Article
Clinical Neurology
Satoshi Ujigo, Naosuke Kamei, Kiyotaka Yamada, Toshio Nakamae, Hideaki Imada, Nobuo Adachi, Yoshinori Fujimoto
Summary: The study aimed to determine the relationship between postural sway and the severity of lumbar spinal canal stenosis as well as the effect on postoperative improvement. Stabilometry was performed on 52 patients who underwent decompression surgery for lumbar spinal canal stenosis. The results showed that the severity of canal stenosis affects postural sway, but it can be improved after surgery.
EUROPEAN SPINE JOURNAL
(2023)
News Item
Biochemistry & Molecular Biology
Grant M. Landwehr, Michael C. Jewett
Summary: Inspired by nature, a synthetic carbon fixation cycle is able to build complex molecules directly from CO2. Several innovative advancements are required to build metabolism from the ground up, and now a strategy to balance carbon demands in a complex metabolic network is being explored.
NATURE CHEMICAL BIOLOGY
(2023)
Review
Clinical Neurology
David B. Anderson, Katie De Luca, Rikke K. Jensen, Jillian P. Eyles, James M. Van Gelder, Jana L. Friedly, Christopher G. Maher, Manuela L. Ferreira
Summary: This review assessed 10 clinical practice guidelines on the treatment of lumbar spinal stenosis, with only 4 of them meeting satisfactory methodological quality. While the evidence supporting different interventions was similar, guidelines tended to endorse surgery and injections over nonsurgical interventions and medications.
Article
Biochemistry & Molecular Biology
Fabienne Louis-Sidney, Jean-Florent Duby, Aissatou Signate, Serge Arfi, Michel De Bandt, Benoit Suzon, Philippe Cabre
Summary: This study compared the clinical response between surgical and conservative treatment in Afro-Caribbean patients with lumbar spine stenosis. The results showed the long-term superiority of decompression surgery over conservative treatment over an 18-month period.
Article
Medicine, General & Internal
Hyung-Youl Park, Ki-Won Kim, Ji-Hyun Ryu, Geon-U Kim, Ho-Young Jung, Youn-Sung Jung, Jun-Seok Lee
Summary: The aim of this study was to investigate the effect of lumbar spinal stenosis (LSS) on bone mineral density (BMD) in patients treated with oral bisphosphonates for osteoporosis. The study found that LSS had a negative impact on BMD increase. Ibandronate and alendronate were more effective in treating osteoporosis compared to risedronate, especially in patients with both osteoporosis and LSS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Lei Wang, Tianyi Wang, Ning Fan, Shuo Yuan, Peng Du, Fangda Si, Aobo Wang, Lei Zang
Summary: This retrospective cohort study aimed to evaluate the efficacy and safety of percutaneous endoscopic lumbar decompression (PELD) in elderly patients with lumbar spinal stenosis (LSS). The results showed that satisfactory outcomes can be achieved with PELD in elderly LSS patients (>=80 years old), comparable to those of younger LSS patients, without increased complications.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Anesthesiology
Sung Hyun Lee, Sung-Ha Hwang, Young-Kwan Moon, Hyun Min Bae, Dong Eon Moon
Summary: This retrospective study evaluated the clinical outcomes and safety of TFFP in 112 patients, showing that TFFP using the Foramoon device was effective in improving pain scores, ODI, and walking distance without serious adverse events.
Article
Orthopedics
Gen Xia, Xueru Li, Yanbing Shang, Bin Fu, Feng Jiang, Huan Liu, Yongdong Qiao
Summary: The study found that in patients with DLSS, the atrophy of muscles in stenotic segments of the spinal canal is significantly greater than in non-stenotic segments, and there is a strong positive correlation between the severity of multifidus atrophy and the severity of spinal stenosis.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Medicine, General & Internal
Huaqiang Zhou, Xuhua Wang, Zhaoyuan Chen, Wuyang Liu, Jiaquan Luo
Summary: This study aimed to evaluate whether unilateral biportal endoscopy had a superior clinical effect compared with microscopic decompression in the treatment of lumbar spinal stenosis. The results showed that unilateral biportal endoscopy was more beneficial in terms of operation time, hospital stays, EuroQol 5-Dimension questionnaire, back pain visual analogue score, leg pain visual analogue score, and C-reactive protein level. There were no significant differences between the two groups in other outcome indicators.
Article
Anesthesiology
Pradeep Suri, Ian B. Stanaway, Yanfei Zhang, Maxim B. Freidin, Yakov A. Tsepilov, David S. Carrell, Frances M. K. Williams, Yurii S. Aulchenko, Hakon Hakonarson, Bahram Namjou, David R. Crosslin, Gail P. Jarvik, Ming Ta Lee
Summary: Identifying genetic risk factors for lumbar spine disorders through genome-wide association studies using electronic health record data may lead to the development of new treatments. The study identified two novel associations with lumbar spine disorders, including lumbosacral radicular syndrome and lumbar spinal stenosis. Replication in an independent sample confirmed the association with lumbar spinal stenosis.
Article
Orthopedics
Christine Comer, Carlo Ammendolia, Michele C. Battie, Andre Bussieres, Jeremy Fairbank, Andrew Haig, Markus Melloh, Anthony Redmond, Michael J. Schneider, Christopher J. Standaert, Christy Tomkins-Lane, Esther Williamson, Arnold Y. L. Wong
Summary: This study developed a treatment algorithm for lumbar spinal stenosis (LSS) based on international multi-professional expert consensus. The algorithm provides different pathway options based on clinical indications, aiming to improve patient outcomes and healthcare resource utilization.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Medicine, General & Internal
Takaya Imai, Sota Nagai, Takehiro Michikawa, Risa Inagaki, Soya Kawabata, Kaori Ito, Kurenai Hachiya, Hiroki Takeda, Daiki Ikeda, Shigeki Yamada, Nobuyuki Fujita, Shinjiro Kaneko
Summary: Treatment for lumbar spinal canal stenosis (LSCS) can be conservative or surgical. This study aimed to examine the impact of lumbar surgery on pharmacological treatment for patients with LSCS. The results showed a significant decrease in LSCS medications after lumbar surgery, but around 15% of the participants experienced an increase in medication use.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Anesthesiology
Ahmed J. Awad, Braden Jex, Gwynne Kirchen, Stacy Peterson, Sarah A. Endrizzi, Peter A. Pahapill
Summary: The study demonstrates the favorable long-term efficacy of SCS in treating neurogenic claudication, especially for patients without prior surgical decompression. Despite its retrospective nature and single-center design, the results suggest that SCS can be considered as part of conservative treatment to help patients alleviate spine-related pain.
Article
Health Care Sciences & Services
Min Cheol Chang, Donghwi Park
Summary: The purpose of this study was to investigate the findings of electrodiagnostic studies in patients with moderate and severe lumbar central spinal stenosis. The results showed significant alterations in NCS and EMG in patients with LCSS, especially in those with severe LCSS. These findings may aid in diagnosing LCSS-induced radiculopathy and differentiating it from other causes of peripheral nerve pathologies.
Article
Geriatrics & Gerontology
Sota Nagai, Risa Inagaki, Takehiro Michikawa, Soya Kawabata, Kaori Ito, Kurenai Hachiya, Hiroki Takeda, Daiki Ikeda, Shinjiro Kaneko, Shigeki Yamada, Nobuyuki Fujita
Summary: This study aimed to review polypharmacy in elderly patients with lumbar spinal canal stenosis and examine how surgical treatment reduces polypharmacy. The results showed that the number of drugs postoperatively was significantly less than preoperatively, especially for pain relief and digestive diseases. Multivariable analysis revealed that a higher score in psychological disorders was associated with a reduction of 3 or more drugs after surgery.