Article
Chemistry, Medicinal
Raef Shams, Akihiro Matsukawa, Yukari Ochi, Yoshihiro Ito, Hideyuki Miyatake
Summary: This study reports a novel nonrapalog inhibitor, WRX606, which efficiently inhibits tumor growth without promoting metastasis by forming a ternary complex with mTOR protein. This finding provides important insights for the development of more effective anticancer drugs.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Polymer Science
Jyorthana Rajappa Muralidhar, Koichi Kodama, Takuji Hirose, Yoshihiro Ito, Masuki Kawamoto
Summary: The introduction of a photocleavable coumarin unit into a polythiophene derivative allowed for controlled changes in the chemical and surface properties of the polymer, opening up new possibilities for the fabrication of optoelectronic devices.
Article
Polymer Science
Mahmoud H. Othman, Yoshihiro Ito, Jun Akimoto
Summary: In this study, water-soluble and highly antibiofouling polymers were synthesized and immobilized on polystyrene surfaces via photoirradiation. These polymers showed excellent solubility in water and suppressed nonspecific interactions between proteins and cells on the substrate, making them useful for biomaterial preparation.
Article
Materials Science, Biomaterials
Liang-Chun Wu, Seiichi Tada, Takashi Isoshima, Takeshi Serizawa, Yoshihiro Ito
Summary: Photo-reactive polymers are essential for biomaterials and have been employed for immobilizing growth factors. Different types of photo-reactive polymers were synthesized and their properties were analyzed. The study found that cell adhesion was influenced by the nature of photo-reactive polymers, while cell growth depended on the amount of immobilized growth factors and the properties of photo-reactive polymers.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Genetics & Heredity
Gokul Gopinathan, Xinmin Zhang, Xianghong Luan, Thomas G. H. Diekwisch
Summary: In this study, the epigenetic events that limit HOX gene expression in craniofacial tissues were investigated. High levels of repressive H3K27me3 marks were found on the HOX gene promoters in undifferentiated neural crest cells, while the ratio of K4/K27 marks was less repressive in differentiated odontogenic progenitors and other craniofacial tissues. The elevated levels of HOX genes, especially those from the HOXA and HOXB clusters, were found in alveolar bone cells. The induction of HOX expression in craniofacial neural crest cells resulted in decreased mineralization markers and promoting HOX gene expression in developing teeth led to increased patterning events and gene expression.
Article
Genetics & Heredity
Gokul Gopinathan, Xianghong Luan, Thomas G. H. Diekwisch
Summary: The nonmineralized state of the mammalian periodontal ligament is controlled by an epigenetic regulation of the RUNX2 and OSX key mineralization gene promoters.
Article
Chemistry, Analytical
Ren-Qi Wang, Ye Geng, Juan-Na Song, Huai-Dong Yu, Kai Bao, Yu-Ru Wang, Jean-Philippe Croue, Hideyuki Miyatake, Yoshihiro Ito, Yan-Ru Liu, Yong-Mei Chen
Summary: This study develops a biogenic solution map based on a 4D fingerprinting method to accurately discriminate and classify unknown species. It allows visualization of the similarities and disparities in molecular compositions of biogenic solutions, as well as the intrinsic correlations and subtle variations among them.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Osama R. M. Metawea, Miyuki Nara, Takeharu Murakami, Satoshi Wada, Katsushi Fujii, Yoshihiro Ito, Masuki Kawamoto
Summary: A highly efficient single-walled carbon nanotube electrocatalyst, loaded with platinum nanoparticles using a newly developed suspension method, exhibits low overpotential for hydrogen evolution and shows high mass activity in a PEM electrolyzer.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Jyorthana Rajappa Muralidhar, Krishnachary Salikolimi, Kiyohiro Adachi, Daisuke Hashizume, Koichi Kodama, Takuji Hirose, Yoshihiro Ito, Masuki Kawamoto
Summary: We report an organic-inorganic halide perovskite compound that can chemically store ammonia through dynamic structural transformation. This compound undergoes a chemical structure change from a one-dimensional columnar structure to a two-dimensional layered structure upon NH3 uptake through addition reaction. The estimated NH3 uptake is 10.2 mmol g(-1) at 1 bar and 25℃. NH3 extraction can be performed by a condensation reaction at 50℃ under vacuum. X-ray diffraction analysis reveals that reversible NH3 uptake/extraction originates from a cation/anion exchange reaction. These findings demonstrate the potential of integrating efficient uptake and extraction in a hybrid perovskite compound through chemical reaction, paving the way for further exploration of dynamic and reversible compounds for chemical storage of NH3.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Nanoscience & Nanotechnology
Osama R. M. Metawea, Miyuki Nara, Takeharu Murakami, Hirotaka Okabe, Naoki Matsuda, Satoshi Wada, Katsushi Fujii, Yoshihiro Ito, Masuki Kawamoto
Summary: Proton exchange membrane (PEM) water electrolysis is a promising method for clean hydrogen production. A new approach using aqueous-dispersed PtNPs as a dispersant for carbon nanomaterials (CNMs) is reported, resulting in efficient PtNP/CNM composites. The PtNP/SWCNT nanocomposite exhibits a mass activity of 89,300 A g(Pt) (-1), 270 times higher than that of Pt/C.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Avanashiappan Nandakumar, Yoshihiro Ito, Motoki Ueda
Summary: A disulfide-tethered peptide-lipid conjugate can self-assemble into a homogeneously distributed peptide-lipid hybrid vesicle. Treatment with dithiothreitol causes the homogeneous peptide-lipid membrane to spontaneously separate into lipid-rich and peptide-rich domains, while the vesicle remains unchanged in size and shape. Membrane phase separation enhances temperature-dependent cargo release.
CHEMICAL COMMUNICATIONS
(2023)
Article
Materials Science, Biomaterials
Mohamed S. S. Elafify, Toru Itagaki, Nermeen A. A. Elkasabgy, Sinar Sayed, Yoshihiro Ito, Motoki Ueda
Summary: The development of stimuli-responsive transformable biomaterials can be effectively controlled by adjusting the molecular design of their structural segments. In this study, we demonstrate a peptide assembly that exhibits morphological transformations between hydrophilic and hydrophobic morphologies. The hydrophobic α-helical unit precisely controls the packing and induces the formation of tubules in the assembly. By analyzing membrane fluidity and the surrounding environment of the assembly, we clarify that the vesicle is kinetically stable while the nanotube is thermodynamically stable.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Biomaterials
Kun Fang, Stefan Muller, Motoki Ueda, Yasuhiro Nakagawa, Katsuko Furukawa, Takashi Ushida, Toshiyuki Ikoma, Yoshihiro Ito
Summary: Fibroblasts confined by gelatin micropatterns and subjected to cyclic stretch showed significant changes in cell morphology. Non-patterned cells exhibited increasing length and decreasing area under the stretch. The width of the micropatterns provided different contact guidance for fibroblasts, resulting in varied cell behaviors under cyclic stretch. Vertical stretch induced a greater increase in cell area and length compared to parallel stretch. These findings provide insights into cell behaviors under geometrical confinement in a dynamic biomechanical environment and can guide biomaterial design for tissue engineering.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Materials Science, Biomaterials
Xiaoyu Guan, Bingyuan Zhang, Zequn Wang, Qingxin Han, Meng An, Motoki Ueda, Yoshihiro Ito
Summary: Tannins, natural plant polyphenols, are widely used in various fields, especially in biomedical applications. However, their water solubility limits their use in specific applications, making separation and regeneration difficult. Tannin-immobilized composites, inspired by composite materials, combine the advantages of each component, allowing for expanded applications in different fields.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Md Mofizur Rahman, Mohammed A. Abosheasha, Yoshihiro Ito, Motoki Ueda
Summary: Peptide-lipid hybrid vesicles were prepared by incorporating complementary DNA strands in their lipid domains. Controlled fusion of the vesicles was induced through hybridization of the complementary DNA strands during repeated heating and cooling cycles. The decrease in Forster resonance energy transfer efficiency and transmission electron microscopy analysis confirmed the presence of vesicle fusion. This approach provides a general strategy for the creation of polymersomes with membrane-fusion functionality.
CHEMICAL COMMUNICATIONS
(2022)