Article
Medicine, Research & Experimental
Gecai Chen, Meixiang Wang, Zhongbao Ruan, Li Zhu, Chengchun Tang
Summary: The study demonstrated that MSCs-derived exosomes have a protective role in myocardial I/R injury by regulating autophagy. miR-143-3p was found to be involved in H/R-induced myocardial autophagy through the CHK2-Beclin2 pathway, reducing cell apoptosis. These findings suggest that exosomal miR-143-3p may serve as a promising therapeutic option for I/R injury.
Review
Cell Biology
Zahra Al Amir Dache, Alain R. Thierry
Summary: In addition to their mobility within cells, mitochondria and their components can exist outside cells, allowing them to act on distant cells and mediate intercellular communication. This horizontal transfer plays a role in various biological processes and can lead to inflammation. This article provides an overview of the current findings on extracellular mitochondria and their functions in physiological and pathological contexts, highlighting the expanding understanding of their role in mammalian organisms.
Review
Medicine, Research & Experimental
Ke Li, Zhu Zhu, Xiumei Sun, Linhong Zhao, Zuolong Liu, Jihong Xing
Summary: Cardiac arrest (CA) is a leading cause of death globally with a low survival rate. Restoration of spontaneous circulation (ROSC) has limited impact on mortality rate and prognosis due to ischemia-reperfusion injury. Mesenchymal stem cell (MSC)-derived exosomes have therapeutic potential in wound repair, tissue reconstruction, inflammation, and ischemic diseases by mediating intercellular communication. This review explores the prospects of using MSC-derived exosomes for the treatment of CA.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell & Tissue Engineering
Yen-Ta Chen, Fei-Chi Chuang, Chih-Chao Yang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Chi-Ruei Huang, Kuan-Hui Huang, Hon-Kan Yip
Summary: The combined use of melatonin and adipose-derived mesenchymal stem cells effectively protects the testis against acute testicular torsion-induced ischemia-reperfusion injury.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Nanoscience & Nanotechnology
Xianyun Wang, Shiqi Hu, Junlang Li, Dashuai Zhu, Zhenzhen Wang, Jhon Cores, Ke Cheng, Gang Liu, Ke Huang
Summary: Extrusion is a highly efficient method to generate a large quantity of therapeutic nanovesicles from MSCs, which exhibit myocardial protective effects and potential therapeutic benefits in vitro. Intramyocardial delivery of these nanovesicles after ischemia-reperfusion reduces scar sizes and preserves cardiac functions, similar to natural EVs from the same MSC parental cells.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Medicine, Research & Experimental
Amira Awadalla, Abdelaziz M. Hussein, Mohamed Ali, Nashwa Barakat, Eman T. Hamam, Raghda W. Magar, Ahmed A. Shokeir
Summary: The study demonstrated that preconditioning of ADMSCs with CD44-targeted HA enhanced their protective effects against ischemic kidney injury, with HA+ADMSCs group showing more significant improvement in renal function and protein expression compared to ADMSCs group.
Article
Cell & Tissue Engineering
Sevil Korkmaz-Icoez, Pengyu Zhou, Yuxing Guo, Sivakkanan Loganathan, Paige Brlecic, Tamas Radovits, Alex Ali Sayour, Mihaly Ruppert, Gabor Veres, Matthias Karck, Gabor Szabo
Summary: The study demonstrates that the use of CM from bone marrow MSCs can protect vascular grafts in BD rats, alleviating endothelial dysfunction caused by IR injury and reducing levels of inflammation and apoptosis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Kaili Chen, Hideaki Obara, Yumiko Matsubara, Kazumasa Fukuda, Hiroshi Yagi, Yukako Ono-Uruga, Kentaro Matsubara, Yuko Kitagawa
Summary: The study compared the therapeutic effects of adipose-derived ASCL and ASCs on hepatic IRI, showing that ASCL significantly improved survival outcomes, decreased liver enzyme levels, and reduced liver tissue damage compared to ASCs. ASCL may be a new candidate for hepatic IRI treatment due to its relatively homogeneous characteristics.
CELL TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Behnaz Mokhtari, Reza Badalzadeh, Nahid Aboutaleb
Summary: This study demonstrated that hAM-MSCs-CM has cardioprotective effects against MI/R injury by modulating autophagy through the mTOR/ULK1 pathway, improving cardiac function and reducing fibrosis. These findings suggest that hAM-MSCs-CM may be a promising candidate for attenuating MI/R injury in the future, although further investigations are needed.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Cell & Tissue Engineering
Wei-Cheng Tseng, Pei-Ying Lee, Ming-Tsun Tsai, Fu-Pang Chang, Nien-Jung Chen, Chiang-Ting Chien, Shih-Chieh Hung, Der-Cherng Tarng
Summary: This study demonstrates that the enhancing effect of MSCs, especially HMSCs, on tissue autophagy can be applied to suppress renal tubular apoptosis and attenuate renal impairment during renal I/R injury in rats. These findings provide further mechanistic support for HMSC therapy and its investigation in clinical trials of ischemic AKI.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Immunology
Aimaiti Yasen, Jun Feng, Xing -Ming Xie, Kai Li, Yu -Hong Cai, Zhi-Hong Liao, Run -Bin Liang, Tian -Xing Dai, Guo-Ying Wang
Summary: This study aimed to evaluate the efficacy of exosomes (EXO) derived from TGF-81-pretreated mesenchymal stem cells (MSCs) on biliary ischemia reperfusion injury (IRI) and further reveal the possible mechanisms. The results showed that pretreatment with TGF-81 significantly enhanced MSCs-EXO production and elevated the levels of massive miRNAs associated with anti-apoptosis and tissue repair. Notable improvement was observed in biliary epithelial cells (EpiCs) after MSCs-EXO treatment, evidenced by reduced cellular apoptosis, increased cellular proliferation and declined oxidative stress. In animal studies, administration of EXO derived from TGF-81-pretreated MSCs more effectively attenuated biliary IRI through reducing oxidative stress, apoptosis, inflammation and enhancing the expression levels of TGF-81 and Jagged1/Notch1/SOX9 pathway-related markers.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Harpreet Kaur, Deepaneeta Sarmah, Pabbala Veeresh, Aishika Datta, Kiran Kalia, Anupom Borah, Dileep R. Yavagal, Pallab Bhattacharya
Summary: The study demonstrates that intrarterially administered mesenchymal stem cells post ischemic stroke provide neuroprotection and can modulate ER stress-induced apoptosis via the BDNF/TrkB signaling pathway.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Cell & Tissue Engineering
Pengyu Zhou, Hao Liu, Ximao Liu, Xiao Ling, Zezhou Xiao, Peng Zhu, Yufeng Zhu, Jun Lu, Shaoyi Zheng
Summary: Preservation of donor hearts with hypoxic CdM derived from BMSCs can improve post-transplant graft function by reducing apoptosis and inflammation. The cardioprotective effects were demonstrated by shorter time to spontaneous contraction, better left ventricular function, lower histopathological scores, higher ejection fraction, and fractional shortening.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biology
Qifang Niu, Yang Yang, Delong Li, Wenwen Guo, Chong Wang, Haoyue Xu, Zhien Feng, Zhengxue Han
Summary: This study found that exosomes derived from bone marrow mesenchymal stem cells (BMSCs-exosomes) can effectively reduce necrotic lesions, alleviate oxidative stress and inflammation, and promote new blood vessel formation in a rat model of free abdomen flap transplantation, thus reducing ischemia-reperfusion injury and improving the survival of skin flaps.
Review
Immunology
Jiale Li, Qinbao Peng, Ronghua Yang, Kunsheng Li, Peng Zhu, Yufeng Zhu, Pengyu Zhou, Gabor Szabo, Shaoyi Zheng
Summary: This review discusses the use of machine perfusion and mesenchymal stem cells to improve the quality and outcomes of marginal organs in transplantation. By continuously perfusing the organs to mimic physiological conditions, evaluating pre-transplant organ function, and treating the organs with pharmacological, gene, and stem cell therapy, the quality and adaptability of the organs can be enhanced. Promising preclinical results indicate the potential clinical translation of this innovative strategy to improve the quality of marginal grafts.
FRONTIERS IN IMMUNOLOGY
(2021)
Meeting Abstract
Biophysics
Dan Bare, Iurii Semenov, Kathrin Banach
BIOPHYSICAL JOURNAL
(2010)
Meeting Abstract
Biophysics
Jaime DeSantiago, Dan J. Bare, Kathrin Banach
BIOPHYSICAL JOURNAL
(2012)
Meeting Abstract
Biophysics
Jaime DeSantiago, Dan J. Bare, Katherine A. Sheehan, Yunbo Ke, R. John Solaro, Kathrin Banach
BIOPHYSICAL JOURNAL
(2012)
Article
Neurosciences
Dan J. Bare, Sara G. Becker-Catania, George H. DeVries
Article
Cardiac & Cardiovascular Systems
Jaime DeSantiago, Dan J. Bare, Yunbo Ke, Katherine A. Sheehan, R. John Solaro, Kathrin Banach
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2013)
Article
Neurosciences
LA Holtzclaw, S Pandhit, DJ Bare, GA Mignery, JT Russell
Article
Biophysics
J Kockskämper, KA Sheehan, DJ Bare, SL Lipsius, GA Mignery, LA Blatter
BIOPHYSICAL JOURNAL
(2001)
Article
Biophysics
J Ramos-Franco, D Bare, S Caenepeel, A Nani, M Fill, G Mignery
BIOPHYSICAL JOURNAL
(2000)