Article
Biochemistry & Molecular Biology
Priscila Faimann Sales, Aline Lopes do Nascimento, Fernanda Cavalcante Pinheiro, Andressa Ketelem Meireles Alberto, Abrahao Victor Tavares de Lima Teixeira dos Santos, Helison de Oliveira Carvalho, Gisele Custodio de Souza, Jose Carlos Tavares Carvalho
Summary: This study found that oils from A. esculentus, E. oleracea, B.orellana, and Chronic SM (R) have therapeutic effects on dyslipidemia, reducing blood sugar, triglycerides, total cholesterol, and LDL-cholesterol, while increasing HDL-cholesterol. Additionally, they were able to inhibit the formation of atheromatous plaques in the vascular endothelium of treated rats.
Article
Hematology
Esmeralda A. Lewis, Rocio Muniz-Anquela, Ibon Redondo-Angulo, Leticia Gonzalez-Cintado, Veronica Labrador-Cantarero, Jacob F. Bentzon
Summary: This study found that LDL retention is the main limiting factor for LDL accumulation in the arterial wall. However, the capacity for LDL retention varies significantly over relatively short distances. The inner curvature region of the aortic arch consists of dorsal and ventral zones with high retention capacity and a central zone with low retention capacity. These features predict the temporal pattern of atherosclerosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
M. Amin Sharifi, Michael Wierer, Tan An Dang, Jelena Milic, Aldo Moggio, Nadja Sachs, Moritz von Scheidt, Julia Hinterdobler, Philipp Mueller, Julia Werner, Barbara Stiller, Zouhair Aherrahrou, Jeanette Erdmann, Andrea Zaliani, Mira Graettinger, Jeanette Reinshagen, Sheraz Gul, Philip Gribbon, Lars Maegdefessel, Juergen Bernhagen, Hendrik B. Sager, Matthias Mann, Heribert Schunkert, Thorsten Kessler
Summary: ADAMTS-7 plays a role in the development of atherosclerotic plaques by reducing the stability of TIMP-1, which in turn promotes the activity of MMP-9 and the degradation of collagen. Disrupting the interaction between ADAMTS-7 and TIMP-1 may be a strategy to increase plaque stability and reduce the risk of atherosclerosis-related events.
CIRCULATION RESEARCH
(2023)
Article
Biology
Hui Zhao, Jianping Zhao, Di Wu, Zhaolin Sun, Yang Hua, Min Zheng, Yumei Liu, Qi Yang, Xiahe Huang, Yuan Li, Yueshan Piao, Yingchun Wang, Sin Man Lam, Huijuan Xu, Guanghou Shui, Yongjun Wang, Haifeng Yao, Liangxue Lai, Zhuo Du, Jidong Mi, Enqi Liu, Xunming Ji, Yong Q. Zhang
Summary: This study demonstrates the generation of ApoE knockout dogs using CRISPR/Cas9 and somatic cell nuclear transfer technologies, which exhibit hypercholesterolemia and severe atherosclerosis with clinical manifestations. The characteristics of hypercholesterolemia and atherosclerosis in mutant dogs and their offspring make them valuable models for developing and evaluating new therapies against atherosclerosis and related disorders, as they closely resemble human patients more than other animal models.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Review
Medicine, General & Internal
Fahad Alnouri, Raul D. Santos
Summary: Familial hypercholesterolemia (FH) is associated with an increased risk of atherosclerosis. In heterozygous FH, cardiovascular risk is not only determined by high cholesterol levels but also by other biomarkers and genes. Specific atherosclerosis risk scores for FH and imaging of subclinical coronary atherosclerosis can help identify high-risk individuals.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Pei-Yu Chen, Lingfeng Qin, Michael Simons
Summary: Apolipoprotein E (Apoe)- or low density lipoprotein receptor (Ldlr)-deficient hyperlipidemic mice are commonly used in atherosclerosis research. This protocol describes a surgical method to dissect, stain, image, and analyze atherosclerotic lesions in mouse aortas.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Hematology
Marco Busnelli, Stefano Manzini, Matteo Chiara, Alice Colombo, Fabrizio Fontana, Roberto Oleari, Francesco Poti, David Horner, Stefano Bellosta, Giulia Chiesa
Summary: The study found that overexpression of ApoA-I in EKO mice aorta modulates the development of atherosclerosis, affecting pathways beyond those associated with inflammation and immune response.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Elaine R. Coutinho, Marcio H. Miname, Viviane Z. Rocha, Marcio S. Bittencourt, Cinthia E. Jannes, Jose E. Krieger, Alexandre C. Pereira, Raul D. Santos
Summary: In older individuals with severe hypercholesterolemia undergoing long-term lipid lowering therapy (LLT), previous clinical ASCVD was unrelated to FH-causing variants, while FH-causing variants were not associated with the occurrence of ASCVD.
Article
Nutrition & Dietetics
Adrien Zimmer, Alyann Otrante, Nada Zoubdane, Michel Nguyen, Tamas Fulop, Abdelouahed Khalil
Summary: This study aimed to investigate the nutraceutical potential of extra virgin olive oil (EVOO) on the inflammatory status of monocytes in participants showing different levels of cardiovascular risk. The results showed that a 6-month EVOO intervention did not induce a monocyte phenotypic change or significantly modify cytokine production, except for an increase in IL-1β in post-infarct patients.
Article
Medicine, Research & Experimental
Ernawati Sinaga, Suprihatin, Yenisbar, Mardian Iswahyudi, Sarwi Setyowati, Vivitri D. Prasasty
Summary: The research demonstrates that supplementation of Rhodomyrtus tomentosa fruit juice has significant effects in preventing cardiovascular diseases caused by high fat high cholesterol, reducing total cholesterol and low-density lipoprotein levels, and increasing high-density lipoprotein levels; it also prevents the development of atherosclerosis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Bence Tanczos, Viktoria Somogyi, Mariann Bombicz, Bela Juhasz, Norbert Nemeth, Adam Deak
Summary: Hypercholesterolemia contributes to the development of atherosclerosis through its impact on hematological and hemorheological parameters. A high-cholesterol diet is associated with higher white blood cell and platelet count, increased viscosity, aggravated RBC aggregation, decreased RBC deformability and membrane stability, ultimately affecting blood flow properties and microcirculation.
Article
Biochemistry & Molecular Biology
Sin-Yu Chen, Yi-Zhen Chen, Yi-Jing Lee, Chung-Lin Jiang, Shao-Chun Lu, Fu-Jung Lin
Summary: Maternal hypercholesterolemia exacerbates atherosclerosis in offspring by altering macrophage development and polarization, contributing to increased macrophage burden within lesions. This study highlights the importance of epigenetic modifications in the offspring's macrophage genome as a potential mechanism for the inheritance of cardiovascular disease susceptibility from hypercholesterolemic mothers.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Hematology
Tarik Zahr, Longhua Liu, Michelle Chan, Qiuzhong Zhou, Bishuang Cai, Ying He, Nicole Aaron, Domenico Accili, Lei Sun, Li Qiang
Summary: This study found that PPARγ deacetylation prevents the development of aging-associated atherosclerosis and hypercholesterolemia. This protective effect may be achieved through suppression of inflammation and promotion of macrophage polarization.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Food Science & Technology
Marco Busnelli, Stefano Manzini, Alice Colombo, Elsa Franchi, Mitja Laaperi, Reijo Laaksonen, Giulia Chiesa
Summary: This study evaluates the effects of different diets on plasma and aorta lipidome in an athero-prone mouse model. Results show that the cholesterol and fatty acid content of the diets are the main factors affecting lipid accumulation in plasma and aorta. Furthermore, specific lipids such as lactosylceramide, glucosyligalactosylceramide, and individual ceramide species are found to accumulate in diseased aortic segments, serving as markers of atherosclerosis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Medicine, General & Internal
Radoslaw Motkowski, Pawel Abramowicz, Jolanta Kubalska, Bozena Mikoluc, Jerzy Konstantynowicz
Summary: This retrospective cohort study presented the 20-year experience of comprehensive care for pediatric patients with familial hypercholesterolemia in a single academic center. The study demonstrated that statin treatment in children with FH is highly effective and safe.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Inorganic & Nuclear
Arnaud De Luca, Alice Kuster, Illa Tea, Dominique Darmaun, Jean-Christophe Roze, Richard Robins, Regis Hankard
Summary: The study indicates a decrease in N-15 natural isotope abundance for plasma amino acid pools in the fetal-placental unit.
ISOTOPES IN ENVIRONMENTAL AND HEALTH STUDIES
(2021)
Article
Gastroenterology & Hepatology
Alexandre Lapillonne, Alain Bocquet, Andre Briend, Jean-Pierre Chouraqui, Dominique Darmaun, Francois Feillet, Marie-Laure Frelut, Dominique Guimber, Regis Hankard, Noel Peretti, Jean-Christophe Roze, Umberto Simeoni, Dominique Turck, Christophe Dupont
Summary: Pregnant and lactating women are frequently exposed to environmental pollutants, but current evidence does not conclusively show any significant health consequences for infants exposed through breastfeeding. Despite this, the benefits of breastfeeding are believed to outweigh any potential harm from pollutant exposure in human milk. Public health measures to reduce contamination levels and support further research in this area are recommended to ensure continued promotion of breastfeeding.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Public, Environmental & Occupational Health
Jean-Pierre Chouraqui, Dominique Turck, Andre Briend, Dominique Darmaun, Alain Bocquet, Francois Feillet, Marie-Laure Frelut, Jean-Philippe Girardet, Dominique Guimber, Regis Hankard, Alexandre Lapillonne, Noel Peretti, Jean-Christophe Roze, Umberto Simeoni, Christophe Dupont
Summary: Most religious dietary rules, when followed according to traditions, are not harmful to health. However, strict adherence to some rules may result in nutritional deficiencies, particularly in populations facing unfavorable socio-economic or environmental conditions.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Nutrition & Dietetics
Diana Cardenas, Maria Isabel Toulson Davisson Correia, Juan B. Ochoa, Gil Hardy, Dolores Rodriguez-Ventimilla, Charles E. Bermudez, Karin Papapietro, Regis Hankard, Andre Briend, Winai Ungpinitpong, Katerina Mary Zakka, Teresa Pounds, Cristina Cuerda, Rocco Barazzoni
Summary: Nutritional care is a human right intrinsically linked to the right to food and health. All individuals should have access to evidence-based medical nutrition therapy. However, this does not imply an obligation to feed all patients, but rather to make the best decisions based on individual circumstances.
CLINICAL NUTRITION
(2021)
Article
Pediatrics
Olivier L. Mantha, Florence Flamein, Mark A. Turner, Ricardo M. Fernandes, Regis Hankard
Summary: The early effects of the COVID-19 pandemic on pediatric clinical research were captured through a collaborative effort from pediatric research networks across 20 countries. Research sites were impacted in mid-March 2020 with changes in site initiation processes and staff redirection to COVID-19 research, highlighting the importance of collaboration between national networks in conducting clinical trials during the pandemic.
JOURNAL OF PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Diana Cardenas, Maria Isabel Toulson Davisson Correia, Juan B. Ochoa, Gil Hardy, Dolores Rodriguez-Ventimilla, Charles E. Bermudez, Karin Papapietro, Regis Hankard, Andre Briend, Winai Ungpinitpong, Katerina Mary Zakka, Teresa Pounds, Cristina Cuerda, Rocco Barazzoni
Summary: Nutritional care is considered a human right that should be linked to the right to food and health. Access to evidence-based medical nutrition therapy is essential, but it does not mean that feeding all patients at any stage of life is mandatory. Ethical decision-making for optimal patient care is crucial, even if it includes the decision not to feed under certain circumstances.
NUTRITION IN CLINICAL PRACTICE
(2021)
Article
Cardiac & Cardiovascular Systems
Antonio Gallo, Leopoldo Perez de Isla, Sybil Charriere, Alexandre Vimont, Rodrigo Alonso, Ovidio Muniz-Grijalvo, Jose L. Diaz-Diaz, Daniel Zambon, Philippe Moulin, Eric Bruckert, Pedro Mata, Sophie Beliard
Summary: The study demonstrated the additional contribution of coronary artery calcium (CAC) score in improving cardiovascular risk stratification and ASCVD prediction in patients with statin-treated HeFH.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Immunology
Lee S. Nguyen, Joe-Elie Salem, Marie-Cecile Bories, Guillaume Coutance, Julien Amour, Adrien Bougle, Caroline Suberbielle, Vissal-David Kheav, Maryvonnick Carmagnat, Philippe Rouvier, Matthias Kirsch, Shaida Varnous, Pascal Leprince, Samir Saheb
Summary: In heart transplantation, perioperative desensitization is associated with fewer antibody-mediated rejections and deaths, with more pronounced efficacy in male patients than in female patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Illa Tea, Arnaud De Luca, Anne-Marie Schiphorst, Mathilde Grand, Sophie Barille-Nion, Eric Mirallie, Delphine Drui, Michel Krempf, Regis Hankard, Guillaume Tcherkez
Summary: The natural abundance of heavy stable isotopes is important in human physiology research, as it can easily identify changes in metabolic fluxes. This suggests the potential for medical diagnosis and prognostic using isotopes at natural abundance.
Article
Hematology
Eric Bruckert, Sonia Caprio, Albert Wiegman, Min-Ji Charng, Cezar A. Zarate-Morales, Marie T. Baccara-Dinet, Garen Manvelian, Anne Ourliac, Michel Scemama, Stephen R. Daniels
Summary: This study examined the efficacy and safety of the PCSK9 inhibitor, alirocumab, in pediatric patients with homozygous familial hypercholesterolemia. The results showed that alirocumab effectively reduced LDL-C levels and achieved good treatment outcomes in some patients. This study is of great importance for improving the treatment of homozygous familial hypercholesterolemia.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Hematology
Florian Mourre, Roch Giorgi, Antonio Gallo, Franck Boccara, Eric Bruckert, Alain Carrie, Regis Hankard, Jocelyn Inamo, Sandrine Laboureau, Philippe Moulin, Rene Valero, Sophie Beliard
Summary: Background: Animal studies have shown that fetal exposure to high maternal cholesterol levels during pregnancy increases the risk of aortic atheroma in the offspring. However, little is known about the consequences of this exposure on the development of atherosclerotic cardiovascular disease in humans. This study aimed to investigate whether maternal/paternal inheritance of familial hypercholesterolemia (FH) gene mutation could be associated with subclinical coronary atherosclerosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Health Care Sciences & Services
Jean Ferrieres, Eric Bruckert, Michel Farnier, Michel Krempf, Jean-Jacques Mourad, Baptiste Roux, Francois Schiele
Summary: This online survey studied French cardiologists' lipid-lowering approaches in patients with hypercholesterolemia and high cardiovascular risk. The results showed that most physicians underestimated the cardiovascular risk and selected higher-than-recommended LDL-C targets and less intensive treatment.
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
(2023)
Article
Pediatrics
Laura Bouvart, Violette Raoult, Regis Hankard, Arnaud De Luca, ePINUT Study Grp
Summary: The aim of this study was to assess the nutritional status of hospitalized children with cystic fibrosis. The findings showed that the frequency of undernutrition in these children is higher compared to those with other chronic diseases.
ARCHIVES DE PEDIATRIE
(2023)
Article
Pharmacology & Pharmacy
Mark A. Turner, Heidrun Hildebrand, Ricardo M. Fernandes, Saskia N. de Wildt, Fenna Mahler, Regis Hankard, Rebecca Leary, Fedele Bonifazi, Patrick Nobels, Katharine Cheng, Sabah Attar, Paolo Rossi, Francesca Rocchi, Joana Claverol, Begonya Nafria, Carlo Giaquinto
Summary: The European Union recognized the need for information about drugs used in children with the implementation of the Paediatric Regulation in 2007. The Collaborative Network for European Clinical Trials for Children (c4c) addresses difficulties in the design and conduct of paediatric clinical trials by providing expert advice, a network of sites, education and training, and data management support. c4c aims to demonstrate the viability of the network through industry and non-industry studies, with plans for a sustainable successor organization before the end of IMI2 funding in 2024.
PHARMACEUTICAL MEDICINE
(2021)