期刊
STEM CELLS
卷 30, 期 5, 页码 797-803出版社
WILEY
DOI: 10.1002/stem.1066
关键词
Stem cells; Embryonic stem cells; Induced pluripotent stem cells; Cell replacement therapy; Immunogenicity; Transplantation; Tolerance; Rejection; Regenerative medicine
资金
- NIH [P20RR018757]
- Rhode Island Foundation
- BD Biosciences
- NSFC [30872346]
- California Institute for Regenerative Medicine [TR1-01277]
- NIH COBRE at Roger Williams Medical Center
Autologous-induced pluripotent stem cells (iPSCs) may eventually be used in cell replacement therapies to treat a wide range of diseases and have been touted as a solution to the vexing problem of immune rejection in this context. Emerging evidence suggests, however, that ostensibly histocompatible iPSCs may be rejected following transplantation. Here, we review the mechanisms that contribute to immunogenicity in iPSCs and forward approaches to permit their acceptance in potential cell replacement therapies. STEM CELLS 2012;30:797803
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