Article
Medicine, General & Internal
Naruchorn Kijpaisalratana, Zsuzsanna Ament, Matthew B. Bevers, Varun M. Bhave, Ana-Lucia Garcia Guarniz, Catharine A. Couch, M. Ryan Irvin, W. Taylor Kimberly
Summary: This cross-sectional study found an association between trimethylamine N-oxide (TMAO) and cerebral small vessel disease, as indicated by white matter hyperintensity volume (WMHV) and acute lacunar infarction. This association was independent of traditional vascular risk factors.
Article
Cardiac & Cardiovascular Systems
Takumi Toya, Jaskanwal D. Sara, Eugene L. Scharf, Ali Ahmad, Valentina Nardi, Ilke Ozcan, Lilach O. Lerman, Amir Lerman
Summary: In patients aged over 50 years, peripheral endothelial dysfunction is associated with increased volume of juxtacortical white matter hyperintensity (WMH), which may serve as a potential marker for predicting future risk of ischemic stroke (IS).
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
L. A. Dobrynina, A. D. Suslina, M. Gubanova, A. Belopasova, A. N. Sergeeva, S. Evers, E. Gnedovskaya, M. Krotenkova
Summary: In migraine patients without vascular risk factors, different subtypes share a similar pattern of WMH, predominantly located in the juxtacortical and/or deep white matter of the frontal, parietal, and temporal lobes. The number of lesions in the frontal lobe juxtacortical white matter is correlated with patients' age and duration since migraine onset.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Imad Derraz, Mohamed Abdelrady, Nicolas Gaillard, Raed Ahmed, Federico Cagnazzo, Cyril Dargazanli, Pierre-Henri Lefevre, Lucas Corti, Carlos Riquelme, Isabelle Mourand, Gregory Gascou, Alain Bonafe, Caroline Arquizan, Vincent Costalat
Summary: This study investigated the association between white matter hyperintensity (WMH) burden and collateral circulation in patients with anterior circulation acute ischemic stroke treated with endovascular thrombectomy, and found that there is no overt relationship between WMH burden and collaterals in large vessel occlusive stroke.
Article
Clinical Neurology
Anisa Dhana, Charles DeCarli, Klodian Dhana, Pankaja Desai, Robert S. Wilson, Denis A. Evans, Kumar B. Rajan
Summary: By studying data from 701 older adults, we found that combining white matter hyperintensity (WMH) with neurofilament light chain (NfL) could provide additional information for cognition. Higher levels of WMH and NfL were associated with a faster rate of cognitive decline during the follow-up period, suggesting different underlying mechanisms affecting cognition.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Imad Derraz, Mohamed Abdelrady, Raed Ahmed, Nicolas Gaillard, Riccardo Morganti, Federico Cagnazzo, Cyril Dargazanli, Pierre-Henri Lefevre, Carlos Riquelme, Lucas Corti, Gregory Gascou, Isabelle Mourand, Caroline Arquizan, Vincent Costalat
Summary: This study aimed to assess whether the burden of white matter hyperintensity (WMH) is associated with an increased risk of symptomatic intracranial hemorrhage (sICH) or poor functional outcome in patients with acute ischemic stroke treated with endovascular thrombectomy (EVT). The results showed that a higher burden of WMH was associated with an increased risk of poor functional outcome at 3 months after EVT.
Article
Geriatrics & Gerontology
Sen Zhang, Yaya Hu, Huilin Yang, Qianqian Li, Jing Chen, Hongying Bai
Summary: This study investigated the correlations of white matter hyperintensities (WMH) volume and white matter (WM) volume with cognitive dysfunction in patients with cerebral small-vessel disease (CSVD). It was found that both WMH volume and WM volume were independent risk factors for cognitive dysfunction. WMH volume primarily affected cognitive dysfunction involving visual space and delayed recall, while WM volume was not strongly associated with different types of cognitive dysfunction. The ratio of WMH to WM volume can be used for more accurate evaluation of cognitive dysfunction in older adults with CSVD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Mark R. Etherton, Ona Wu, Anne-Katrin Giese, Natalia S. Rost
Summary: In this study of 319 patients with acute ischemic stroke, it was found that normal-appearing white matter axial diffusivity increases with age and independently predicts white matter hyperintensity volume. Increasing age and admission diastolic blood pressure were also identified as independent predictors of normal-appearing white matter axial diffusivity.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Immunology
Lucie Rascle, Norbert Nighoghossian, Tae-Hee Cho, Thomas Bochaton, Alexandre Paccalet, Claire Crola Da Silva, Marielle Buisson, Camille Amaz, Julia Fontaine, Elodie Ong, Laurent Derex, Yves Berthezene, Omer Faruk Eker, Nathan Mewton, Michel Ovize, Laura Mechtouff
Summary: This study aimed to investigate whether inflammation related to white matter hyperintensities (WMH), a key component of small vessel disease (SVD), may affect the inflammatory response in acute ischemic stroke (AIS) patients. The study measured inflammatory markers and assessed WMH burden and found that a high WMH burden was associated with four marker levels but not in multivariable analyses.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Article
Clinical Neurology
Robin B. Brown, Daniel J. Tozer, Marco Egle, Anil M. Tuladhar, Frank-Erik de Leeuw, Hugh S. Markus
Summary: This study investigated the regression of white matter hyperintensity lesions (WMHs) in patients with cerebral small vessel disease (SVD). It found that only a small proportion of patients showed regression, and this regression was associated with smaller initial lesion volume and better white matter microstructural integrity.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Review
Biochemistry & Molecular Biology
Gianmaria Salvio, Alessandro Ciarloni, Melissa Cutini, Giancarlo Balercia
Summary: Erectile Dysfunction (ED) is linked to cardiovascular conditions, with hyperhomocysteinemia playing a central role in causing endothelial damage and affecting male sexual function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Chia-Ling Phuah, Yasheng F. Chen, Jeremy Strain, Nirupama J. Yechoor, Osvaldo M. Laurido-Soto, Beau Ances, Jin-Moo Lee
Summary: The study used a pattern discovery approach to identify distinct spatial patterns of WMH and investigate their association with different etiologies.
Article
Clinical Neurology
Joomee Song, Keon-ha Kim, Pyoung Jeon, Young-Wook Kim, Dong-Ik Kim, Yang-Jin Park, Moo-Seok Park, Jong-Won Chung, Woo-Keun Seo, Oh Young Bang, Hakan Ay, Gyeong-Moon Kim
Summary: This study found that larger white matter hyperintensity (WMH) volume is associated with increased stroke severity and poorer prognosis in patients with symptomatic carotid artery stenosis.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Sungmin Hong, Anne-Katrin Giese, Markus D. Schirmer, Anna K. Bonkhoff, Martin Bretzner, Pamela Rist, Adrian Dalca, Robert W. Regenhardt, Mark R. Etherton, Kathleen L. Donahue, Marco Nardin, Steven J. T. Mocking, Elissa C. McIntosh, John Attia, Oscar R. Benavente, John W. Cole, Amanda Donatti, Christoph J. Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Jaume Roquer, Steven J. Kittner, Robin Lemmens, Christopher R. Levi, Caitrin W. McDonough, James F. Meschia, Chia-Ling Phuah, Arndt Rolfs, Stefan Ropele, Jonathan Rosand, Tatjana Rundek, Ralph L. Sacco, Reinhold Schmidt, Christian Enzinger, Pankaj Sharma, Agnieszka Slowik, Alessandro Sousa, Tara M. Stanne, Daniel Strbian, Turgut Tatlisumak, Vincent Thijs, Achala Vagal, Johan Wasselius, Daniel Woo, Ramin Zand, Patrick F. McArdle, Bradford B. Worrall, Ona Wu, Christina Jern, Arne G. Lindgren, Jane Maguire, Liisa Tomppo, Polina Golland, Natalia S. Rost
Summary: The excessive burden of unaccounted white matter hyperintensities (WMH) in post-stroke patients, not explained by traditional risk factors, is associated with poorer long-term functional outcomes. This suggests that white matter hyperintensities unrelated to conventional risk factors may play a crucial role in stroke recovery and serve as an indicator of brain health.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Hailing Liu, Bin Deng, Fen Xie, Xiaohua Yang, Zhenchao Xie, Yonghua Chen, Zhi Yang, Xiyan Huang, Shuzhen Zhu, Qing Wang
Summary: This meta-analysis found that patients with Parkinson's disease and mild cognitive impairment (PD-MCI) had significantly different white matter hyperintensity (WMH) burden compared to those with normal cognition (PD-NC), while patients with Parkinson's disease dementia (PDD) had significantly higher WMH burden compared to those without dementia (PD-ND).
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)