Review
Oncology
Sara Santagata, Caterina Ierano, Anna Maria Trotta, Anna Capiluongo, Federica Auletta, Giuseppe Guardascione, Stefania Scala
Summary: CXCR4 and CXCR7, activated by CXCL12, play a key role in promoting tumor progression and recruiting immune cells in multiple human cancers. Inhibiting these receptors may prevent tumor growth and metastasis by altering the tumor microenvironment and immune response.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell & Tissue Engineering
Mengqin Yuan, Xue Hu, Lichao Yao, Yingan Jiang, Lanjuan Li
Summary: Mesenchymal stem cell (MSC) transplantation is an effective strategy for treating end-stage liver disease by regenerating tissues and self-renewing to repair the liver. However, the low homing efficiency of MSCs after systemic administration is a major limitation in its application for liver disease treatment.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Martyna Parol-Kulczyk, Arkadiusz Gzil, Joanna Ligmanowska, Dariusz Grzanka
Summary: The tendency for chronic inflammation to convert into malignancy is a characteristic trait of tumors that promotes their progression to the metastatic stage. Inflammatory cells within the tumor communicate with cancer cells and become cells that support tumor growth. Epithelial-mesenchymal transition (EMT) is a program that allows malignant cells to switch into a metastatic form, enabling them to loosen cell-cell adhesion and enhance migratory and invasive features. Tumor cells that undergo EMT become more aggressive and resistant to apoptosis. Furthermore, malignant cells can stimulate the production of proinflammatory factors through the EMT program. Chronic inflammation is responsible for inducing EMT in malignancies. Developing tumors induce inflammatory responses by releasing cytokines, chemokines, and growth factors, which recruit populations of infiltrating immune cells to the tumor microenvironment. This inflammatory reaction potentially exerts tumor control but can also be intercepted by the tumor to stimulate its own development towards a metastatic form. Our study confirmed that the SDF-1 chemokine and its receptors, CXCR4 and CXCR7, may contribute to the initiation of metastasis formation and the EMT process.
Article
Biochemistry & Molecular Biology
Yizuo Song, Ruyi Li, Miaomiao Ye, Chunyu Pan, Lihong Zheng, Zhi-wei Wang, Xueqiong Zhu
Summary: This study found that MSCs from different tissues exhibit different chemotaxis towards cervical cancer cells, with chorion-derived MSC (CD-MSC) showing the strongest tropic capacity. The CXCL12/CXCR4 pathway was identified to contribute to the differential chemotaxis of MSCs to cervical cancer cells.
Article
Biochemistry & Molecular Biology
Yi Xu, David J. Baylink, Huynh Cao, Jeffrey Xiao, Maisa Abdalla, Samiksha Wasnik, Xiaolei Tang
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease affecting the gut. Current drugs aim to suppress inflammation but novel therapies are needed as the disease progresses. Alongside chronic gut inflammation, IBD patients also suffer from a leaky gut issue, with no current treatments to enhance intestinal stem cell regeneration and repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Huiying Shi, Chen Jiang, Hailing Yao, Yurui Zhang, Qin Zhang, Xiaohua Hou, Rong Lin
Summary: Fucosylation modification of CD44 on BMSCs enhances their homing ability to the gastrointestinal tract and promotes gastrointestinal motility and ENS remodeling in diabetic mice.
CELL AND BIOSCIENCE
(2021)
Review
Cell & Tissue Engineering
Shaoxiong Yu, Saihua Yu, Haiyan Liu, Naishun Liao, Xiaolong Liu
Summary: This review summarizes the current status and challenges of mesenchymal stem cell (MSC) transplantation for end-stage liver disease (ESLD). It highlights the importance of improving cell engraftment efficiency in enhancing MSC therapy for liver diseases.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Hematology
Marta Biondi, Sarah Tettamanti, Stefania Galimberti, Beatrice Cerina, Chiara Tomasoni, Rocco Piazza, Samantha Donsante, Simone Bido, Vincenzo Maria Perriello, Vania Broccoli, Andrea Doni, Francesco Dazzi, Alberto Mantovani, Gianpietro Dotti, Andrea Biondi, Alice Pievani, Marta Serafini
Summary: Acute myeloid leukemia (AML) is a hematological malignancy characterized by abnormal clonal proliferation and differentiation. The efficacy of chimeric antigen receptor (CAR)-T-cell therapy in AML has been hindered by factors such as poor accumulation in the leukemia bone marrow niche. Overexpression of CXCR4 in CAR-T cells may improve T-cell homing to the bone marrow and enhance their contact with AML cells, potentially increasing their therapeutic potential. In conclusion, arming CAR-T cells with CXCR4 represents a promising strategy for AML treatment.
Review
Medicine, Research & Experimental
Jianghong Huang, Qisong Liu, Jiang Xia, Xi Chen, Jianyi Xiong, Lei Yang, Yujie Liang
Summary: This article comprehensively reviews the homing effect of stem cells in joints and highlights progress towards the targeted modification of MSCs.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Long Chen, Wei Luo, Yuanzheng Wang, Xiongbo Song, Senlei Li, Jun Wu, Li Sun
Summary: This study demonstrates that glycosylation modification enhances the directional homing ability of BMSCs to bone defect sites by enabling them to express high levels of sLe(X) antigen. Results show that glycosylation-modified BMSCs can improve the repair of bone defects in mice.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Jing Fang, Qiang Ji, Siqi Gao, Zhun Xiao, Wei Liu, Yonghong Hu, Ying Lv, Gaofeng Chen, Yongping Mu, Hong Cai, Jiamei Chen, Ping Liu
Summary: This study found that the HIF-1 alpha/CXCR4/PDGF-BB/CXCR7 axis promotes the dedifferentiation of LSECs, thereby triggering the activation of HSCs and liver fibrosis.
Review
Biochemistry & Molecular Biology
Andreas S. Croft, Svenja Illien-Junger, Sibylle Grad, Julien Guerrero, Sebastian Wangler, Benjamin Gantenbein
Summary: The use of MSCs for IVD regeneration has shown significant potential in recent years, with efforts focused on utilizing their homing capabilities to repair damaged or degenerated IVDs. This review provides an overview of achievements in both preclinical and clinical applications, as well as current limitations and future perspectives in utilizing MSCs for IVD regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Ameng Shi, Ting Wang, Miao Jia, Lei Dong, Haitao Shi
Summary: The study revealed that the SDF-1/CXCR7 axis is crucial in promoting migration, invasion, and EMT in gastric cancer cells, suggesting that targeting CXCR7 suppression could be a potential strategy for inhibiting gastric cancer metastasis.
FRONTIERS IN GENETICS
(2021)
Article
Biotechnology & Applied Microbiology
Xiqiang He, Chenyan Li, Hua Yin, Xiaojun Tan, Jun Yi, Shujun Tian, Yan Wang, Jian Liu
Summary: Mesenchymal stem cells have potential therapeutic potential in the treatment of diseases due to their anti-inflammatory and immunomodulatory effects. This study explores the effects of MSCs on lung cancer cells and acute respiratory distress syndrome (ARDS) in mice, indicating that MSCs can attenuate lung injury and inhibit inflammation.
Review
Cell & Tissue Engineering
Renata Szydlak
Summary: MSCs are a population of primary and non-specialized cells that play a key role in cellular therapy and regenerative medicine. Recent findings have shed light on the mechanism of recruitment and tissue homing by MSCs, along with discussing hypotheses for how MSCs can reach target tissues.
WORLD JOURNAL OF STEM CELLS
(2021)
Article
Hematology
Mahmoudreza Taghizadeh, Mehdi Kargarfard, Steffen Braune, Friedrich Jung, Mahmood Naderi
Summary: This study found that long-term moderate-intensity aerobic training can reduce the risk of atherothrombotic events in T2DM patients by modulating the expression of miRNA-223, P2RY12, and platelet function.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2022)
Article
Materials Science, Biomaterials
Mehri Sadat Marvi, Jhamak Nourmohammadi, Maryam Ataie, Babak Negahdari, Mahmood Naderi
Summary: A bioactive nanofibrous coating containing different amounts of Equisetum arvense (EA) was successfully obtained by electrospinning process, leading to the deposition of coral-like apatite layers on titanium plates after soaking in simulated body fluid. Increasing EA content enhanced the adhesive strength and the amount of deposited apatite layer, improving the bioactivity and osteoinductivity of the titanium plates.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Negar Mozaheb, Ehsan Arefian, Amir Aliyan, Mohammad Ali Amoozegar
Summary: The study evaluated the antioxidant effectiveness of carotenoid extract from extremely halophilic archaeon Halovenus aranensis strain EB27(T). The extracted carotenoids showed strong antioxidant activity, suggesting high potential for clinical and industrial applications.
INTERNATIONAL MICROBIOLOGY
(2022)
Review
Oncology
Sara Shayan, Arash Arashkia, Kayhan Azadmanesh
Summary: Viruses rely on the machinery of host cells for replication, and factors such as cellular state and oxygen levels can influence the outcome of viral infections. In the case of oncolytic virotherapy, understanding how viruses adapt to low oxygen environments is crucial for improving treatment.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Aref Farokhi-Fard, Elham Bayat, Arezoo Beig Parikhani, Samira Komijani, Hooman Aghamirza Moghim Aliabadi, Soroush Sardari, Behrouz Gharib, Farzaneh Barkhordari, Kayhan Azadmanesh, Morteza Karimipoor, Haleh Bakhshandeh, Fatemeh Davami
Summary: This study successfully prepared a single-chain variable fragment construct against the membrane-bound isoform of human IL-1RAP, demonstrating good biological functionality, homogeneity, and stability. This soluble expression of the antibody fragment could serve as an important tool for developing new therapeutic or diagnostic methods for myeloid leukemia.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Genetics & Heredity
Amir Roointan, Alieh Gholaminejad, Behrokh Shojaie, Kelly L. Hudkins, Yousof Gheisari
Summary: This study performs a meta-analysis of miRNA profiles in LN patients to propose three panels of potential miRNA biomarkers, which could be the target of further research as therapeutic targets/biomarkers in LN disease.
MOLECULAR DIAGNOSIS & THERAPY
(2023)
Article
Multidisciplinary Sciences
Rezvan Adibi, Shiva Moein, Yousof Gheisari
Summary: Research shows that zoledronic acid (ZA) can effectively eliminate polyploid giant cancer cells (PGCCs) and alter their metabolism. This study provides a potential strategy for improving the success rate of current therapies for tumor resistance and relapse.
SCIENTIFIC REPORTS
(2023)
Review
Immunology
Somaye Sadeghi, Fahimeh Ramezani Tehrani, Safa Tahmasebi, Abbas Shafiee, Seyed Mahmoud Hashemi
Summary: Cell-derived exosomes have great potential in modern therapy for drug delivery and therapeutic applications, thanks to their unique characteristics. However, challenges including short circulation time, weak targeting capacity, and inadequate controls hinder large-scale production and clinical application.
INFLAMMOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Motaharesadat Hosseini, Andrew J. Dalley, Abbas Shafiee
Summary: This review discusses the challenges and opportunities in cell therapies for skin wound treatment and emphasizes the importance of biofabricated matrices for skin reconstruction. Emerging biofabrication technologies have the potential to create complex matrices that enhance the effectiveness of cell therapy.
Article
Pharmacology & Pharmacy
Xuping Jin, Seyed Ebrahim Alavi, Abbas Shafiee, Vania Rodrigues Leite-Silva, Kiarash Khosrotehrani, Yousuf Mohammed
Summary: The study found that the decrease in drug permeation during volatile solvent evaporation is due to increased viscosity and drug crystallization, rather than depletion of the applied dose. This study provides the necessary background for building complex models that incorporate evaporation, viscosity, and drug permeation.
Article
Cell & Tissue Engineering
Shiva Moein, Naser Ahmadbeigi, Rezvan Adibi, Sara Kamali, Kobra Moradzadeh, Pardis Nematollahi, Nance Beyer Nardi, Yousof Gheisari
Summary: Large multinucleated cells (LMCs) found in long-term culture of bone marrow mesenchymal cells play an important role in tissue regeneration and resistance to stressors. This study investigates the presence and characteristics of LMCs in native bone marrow and their role in bone marrow reconstitution following injury. The results indicate that LMCs can produce mononucleated cells that contribute to tissue repair and are associated with adipogenesis and bone marrow reconstruction.
STEM CELL RESEARCH & THERAPY
(2023)
Meeting Abstract
Cell & Tissue Engineering
Tina Frankenbach, Marietta Landgraf, Nicholas Fletcher, Christopher Howard, Akhilandeshwari Ravichandran, Dewan Akhter, Abbas Shafiee, Boris M. Holzapfel, Kristofer Thurecht, Jacqui McGovern, Dietmar W. Hutmacher
TISSUE ENGINEERING PART A
(2023)
Article
Biochemical Research Methods
Pooya Borzou, Jafar Ghaisari, Iman Izadi, Yasin Eshraghi, Yousof Gheisari
Summary: This study proposes a pipeline for the automatic construction of large-scale dynamic models, which fill the gap between large-scale static and small-scale dynamic modeling strategies. The pipeline constructs an interaction network of biomolecules, translates it into a map of biochemical reactions, generates ordinary differential equations for kinetics, and estimates the parameters using a novel method. The high performance of this pipeline is demonstrated by modeling the response of colorectal cancer cells to different chemotherapy regimens. This simulation approach allows for holistic quantitative predictions critical for precision medicine.
Article
Pharmacology & Pharmacy
Masoud Sotoudeh, Vahid Mansouri, Ramin Shakeri, Bahareh Sharififard, Nasim Sajadi, Vahid Haghpanah, Mahmood Naderi
Summary: Based on bioinformatics analysis, the study identifies MUC3A as a potential candidate for immunotherapy against gastric adenocarcinoma. Immunohistochemistry is used to measure the expression of MUC3A in primary and metastatic tumor sites of 190 patients. The study finds a positive correlation between MUC3A expression in primary and metastatic sites, with higher expression in intestinal type tumors. History of neoadjuvant therapy does not affect MUC3A expression. Higher MUC3A expression is associated with improved survival.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Chemistry, Multidisciplinary
Abbas Shafiee, Jane Sun, Imaan A. Ahmed, Felicia Phua, Gustavo R. Rossi, Cheng-Yu Lin, Fernando Souza-Fonseca-Guimaraes, Ernst J. Wolvetang, Jason Brown, Kiarash Khosrotehrani
Summary: This study successfully generated skin organoids with appendages from induced pluripotent stem cells, providing a valuable platform for researching human skin development, disease modeling, or reconstructive surgeries.