期刊
SPECTROSCOPY-AN INTERNATIONAL JOURNAL
卷 23, 期 2, 页码 81-101出版社
HINDAWI LTD
DOI: 10.1155/2009/587956
关键词
DNA; protein; binding mode; binding constant; secondary structure; FTIR spectroscopy
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- FCAR (Quebec)
In this chapter the fundamental question of how does protein-DNA or protein-RNA interaction affect the structures and dynamics of DNA, RNA and protein is addressed. Models for calf-thymus DNA and transfer RNA interactions with human serum albumin (HSA), ribonuclease A (RNase A) and deoxyribonuclease I (DNase I) are presented here, using Fourier Transform Infrared (FTIR) spectroscopy in conjunction with UV-visible and CD spectroscopic methods. In the models considered, the binding sites, stability and structural aspects of protein-DNA and protein-RNA are discussed and the effects of protein interaction on the secondary structures of DNA, RNA and protein were determined.
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