期刊
STATISTICAL METHODS IN MEDICAL RESEARCH
卷 17, 期 5, 页码 477-486出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0962280207081863
关键词
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A variety of approaches have been proposed to provide formal and informal validation of proposed surrogate markers. To achieve true clinical impact, the validation mast convince both the statistical and clinical communities. In this paper, we argue that the best approach is not a single method but a multi-faceted exploration, using multiple approaches, including those that directly appeal to clinicians but with less statistical foundation and those arising from statistical considerations but snore difficult to interpret clinically. We illustrate our approach using data from clinical trials in both early and advanced colorectal cancer.
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