期刊
STATISTICS IN MEDICINE
卷 27, 期 9, 页码 1421-1428出版社
WILEY-BLACKWELL
DOI: 10.1002/sim.3014
关键词
constrained permuted block design; maximal procedure; restricted randomization; selection bias
Selection bias is a potential problem, especially in trials where blinding is not possible. Randomization with a constrained block of large size provides better protection from selection bias than using a sequence of blocks of small size with the same maximum imbalance. We propose an algorithm that efficiently generates constrained block allocation sequences, and we describe two clinical trials in which such a constrained randomization was used. Copyright (C) 2007 John Wiley & Sons, Ltd.
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