The Rise of Cell Therapy Trials for Stroke: Review of Published and Registered Studies

Selective Elimination of Human Pluripotent Stem Cells by an Oleate Synthesis Inhibitor Discovered in a High-Throughput Screen

(2013) Uri Ben-David et al.   Cell Stem Cell

Feasibility of Delivering Mesenchymal Stem Cells via Catheter to the Proximal End of the Lesion Artery in Patients with Stroke in the Territory of the Middle Cerebral Artery

(2013) Yongjun Jiang et al.   CELL TRANSPLANTATION

Repeated Mesenchymal Stem Cell Treatment after Neonatal Hypoxia-Ischemia Has Distinct Effects on Formation and Maturation of New Neurons and Oligodendrocytes Leading to Restoration of Damage, Corticospinal Motor Tract Activity, and Sensorimotor Function

(2013) C. T. J. van Velthoven et al.   JOURNAL OF NEUROSCIENCE

Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells

(2013) Ryoko Araki et al.   NATURE

Biodistribution of bone marrow mononuclear cells after intra-arterial or intravenous transplantation in subacute stroke patients

(2013) Paulo Henrique Rosado-de-Castro et al.   Regenerative Medicine

Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice

(2012) Hiroyuki Sakata et al.   BRAIN

Different routes of administration of human umbilical tissue-derived cells improve functional recovery in the rat after focal cerebral ischemia

(2012) Li Zhang et al.   BRAIN RESEARCH

Direct Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors

(2012) Dong Wook Han et al.   Cell Stem Cell

Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease

(2012) Sudhir H. Ranganath et al.   Cell Stem Cell

Intra-Arterial Infusion of Autologous Bone Marrow Mononuclear Cells in Patients with Moderate to Severe Middle Cerebral Artery Acute Ischemic Stroke

(2012) Maurício A. G. Friedrich et al.   CELL TRANSPLANTATION

Adult Bone Marrow Cell Therapy Improves Survival and Induces Long-Term Improvement in Cardiac Parameters

(2012) Vinodh Jeevanantham et al.   CIRCULATION

Autologous bone marrow mononuclear cell implantation for intracerebral hemorrhage—A prospective clinical observation

(2012) Zhong-Min Li et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Neuroblast survival depends on mature vascular network formation after mouse stroke: role of endothelial and smooth muscle progenitor cell co-administration

(2012) Lina R. Nih et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Intra-arterial infusion of human bone marrow-derived mesenchymal stem cells results in transient localization in the brain after cerebral ischemia in rats

(2012) Bhimashankar Mitkari et al.   EXPERIMENTAL NEUROLOGY

Stem Cell-Based Therapy for Experimental Stroke: A Systematic Review and Meta-Analysis

(2012) Jennifer S. Lees et al.   International Journal of Stroke

Comparison of Allogeneic vs Autologous Bone Marrow–Derived Mesenchymal Stem Cells Delivered by Transendocardial Injection in Patients With Ischemic Cardiomyopathy

(2012) Joshua M. Hare et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Phase I Study of Intravenous Low-dose Granulocyte Colony-stimulating Factor in Acute and Subacute Ischemic Stroke

(2012) Yusuke Moriya et al.   Journal of Stroke & Cerebrovascular Diseases

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Christopher J L Murray et al.   LANCET

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Neural progenitor cells regulate microglia functions and activity

(2012) Kira I Mosher et al.   NATURE NEUROSCIENCE

Grafted human neural stem cells enhance several steps of endogenous neurogenesis and improve behavioral recovery after middle cerebral artery occlusion in rats

(2012) Yutaka Mine et al.   NEUROBIOLOGY OF DISEASE

Umbilical cord blood mononuclear cell transplantation for neonatal hypoxic–ischemic encephalopathy

(2012) Pedro M. Pimentel-Coelho et al.   PEDIATRIC RESEARCH

Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells

(2012) E. Lujan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular replacement and regenerative medicine therapies in ischemic stroke

(2012) John W Thwaites et al.   Regenerative Medicine

Intravenous and intra-arterial administration of bone marrow mononuclear cells after focal cerebral ischemia: Is there a difference in biodistribution and efficacy?

(2012) Andréia Vasconcelos-dos-Santos et al.   Stem Cell Research

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

(2012) Hongqi Xin et al.   STEM CELLS

Human-Induced Pluripotent Stem Cells form Functional Neurons and Improve Recovery After Grafting in Stroke-Damaged Brain

(2012) Koichi Oki et al.   STEM CELLS

Ischemic Stroke May Activate Bone Marrow Mononuclear Cells to Enhance Recovery After Stroke

(2012) Bing Yang et al.   STEM CELLS AND DEVELOPMENT

Challenges Enrolling Patients with Acute Ischemic Stroke into Cell Therapy Trials

(2012) Farhaan S. Vahidy et al.   STEM CELLS AND DEVELOPMENT

Intra-Arterial Bone Marrow Mononuclear Cells in Ischemic Stroke

(2012) Francisco Moniche et al.   STROKE

Intravenous autologous bone marrow mononuclear cells for ischemic stroke

(2011) Sean I. Savitz et al.   ANNALS OF NEUROLOGY

Isolation of neurosphere-like bodies from an adult patient with refractory temporal lobe epilepsy

(2011) Ricardo Luiz Azevedo-Pereira et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke

(2011) O. Honmou et al.   BRAIN

Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain

(2011) Robert H. Andres et al.   BRAIN

Cell therapy for ischaemic stroke

(2011) D. C. Hess et al.   CELL PROLIFERATION

Assessing the Safety of Stem Cell Therapeutics

(2011) Chris E.P. Goldring et al.   Cell Stem Cell

Cell replacement therapies for nervous system regeneration

(2011) Guillermina López-Bendito et al.   Developmental Neurobiology

Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes angiogenesis and neurogenesis after cerebral ischemia in rats

(2011) Xinjie Bao et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Isolation and characterization of mesenchymal stem cells from human umbilical cord blood: Reevaluation of critical factors for successful isolation and high ability to proliferate and differentiate to chondrocytes as compared to mesenchymal stem cells fro

(2011) Xiaohong Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Therapeutic time window and dose response of autologous bone marrow mononuclear cells for ischemic stroke

(2011) Bing Yang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Immunogenicity of induced pluripotent stem cells

(2011) Tongbiao Zhao et al.   NATURE

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Perivascular instruction of cell genesis and fate in the adult brain

(2011) Steven A Goldman et al.   NATURE NEUROSCIENCE

Granulocyte-Colony Stimulating Factor (G-CSF) in Stroke Patients with Concomitant Vascular Disease—A Randomized Controlled Trial

(2011) Agnes Floel et al.   PLoS One

Mobilisation of Hematopoietic CD34+ Precursor Cells in Patients with Acute Stroke Is Safe - Results of an Open-Labeled Non Randomized Phase I/II Trial

(2011) Sandra Boy et al.   PLoS One

Transplanted Stem Cell-Secreted Vascular Endothelial Growth Factor Effects Poststroke Recovery, Inflammation, and Vascular Repair

(2011) Nobutaka Horie et al.   STEM CELLS

Implantation Site and Lesion Topology Determine Efficacy of a Human Neural Stem Cell Line in a Rat Model of Chronic Stroke

(2011) Edward J. Smith et al.   STEM CELLS

In Vitro Characterization of Trophic Factor Expression in Neural Precursor Cells

(2011) Gregory W.J. Hawryluk et al.   STEM CELLS AND DEVELOPMENT

Intra-Arterial Delivery of Cell Therapies for Stroke

(2011) Vivek Misra et al.   STEM CELLS AND DEVELOPMENT

Human Umbilical Mesenchymal Stem Cells Promote Recovery After Ischemic Stroke

(2011) Yu-Ching Lin et al.   STROKE

Adverse Effects of Bone Marrow Stromal Cell Treatment of Stroke in Diabetic Rats

(2011) Jieli Chen et al.   STROKE

Delayed Administration of Human Umbilical Tissue-Derived Cells Improved Neurological Functional Recovery in a Rodent Model of Focal Ischemia

(2011) Li Zhang et al.   STROKE

The CCR2/CCL2 Interaction Mediates the Transendothelial Recruitment of Intravascularly Delivered Neural Stem Cells to the Ischemic Brain

(2011) Robert H. Andres et al.   STROKE

Stem Cell Research in Stroke

(2011) Olle Lindvall et al.   STROKE

Granulocyte-Colony Stimulating Factor for Mobilizing Bone Marrow Stem Cells in Subacute Stroke

(2011) Timothy J. England et al.   STROKE

A Step-up Approach for Cell Therapy in Stroke: Translational Hurdles of Bone Marrow-Derived Stem Cells

(2011) Loren E. Glover et al.   Translational Stroke Research

The Effect of Transcatheter Injections on Cell Viability and Cytokine Release of Mononuclear Cells

(2010) R. El Khoury et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Toll-like receptor 2 mediates mesenchymal stem cell-associated myocardial recovery and VEGF production following acute ischemia-reperfusion injury

(2010) Aaron M. Abarbanell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Therapeutic time window of mesenchymal stem cells derived from bone marrow after cerebral ischemia

(2010) Katsuya Komatsu et al.   BRAIN RESEARCH

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Safety of autologous bone marrow mononuclear cell transplantation in patients with nonacute ischemic stroke

(2010) Valeria Battistella et al.   Regenerative Medicine

A Long-Term Follow-Up Study of Intravenous Autologous Mesenchymal Stem Cell Transplantation in Patients With Ischemic Stroke

(2010) Jin Soo Lee et al.   STEM CELLS

SDF-1α Secreted by Human CD133-Derived Multipotent Stromal Cells Promotes Neural Progenitor Cell Survival Through CXCR7

(2010) Benjamin Bakondi et al.   STEM CELLS AND DEVELOPMENT

AXIS

(2010) Wolf R. Schäbitz et al.   STROKE

Reperfusion Therapies for Acute Ischemic Stroke: Current Pharmacological and Mechanical Approaches

(2010) C. A. Molina   STROKE

Endothelial progenitor cell transplantation improves long-term stroke outcome in mice

(2009) Yongfeng Fan et al.   ANNALS OF NEUROLOGY

Autologous stem cell therapy for peripheral arterial disease

(2009) Gian Paolo Fadini et al.   ATHEROSCLEROSIS

Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms

(2009) Marco Bacigaluppi et al.   BRAIN

Treatment with bone marrow mononuclear cells induces functional recovery and decreases neurodegeneration after sensorimotor cortical ischemia in rats

(2009) Arthur Giraldi-Guimarães et al.   BRAIN RESEARCH

Therapeutic window for treatment of cortical ischemia with bone marrow-derived cells in rats

(2009) Andréia de Vasconcelos dos Santos et al.   BRAIN RESEARCH

Early Tissue Distribution of Bone Marrow Mononuclear Cells After Intra-Arterial Delivery in a Patient With Chronic Stroke

(2009) Lea Mirian Barbosa da Fonseca et al.   CIRCULATION

Migration and homing of bone-marrow mononuclear cells in chronic ischemic stroke after intra-arterial injection

(2009) Lea Mirian Barbosa da Fonseca et al.   EXPERIMENTAL NEUROLOGY

Autologous Bone Marrow Mononuclear Cells Enhance Recovery after Acute Ischemic Stroke in Young and Middle-Aged Rats

(2009) Miranda Brenneman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effects of Administration Route on Migration and Distribution of Neural Progenitor Cells Transplanted into Rats with Focal Cerebral Ischemia, an MRI Study

(2009) Lian Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain Injury Does Not Alter the Intrinsic Differentiation Potential of Adult Neuroblasts

(2009) F. Liu et al.   JOURNAL OF NEUROSCIENCE

Molecular and Magnetic Resonance Imaging of Human Embryonic Stem Cell–Derived Neural Stem Cell Grafts in Ischemic Rat Brain

(2009) Marcel M Daadi et al.   MOLECULAR THERAPY

Optimizing the success of cell transplantation therapy for stroke

(2009) Tonya M. Bliss et al.   NEUROBIOLOGY OF DISEASE

Chemically-Induced RAT Mesenchymal Stem Cells Adopt Molecular Properties of Neuronal-Like Cells but Do Not Have Basic Neuronal Functional Properties

(2009) Gabriela F. Barnabé et al.   PLoS One

Notch-Induced Rat and Human Bone Marrow Stromal Cell Grafts Reduce Ischemic Cell Loss and Ameliorate Behavioral Deficits in Chronic Stroke Animals

(2009) Takao Yasuhara et al.   STEM CELLS AND DEVELOPMENT

Increased Neuronal Proliferation in the Dentate Gyrus of Aged Rats Following Neural Stem Cell Implantation

(2009) Dong-Hyuk Park et al.   STEM CELLS AND DEVELOPMENT

The Postischemic Environment Differentially Impacts Teratoma or Tumor Formation After Transplantation of Human Embryonic Stem Cell-Derived Neural Progenitors

(2009) Christine Seminatore et al.   STROKE

Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease

(2009) Olle Lindvall et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

SDF-1α/CXCR4-mediated migration of systemically transplanted bone marrow stromal cells towards ischemic brain lesion in a rat model

(2008) Ye Wang et al.   BRAIN RESEARCH

Clinical Applications of Blood-Derived and Marrow-Derived Stem Cells for Nonmalignant Diseases

(2008) Richard K. Burt   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Stroke

(2008) Geoffrey A Donnan et al.   LANCET

Intra-arterial transplantation of bone marrow mononuclear cells immediately after reperfusion decreases brain injury after focal ischemia in rats

(2008) Nobuo Kamiya et al.   LIFE SCIENCES

Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses

(2008) H. Ohtaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracarotid Injection of Fluorescence Activated Cell-Sorted CD49d-Positive Neural Stem Cells Improves Targeted Cell Delivery and Behavior After Stroke in a Mouse Stroke Model

(2008) Raphael Guzman et al.   STROKE

Mechanisms Underlying Improved Recovery of Neurological Function After Stroke in the Rodent After Treatment With Neurorestorative Cell-Based Therapies

(2008) M. Chopp et al.   STROKE

Hematopoietic Stem Cells Reduce Postischemic Inflammation and Ameliorate Ischemic Brain Injury

(2008) Sönke Schwarting et al.   STROKE

Dual-Modality Monitoring of Targeted Intraarterial Delivery of Mesenchymal Stem Cells After Transient Ischemia

(2008) Piotr Walczak et al.   STROKE