Article
Biochemistry & Molecular Biology
Giuseppe Forte, Valentina Giuffrida, Angelica Scuderi, Mariella Pazzaglia
Summary: Neuropathic pain is a common chronic condition that severely affects patients with spinal cord injuries. Current treatment options are limited, but nanomedicine shows potential for improving therapeutic efficacy. However, its application in treating neuropathic pain following spinal cord injuries still needs further improvement.
Article
Clinical Neurology
Dongwoo Yu, Seul Ah Mun, Sang Woo Kim, Dae-Chul Cho, Chi Heon Kim, Inbo Han, Subum Lee, Sang -Woo Lee, Kyoung-Tae Kim
Summary: D-serine exacerbates neuropathic pain after traumatic spinal cord injury by mediating the NMDA receptor. NMDA receptor antagonists alleviate neuropathic pain after traumatic spinal cord injury.
Article
Public, Environmental & Occupational Health
Eva Widerstrom-Noga, Kimberly D. Anderson, Linda E. Robayo, Salome Perez, Alberto Martinez-Arizala, Lindsey Calle-Coule, Nicholas P. Cherup, Gabriel E. Fernandez
Summary: Many people with spinal cord injury (SCI) suffer from chronic pain, including neuropathic pain, which is often difficult to treat due to its complex nature. A multimodal approach, involving pharmacological treatments, physical rehabilitation, cognitive training, and pain education, may be the most effective strategy for managing pain in this population. This study developed an educational resource called SeePain, which was evaluated and modified based on stakeholder input, including SCI patients, their loved ones, and healthcare providers. The final resource is a comprehensive guide intended to improve health literacy and enhance communication between SCI patients and their healthcare providers. Future research will validate the effectiveness of SeePain using a large sample of SCI patients.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Pharmacology & Pharmacy
Fangliang Guo, Xiaolong Zheng, Ziyu He, Ruoying Zhang, Song Zhang, Minghuan Wang, Hong Chen, Wei Wang
Summary: The study found that long-term treatment with NMD helps to improve locomotion, pain-related behaviors, and spasticity-like symptoms in rats with SCI, but has less effect on open-field activity, hind limb grip strength, and bladder function. Additionally, NMD-treated rats showed greater tissue preservation, reduced lesion areas, and increased perilesional neuronal sparing, suggesting a potential therapeutic strategy for SCI treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
You-You Lv, Han Wang, Hai-Ting Fan, Ting Xu, Wen-Jun Xin, Rui-Xian Guo
Summary: The present study found that SUMOylation of spinal Kir7.1 may contribute to the development of mechanical allodynia in neuropathic pain by decreasing the surface expression of Kir7.1.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Rehabilitation
Tim C. Crul, Marcel W. M. Post, Johanna M. A. Visser-Meily, Janneke M. Stolwijk-Swuste
Summary: This study aimed to investigate the prevalence and characteristics of SCI-related pain during initial inpatient rehabilitation and explore their relationships with demographic and lesion characteristics. The results showed that SCI-related pain was highly prevalent during inpatient rehabilitation and different factors such as sex, age, and type of injury were associated with the presence of pain.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Clinical Neurology
Luciana Mendonca Barbosa, Fernanda da Valerio, Samira Luisa Apostolos Pereira, Valquiria Aparecida da Silva, Antonia Lilian de Lima Rodrigues, Ricardo Galhardoni, Lin Tchia Yeng, Jefferson Rosi Jr, Adriana Bastos Conforto, Leandro Tavares Lucato, Marcelo Delboni Lemos, Manoel Jacobsen Teixeira, Daniel Ciampi de Andrade
Summary: This study examined the relationships between symptoms and somatosensory profiles in patients with central neuropathic pain (CNP) caused by different types of lesions to the central nervous system. The results suggest that CNP of different etiologies may have different pain descriptors and somatosensory profiles, likely due to differences in lesion locations.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Mustafa Umut Etli, Caner Sarikaya, Mehmet Resid Onen, Sait Naderi
Summary: This study found that neuropathic pain (NP) may occur in both pre-and postoperative periods in patients with spinal hemangioblastomas. The main factors affecting NP include the proximity of the tumor to the dorsal root entry zone, especially the presence of rostral syrinx.
WORLD NEUROSURGERY
(2021)
Article
Neurosciences
Zhihao Zhang, Zhijie Zhu, Xiaoshuang Zuo, Xuankang Wang, Cheng Ju, Zhuowen Liang, Kun Li, Jiawei Zhang, Liang Luo, Yangguang Ma, Zhiwen Song, Xin Li, Penghui Li, Huilin Quan, Peipei Huang, Zhou Yao, Ning Yang, Jie Zhou, Zhenzhen Kou, Beiyu Chen, Tan Ding, Zhe Wang, Xueyu Hu
Summary: This study investigated the mechanisms of photobiomodulation (PBM) in relieving neuropathic pain (NP) after spinal cord injury (SCI). It was found that PBM therapy inhibited the activation of microglia and astrocytes, decreased the expression of CXCL10 in glial cells, and mediated the NF-κB signaling pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Rehabilitation
Emma L. Karran, Louise K. Wiles, Dianne J. Wilson, G. Lorimer Moseley
Summary: By reviewing clinical practice guidelines and recent literature, common recommendations for best practice pain care in adults with spinal cord injury (SCI) have been identified. These recommendations can guide consumers, clinicians, researchers, and policy makers in understanding and implementing evidence-based best practice pain management in adults with SCI.
DISABILITY AND REHABILITATION
(2023)
Review
Biochemistry & Molecular Biology
Vinicius Tieppo Francio, Keith F. Polston, Micheal T. Murphy, Jonathan M. Hagedorn, Dawood Sayed
Summary: Since 1967, spinal cord stimulation (SCS) technology has evolved significantly, with the introduction of the 10 kHz SCS system that selectively activates inhibitory interneurons in the dorsal horn. This high-frequency stimulation pattern has demonstrated significant pain control superiority in patients with chronic back pain and neuropathic pain.
Review
Neurosciences
Chang Sun, Junhao Deng, Yifei Ma, Fanqi Meng, Xiang Cui, Ming Li, Jiantao Li, Jia Li, Pengbin Yin, Lingjie Kong, Licheng Zhang, Peifu Tang
Summary: This article presents a comprehensive overview of recent advances in understanding the role of microglia in the development of neuropathic pain following spinal cord injury (SCI). It delves into the detrimental and protective effects of microglia on neuropathic pain following SCI, as well as the mechanisms underlying their interconversion. The article also provides a thorough overview of potential avenues for future research in this area.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Rehabilitation
Elizabeth R. Felix, Diana D. Cardenas, Thomas N. Bryce, Susan Charlifue, Tae Kyong Lee, Bria MacIntyre, Sara Mulroy, Heather Taylor
Summary: This study compared the prevalence, intensity ratings, and interference ratings of neuropathic pain and nociceptive pain in chronic spinal cord injury patients, finding significant differences in intensity and interference levels between neuropathic pain and non-neuropathic pain. Additionally, women and paraplegic patients were found to have a higher prevalence of neuropathic pain, providing important insights for treatment strategies.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Review
Medicine, General & Internal
Dominika Mech, Katarzyna Korgol, Antonina Kurowska, Bartlomiej Adamski, Malgorzata Miazga, Grazyna Biala, Marta Kruk-Slomka
Summary: Spinal cord injury is a neurological condition that causes significant motor dysfunction, and current treatments only provide moderate efficacy, leaving patients with long-term disabilities. A scientific review is needed to summarize recent developments in therapeutic methods for SCI. This review focuses on pharmacological treatments and the challenges faced by patients depending on the location of the injury, addressing issues such as spasticity, neuropathic pain, neuroprotection, neurotransmission, and oxidative stress.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Immunology
Jing Zhu, Fei Huang, Yonglin Hu, Wei Qiao, Yingchao Guan, Zhi-Jun Zhang, Su Liu, Ying Liu
Summary: Secondary chronic neuropathic pain (NP) after spinal cord injury (SCI) significantly reduces quality of life. The mechanisms of NP in SCI have been studied, and reducing neuroinflammation has shown potential for improving NP-related behaviors. Non-coding RNAs have been found to play important roles in SCI, regulating gene expression, inhibiting inflammation, and influencing the prognosis of NP.
JOURNAL OF INFLAMMATION RESEARCH
(2023)