Article
Cell Biology
Fan Yang, Eoin C. Whelan, Xuebing Guan, Bingquan Deng, Shu Wang, Jiachen Sun, Mary R. Avarbock, Xin Wu, Ralph L. Brinster
Summary: Overexpression of Fgf9 in vivo results in arrested spermatogenesis and accumulation of undifferentiated spermatogonia; exposure of germ cell cultures to FGF9 leads to increased numbers of SSCs over time; inhibition of p38 MAPK phosphorylation negates the growth advantage provided by FGF9.
CELL PROLIFERATION
(2021)
Review
Chemistry, Medicinal
Fatemeh Meshkini, Nahid Ramezani-Jolfaie, Saman Sargazi, Cain C. T. Clark, Sepideh Soltani
Summary: A systematic review of the effects of lycopene on circulating IGF-1 and IGFBPs in adults found no consistent modifying effect of lycopene supplementation on IGF-1 and IGFBP levels. More research is needed to explore the effect of lycopene on the IGF-1 system.
PHYTOTHERAPY RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Nobukatsu Horita, Theresa M. Keeley, Elise S. Hibdon, Elizabeth Delgado, Daniel Lafkas, Christian W. Siebel, Linda C. Samuelson
Summary: This study identified specific Notch ligands and Niche cells that regulate stem cell proliferation in the distal mouse stomach. DLL1 was found to be the key Notch ligand that regulates epithelial cell proliferation in the gastric antrum.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medical Laboratory Technology
Jason K. Y. Lee, Kendall Cradic, Ravinder J. Singh, JoAnna Jones, Jieli Li
Summary: This study compared the measurement of IGF-1 on four different platforms and found significant variations between them. These variations should be considered when managing patients with pituitary disorders.
CLINICA CHIMICA ACTA
(2023)
Article
Hematology
Sarah Weischendorff, Henrik Sengelov, Anders Juul, Claus H. Nielsen, Lars P. Ryder, Katrine Kielsen, Klaus Mueller
Summary: The study found that high levels of IGF-1 and IGFBP-3 are associated with faster reconstitution of different blood cell populations after HSCT, including reticulocytes, thrombocytes, lymphocytes, neutrophil engraftment time, and circulating natural killer cells.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2022)
Article
Cell Biology
Charmaine J. Green, Miriam Span, Monique H. Rayhanna, Marisa Perera, Margot L. Day
Summary: The viability of embryos cultured in vitro is poor compared to those that develop in vivo. This study investigated the role of autocrine and exogenous IGFBP3 in mouse preimplantation embryos. Addition of exogenous IGFBP3 to embryo culture media increased the rate of development, and the effect was mediated by IGF1 and EGF receptors. Acute exposure to IGFBP3 activated the PI3-kinase/Akt pathway to promote cell proliferation and survival. Therefore, addition of IGFBP3 to IVF culture media should be considered.
Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Article
Medicine, Research & Experimental
Wang Wu, Wei Zhou, Jingwei Jiang, Mengyue Wang, Jinwei Zhang, Jing Yang, Qu Tang, Huawen Liu, Deming Liu, Wei Xu, Julia Li Zhong, Li Yang, Mingxing Lei
Summary: Mechanical stimulus induces hair regeneration by enhancing cell multipotency in the microenvironment. Skin cells harvested from post-plucking day 3 show the best self-organizing ability and highest hair regeneration. The chemokine signaling pathway, including CCL2, is significantly increased in these cells and plays a role in immune regulation of hair regeneration.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Review
Biochemistry & Molecular Biology
Julian Bailes, Mikhail Soloviev
Summary: IGF-1, the principal mediator of GH, plays a crucial role in cell growth, differentiation, and apoptosis, with its bioavailability affected by IGFBPs. The varying expression levels of IGF-1 in clinical conditions and its misuse in sports have raised significant concerns.
Article
Geriatrics & Gerontology
Hiroyasu Sakai, Maho Asami, Hiroaki Naito, Satoko Kitora, Yuta Suzuki, Yu Miyauchi, Rei Tachinooka, Satoshi Yoshida, Risako Kon, Nobutomo Ikarashi, Yoshihiko Chiba, Junzo Kamei
Summary: Exogenous recombinant human IGF-1 attenuated cisplatin-induced muscle atrophy by restoring IGF-1/PI3K/Akt signaling pathway activity, inhibiting muscle protein degradation, and reducing muscle atrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Immunology
Rianne Nederlof, Sophia Reidel, Andre Spychala, Stefanie Goedecke, Andre Heinen, Tobias Lautwein, Patrick Petzsch, Karl Koehrer, Axel Goedecke
Summary: IGF1 treatment induces an anti-inflammatory phenotype in bone marrow derived neutrophils and attenuates inflammation after myocardial infarction (MI). The effect of IGF1 is mediated through the JAK2/STAT6 pathway rather than the canonical Ras/Raf/ERK or PI3K/AKT pathway. Single cell sequencing analysis shows that IGF1 treatment downregulates pro-inflammatory genes and upregulates anti-inflammatory genes in neutrophils and macrophages after MI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Lianlian Wu, Ying Qin, Honghua Yuan, Yuhua Zhu, Ankang Hu
Summary: Overexpression of insulin-like growth factor-1 (IGF-1) demonstrates long-term anti-epileptogenic effects in a mouse model of chronic epilepsy, reducing the severity of epilepsy and mitigating inflammation in the hippocampus. IGF-1 also promotes long-term neurogenesis.
Article
Endocrinology & Metabolism
In-Ho Jung, Seonah Choi, Cheol Ryong Ku, Sang-Guk Lee, Eun Jig Lee, Sun Ho Kim, Eui Hyun Kim
Summary: This study evaluated the reliability of IGF-1 levels as an alternative for disease monitoring after surgical treatment of acromegaly. The results showed that IGF-1 levels can serve as a reliable alternative to OGTT and play a valuable role in monitoring acromegaly status.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Behavioral Sciences
Ana V. Pejcic, Slobodan M. Jankovic, Vladimir Janjic, Milan Djordjic, Jovana Z. Milosavljevic, Milos N. Milosavljevic
Summary: Schizophrenia patients under antipsychotic treatment appear to have lower peripheral IGF-1 levels compared to healthy controls. Additional studies with larger and more homogenous samples are needed to confirm these findings.
BRAIN AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Xiaobing Jiang, Greice Lubini, Jose Hernandes-Lopes, Kim Rijnsburger, Vera Veltkamp, Ruud A. de Maagd, Gerco C. Angenent, Marian Bemer
Summary: Tomato FUL-like genes FUL2 and MADS-BOX PROTEIN 20 (MBP20) promote the transition from vegetative to reproductive state and repress inflorescence branching by inducing floral meristem maturation. The control of inflorescence branching may be regulated by repression of transcription factors such as TOMATO MADS-box gene 3 (TM3) and APETALA 2b (AP2b). The tomato FUL-like proteins can form heterodimers with various MADS-domain proteins, potentially forming distinct complexes to regulate flowering time and inflorescence architecture.
Article
Oncology
Silvia Belluti, Valentina Semeghini, Giovanna Rigillo, Mirko Ronzio, Daniela Benati, Federica Torricelli, Luca Reggiani Bonetti, Gianluca Carnevale, Giulia Grisendi, Alessia Ciarrocchi, Massimo Dominici, Alessandra Recchia, Diletta Dolfini, Carol Imbriano
Summary: The regulation of NF-YA isoforms plays a crucial role in the progression and aggressiveness of prostate cancer, with elevated levels of NF-YAs associated with malignancy. NF-YAI overexpression increases cell motility, while NF-YAs enhances cell proliferation. The transcriptome of NF-YAs-spheroids shows extensive overlap with localized and metastatic prostate cancer profiles.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Giulia Golinelli, Giulia Grisendi, Massimiliano Dall'Ora, Giulia Casari, Carlotta Spano, Rebecca Talami, Federico Banchelli, Malvina Prapa, Chiara Chiavelli, Filippo Rossignoli, Olivia Candini, Roberto D'Amico, Milena Nasi, Andrea Cossarizza, Livio Casarini, Massimo Dominici
Summary: The study demonstrates that bi-functional MSCs expressing TRAIL and GD2 tCAR can effectively target and kill ES tumor cells, showing good efficacy in targeting and eliminating ES in the lungs but not in the liver.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Cell & Tissue Engineering
Valentina Masciale, Federico Banchelli, Giulia Grisendi, Roberto D'Amico, Antonino Maiorana, Alessandro Stefani, Uliano Morandi, Franco Stella, Massimo Dominici, Beatrice Aramini
Summary: This study assessed the relationship between cancer stem cells (CSCs) and relapse rates in patients with adenocarcinoma (ADL) and squamous cell carcinoma of the lung (SCCL). The results showed no association between CSCs and relapse rates in early-stage patients, but a positive correlation was observed in locally advanced patients.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Sofia Avnet, Silvia Lemma, Margherita Cortini, Gemma Di Pompo, Francesca Perut, Maria Veronica Lipreri, Laura Roncuzzi, Marta Columbaro, Costantino Errani, Alessandra Longhi, Nicoletta Zini, Dominique Heymann, Massimo Dominici, Giulia Grisendi, Giulia Golinelli, Lorena Consolino, Dario Livio Longo, Cristina Nanni, Alberto Righi, Nicola Baldini
Summary: The study validated the correlation between tumor glycolysis/acidosis and metastasis, and investigated the role of acidity-induced inflammation in the development of metastasis in osteosarcoma.
Review
Oncology
Beatrice Aramini, Valentina Masciale, Giulia Grisendi, Federica Bertolini, Michela Maur, Giorgia Guaitoli, Isca Chrystel, Uliano Morandi, Franco Stella, Massimo Dominici, Khawaja Husnain Haider
Summary: Cancer stem cells (CSCs) play a crucial role in tumor initiation, progression, and metastasis. They share characteristics with normal stem cells, such as self-renewal and differentiation potential. CSCs establish their niche, a unique microenvironment within the tissue, which sustains their functions. The interactions between CSCs and their niches regulate their self-renewal and tumorigenesis. Understanding the primary mechanisms involved in CSC tumorigenesis is essential for developing targeted therapies. Moreover, CSCs' resistance to standard treatments and their phenotypic plasticity pose challenges in cancer therapeutics.
Article
Cell Biology
Giulia Golinelli, Rebecca Talami, Stella Frabetti, Olivia Candini, Giulia Grisendi, Carlotta Spano, Chiara Chiavelli, Gaelle F. Arnaud, Giorgio Mari, Massimo Dominici
Summary: In this study, the dynamic cell-to-cell interactions between tumor and MSCs were investigated using a customized VITVO50 3D bioreactor. The process of tissue colonization and formation of metastatic nodules was recreated under dynamic conditions. The results showed that VITVO50 is an easy handling and versatile bioreactor for developing in vivo-like tumor nodules and investigating dynamic cell-to-cell interactions with MSCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Valentina Masciale, Federico Banchelli, Giulia Grisendi, Roberto D'Amico, Antonino Maiorana, Alessandro Stefani, Uliano Morandi, Franco Stella, Massimo Dominici, Beatrice Aramini
Summary: This study found that the frequency of cancer stem cells (CSCs) and the expression of recurrence-related genes (RG) are independent predictors of disease-free survival in lung cancer. The frequency of CSCs is not related to disease-free survival in early-stage patients, but is a risk factor for locally advanced-stage patients. Moreover, measuring the expression of RG in CSCs is associated with a higher risk of recurrence. These findings suggest that CSCs and RG may have implications for targeted therapy and prognosis in lung cancer.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Biology
Paolo Cameli, Paola Faverio, Katia Ferrari, Viola Bonti, Stefania Marsili, Maria Antonietta Mazzei, Francesca Mazzoni, Maurizio Bartolucci, Vieri Scotti, Federica Bertolini, Fausto Barbieri, Cinzia Baldessari, Chiara Veronese, Roberto Boffi, Matteo Brighenti, Diego Cortinovis, Massimo Dominici, Alberto Pesci, Elena Bargagli, Fabrizio Luppi
Summary: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, but can lead to immune-related adverse events, including lung toxicity. This study describes the clinical, radiological features, and survival of patients with ICI-related lung toxicity. The results showed that the latency of toxicity was not limited to the first year of treatment, emphasizing the importance of long-term follow-up for early diagnosis and appropriate management.
Article
Cell Biology
Maria Serena Piccinno, Tiziana Petrachi, Marco Pignatti, Alba Murgia, Giulia Grisendi, Olivia Candini, Elisa Resca, Valentina Bergamini, Francesco Ganzerli, Alberto Portone, Ilenia Mastrolia, Chiara Chiavelli, Ilaria Castelli, Daniela Bernabei, Mara Tagliazucchi, Elisa Bonetti, Francesca Lolli, Giorgio De Santis, Massimo Dominici, Elena Veronesi
Summary: This study investigates the use of adipose-derived mesenchymal stromal/stem cells (AD-MSCs) in autologous fat transfer (AFT) for tissue reconstruction. The results show that AD-MSCs can improve graft persistence and reduce tissue resorption after AFT. The implanted AD-MSCs can persist and differentiate into mature adipocytes, leading to better outcomes in terms of graft weight and reduced cyst formation. This suggests a long-term protective and anti-inflammatory/proangiogenic role of AD-MSCs in autologous AFT tissue resorption.
Article
Pharmacology & Pharmacy
Ilenia Mastrolia, Andrea Giorgini, Alba Murgia, Pietro Loschi, Tiziana Petrachi, Valeria Rasini, Massimo Pinelli, Valentina Pinto, Francesca Lolli, Chiara Chiavelli, Giulia Grisendi, Maria Cristina Baschieri, Giorgio De Santis, Fabio Catani, Massimo Dominici, Elena Veronesi
Summary: In this study, a rabbit model was established to mimic human osteonecrosis of the femoral head (ONFH) and evaluate the autologous MSC-based treatment. Results showed that implantation of autologous BM-MSCs could restore the damaged tissue in rabbit femurs. Furthermore, the study found that osteonecrosis did not affect the behavior of MSCs.
Article
Cell Biology
Elisa Pardella, Erica Pranzini, Ilaria Nesi, Matteo Parri, Pietro Spatafora, Eugenio Torre, Angela Muccilli, Francesca Castiglione, Massimiliano Fambrini, Flavia Sorbi, Paolo Cirri, Anna Caselli, Martin Puhr, Helmut Klocker, Sergio Serni, Giovanni Raugei, Francesca Magherini, Maria Letizia Taddei
Summary: Cancer progression is supported by the interaction between tumor cells and the surrounding stroma. Chemotherapy-induced senescence in both tumor and non-cancerous cells contributes to the adverse effects of therapies. It has been found that chemotherapy drugs promote senescence in stromal fibroblasts, leading to metabolic alterations and secretion of paracrine factors, thereby enhancing the invasive and clonogenic potential of prostate and ovarian cancer cells. Clearance of senescent stromal cells can reverse the malignant phenotype of tumor cells. This has important implications for combining traditional anticancer strategies with innovative senotherapy to enhance anticancer treatments and overcome the adverse effects of chemotherapy.
Article
Oncology
Elisa Bianchi, Sebastiano Rontauroli, Lara Tavernari, Margherita Mirabile, Francesca Pedrazzi, Elena Genovese, Stefano Sartini, Massimiliano Dall'Ora, Giulia Grisendi, Luca Fabbiani, Monica Maccaferri, Chiara Carretta, Sandra Parenti, Sebastian Fantini, Niccolo Bartalucci, Laura Calabresi, Manjola Balliu, Paola Guglielmelli, Leonardo Potenza, Enrico Tagliafico, Lorena Losi, Massimo Dominici, Mario Luppi, Alessandro Maria Vannucchi, Rossella Manfredini
Summary: BM fibrosis is a major pathology in myelofibrosis and is associated with overexpression of OPN protein. ERK1/2 is a key regulator of OPN production, and inhibiting ERK1/2 activity can reduce OPN production and hinder the development of BM fibrosis. Targeting OPN and ERK1/2 could be potential therapeutic strategies for myelofibrosis.
Review
Oncology
Claudia Piombino, Marco Oltrecolli, Elena Tonni, Marta Pirola, Rossana Matranga, Cinza Baldessari, Stefania Pipitone, Massimo Dominici, Roberto Sabbatini, Maria Giuseppa Vitale
Summary: De novo metastatic hormone-sensitive prostate cancer usually has a poor prognosis, but recent advancements in new hormonal agents and combination therapy have slightly improved outcomes. Ongoing clinical trials are exploring new therapeutic approaches and personalized treatment options based on genomic features and biomarker-guided treatment.
Meeting Abstract
Biotechnology & Applied Microbiology
Daniela Benati, Tommaso Ferrari, Valentina Masciale, Giulia Grisendi, Beatrice Aramini, Uliano Morandi, Antonino Maiorana, Massimo Dominici, Alessandra Recchia
Meeting Abstract
Cell & Tissue Engineering
C. Chiavelli, M. Prapa, G. Neri, G. Pugliese, G. Rovesti, L. Trudu, G. Grisendi, M. dall'ora, G. Golinelli, M. Bestagno, O. Candini, C. Spano, R. Di Tinco, L. Bertoni, G. Carnevale, R. Papapietro, R. Depenni, A. Feletti, C. Iaccarino, G. Pavesi, M. Dominici