSCs). The results showed that Tideglusib promoted the odonto/osteogenic differentiation of hDPSCs by activating the Wnt signaling pathway, but had no significant effects on cell proliferation, apoptosis, and migration.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Eun-Ji Choi, Cheul-Hong Kim, Ji -Young Yoon, Joo-Young Kim, Hyang-Sook Kim, Ji-Uk Yoon, Ah-Reum Cho, Eun-Jung Kim
Summary: This study investigated the impact of propofol on the odontogenic/osteogenic differentiation of human dental pulp stem cells. The results showed that propofol attenuated the odontogenic/osteogenic differentiation of hDPSCs in vitro.
JOURNAL OF DENTAL SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Xiaohan Zhu, Chenguang Niu, Juxiu Chen, Keyong Yuan, Qiaoqiao Jin, Lili Hou, Zhengwei Huang
Summary: This study aimed to determine the role of ZBTB16 in odontogenic differentiation of dental pulp stem cells. Silencing ZBTB16 gene using RNA interference technique attenuated the odontoblastic differentiation ability of dental pulp stem cells and affected the expression of related differentiation markers.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Materials Science, Biomaterials
Yun Hee Youn, Sang Jin Lee, Go Ro Choi, Hak Rae Lee, Donghyun Lee, Dong Nyong Heo, Byung-Soo Kim, Jae Beum Bang, Yu-Shik Hwang, Vitor M. Correlo, Rui L. Reis, Sung Gap Im, Il Keun Kwon
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Dong Nyoung Heo, Han-Jun Kim, Donghyun Lee, Hyosung Kim, Sang Jin Lee, Hye-Rim Lee, Il Keun Kwon, Sun Hee Do
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Dentistry, Oral Surgery & Medicine
Hyun-Chang Lim, Seongwoo Seo, Daniel S. Thoma, Jung-Chul Park, Ji-Youn Hong, Seung-Yun Shin
JOURNAL OF CLINICAL PERIODONTOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Yeon-Hee Lee, Hee-Kyung Park, Q-Schick Auh, Haram Nah, Jae Seo Lee, Ho-Jin Moon, Dong Nyoung Heo, In San Kim, Il Keun Kwon
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Nanoscience & Nanotechnology
Wan-Kyu Ko, Seong Jun Kim, Dong Nyoung Heo, In-Bo Han, Sewha Kim, Il Keun Kwon, Seil Sohn
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2020)
Article
Chemistry, Multidisciplinary
Na Re Ko, Se Young Van, Sung Hwa Hong, Seog-Young Kim, Miran Kim, Jae Seo Lee, Sang Ju Lee, Yong-kyu Lee, Il Keun Kwon, Seung Jun Oh
Article
Multidisciplinary Sciences
Kwantae Noh, Daniel S. Thoma, Jung-Chul Park, Dong-Woon Lee, Seung-Yun Shin, Hyun-Chang Lim
Summary: This study compared profilometric tissue changes following late implant placement with alveolar ridge preservation (LP/ARP) and early implantation (EP) in periodontally compromised non-molar extraction sites. The study found minimal changes in tissue contour and an overall increase in tissue volume in both groups between final prosthesis insertion and 12 months post-implantation, indicating similar stability in peri-implant tissue contour.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Sangyup Kim, Jong-Hyuk Chung, Seung-Yun Shin, Seung-Il Shin, Ji-Youn Hong, Hyun-Chang Lim
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Dentistry, Oral Surgery & Medicine
Ji-Yeong Lee, Sangyup Kim, Seung-Yun Shin, Jong-Hyuk Chung, Yeek Herr, Hyun-Chang Lim
Summary: In this study, hydraulic pressure-assisted sinus augmentation led to new bone formation in areas distant from the bone access hole, but showed a similar histological healing pattern to conventional sinus augmentation in a rabbit sinus model.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Kwang-Seok Lee, Seung-Yun Shin, Christoph H. F. Haemmerle, Ui-Won Jung, Hyun-Chang Lim, Daniel S. Thoma
Summary: This study aimed to investigate the effect of implant placement timing and the type of soft tissue graft on ridge profile changes. The results showed that dimensional ridge changes varied between different treatment protocols, with the ARP/CTG group exhibiting the smallest difference in ridge profile. Both CTG and VCMX enhanced the contour of the ridge.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Gil-Jong Seo, Hyun-Chang Lim, Dong-Wook Chang, Ji-Youn Hong, Seung-Il Shin, Gyutae Kim, Seung-Yun Shin
Summary: This study aimed to investigate the effect of primary wound closure on alveolar ridge preservation in periodontally damaged sockets. The results showed that there was no significant difference in new bone formation and ridge change between sockets with primary wound closure and sockets without primary wound closure.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Gil-Jong Seo, Hyun-Chang Lim, Jong-Hyuk Chung, Gyutae Kim, Seung-Il Shin, Dong-Wook Chang, Seung-Yun Shin
Summary: This study found that alveolar ridge preservation with primary flap closure can result in less soft tissue shrinkage compared to ARP without primary flap closure. The selection of an appropriate incision site during ARP is also crucial.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Geriatrics & Gerontology
Ji-hye Yun, Seung-kook Ki, Jinhee Kim, Doukyoung Chon, Seung-yun Shin, Yunhwan Lee
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2020)
Article
Chemistry, Multidisciplinary
Sang Jin Lee, Ji Suk Choi, Min Rye Eom, Ha Hyeon Jo, Il Keun Kwon, Seong Keun Kwon, Su A. Park
Article
Dentistry, Oral Surgery & Medicine
Hyun-Chang Lim, Do-Uk Kang, Hyehyeon Baek, Ji-Youn Hong, Seung-Yun Shin, Jong-Hyuk Chung, Yeek Herr, Seung-Il Shin
JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
(2019)