期刊
STEM CELLS
卷 32, 期 4, 页码 852-859出版社
WILEY
DOI: 10.1002/stem.1621
关键词
Niche physiology; Stem cell niche; Tissue repairAging; Tissue homeostasis
资金
- Spanish Ministerio de Economia y Competitividad and the FEDER program [BMC2012-35446]
- Junta de Andalucia (Proyecto de Excelencia) [P09-CVI-5058]
- CONSOLIDER program [CSD-2007-00008]
- I3P-CSIC studentship
Stem cell activity is tightly regulated during development and in adult tissues through the combined action of local and systemic effectors. While stem cells and their microenvironments are capable of sustaining homeostasis in normal physiological circumstances, they also provide host tissues with a remarkable plasticity to respond to perturbations. Here, we review recent discoveries that shed light on the adaptive response of niches to systemic signals and aging, and on the ability of niches to modulate signaling upon local perturbations. These characteristics of stem cells and their niches give organs an essential advantage to deal with aging, injury or pathological conditions. Stem Cells 2014;32:852-859
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