Article
Orthopedics
Tomohiro Banno, Tomohiko Hasegawa, Yu Yamato, Go Yoshida, Hideyuki Arima, Shin Oe, Yuki Mihara, Koichiro Ide, Yuh Watanabe, Kenta Kurosu, Keiichi Nakai, Yukihiro Matsuyama
Summary: This study aimed to determine if perioperative lumbar subarachnoid drainage could reduce the incidence of postoperative cerebrospinal fluid (CSF) leakage in cases of dural repair using artificial dura mater. The results showed that drainage did not reduce the incidence of CSF leakage, but it might shorten the treatment period and reduce refractory CSF leakage.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2023)
Article
Engineering, Mechanical
Xiancheng Yu, Tianchi Wu, Thuy-Tien Ngoc Nguyen, Mazdak Ghajari
Summary: This study investigated the possibility and mechanism of blast induced CSF cavitation, finding that pressure waves through the skull and tissue were responsible for the generation and collapse of cavitation bubbles. The results suggested that CSF cavitation is likely to occur in the human head under blast loading, and that head length significantly affects CSF cavitation. These findings highlight the potential drawbacks of using small animals to study bTBI in the human head.
INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
(2022)
Article
Clinical Neurology
Hongfeng Wen, Di Jin, Lina Cai, Tao Wu, Haichao Liu
Summary: Neurobrucellosis can present symptoms similar to stroke and transverse myelitis. It is a treatable infectious disease that should be considered in differential diagnosis, especially when there are risk factors.
Article
Clinical Neurology
Jianquan Zhao, Heng Jiang, Huan Jiang, Yicheng Meng, Rui Gao, Jun Ma, Ce Wang, Xuhui Zhou
Summary: This retrospective study analyzed the occurrence of acute SAH after spinal surgery and identified hypertension, intraoperative CSF leakage, and postoperative CSF continuous drainage speed as risk factors for SAH.
WORLD NEUROSURGERY
(2022)
Article
Biology
Yuka Nakamura, Miyuki Kurabe, Mami Matsumoto, Tokiharu Sato, Satoshi Miytashita, Kana Hoshina, Yoshinori Kamiya, Kazuki Tainaka, Hitoshi Matsuzawa, Nobuhiko Ohno, Masaki Ueno
Summary: Recent studies have shown that cerebrospinal fluid-contacting neurons (CSF-cNs) in zebrafish larvae and lampreys control postures and movements via spinal connections. This study developed a method to genetically target and characterize CSF-cNs in mice, revealing their structures, connectivity, and functions. The findings provide important insights into the role of CSF-cNs in controlling spinal motor circuits for proper locomotion in mammals.
Article
Clinical Neurology
Pablo C. Zambrano-Rodriguez, Sirio Bolanos-Puchet, Horacio J. Reyes-Alva, Roberto A. de los Santos, Angelina Martinez-Cruz, Gabriel Guizar-Sahagun, Luis A. Medina
Summary: This study used high-resolution micro-CT myelography to assess changes in the SSAS after SCI in rats, finding that the changes varied in severity and time post-injury, with SSAS blockage being the main alteration observed. The method was able to provide fine details in small animals and is a useful tool for future experimental studies involving rat SCI in vivo.
JOURNAL OF NEUROIMAGING
(2021)
Article
Clinical Neurology
Ahmet Kinaci, Emma M. H. Slot, Mare Kollen, Menno R. Germans, Sepideh Amin-Hanjani, Andrew P. Carlson, Kashif Majeed, Paul R. A. M. Depauw, Pierre A. Robe, Luca Regli, Fady T. Charbel, Tristan P. C. van Doormaal
Summary: This retrospective study analyzed patients who underwent intradural cranial surgery from 2017 to 2018 at 5 neurosurgical centers. The incidence of incisional cerebrospinal fluid (iCSF) leakage was 7.1%. Risk factors for iCSF leakage included younger age, male gender, higher body mass index, smoking, infratentorial surgery, and use of a dural substitute. The use of a sealant reduced the risk of iCSF leakage. iCSF leakage increased the risk of postoperative infections and required immediate external cerebrospinal fluid drainage or wound revision.
Article
Surgery
Federica Locatelli, Petroula Nana, Thomas Le Houerou, Avit Guirimand, Marwan Nader, Antoine Gaudin, Come Bosse, Dominique Fabre, Stephan Haulon
Summary: This study evaluated the rate of spinal cord ischemia (SCI) and the impact of prophylactic cerebrospinal fluid drainage (pCSFD) following complex endovascular repair for thoracoabdominal aortic aneurysm (TAAA). The results showed a low incidence of SCI after the repair, which was associated with increased major adverse cardio-vascular events (MACE) and intensive care unit stay. The prophylactic use of cerebrospinal fluid drainage did not reduce the rate of SCI in type I to III TAAAs and may not be necessary routinely.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Mechanics
F. Moral-Pulido, J. I. Jimenez-Gonzalez, C. Gutierrez-Montes, W. Coenen, A. L. Sanchez, C. Martinez-Bazan
Summary: This paper presents experimental results on solute transport in a simplified model of the spinal canal, providing a deeper understanding of drug dispersion in intrathecal drug delivery procedures. The model consists of an annular channel with a rigid transparent tube representing the dura mater and a compliant insert representing the spinal cord. Laser induced fluorescence is used to characterize solute dispersion along the canal and into the cranial cavity. The study confirms the existence of a steady bulk flow that plays a key role in solute transport along the spinal canal.
Review
Biochemistry & Molecular Biology
Irina Baichurina, Victor Valiullin, Victoria James, Albert Rizvanov, Yana Mukhamedshina
Summary: Despite extensive research, the molecular mechanisms underlying neurological disorders, especially spinal cord injury and neurodegenerative diseases, remain unclear. microRNAs (miRNAs) in cerebrospinal fluid (CSF) have been proposed as potential biomarkers, but their isolation and detection are technically challenging. This review evaluates recent studies on CSF miRNAs as biomarkers and provides an overview of research methods and possible solutions for studying miRNAs in CSF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Shinuo Liu, Lynne E. Bilston, Marcus A. Stoodley, Sarah J. Hemley
Summary: The disruption of cerebrospinal fluid/interstitial fluid exchange in the spinal cord can lead to CNS diseases involving abnormal fluid accumulation. This study aimed to investigate the effects of cardiac pulsations and respiration on fluid transport in the spinal cord. The results showed that tachycardia and hypertension increased tracer efflux, while intrathoracic pressure changes during spontaneous breathing did not have a significant impact.
FLUIDS AND BARRIERS OF THE CNS
(2021)
Article
Medical Laboratory Technology
Marcus Clarin, Annika Petersson, Henrik Zetterberg, Kim Ekblom
Summary: This study evaluated two methods for interpreting absorption curves of cerebrospinal fluid, with the UK-NEQAS method showing higher specificity and accuracy compared to the Equalis method. The semi-automated UK-NEQAS method is recommended for routine interpretation of CSF spectrophotometric curves due to its efficiency and accuracy.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Soham Bandyopadhyay, Patrick Garland, Ben Gaastra, Ardalan Zolnourian, Diederik Bulters, Ian Galea
Summary: This study investigated the response of haptoglobin in cerebrospinal fluid (CSF) and serum after subarachnoid hemorrhage (SAH). The results showed a severe deficiency of haptoglobin in CSF after SAH, while haptoglobin levels in serum increased. The changes in serum haptoglobin were correlated with cytokine levels in CSF. This suggests that the importance of haptoglobin in long-term clinical outcomes is limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sara Diana Lolansen, Nina Rostgaard, Tenna Capion, Nicolas H. Norager, Markus Harboe Olsen, Marianne Juhler, Tiit Illimar Mathiesen, Nanna MacAulay
Summary: The molecular mechanisms underlying the development of posthemorrhagic hydrocephalus (PHH) remain unclear, but elevated cerebrospinal fluid (CSF) osmolality is not the cause of PHH. The pathological CSF accumulation observed in these patients is instead attributed to other pathological alterations associated with the abnormal presence of blood within the CSF compartments following subarachnoid hemorrhage (SAH).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Hongxiang Huang, Changliang Zhu, Hao Qin, Li Deng, Chunming Huang, Comron Saifi, Kevin Bondar, Enrico Giordan, Olumide Danisa, Jun Ho Chung, Hossein Elgafy, Rannulu Dineth Fonseka, Chuixue Huang, Qingchun Mu
Summary: Intracranial hemorrhage following spinal surgery is a rare but severe complication. This literature review analyzes its incidence, clinical manifestations, hemorrhage location, current treatment strategies, and aims to provide insights for prompt identification and prevention by clinicians.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Orthopedics
Shun Yamamoto, Luis Dias, John Street, Peter A. Cripton, Thomas R. Oxland
Summary: Biomechanical properties of the upper thoracic spine were evaluated with anterior-posterior shear loading at various displacement rates. The stiffness of the specimens was significantly higher in the anterior direction compared to the posterior direction, with the shear displacement rate having a minor effect on the load response. The shear stiffness in the upper thoracic spine is greatest in the anterior loading direction due to facet interactions.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Engineering, Biomedical
S. Cavelier, R. D. Quarrington, C. F. Jones
Summary: The mechanical properties of porcine pericranium and spinal dura mater were characterized and compared in this study. The findings suggest that longitudinally oriented pericranium is mechanically compatible with spinal duraplasty procedures. However, further analysis is needed to study the effect of the lower yield strain of circumferential pericranium compared to spinal dura.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Materials Science, Coatings & Films
Erfan Abedi Esfahani, Ogbemi Bukuaghangin, Sarah Banfield, Yenal Vangolu, Liuquan Yang, Anne Neville, Richard Hall, Michael Bryant
Summary: Surface engineering has a beneficial effect on the wear and corrosion performance of Ti-6Al-4V alloy for biomedical purposes. TiN ceramic coatings have been proven to be effective in improving the tribocorrosion properties of Ti-based alloys. A duplex TPON + TiN treatment process has been suggested for high contact load applications. The coated ALM materials show improved bio-tribology and corrosion resistance compared to conventional wrought manufactured alloy.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Engineering, Biomedical
Ryan D. Quarrington, Darcy W. Thompson-Bagshaw, Claire F. Jones
Summary: This study investigated the effects of intervertebral distraction and compression on facet joint cartilage apposition area (CAA) during cervical spine trauma. The results showed that distraction significantly decreased CAA and shifted the apposition region towards the facet tip. These findings may provide insights into the mechanisms of cervical facet dislocation and fracture.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Neurosciences
Jessica M. Sharkey, Ryan D. Quarrington, Charlie C. Magarey, Claire F. Jones
Summary: This study aimed to determine the mass properties of the sheep head and brain, and define a virtual anatomical coordinate system for the head and brain, in order to facilitate comparison of head kinematics between ovine models and humans in the context of traumatic brain injury.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Engineering, Biomedical
Charlotte Skjoldebrand, Joanne L. Tipper, Peter Hatto, Michael Bryant, Richard M. Hall, Cecilia Persson
Summary: Hip and knee joint replacements are common and successful surgeries, but the release of metallic ions and particles from the implants can cause hypersensitivity and tissue necrosis. Coatings have the potential to improve implant properties and act as barriers to inhibit ion release. There are commercially available coatings for clinical use and ongoing research on new coatings. Adhesion of coatings remains a concern, but zirconium and TiNbN coatings have shown comparable results to traditional implants in terms of revision numbers and allergy symptom relief.
MATERIALS TODAY BIO
(2022)
Article
Orthopedics
Claire F. Jones, Ryan D. Quarrington, Helen Tsangari, Yolandi Starczak, Adnan Mulaibrahimovic, Anouck L. S. Burzava, Chris Christou, Alex J. Barker, James Morel, Richard Bright, Dan Barker, Toby Brown, Krasimir Vasilev, Paul H. Anderson
Summary: The study compared the osseointegration of medical-grade titanium implants with a unique nanostructured surface modification to a clinically accepted control surface in a sheep model. The results showed that the implants with the nanostructured surface had stronger bone integration compared to the control surface.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2022)
Article
Critical Care Medicine
Christine D. Gayen, Madeleine A. Bessen, Ryan M. Dorrian, Ryan D. Quarrington, Adnan Mulaibrahimovic, Ryan L. O'Hare Doig, Brian J. C. Freeman, Anna V. Leonard, Claire F. Jones
Summary: Spinal cord injury (SCI) can cause motor, sensory, and autonomic dysfunction, and there is currently no cure. Large animal models, such as domestic pigs, can help in the study of SCI and potential treatments. This study characterized two severities of thoracic contusion SCI in female domestic pigs and examined motor function and spinal cord lesion characteristics. The results showed differences in motor function, lesion volume, and white matter sparing between the two severities of SCI. This model provides a valuable tool for SCI research and potential therapeutic interventions.
JOURNAL OF NEUROTRAUMA
(2023)
Editorial Material
Public, Environmental & Occupational Health
Gabrielle R. Booth, Carolyn W. Roberts, Sarah Romani, Olivia Mergler, Honglin Zhang, Bengt Pipkorn, Gunter P. Siegmund, Peter A. Cripton, Jason Forman
Summary: This study developed a method using MRI imaging to visualize automotive postures and seat belt fit from the pelvis to the clavicle. It also established techniques to quantify belt fit by digitizing spinal and pelvic landmarks. This method provides opportunities to study variation in seat belt fit for different automotive postures, occupants of different sexes, ages, BMIs, anthropometries, and pregnant occupants.
TRAFFIC INJURY PREVENTION
(2022)
Article
Polymer Science
Ben Golland, Joanne L. Tipper, Richard M. Hall, Giuseppe Tronci, Stephen J. Russell
Summary: This study investigates the effects of a new scaffold material on neural regeneration. The scaffold is able to mimic native spinal cord tissue and provides optimized mechanical properties and a hydrated environment. The results demonstrate that the scaffold promotes neural cell extension and viability, as well as aligned tissue regeneration.
Article
Engineering, Biomedical
G. Fonseca, P. Vakiel, P. A. Cripton
Summary: In this study, a biofidelic functional spinal unit (FSU) named UBC Neck C4-C5 was designed and created to replicate the multiplane loading experienced in real-world scenarios leading to spinal cord injuries. Anatomically accurate C4 and C5 vertebrae were 3D printed, and surrogate materials for the intervertebral disc and cervical ligaments were selected. The assembled FSU showed good biofidelity and will contribute to the development of a full surrogate neck for testing safety equipment.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Sushil Kandel, Steven Su, Richard M. Hall, Joanne L. Tipper
Summary: Polymer wear debris is a major concern in total joint replacements due to potential biological reactions. This study proposes an automatic particle segmentation algorithm using adaptive thresholding and Convolution Neural Network (CNN) classification. The use of computer algorithms and CNN allows for more efficient analysis of wear debris with complex characteristics, resulting in robust size and volume distribution graphs for estimation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Nikoo Soltan, Gunter P. Siegmund, Peter A. Cripton, Claire F. Jones
Summary: This study characterized the mass, center of mass, and mass moments of inertia of the head and brain of pre-adolescent domestic pigs, and proposed an anatomical coordinate system. The data obtained can be used for comparing head and brain kinematics data and translating them to human injury models.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Robert J. Elkington, Richard M. Hall, Andrew R. Beadling, Hemant Pandit, Michael G. Bryant
Summary: To preserve the function of synovial joint counter-face during osteochondral defect repairs, it is important to develop surfaces optimized for healthy cartilage function. In this study, PEEK surfaces were modified with a hydrophilic coating (SPMK-g-PEEK) to provide a low friction and compliant sliding interface. The results showed that SPMK-g-PEEK maintained low friction and minimized forces on the cartilage interface, providing an enhanced cartilage counter-surface.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Kaushikk Iyer, David Keeling, Richard M. Hall
Summary: This paper presents the application of hardware-in-the-loop simulation technology in the development and testing of an artificial joint wear simulator. The simulation enables rapid testing of different control strategies and validates the accuracy and robustness of the prospective controller, supporting the reliability of the experimental results.
2022 8TH INTERNATIONAL CONFERENCE ON MECHATRONICS AND ROBOTICS ENGINEERING (ICMRE 2022)
(2022)
