Article
Medicine, Research & Experimental
Ruhua Deng, Kai Jiang, Feng Chen, Yutong Miao, Yanqiao Lu, Fanghua Su, Jiayi Liang, Jie Qian, Dandan Wang, Yaozu Xiang, Lan Shen
Summary: Patients with acute myocardial infarction and hyperglycemia have poorer prognosis. SGLT2 inhibitors can improve myocardial injury in nondiabetic myocardial infarction with acute hyperglycemia by suppressing autophagy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Medicine, Research & Experimental
Yu-Yan Xiong, Zhao-Ting Gong, Rui-Jie Tang, Yue-Jin Yang
Summary: AMI is a leading cause of mortality globally, with inflammatory response playing a pivotal role in myocardial necrosis and ventricular remodeling. Exosomes, containing biologically active substances, have emerged as key players in immune regulation post AMI, alongside a variety of immune cells working together for tissue cleanup and repair. Research into exosomes from both endogenous immune cells and exogenous stem cells has shown promising therapeutic effects in immunomodulation for myocardial repair post AMI.
Article
Biology
Gustavo Gavazzoni Blume, Paulo Andre Bispo Machado-Junior, Rossana Baggio Simeoni, Giovana Paludo Bertinato, Murilo Sgarbossa Tonial, Seigo Nagashima, Ricardo Aurino Pinho, Lucia de Noronha, Marcia Olandoski, Katherine Athayde Teixeira de Carvalho, Julio Cesar Francisco, Luiz Cesar Guarita-Souza
Summary: The study suggests that cell-based therapies using bone marrow stem cells and human amniotic membrane can effectively improve ventricular function and volume in heart failure rat models after myocardial infarction, increasing angiogenesis and cardiomyocyte expression.
Article
Integrative & Complementary Medicine
Bing-Jing Han, Gui-Yun Cao, Li-Ying Jia, Guo Zheng, Liang Zhang, Ping Sheng, Ji-Zhen Xie, Chun-Feng Zhang
Summary: Tetrahydropalmatine (THP) may protect the myocardium by antioxidant and anti-apoptotic effects, improving cardiac function and reducing myocardial cell damage.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Carlos G. Santos-Gallego, Juan Antonio Requena-Ibanez, Belen Picatoste, Brian Fardman, Kiyotake Ishikawa, Renata Mazurek, Michael Pieper, Samantha Sartori, Jorge Rodriguez-Capitan, Valentin Fuster, Juan J. Badimon
Summary: This study investigates the cardioprotective potential of empagliflozin and ketone bodies during acute myocardial infarction. Pretreatment with empagliflozin for one week reduces ischemia reperfusion injury, MI size, microvascular obstruction, and increases myocardial salvage, while preserving left ventricle systolic function and reducing apoptosis and oxidative stress. Intravenous infusion of BOHB during myocardial ischemia also induces cardioprotection.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Endocrinology & Metabolism
Brent A. McLean, Chi Kin Wong, M. Golam Kabir, Daniel J. Drucker
Summary: GLP-1R is expressed in endocardial cells in mouse hearts and in atrial and ventricular cardiomyocytes in human hearts. The expression of GLP-1R in endothelial cells plays a cardioprotective role in the context of acute myocardial infarction. However, there is no transcriptional response of GLP-1R in the ventricular tissue after acute myocardial infarction in mice.
MOLECULAR METABOLISM
(2022)
Article
Biotechnology & Applied Microbiology
Huifeng Zheng, Xiaoting Liang, Qian Han, Zhuang Shao, Yuxiao Zhang, Linli Shi, Yimei Hong, Weifeng Li, Cong Mai, Qingwen Mo, Qingling Fu, Xiaoxue Ma, Fang Lin, Mimi Li, Bei Hu, Xin Li, Yuelin Zhang
Summary: The study demonstrates that Hemin-pretreated MSC-derived exosomes are more effective in treating myocardial infarction compared to regular MSC-derived exosomes, with exosomal miR-183-5p playing a key role in inhibiting cardiomyocyte senescence through regulation of the HMGB1/ERK pathway.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Cell Biology
Rafael Sanchez-Sanchez, Marta Gomez-Ferrer, Ignacio Reinal, Marc Buigues, Estela Villanueva-Badenas, Imelda Ontoria-Oviedo, Amparo Hernandiz, Hernan Gonzalez-King, Esteban Peiro-Molina, Akaitz Dorronsoro, Pilar Sepulveda
Summary: Extracellular vesicles derived from mesenchymal stromal cells (MSCs) and containing miR-4732-3p microRNA show potential for cardioprotection, with miR-4732-3p being regulated by hypoxia and exerting protective actions against ischemic insult.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Miriam M. Cortese-Krott, Tatsiana Suvorava, Francesca Leo, Sophia K. Heuser, Anthea LoBue, Junjie Li, Stefanie Becher, Rebekka Schneckmann, Tanu Srivrastava, Ralf Erkens, Georg Wolff, Joachim P. Schmitt, Maria Grandoch, Jon O. Lundberg, John Pernow, Brant E. Isakson, Eddie Weitzberg, Malte Kelm
Summary: This study reveals that red blood cell endothelial nitric oxide synthase (RBC eNOS) plays a role in limiting infarct size in acute myocardial infarction (AMI) and regulates coronary blood flow and cardiac function. These findings suggest that RBC eNOS signaling may represent a novel target for interventions in ischemia/reperfusion after myocardial infarction.
Article
Biochemistry & Molecular Biology
Tzu-Jou Chen, Yen-Ting Yeh, Fu-Shiang Peng, Ai-Hsien Li, Shinn-Chih Wu
Summary: The study demonstrates that S100A8/A9 enhances the paracrine therapeutic effects of hAMSCs after myocardial infarction, leading to superior anti-inflammatory, anti-fibrotic, and cardiac function preservation outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yushi Abe, Daigo Ochiai, Masako Taguchi, Seiji Kanzaki, Satoru Ikenoue, Yoshifumi Kasuga, Mamoru Tanaka
Summary: Human amniotic fluid stem cells (hAFSCs) can form aggregates with host immune cells and alleviate inflammation. Additionally, hAFSCs can increase regulatory T cells in the acquired immune system. Therefore, hAFSCs play an important role in the treatment of inflammation-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Boda Zhou, Min Xiao, Hao Hu, Xiaoxia Pei, Yajun Xue, Guobin Miao, Jifeng Wang, Wanqi Li, Yipeng Du, Ping Zhang, Taotao Wei
Summary: This study found that SIRT5 may have a cardioprotective effect in response to acute myocardial infarction, possibly through a liver-cardiac crosstalk mechanism, most likely by increasing the secretion of FGF21 and improving energy metabolism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katharina Feige, Janine Rubbert, Annika Raupach, Martin Stroethoff, Andre Heinen, Markus W. Hollmann, Ragnar Huhn, Carolin Torregroza
Summary: Mannitol can induce myocardial infarct size reduction through both preconditioning and postconditioning pathways, providing cardioprotection via activation of mK(ATP) channels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yi-Qing Zhang, Lu Hong, Yu-Feng Jiang, Sheng-Da Hu, Nan-Nan Zhang, Lang-Biao Xu, Hong-Xia Li, Gui-Dong Xu, Ya-Feng Zhou, Kang-Yun Sun
Summary: The study found that hAECs and their exosomes can improve cardiac function in rats with AMI by promoting angiogenesis and reducing apoptosis of cardiac myocytes, as evidenced by improved heart function and reduced tissue fibrosis.
Article
Cell Biology
Francesca Casciaro, Silvia Zia, Mattia Forcato, Manuela Zavatti, Francesca Beretti, Emma Bertucci, Andrea Zattoni, Pierluigi Reschiglian, Francesco Alviano, Laura Bonsi, Matilde Yung Follo, Marco Demaria, Barbara Roda, Tullia Maraldi
Summary: This study utilized Celector® technology to classify and characterize hAFSCs, uncovering deep intra-population differences and validating their impact on stemness properties. The results suggest the importance of selecting cellular fractions with the highest potential for use in regenerative medicine.
Article
Cardiac & Cardiovascular Systems
Juan Tang, Huan Zhu, Xueying Tian, Haixiao Wang, Shaoyan Liu, Kuo Liu, Huan Zhao, Lingjuan He, Xiuzhen Huang, Zhao Feng, Zhangheng Ding, Ben Long, Yan Yan, Nicola Smart, Hui Gong, Qingming Luo, Bin Zhou
Summary: A subset of intramyocardial coronary arteries form in the neonatal heart through angiogenic extension of endocardium-derived vascular tunnels, which persist into adulthood and play a protective role after myocardial infarction.
CIRCULATION RESEARCH
(2022)
Article
Ophthalmology
Sunil Mamtora, Oliver Riley, Jordan Chervenkoff, Panayiotis Maghsoudlou, Asif Kiani, Alexander Chiu, Jonathan Boulton, Jonathan Luck
Summary: This study demonstrates that a low-cost smartphone lens attachment and standardized clinical questionnaire can improve the referral pathway in eye casualty clinics by reducing unnecessary appointments, improving clinical confidence, and increasing diagnostic accuracy during triage.
Article
Biochemical Research Methods
Laween Meran, Lucinda Tullie, Simon Eaton, Paolo De Coppi, Vivian S. W. Li
Summary: The authors present a protocol for bioengineering human intestinal mucosal grafts using patient-derived materials. This technology has significant potential for treating intestinal failure and studying human gastrointestinal diseases.
Review
Biotechnology & Applied Microbiology
Michela Pozzobon, Stefania D'Agostino, Maria G. G. Roubelakis, Anna Cargnoni, Roberto Gramignoli, Susanne Wolbank, Florelle Gindraux, Sveva Bollini, Halima Kerdjoudj, Mathilde Fenelon, Roberta Di Pietro, Mariangela Basile, Veronika Borutinskaite, Roberta Piva, Andreina Schoeberlein, Guenther Eissner, Bernd Giebel, Peter Ponsaerts
Summary: Perinatal tissues contain various types of stem cells that have the potential for regenerative therapies. This review summarizes the therapeutic approaches using perinatal derivatives (PnD) products and discusses the importance of validating their therapeutic efficacy and the concept of PnD application in tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Immunology
Sonali Munshaw, Andia N. Redpath, Benjamin T. Pike, Nicola Smart
Summary: In a hypercholesterolemic model, knockout of the T beta 4 gene exacerbates atherosclerotic lesions, induces phenotypic changes in vascular smooth muscle cells, and is associated with hyperactivation of the low density lipoprotein receptor-related protein 1 (LRP1)-mediated growth factor signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Maria Peppa, Bianca L. De Stavola, Stavros Loukogeorgakis, Ania Zylbersztejn, Ruth Gilbert, Paolo De Coppi
Summary: This study utilized national birth cohort data in England to compare the birth prevalence, relationship with maternal age, and 1-year mortality rates of different subtypes of congenital diaphragmatic hernia (CDH). The results showed that the risk of complex CDH was associated with maternal age, and the 1-year mortality rate for complex CDH was slightly higher than for isolated CDH.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Letter
Cell Biology
Mingjun Zhang, Wenjuan Pu, Jie Li, Maoying Han, Ximeng Han, Zhenqian Zhang, Zan Lv, Nicola Smart, Lixin Wang, Bin Zhou
Article
Pediatrics
Cunera M. C. de Beaufort, Dalia Aminoff, Ivo de Blaauw, Celia Cretolle, Jens Dingemann, Natalie Durkin, Wout F. J. Feitz, JoAnne Fruithof, Caterina Grano, Carmen Mesas Burgos, Nicole Schwarzer, Graham Slater, Tutku Soyer, Cristiano Violani, Rene Wijnen, Paolo de Coppi, Ramon R. Gorter
Summary: The aim of this international study was to assess the current status of transition of care (TOC) and adult care (AC) programs for patients with anorectal malformations (ARM) and Hirschsprung disease (HD). The results showed that less than 50% of the participating centers had installed these programs, and there was considerable heterogeneity in the content and implementation of the programs. Sharing best practice examples and considering local and national healthcare programs may improve the continuity of care in the future.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Acoustics
S. Vergote, F. R. De Bie, J. M. N. Duffy, J. Bosteels, A. Benachi, B. Power, F. Meijer, H. L. Hedrick, C. J. Fernandes, I. K. M. Reiss, P. De Coppi, K. P. Lally, J. A. Deprest
Summary: A core outcome set for evaluating perinatal interventions in congenital diaphragmatic hernia was developed with the input of stakeholders, standardizing the selection and definition of outcomes and facilitating future research to guide clinical practice.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Multidisciplinary Sciences
Anna Urciuolo, Giovanni Giuseppe Giobbe, Yixiao Dong, Federica Michielin, Luca Brandolino, Michael Magnussen, Onelia Gagliano, Giulia Selmin, Valentina Scattolini, Paolo Raffa, Paola Caccin, Soichi Shibuya, Dominic Scaglioni, Xuechun Wang, Ju Qu, Marko Nikolic, Marco Montagner, Gabriel L. Galea, Hans Clevers, Monica Giomo, Paolo De Coppi, Nicola Elvassore
Summary: This study develops a hydrogel-in-hydrogel bioprinting approach to dynamically control the growth landscape of three-dimensional cell cultures. The technique enables modulation of hydrogel characteristics to guide neural axon directionality, control cell migration in cancer organoids, and promote cell polarity in liver and small intestinal organoids, as well as control lung tip bifurcation.
NATURE COMMUNICATIONS
(2023)
Correction
Cell Biology
Mingjun Zhang, Wenjuan Pu, Jie Li, Maoying Han, Ximeng Han, Zhenqian Zhang, Zan Lv, Nicola Smart, Lixin Wang, Bin Zhou
Article
Pediatrics
Amulya Saxena, Annika Mutanen, Ramon Gorter, Andrea Conforti, Pietro Bagolan, Paolo De Coppi, Tutku Soyer
Summary: This study reviewed the literature on the management of neonatal ovarian simple cysts and formulated a consensus statement based on current evidence and peer practice. Although there is limited data on the potential benefits and complications of prenatal ultrasound-guided aspiration, neonates after such procedures should be followed for 6 months. Neonates with simple ovarian cysts larger than 4 cm should undergo surgical interventions within the first two weeks of life, with laparoscopic cyst aspiration and fenestration using bipolar instruments as the preferred approach. Ultrasound follow-up should be done at 3 months after surgical intervention and every 3 to 4 months with the conservative approach until 1 year.
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2023)
Review
Biotechnology & Applied Microbiology
Giada Benedetti, Beatriz Fournon Berodia, Paolo De Coppi, Giovanni Giuseppe Giobbe
Summary: Gastrointestinal organ failure is a leading cause of death globally, and the engineering of human organoids in the gastrointestinal tract shows promising potential for personalized and regenerative medicine.
FRONTIERS IN CHEMICAL ENGINEERING
(2023)
Article
Physiology
Ian R. McCracken, Andrew H. Baker, Nicola Smart, Sarah De Val
Summary: The vascular network of arteries, veins, and capillaries is complex and hierarchical, with considerable endothelial heterogeneity. However, the pathways regulating arteriovenous specification, differentiation, and identity are still not fully understood. Recent advances in analysis of endothelial-specific gene-regulatory elements, single-cell RNA sequencing, and cell lineage tracing have shed light on the transcriptional regulation and mechanism of specification within the endothelium. This review discusses the recent understanding of how endothelial cells acquire arterial and venous identity and the role of different transcription factors in this process.
CURRENT OPINION IN PHYSIOLOGY
(2023)
Review
Ophthalmology
P. Maghsoudlou, A. R. Abraham, M. El-Ashry, C. Chew, N. Mohd, A. V. Ramanan, A. D. Dick
Summary: This review examines the clinical features of monogenic autoinflammatory syndromes (MAISs), with a special focus on uveitis. It evaluates treatment options and assesses the effects of activating molecular and cytokine pathways.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)