Article
Hematology
Yu-Tai Chang, Ian Chiu, Qiuju Wang, Jorge Bustamante, Wenxuan Jiang, Kiera Rycaj, Song Yi, Joey Li, Jeanne Kowalski-Muegge, William Matsui
Summary: Tumor relapse and drug resistance pose challenges in the curability of multiple myeloma (MM), particularly for patients with high-risk features such as chromosome 17p13 deletion (del17p). This study reveals that the loss of p53 increases the frequency and drug resistance of tumor-initiating MM cells (TICs) through the activation of the Notch signaling pathway and upregulation of ID1 genes. The findings suggest that targeting the Notch signaling pathway with a gamma-secretase inhibitor (GSI) may be effective for treating p53 mutant MM.
Review
Pharmacology & Pharmacy
Danielle Wallace, Patrick M. Reagan
Summary: Mantle cell lymphoma is a rare and incurable lymphoma, currently being targeted with therapies addressing dysregulation of B-cell signaling pathways to improve prognosis. Recent studies have shown successful treatment outcomes with novel drugs in the relapsed/refractory population.
Review
Biochemistry & Molecular Biology
Thomas Dittmar
Summary: CS/ICs play a crucial role in cancer research and therapy, but their complexity makes identification challenging. Cell-cell fusion could lead to the generation of tumor hybrids with different CS/IC properties, contributing to the heterogeneity of the CS/IC pool within tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Dahai Liu, Fei Qi, Wei Liu, Justin Liu, Jun Wang, Dao-Qiang Lu, Yang Xun, Min-Min Chen, Xin Chen, Shu-Ting Yang, Wen-Qiao Jiao, Zong-Ye Li, Fang Liu, Hua Yang, Wen-Xing Li
Summary: This study explored the expression and function of cytokines in Hodgkin's lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), and mantle cell lymphoma (MCL). The results showed shared immune functions and signal pathway damage in all three types of lymphoma, and these functions were related to cytokines. Furthermore, CXCL14 was identified as a key regulator affecting cell chemotaxis and migration functions.
Review
Oncology
Panruo Jiang, Aakash Desai, Haige Ye
Summary: Mantle cell lymphoma (MCL) is known as one of the most aggressive lymphoid tumors, but some cases may exhibit indolent behavior referred to as smoldering MCL (SMCL). Understanding the molecular mechanisms of indolent MCL, which differ significantly from classical MCL, can help differentiate these two types of lymphoma and guide appropriate treatment strategies.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Zoufang Huang, Vivek P. Chavda, Rajashri Bezbaruah, Hemant Dhamne, Dong-Hua Yang, Hong-Bing Zhao
Summary: Mantle cell lymphoma (MCL) is a subtype of Non-Hodgkin lymphoma characterized by translocation of Cyclin D1. Despite progress in understanding the causes and available treatments, MCL remains incurable. CAR-T cell therapy shows potential for treating B-cell malignancies and MCL.
Review
Biochemistry & Molecular Biology
Leigh Deshotels, Firas M. M. Safa, Nakhle S. S. Saba
Summary: Although major progress has been made in mantle cell lymphoma (MCL) therapeutics, MCL still has a poor prognosis with a median survival of less than four years. Several genes, including NOTCH1 and NOTCH2, have been found to be mutated in MCL, leading to upregulation of genes involved in angiogenesis, cell cycle progression, and cell migration and adhesion. Mutated NOTCH genes are associated with aggressive features in MCL and inferior survival. This article discusses the role of NOTCH signaling in MCL biology and ongoing efforts for targeted therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xiaoling Xu, Tao Zhang, Meiju Zhang, Lanlan Li, Ge Deng, Zheng Lu, Zhenyu Zhang, Yan Du, Yubin Feng, Xiaowen Feng, Xiaoqing Peng, Feihu Chen
Summary: This study found that ATPR can promote the differentiation of MCL cells and achieve it through regulating the SOX11/CyclinD1/Rb/E2F1 pathway. This provides experimental foundation for developing differentiation therapy for MCL using ATPR.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Jimena Alvarez Freile, Natasha Ustyanovska Avtenyuk, Macarena Gonzalez Corrales, Harm Jan Lourens, Gerwin Huls, Tom van Meerten, Ewa Cendrowicz, Edwin Bremer
Summary: This study investigates the expression and therapeutic effects of CD24 and CD47, two immune checkpoints, in B-cell lymphoma. The results show that CD24 is associated with poor survival in MCL patients, while CD47 is associated with survival in DLBCL patients. CD24 antibody treatment exhibits potent phagocytic effects in MCL, but not in DLBCL.
Article
Oncology
Husain Yar Khan, Md. Hafiz Uddin, Suresh Kumar Balasubramanian, Noor Sulaiman, Marium Iqbal, Mahmoud Chaker, Amro Aboukameel, Yiwei Li, William Senapedis, Erkan Baloglu, Ramzi M. Mohammad, Jeffrey Zonder, Asfar S. Azmi
Summary: Targeting PAK4 and NAMPT using the small molecule inhibitor KPT-9274 can inhibit cell proliferation, deplete energy, and induce apoptosis in various NHL subtypes. KPT-9274 treatment shows potent anti-tumor effects in experimental models, suggesting its potential as a novel therapy for NHL.
Review
Oncology
Krista M. Isaac, Craig A. Portell, Michael E. Williams
Summary: LV-MCL is a unique subtype of mantle cell lymphoma with distinct biological and clinical characteristics compared to classical MCL. Limited data exists on the treatment of LV-MCL, and many patients may have a clinically indolent course and do not require active treatment. Future prospective clinical trials are needed to optimize management strategies for LV-MCL.
CURRENT ONCOLOGY REPORTS
(2021)
Article
Oncology
Juliana Carvalho Santos, Nuria Profitos-Peleja, Marcelo Lima Ribeiro, Gael Roue
Summary: This study demonstrates that treatment with simvastatin can impede MCL proliferation, inhibit migration and invasion ability, and induce cell death, suggesting the potential of simvastatin as a precise therapy for MCL.
Article
Oncology
Reza Mirzaei, Charlotte D'Mello, Marina Liu, Ana Nikolic, Mehul Kumar, Frank Visser, Pinaki Bose, Marco Gallo, V. Wee Yong
Summary: This study spatially characterized the heterogeneity of glioblastoma microenvironment and identified the potential therapeutic target of the biglycan-LRP6 axis in regulating tumor growth and brain tumor-initiating cells in GBM.
Article
Oncology
Keman Zhang, Nand K. Roy, Yorleny Vicioso, Janghee Woo, Rose Beck, Marcos de Lima, Paolo Caimi, Daniel Feinberg, Reshmi Parameswaran
Summary: Mantle cell lymphoma (MCL) is an aggressive form of B cell non-Hodgkin's lymphoma that remains incurable under current treatment modalities. Research shows that B cell activating factor (BAFF) and BAFF receptor (BAFF-R) play important roles in the proliferation and survival of MCL cells, with high serum BAFF levels often correlated with poor drug response. Targeting BAFF-R using antibody therapy shows promise in overcoming drug resistance in MCL patients and improving treatment efficacy.
Review
Hematology
Elisabeth Silkenstedt, Kim Linton, Martin Dreyling
Summary: Mantle cell lymphoma (MCL) exhibits heterogeneous behavior, with treatment options needing to be tailored based on individual risk profiles for optimal outcomes. Recent advances in understanding the molecular background of MCL have led to innovative therapies and improved treatment recommendations for primary and relapsed/refractory MCL.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Hematology
Alex F. Herrera, Scott J. Rodig, Joo Y. Song, Young Kim, Gabriel K. Griffin, Dongyun Yang, Liana Nikolaenko, Matthew Mei, Victoria Bedell, Paola Dal Cin, Christine Pak, Edwin P. Alyea, Lihua E. Budde, Robert Chen, Yi-Bin Chen, Wing C. Chan, Corey S. Cutler, Vincent T. Ho, John Koreth, Amrita Krishnan, Joyce L. Murata-Collins, Sarah Nikiforow, Joycelynne Palmer, German A. Pihan, Raju Pillai, Leslie Popplewell, Steven T. Rosen, Tanya Siddiqi, Aliyah R. Sohani, Jasmine Zain, Larry W. Kwak, Dennis D. Weisenburger, David M. Weinstock, Robert J. Soiffer, Joseph H. Antin, Stephen J. Forman, Auayporn R. Nademanee, Philippe Armand
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2018)
Article
Oncology
Sheeba K. Thomas, Soung-chul Cha, D. Lynne Smith, Kun Hwa Kim, Sapna R. Parshottam, Sheetal Rao, Michael Popescu, Vincent Y. Lee, Sattva S. Neelapu, Larry W. Kwak
Article
Oncology
Jorge E. Romaguera, Michael Wang, Lei Feng, Luis E. Fayad, Frederick Hagemeister, Peter McLaughlin, M. Alma Rodriguez, Michelle Fanale, Robert Orlowski, Larry W. Kwak, Sattva Neelapu, Yasuhiro Oki, Barbara Pro, Anas Younes, Felipe Samaniego, Nathan Fowler, Kimberly Hartig, Marisa Valentinetti, Judy Smith, Peggy Ford, Adam Naig, L. Jeffrey Medeiros, Hagop M. Kantarjian, Andre Goy
Review
Oncology
Yijun Liu, Guowei Wei, Wesley A. Cheng, Zhenyuan Dong, Han Sun, Vincent Y. Lee, Soung-Chul Cha, D. Lynne Smith, Larry W. Kwak, Hong Qin
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2018)
Article
Oncology
Robert W. Chen, Joycelynne M. Palmer, Sarah Tomassetti, Leslie L. Popplewell, Jessica Alluin, Pritsana Chomchan, Auayporn P. Nademanee, Tanya Siddiqi, Ni-Chun Tsai, Lu Chen, Fay Zuo, Rosemarie Abary, Ji-Lian Cai, Alex F. Herrera, John J. Rossi, Steven T. Rosen, Stephen J. Forman, Larry W. Kwak, Leona A. Holmberg
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Xingli Zhao, Zhuoran Zhang, Dayson Moreira, Yu-Lin Su, Haejung Won, Tomasz Adamus, Zhenyuan Dong, Yong Liang, Hongwei H. Yin, Piotr Swiderski, Raju K. Pillai, Larry Kwak, Stephen Forman, Marcin Kortylewski
Article
Hematology
Atish Mohanty, Natalie Sandoval, An Phan, Thang V. Nguyen, Robert W. Chen, Elizabeth Budde, Matthew Mei, Leslie Popplewell, Lan V. Pham, Larry W. Kwak, Dennis D. Weisenburger, Steven T. Rosen, Wing C. Chan, Markus Muschen, Vu N. Ngo
Article
Hematology
Michinori Ogura, Juan Manuel Sancho, Seok-Goo Cho, Hideyuki Nakazawa, Junji Suzumiya, Gayane Tumyan, Jin Seok Kim, Anne Lennard, Jose Mariz, Nikolai Ilyin, Wojciech Jurczak, Aurelio Lopez Martinez, Olga Samoilova, Edvard Zhavrid, Eduardo Yanez Ruiz, Marek Trneny, Leslie Popplewell, Bertrand Coiffier, Christian Buske, Woo-Seog Kim, Sang Joon Lee, Sung Young Lee, Yun Ju Bae, Larry W. Kwak
LANCET HAEMATOLOGY
(2018)
Article
Hematology
Tamer Khashab, Fredrick Hagemeister, Jorge E. Romaguera, Michelle A. Fanale, Barbara Pro, Peter McLaughlin, M. Alma Rodriguez, Sattva S. Neelapu, Luis Fayad, Anas Younes, Lei Feng, Francisco Vega, Larry W. Kwak, Felipe Samaniego
BRITISH JOURNAL OF HAEMATOLOGY
(2019)
Article
Cell Biology
Hong Qin, Zhenyuan Dong, Xiuli Wang, Wesley A. Cheng, Feng Wen, Weili Xue, Han Sun, Miriam Walter, Guowei Wei, D. Lynne Smith, Xiuhua Sun, Fan Fei, Jianming Xie, Theano I. Panagopoulou, Chun-Wei Chen, Joo Y. Song, Ibrahim Aldoss, Clarisse Kayembe, Luisa Sarno, Markus Muschen, Giorgio G. Inghirami, Stephen J. Forman, Larry W. Kwak
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Oncology
Hong Qin, Guowei Wei, Ippei Sakamaki, Zhenyuan Dong, Wesley A. Cheng, D. Lynne Smith, Feng Wen, Han Sun, Kunhwa Kim, Soungchul Cha, Laura Bover, Sattva S. Neelapu, Larry W. Kwak
CLINICAL CANCER RESEARCH
(2018)
Article
Hematology
Matthew G. Mei, Thai M. Cao, Lu Chen, Joo Y. Song, Tanya Siddiqi, Ji-Lian Cai, Leonardo T. Farol, Monzr M. Al Malki, Amandeep Salhotra, Ibrahim Aldoss, Joycelynne Palmer, Alex F. Herrera, Jasmine Zain, Leslie L. Popplewell, Robert W. Chen, Steven T. Rosen, Stephen J. Forman, Larry Kwak, Auayporn P. Nademanee, Lihua E. Budde
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2017)
Article
Oncology
Andreas Herrmann, Christoph Lahtz, Toshikage Nagao, Joo Y. Song, Wing C. Chan, Heehyoung Lee, Chanyu Yue, Thomas Look, Ronja Mulfarth, Wenzhao Li, Kurt Jenkins, John Williams, Lihua E. Budde, Stephen Forman, Larry Kwak, Thomas Blankenstein, Hua Yu
Article
Cell Biology
Young-hee Lee, Natalia Martin-Orozco, Peilin Zheng, Jing Li, Peng Zhang, Haidong Tan, Hyun Jung Park, Mira Jeong, Seon Hee Chang, Byung-Seok Kim, Wei Xiong, Wenjuan Zang, Li Guo, Yang Liu, Zhong-jun Dong, Willem W. Overwijk, Patrick Hwu, Qing Yi, Larry Kwak, Zhiying Yang, Tak W. Mak, Wei Li, Laszlo G. Radvanyi, Ling Ni, Dongfang Liu, Chen Dong
Article
Oncology
A. F. Herrera, J. Palmer, P. Martin, S. Armenian, N-C Tsai, N. Kennedy, F. Sahebi, T. Cao, L. E. Budde, M. Mei, T. Siddiqi, L. Popplewell, S. T. Rosen, L. W. Kwak, A. Nademanee, S. J. Forman, R. Chen
ANNALS OF ONCOLOGY
(2018)