期刊
STEM CELLS
卷 31, 期 10, 页码 2218-2230出版社
WILEY
DOI: 10.1002/stem.1470
关键词
Bone morphogenetic proteins; Adult retinal stem cells; Secreted Frizzled Related Protein 2; Lens; Quiescence; Cornea
资金
- St Georges' Society (McEwen Centre for Regenerative Medicine) fellowship
- Canadian Institutes of Health Research
- Foundation Fighting Blindness
Rare retinal stem cells (RSCs) within the ciliary epithelium at the retinal margin of the adult mouse and human eyes can divide in vitro in the absence of growth factors to generate clonal, self-renewing spheres which can generate all the retinal cell types. Since no regenerative properties are seen in situ in the adult mammalian eye, we sought to determine the factors that are involved in the repression of endogenous RSCs. We discovered that factors secreted by the adult lens and cornea block the proliferation of adult RSCs in vitro. Bone morphogenetic protein (BMP)2, BMP4, and secreted frizzled related protein 2 were identified as principal effectors of the anti-proliferative effects on RSCs. As a similar induced quiescence was observed in vitro on both mouse and human RSCs, targeting these molecules in vivo may reactivate RSCs directly in situ in the eyes of the blind. Stem Cells 2013;31:2218-2230
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