Article
Cell & Tissue Engineering
Sakura Uto, Atsuhiko Hikita, Daisuke Mori, Tomoaki Sakamoto, Fumiko Yano, Shinsuke Ohba, Taku Saito, Tsuyoshi Takato, Kazuto Hoshi
Summary: Cartilage is generally considered to be immune privileged. In this study, we investigated the transplantation of allogeneic cartilage with live chondrocytes subcutaneously in mice. The results showed signs of immune reaction in allogeneic and xenogeneic transplantations, suggesting the need for careful investigation for appropriate measures to control immune reaction.
TISSUE ENGINEERING PART A
(2023)
Review
Oncology
Chiara Visintini, Irene Mansutti, Alvisa Palese
Summary: This review aims to summarize the prevalence of medication adherence (MA) among adult recipients of allogeneic hematopoietic stem cell transplantation (HSCT) and the tools used to measure it. It also examines factors affecting medication non-adherence (MNA), interventions promoting MA, and the clinical outcomes of MNA. The review found that MA is still an issue among these patients, with suboptimal prevalence rates. Subjective measures have been most commonly used to evaluate MA. Younger age, higher psychosocial risk, daily immunosuppressors, decreased concomitant therapies, and experiencing more side effects are among the factors affecting MNA. The review suggests the need for multidisciplinary care models and further research on risk factors and interventions.
Article
Multidisciplinary Sciences
Tobias Deuse, Grigol Tediashvili, Xiaomeng Hu, Alessia Gravina, Annika Tamenang, Dong Wang, Andrew Connolly, Christian Mueller, Benat Mallavia, Mark R. Looney, Malik Alawi, Lewis L. Lanier, Sonja Schrepfer
Summary: This study demonstrates that gene-edited, immune-evasive cell grafts can survive and successfully treat diseases in fully allogeneic recipients, improving conditions like critical limb ischemia, genetic A1AT deficiency, and emphysematous lung disease in mouse models. Furthermore, a mixture of endothelial cells and cardiomyocytes engrafted in infarcted mouse hearts, leading to an improvement in invasive hemodynamic heart failure parameters. The study supports the development of hypoimmune, universal regenerative cell therapeutics for cost-effective treatments of major diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Dagmara Szypulska-Koziarska, Aleksandra Wilk, Malgorzata Marchelek-Mysliwiec, Daria Sleboda-Taront, Barbara Wiszniewska
Summary: Renal transplant recipients need lifelong immunosuppressive therapy, which can affect the hormonal balance of sex hormones in both men and women. A tacrolimus-based immunosuppressive regimen may lead to hormonal imbalance that influences fertility, so careful consideration is needed when choosing the treatment plan for reproductive-age recipients.
Review
Health Care Sciences & Services
Andrea Pession, Daniele Zama, Edoardo Muratore, Davide Leardini, Davide Gori, Federica Guaraldi, Arcangelo Prete, Silvia Turroni, Patrizia Brigidi, Riccardo Masetti
Summary: FMT has been used in allo-HSCT patients for therapeutic and preventive purposes, but further research on the biological mechanisms is needed. Concerns exist regarding the safety and efficacy of administering microbial consortia in immune-compromised patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Riccardo Masetti, Daniele Zama, Davide Leardini, Edoardo Muratore, Silvia Turroni, Patrizia Brigidi, Andrea Pession
Summary: The gut microbiome plays a significant role in hematopoietic stem cell transplantation, with its metabolites mediating interactions between intestinal microbial communities and the host. New data offer a fresh perspective on the role of microbiome-derived metabolites in transplant settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mengzhu Lv, Simeng Zhang, Bo Jiang, Sunrun Cao, Yuqing Dong, Liu Cao, Shu Guo
Summary: The study demonstrated that adipose-derived stem cell therapy can delay replicative senescence and shift metabolic homeostasis, ultimately delaying the aging process by promoting mitophagy and improving mitochondrial quality in cells. The research also showed that ADSC therapy can improve aging-related symptoms and phenotypes through mitochondrial quality control, offering significant potential for future applications in aging-related diseases.
Article
Cell & Tissue Engineering
Rashin Mohseni, Pouya Mahdavi Sharif, Maryam Behfar, Mohammad Reza Modaresi, Rohola Shirzadi, Mahta Mardani, Leila Jafari, Fahimeh Jafari, Zeynab Nikfetrat, Amir Ali Hamidieh
Summary: This study aimed to assess the safety and effectiveness of adipose tissue-derived mesenchymal stem cells (AT-MSCs) for pediatric patients with bronchiolitis obliterans syndrome (BoS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The results showed that a single injection of AT-MSCs partially improved the symptoms of patients and the treatment was safe and tolerable.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell Biology
Xiaoyun Wu, Yongxu Mu, Jingyi Yao, Fuhong Lin, Daocheng Wu, Zhijie Ma
Summary: The study revealed that ADSCs from UC patients exhibited defective immunosuppression, indicating their unsuitability for autologous transplantation in treating UC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Kimberley Joanne Hatfield, Oystein Bruserud, Hakon Reikvam
Summary: This study found that the pretransplant lipid profiles can be used for the subclassification of patients and possibly identify those with an increased risk of death due to disease relapse or treatment toxicity. Therapeutic targeting of lipid metabolism should be further explored in these transplant recipients.
Article
Cell & Tissue Engineering
Chun-Wei Li, Tai-Horng Young, Mu-Hui Wang, Ming-Ying Pei, Tsung-Yu Hsieh, Chia-Lang Hsu, Nai-Chen Cheng
Summary: Our study demonstrates that a diabetic environment has an adverse effect on ASCs, and adopting a low glucose culture condition is a simple and effective way to enhance the wound healing capabilities of diabetic ASCs. This finding is valuable for the clinical application of autologous ASCs from diabetic patients.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Multidisciplinary Sciences
Yu Chiuan Wu, Guan Xuan Wu, Kuan Wei Chen, Li-Yen Shiu, Satheesh Kumar, Guei-Sheung Liu, Shyh Ming Kuo
Summary: This study demonstrates the regenerative capacity of collagen fiber-based 3D ADSC/hepatocyte spheroids in response to TAA-induced liver injury, providing a promising alternative therapeutic strategy for liver cirrhosis.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Mathieu Leclerc, Rabah Redjoul, Anne Le Bouter, Florence Beckerich, Christine Robin, Vincent Parinet, Cecile Pautas, Dehbia Menouche, Selwa Bouledroua, Lydia Roy, Ludovic Cabanne, Yakout Nait-Sidenas, Slim Fourati, Sebastien Maury
Summary: Hematopoietic stem cell transplant recipients show lower immune response to BNT162b2 mRNA vaccine after 6 months, with peak antibody levels predicting persistent protection. Immunosuppressive drugs and low lymphocyte counts correlate with lower antibody levels.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Immunology
Hideaki Fujiwara
Summary: This article discusses the impact of allo-HSCT on intestinal microbiota and metabolites, as well as the mechanisms for regulating experimental GVHD through dietary intervention or metabolites produced by intestinal bacteria post-allo-HSCT. It also summarizes the major findings of microbiome-based immunotherapeutic approaches for tissue protection against experimental GVHD. Understanding the complex relationships within the gut microbiota-metabolites-host tissues axis is crucial for insight into GVHD pathogenesis and the development of new therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Edoardo Muratore, Davide Leardini, Francesco Baccelli, Francesco Venturelli, Arcangelo Prete, Riccardo Masetti
Summary: Allogeneic hematopoietic stem cell transplantation is a potentially curative strategy, but it is associated with complications and mortality. The disruption of gut microbiota has been linked to these complications, and nutritional strategies are being considered as effective methods of modulating the gut microbiota and improving clinical outcomes.
FRONTIERS IN NUTRITION
(2022)