Article
Biochemistry & Molecular Biology
Nicole Schaefer, Susanne Graessel
Summary: Osteoarthritis affects over 500 million people worldwide, causing significant suffering and societal cost. Chronic, low-grade inflammation is central to its pathogenesis, with the complement system possibly playing a crucial role in its development. Despite potential side effects, targeting the complement system shows promising effects in alleviating inflammatory responses in joint tissues.
Article
Respiratory System
Signe Vedel-Krogh, Katrine L. Rasmussen, Borge G. Nordestgaard, Sune F. Nielsen
Summary: This study found that high plasma complement C3 concentration is associated with an increased risk of asthma development and severity, particularly in individuals with allergic asthma. The findings support a causal role of the complement system in asthma severity.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Jie Xiong, Xingyi Kuang, Tingting Lu, Kunlin Yu, Xu Liu, Zhaoyuan Zhang, Weili Wang, Lu Zhao, Qin Fang, Depei Wu, Jishi Wang
Summary: The study demonstrates that levels of C3a and C5a are elevated in MM patients and their receptors are highly expressed on myeloma cells. These anaphylatoxins promote migration, invasion, and adhesion of MM cells through MEK/ERK pathway activation and Nrf2 nuclear translocation. Nrf2 downregulation could attenuate the migration of C3a and C5a-stimulated MM cells in vivo, suggesting potential therapeutic targets for MM treatment.
CANCER GENE THERAPY
(2021)
Article
Pharmacology & Pharmacy
Xaria X. Li, Vinod Kumar, Richard J. Clark, John D. Lee, Trent M. Woodruff
Summary: The study found that SB290157 exhibits partial agonist activity on C5aR2 and significantly dampens C5a-induced signaling in human and mouse macrophages. The drug's effects on human C3aR and C5aR1 are unclear, making it unsuitable for exploring C3aR function. This cautionary research indicates that the observed functions of SB290157 may be due to its off-target activities.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sandeep Silawal, Benjamin Kohl, Jingjian Shi, Gundula Schulze-Tanzil
Summary: The study found that C5a stimulation did not affect cell survival, but had a significant impact on the gene expression of C5aR, CRPs, and inflammatory cytokines at different stages. C5a may directly contribute to cell activation, thereby being involved in tendon healing and tendinopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Miao-Miao Tang, Shu-Ting Zhao, Ran-Qi Li, Wei Hou
Summary: Coronary heart disease (CHD) is a common clinical manifestation of cardiovascular disease, characterized by myocardial ischemia caused by coronary atherosclerosis. Ginseng has been found to improve cardiac function by regulating blood glucose levels, reducing blood pressure, oxidative stress, platelet aggregation, and lipid dysregulation. It can be considered as an alternative therapy for CHD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Jolimar Hanna, Franck Ah-Pine, Chailas Boina, Yosra Bedoui, Philippe Gasque, Axelle Septembre-Malaterre
Summary: The study investigated the effects of C3a anaphylatoxin on tumor cells and the tumor microenvironment. It found that C3a plays a crucial role in the tumor microenvironment by modulating the expression of cytokines, chemokines, Cox-2, HO-1, and upregulating the oxidative stress response. C3a also regulates VEGF expression, suggesting a role in angiogenesis.
Article
Immunology
Daria Kowalska, Alicja Kuzniewska, Yaiza Senent, Beatriz Tavira, Susana Inoges, Ascension Lopez-Diaz de Cerio, Ruben Pio, Marcin Okroj, Jose Ramon Yuste
Summary: This study found that high levels of complement C5a in COVID-19 patients are associated with disease severity, but there is no clear link with markers of upstream complement activation, suggesting the existence of a non-canonical source of C5a.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Oliver Buchhave Pedersen, Sanne Bojet Larsen, Steen Dalby Kristensen, Anne-Mette Hvas, Erik Lerkevang Grove
Summary: Immature platelet markers cannot predict cardiovascular events in stable CAD patients.
Article
Immunology
Farhan S. Cyprian, Muhammad Suleman, Ibrahim Abdelhafez, Asmma Doudin, Ibn Mohammed Masud Danjuma, Fayaz Ahmad Mir, Aijaz Parray, Zohaib Yousaf, Mohammed Yaseen Ahmed Siddiqui, Alaaedin Abdelmajid, Mohammad Mulhim, Shaikha Al-Shokri, Mohammad Abukhattab, Ranad Shaheen, Eyad Elkord, Abdul Latif Al-khal, Abdel-Naser Elzouki, Guillermina Girardi
Summary: This study aimed to identify high-risk patients at the time of SARS-COV-2 infection who may develop severe disease associated with low survival using blood parameters, including inflammation and coagulation mediators, vital signs, and pre-existing comorbidities.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pei Qiao, Dalong Zhi, Chen Yu, Chen Zhang, Kunyi Wu, Hui Fang, Shuai Shao, Wen Yin, Erle Dang, Ke Li, Gang Wang
Summary: Studies have shown that C3aR plays a protective role in psoriasis by negatively regulating the expression of K6, K16, and K17 in keratinocytes to inhibit cell proliferation and help reverse the progression of the disease.
Review
Biochemistry & Molecular Biology
Jing Li, Bin Liu
Summary: Emerging evidence suggests a strong association between multisystem organ failure in COVID-19 patients and various coagulopathies, presenting a clinical challenge for treatment. Understanding the mechanisms of complement cascade activation in the genesis of COVID-19-associated coagulopathy could lead to the development of novel anticoagulant drugs targeting C5a/C5aRs signaling.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Hematology
Samuel K. Lee, Rida A. Malik, Ji Zhou, Wei Wang, Peter L. Gross, Jeffrey I. Weitz, Rithwik Ramachandran, Bernardo L. Trigatti
Summary: This study investigated the effects of PAR4 inhibitory pepducin (RAG8) on coronary artery disease in SR-B1/LDLR double knockout mice fed a high-fat, high-cholesterol diet. The results showed that RAG8 reduced coronary artery atherosclerosis and myocardial fibrosis, as well as platelet and leukocyte accumulation in atherosclerotic coronary arteries.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cell Biology
Sandeep Silawal, Miriam Wagner, Dominik Roth, Thomas Bertsch, Silke Schwarz, Maximilian Willauschus, Markus Gesslein, Jakob Triebel, Gundula Schulze-Tanzil
Summary: This study investigated the possible crosstalk between the complement system (CS) and the prolactin (PRL) hormone system in chondrocytes. The results suggest that Cathepsin D (CatD) and C5 have a negative feedback regulation on their own gene expression, and there is an interrelation between the CS and the PRL systems.
Article
Medicine, Research & Experimental
Da-Wei Chen, Tian Kang, Xiu-Zhang Xu, Wen-Jie Xia, Xin Ye, Yong-Bin Wu, Yao-Ri Xu, Jing Liu, Hui Ren, Jing Deng, Yang-Kai Chen, Hao-Qiang Ding, Muhammad Aslam, Wioleta M. Zelek, B. Paul Morgan, Rick Kapur, Sentot Santoso, Yong-Shui Fu
Summary: Anti-CD36 antibodies can cause transfusion-related acute lung injury (TRALI), especially in Asian populations. However, the pathological mechanism of anti-CD36 Ab-mediated TRALI and potential therapies are not well understood. In this study, a mouse model of anti-CD36 Ab-mediated TRALI was developed, and it was found that TRALI could be prevented and treated by targeting Fc and complement C5 activation. These findings suggest the potential for anti-C5 drugs in the treatment of TRALI caused by anti-CD36 antibodies.