Do Cryopreserved Mesenchymal Stromal Cells Display Impaired Immunomodulatory and Therapeutic Properties?

Mesenchymal stem cells: immune evasive, not immune privileged

(2014) James A Ankrum et al.   NATURE BIOTECHNOLOGY

Do ABO Blood Group Antigens Hamper the Therapeutic Efficacy of Mesenchymal Stromal Cells?

(2014) Guido Moll et al.   PLoS One

Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolism

(2013) Kohei Tatsumi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autologous and allogeneic mesenchymal stem cells in organ transplantation

(2013) Senthilkumar Alagesan et al.   Current Opinion in Organ Transplantation

Duration of in vitro storage affects the key stem cell features of human bone marrow-derived mesenchymal stromal cells for clinical transplantation

(2013) Hoon Sang Sohn et al.   CYTOTHERAPY

The mesenchymal stromal cells dilemma—does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?

(2013) Jacques Galipeau   CYTOTHERAPY

Regulation of stem cell therapies under attack in Europe: for whom the bell tolls

(2013) Paolo Bianco et al.   EMBO JOURNAL

Study of the stability of packaging and storage conditions of human mesenchymal stem cell for intra-arterial clinical application in patient with critical limb ischemia

(2013) Patricia Gálvez-Martín et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine

(2013) Paolo Bianco et al.   NATURE MEDICINE

Mesenchymal Stem Cells Engineered to Inhibit Complement-Mediated Damage

(2013) Melisa A. Soland et al.   PLoS One

Safety and efficacy of intravenous infusion of allogeneic cryopreserved mesenchymal stem cells for treatment of chronic kidney disease in cats: results of three sequential pilot studies

(2013) Jessica M Quimby et al.   Stem Cell Research & Therapy

Mesenchymal stem cells are injured by complement after their contact with serum

(2012) Y. Li et al.   BLOOD

Bivalirudin in Combination with Heparin to Control Mesenchymal Cell Procoagulant Activity

(2012) Xavier Stephenne et al.   PLoS One

Are Therapeutic Human Mesenchymal Stromal Cells Compatible with Human Blood?

(2012) Guido Moll et al.   STEM CELLS

Analysis of Tissues Following Mesenchymal Stromal Cell Therapy in Humans Indicates Limited Long-Term Engraftment and No Ectopic Tissue Formation

(2012) L. von Bahr et al.   STEM CELLS

Mesenchymal Stem Cells: Mechanisms of Inflammation

(2011) Nora G. Singer et al.   Annual Review of Pathology-Mechanisms of Disease

Long-Term Complications, Immunologic Effects, and Role of Passage for Outcome in Mesenchymal Stromal Cell Therapy

(2011) Lena von Bahr et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Tissue-Engineered Airway: A Regenerative Solution

(2011) P Jungebluth et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-γ licensing

(2011) Moïra François et al.   CYTOTHERAPY

Mesenchymal Stromal Cells Engage Complement and Complement Receptor Bearing Innate Effector Cells to Modulate Immune Responses

(2011) Guido Moll et al.   PLoS One

Oral Mucosal Progenitor Cells Are Potently Immunosuppressive in a Dose-Independent Manner

(2011) Lindsay C. Davies et al.   STEM CELLS AND DEVELOPMENT

Therapeutic Applications of Mesenchymal Stromal Cells: Paracrine Effects and Potential Improvements

(2011) Joyce Doorn et al.   TISSUE ENGINEERING PART B-REVIEWS

Evaluation of Bone Marrow-Derived Mesenchymal Stem Cells After Cryopreservation and Hypothermic Storage in Clinically Safe Medium

(2011) Irene Ginis et al.   TISSUE ENGINEERING PART C-METHODS

Intravenous apoptotic cell infusion as a cell-based therapy toward improving hematopoietic cell transplantation outcome

(2010) Philippe Saas et al.   Annals of the New York Academy of Sciences

What do we mean when we write “senescence,”“apoptosis,”“necrosis,” or “clearance of dying cells”?

(2010) Dror Mevorach et al.   Annals of the New York Academy of Sciences

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Mesenchymal stem cell therapy: Two steps forward, one step back

(2010) James Ankrum et al.   TRENDS IN MOLECULAR MEDICINE

Properdin: Emerging Roles of a Pattern-Recognition Molecule

(2009) Claudia Kemper et al.   Annual Review of Immunology

Optimizing in vitro conditions for immunomodulation and expansion of mesenchymal stromal cells

(2009) H. Samuelsson et al.   CYTOTHERAPY

Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition?

(2009) Bo Nilsson et al.   TRENDS IN IMMUNOLOGY

Effect of holding time, temperature and different parenteral solutions on viability and functionality of adult bone marrow-derived mesenchymal stem cells before transplantation

(2008) Rakhi Pal et al.   Journal of Tissue Engineering and Regenerative Medicine

Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study

(2008) Katarina Le Blanc et al.   LANCET