Article
Medicine, General & Internal
Xiaoqin Liu, Chun Pan, Lining Si, Shijun Tong, Yi Niu, Haibo Qiu, Guifen Gan
Summary: This study aimed to determine the value of the Berlin Definition altitude-PaO2/FiO(2)-corrected criteria for ARDS in Xining, Qinghai. The results showed that this criteria can distinguish the severity of ARDS, but further confirmation is needed through larger sample and multicenter clinical studies.
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Sunitha Palanidurai, Jason Phua, Yiong Huak Chan, Amartya Mukhopadhyay
Summary: The new P/FP ratio formula, incorporating PEEP into the P/F ratio, better predicts hospital mortality in ARDS patients compared to the traditional P/F ratio. Changes in severity classification with the P/FP ratio reflect both true illness severity and the applied PEEP strategy.
ANNALS OF INTENSIVE CARE
(2021)
Article
Virology
Enric Monreal, Sainz S. de la Maza, Pedro Gullon, Elena Natera-Villalba, Juan Luis Chico-Garcia, Alvaro Beltran-Corbellini, Javier Martinez-Sanz, Nuria Garcia-Barragan, Javier Buisan, Rafael Toledano, Araceli Alonso-Canovas, Paula Perez-Torre, Maria C. Matute-Lozano, Jose Luis Lopez-Sendon, Guillermo Garcia-Ribas, Inigo Corral, Jesus Fortun, Beatriz Montero-Errasquin, Luis Manzano, Luis Maiz-Carro, Lucienne Costa-Frossard, Jaime Masjuan
Summary: This study found that immunosuppression may reduce the risk of moderate to severe ARDS in COVID-19 patients, especially among those with autoimmune diseases.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Miguel Hueda-Zavaleta, Cesar Copaja-Corzo, Brayan Miranda-Chavez, Rodrigo Flores-Palacios, Jonathan Huanacuni-Ramos, Juan Mendoza-Laredo, Diana Minchon-Vizconde, Juan Carlos Gomez de la Torre, Vicente A. Benites-Zapata
Summary: This study aimed to determine whether PaO2/FiO2 24 h after IMV and Delta PaO2/FiO2 24 h can predict survival in patients with COVID-19-induced ARDS. The results showed that PaO2/FiO2 24 h after IMV and Delta PaO2/FiO2 24 h were associated with higher hospital mortality. These findings are useful in identifying patients at higher risk of death upon ICU admission.
Article
Obstetrics & Gynecology
B. L. Pineles, A. Stephens, L. M. Narendran, M. A. Tigner, C. Leidlein, C. Pedroza, H. Mendez-Figueroa, B. M. Sibai
Summary: The study found that delivery improves the P/F ratio in pregnant patients with COVID-19-related ARDS, highlighting the need for individualized delivery management in these patients.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Critical Care Medicine
Michelle W. Rudolph, Martin C. J. Kneyber, Lisa A. Asaro, Ira M. Cheifetz, David Wypij, Martha A. Q. Curley
Summary: This study aims to evaluate the use of neuromuscular blocking agents in pediatric acute respiratory distress syndrome (PARDS). It was found that early NMBA use was associated with a longer duration of mechanical ventilation (MV), but not with mortality or long-term cognitive and functional impairment.
CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Vincent J. H. S. Gilissen, Mark Koning, Markus Klimek
Summary: This study investigates the difference between standard and corrected Pao(2)/Fio(2) ratios and their correlation with the mortality of acute respiratory distress syndrome classification. The study finds that using the corrected ratio improves the correlation with mortality and provides a web-based tool for calculation.
CRITICAL CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Thomas S. Metkus, Lori J. Sokoll, Andreas S. Barth, Matthew J. Czarny, Allison G. Hays, Charles J. Lowenstein, Erin D. Michos, Eric P. Nolley, Wendy S. Post, Jon R. Resar, David R. Thiemann, Jeffrey C. Trost, Rani K. Hasan
Summary: The study found that over 50% of intubated patients with severe COVID-19 had myocardial injury, which was associated with a higher mortality rate. Myocardial injury in COVID-19 was closely related to baseline comorbidities, age, and multisystem organ dysfunction. Compared with ARDS patients without COVID-19, COVID-19 patients were older and had poorer cardiac function, but had a lower incidence of myocardial injury.
Article
Biochemistry & Molecular Biology
Toshihiro Kita, Kazuo Kitamura
Summary: This review discusses the role of adrenomedullin (AM) in severe inflammatory diseases, including COVID-19. While current methods can reduce the severity of COVID-19, there is still a lack of effective treatment for severe cases. Research suggests that exogenous AM administration can reduce inflammation and organ damage. The researchers are conducting a trial to evaluate the efficacy of an AM formulation in treating COVID-19.
Article
Critical Care Medicine
Sachin Sud, Jan O. Friedrich, Neill K. J. Adhikari, Eddy Fan, Niall D. Ferguson, Gordon Guyatt, Maureen O. Meade
Summary: The study suggests that combining low tidal volume with prone ventilation is associated with the greatest reduction in mortality for critically ill adults with moderate-to-severe ARDS.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Jessica A. Palakshappa, Gregory B. Russell, Kevin W. Gibbs, Chad Kloefkorn, Douglas Hayden, Marc Moss, Catherine L. Hough, D. Clark Files
Summary: There is no association between early depth of sedation and clinical outcomes in patients with acute respiratory distress syndrome (ARDS).
JOURNAL OF CRITICAL CARE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
David J. Hall, Jefree J. Schulte, Erik E. Lewis, Swaroop R. Bommareddi, Charles T. Rohrer, Samir Sultan, James D. Maloney, Malcolm M. DeCamp, Daniel P. McCarthy
Summary: This article reports a case of lung transplantation for post-COVID-19 pulmonary fibrosis. The patient recovered rapidly after the surgery and has done well in follow-up.
ANNALS OF THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Hong Ren, Li Xie, Zhulin Wang, Xiaoliao Tang, Botao Ning, Teng Teng, Juan Qian, Ying Wang, Lijun Fu, Zhanqi Zhao, Long Xiang
Summary: The study aims to compare the difference in positive end-expiratory pressure (PEEP) selection between chest electrical impedance tomography (EIT) and global dynamic respiratory system compliance (C-rs) in moderate-to-severe pediatric acute respiratory distress syndrome (pARDS). The results suggest that in moderate-to-severe pARDS, PEEP selected based on C-rs might not be inferior to EIT-guided regional ventilation.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Huili Shen, Dong Qu, Weilan Na, Shuang Liu, Siyuan Huang, Yi Hui
Summary: The study found that in designating patients with severe PARDS, both the OI and P/F were consistent. For patients with mild to moderate diseases, P/F may be more useful for rapid determination due to its simpler calculation, while OI proved to be more accurate when combined with prognostic factors.
PEDIATRIC PULMONOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaoting Yang, Jing Wang, Wei Liu
Summary: In this study, molecular markers associated with type II alveolar epithelial cell injury in acute lung injury (ALI) were identified using bioinformatics methods. The results provide new insights for the diagnosis and treatment of ALI/ARDS.
SCIENTIFIC REPORTS
(2023)
Article
Anesthesiology
N. I. Echeverria, A. G. Scandurra, C. M. Acosta, G. J. Meschino, F. Suarez Sipmann, G. Tusman
Summary: This study aimed to test the ability of a Shallow Neural Network (S-NN) to detect and classify vascular tone dependent changes in arterial blood pressure (ABP) using advanced photopletysmographic (PPG) waveform analysis. The results showed that the S-NN performed well in accurately classifying ABP conditions.
REVISTA ESPANOLA DE ANESTESIOLOGIA Y REANIMACION
(2023)
Article
Respiratory System
Esther Herrera-Luis, Angel C. Y. Mak, Javier Perez-Garcia, Elena Martin-Gonzalez, Celeste Eng, Kenneth B. Beckman, Scott Huntsman, Donglei Hu, Ruperto Gonzalez-Perez, Jose M. Hernandez-Perez, Elena Mederos-Luis, Yang Yie Sio, Paloma Poza-Guedes, Olaia Sardon, Paula Corcuera, Inmaculada Sanchez-Machin, Javier Korta-Murua, Carlos Martinez-Rivera, Joaquim Mullol, Xavier Munoz, Antonio Valero, Joaquin Sastre, Judith Garcia-Aymerich, Sabrina Llop, Maties Torrent, Maribel Casas, Jose R. Rodriguez-Santana, Jesus Villar, Victoria del Pozo, Fabian Lorenzo-Diaz, L. Keoki Williams, Erik Melen, Fook Tim Chew, Luisa N. Borrell, Esteban G. Burchard, Maria Pino-Yanes
Summary: This study used admixture mapping analyses and fine mapping to identify genetic variants associated with severe asthma exacerbations in Hispanic/Latino subgroups. The results showed limited transferability of these variants to other populations and their potential regulation of DPYSL3 and SCGB3A2 genes.
Article
Respiratory System
Jordi Riera, Enric Barbeta, Adrian Tormos, Ricard Mellado-Artigas, Adrian Ceccato, Anna Motos, Laia Fernandez-Barat, Ricard Ferrer, Dario Garcia-Gasulla, Oscar Penuelas, Jose Angel Lorente, Rosario Menendez, Oriol Roca, Andrea Palomeque, Carlos Ferrando, Jordi Sole-Violan, Mariana Novo, Maria Victoria Boado, Luis Tamayo, Angel Estella, Cristobal Galban, Josep Trenado, Arturo Huerta, Ana Loza, Luciano Aguilera, Jose Luis Garcia Garmendia, Carme Barbera, Victor Gumucio, Lorenzo Socias, Nieves Franco, Luis Jorge Valdivia, Pablo Vidal, Victor Sagredo, Angela Leonor Ruiz-Garcia, Ignacio Martinez Varela, Juan Lopez, Juan Carlos Pozo, Maite Nieto, Jose M. Gomez, Aaron Blandino, Manuel Valledor, Elena Bustamante-Munguira, Angel Sanchez-Miralles, Yhivian Penasco, Jose Barberan, Alejandro Ubeda, Rosario Amaya-Villar, Maria Cruz Martin, Ruth Jorge, Jesus Caballero, Judith Marin, Jose Manuel Anon, Fernando Suarez Sipmann, Guillermo M. Albaiceta, Alvaro Castellanos-Ortega, Berta Adell-Serrano, Mercedes Catalan, Amalia Martinez de la Gandara, Pilar Ricart, Cristina Carbajales, Alejandro Rodriguez, Emili Diaz, Mari C. de la Torre, Elena Gallego, Luisa Canton-Bulnes, Nieves Carbonell, Jessica Gonzalez, David de Gonzalo-Calvo, Ferran Barbe, Antoni Torres
Summary: The study investigated the association between intubation timing and hospital mortality in critically ill COVID-19 patients. Delayed intubation was found to be associated with a higher risk of mortality, while early intubation reduced mortality. The use of early intubation decreased as the pandemic progressed.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Correction
Critical Care Medicine
Gonzalo Hernandez, Irene Paredes, Francisco Moran, Marcos Buj, Laura Colinas, Maria Luisa Rodriguez, Alfonso Velasco, Patricia Rodriguez, Maria Jose Perez-Pedrero, Fernando Suarez-Sipmann, Alfonso Canabal, Rafael Cuena, Lluis Blanch, Oriol Roca
INTENSIVE CARE MEDICINE
(2023)
Article
Allergy
Javier Perez-Garcia, Mario Gonzalez-Carracedo, Antonio Espuela-Ortiz, Jose M. Hernandez-Perez, Ruperto Gonzalez-Perez, Olaia Sardon-Prado, Elena Martin-Gonzalez, Elena Mederos-Luis, Paloma Poza-Guedes, Paula Corcuera-Elosegui, Ariel Callero, Inmaculada Sanchez-Machin, Javier Korta-Murua, Jose A. Perez-Perez, Jesus Villar, Maria Pino-Yanes, Fabian Lorenzo-Diaz
Summary: This study investigated the association between the upper-airway microbiome and asthma exacerbations despite treatment with inhaled corticosteroids (ICS) in 250 asthma patients. The results showed that case subjects had lower bacterial diversity in nasal and saliva samples compared to control subjects. Additionally, the salivary microbiome was identified as a potential biomarker for asthma exacerbations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Letter
Infectious Diseases
Catia Cilloniz, Anna Motos, Tatiana Castaneda, Albert Gabarrus, Ferran Barbe, Antoni Torres
JOURNAL OF INFECTION
(2023)
Article
Multidisciplinary Sciences
Jesus Villar, Jesus M. Gonzalez-Martin, Jose M. Anon, Carlos Ferrando, Juan A. Soler, Fernando Mosteiro, Juan M. Mora-Ordonez, Alfonso Ambros, Lorena Fernandez, Raquel Montiel, Anxela Vidal, Tomas Munoz, Lina Perez-Mendez, Pedro Rodriguez-Suarez, Cristina Fernandez, Rosa L. L. Fernandez, Tamas Szakmany, Karen E. A. Burns, Ewout W. Steyerberg, Arthur S. Slutsky
Summary: Mortality assessment in clinical studies of acute respiratory distress syndrome (ARDS) has not been well-defined. This study aimed to determine the timing of mortality assessment in ICU patients with moderate-to-severe ARDS, and its predictive value for treatment response. Observational cohorts and a randomized trial were analyzed, and it was found that ICU mortality rates closely approximated 28-day mortality rates. ICU mortality assessment within the first week of a trial could serve as an early predictor of treatment response for moderate-to-severe ARDS patients.
SCIENTIFIC REPORTS
(2023)
Article
Critical Care Medicine
Giacomo Grasselli, Carolyn S. Calfee, Luigi Camporota, Daniele Poole, Marcelo B. P. Amato, Massimo Antonelli, Yaseen M. Arabi, Francesca Baroncelli, Jeremy R. Beitler, Giacomo Bellani, Geoff Bellingan, Bronagh Blackwood, Lieuwe D. J. Bos, Laurent Brochard, Daniel Brodie, Karen E. A. Burns, Alain Combes, Sonia D'Arrigo, Daniel De Backer, Alexandre Demoule, Sharon Einav, Eddy Fan, Niall D. Ferguson, Jean-Pierre Frat, Luciano Gattinoni, Claude Guerin, Margaret S. Herridge, Carol Hodgson, Catherine L. Hough, Samir Jaber, Nicole P. Juffermans, Christian Karagiannidis, Jozef Kesecioglu, Arthur Kwizera, John G. Laffey, Jordi Mancebo, Michael A. Matthay, Daniel F. McAuley, Alain Mercat, Nuala J. Meyer, Marc Moss, Laveena Munshi, Sheila N. Myatra, Michelle Ng Gong, Laurent Papazian, Bhakti K. Patel, Mariangela Pellegrini, Anders Perner, Antonio Pesenti, Lise Piquilloud, Haibo Qiu, Marco Ranieri, Elisabeth Riviello, Arthur S. Slutsky, Renee D. Stapleton, Charlotte Summers, Taylor B. Thompson, Carmen Valente Barbas, Jesus Villar, Lorraine B. Ware, Bjoern Weiss, Fernando G. Zampieri, Elie Azoulay, Maurizio Cecconi
Summary: The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to adult patients and to non-pharmacological respiratory support strategies across different aspects of acute respiratory distress syndrome (ARDS), including ARDS due to coronavirus disease 2019 (COVID-19). These guidelines were formulated by an international panel of clinical experts, one methodologist and patients' representatives on behalf of the ESICM.
INTENSIVE CARE MEDICINE
(2023)
Article
Allergy
Javier Perez-Garcia, Esther Herrera-Luis, Annie Li, Angel C. Y. Mak, Scott Huntsman, Sam S. Oh, Jennifer R. Elhawary, Celeste Eng, Kenneth B. Beckman, Donglei Hu, Fabian Lorenzo-Diaz, Michael A. Lenoir, Jose Rodriguez-Santana, Noah Zaitlen, Jesus Villar, Luisa N. Borrell, Esteban G. Burchard, Maria Pino-Yanes
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Javier Perez-Garcia, Antonio Espuela-Ortiz, Jose M. Hernandez-Perez, Ruperto Gonzalez-Perez, Paloma Poza-Guedes, Elena Martin-Gonzalez, Celeste Eng, Olaia Sardon-Prado, Elena Mederos-Luis, Paula Corcuera-Elosegui, Inmaculada Sanchez-Machin, Javier Korta-Murua, Jesus Villar, Esteban G. Burchard, Fabian Lorenzo-Diaz, Maria Pino-Yanes
Summary: This study analyzed samples from 257 European patients with asthma and conducted replication studies in African American and Latino children. Genes and biological pathways regulating asthma-related airway microbiome traits were identified. These genes may influence asthma comorbidities by regulating trichostatin A, nuclear factorKB, glucocorticosteroid receptor, and CCAAT/enhancer binding protein.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Eva Suarez-Pajes, Eva Tosco-Herrera, Melody Ramirez-Falcon, Silvia Gonzalez-Barbuzano, Tamara Hernandez-Beeftink, Beatriz Guillen-Guio, Jesus Villar, Carlos Flores
Summary: Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition caused by various factors. Understanding the genetic and molecular mechanisms of ARDS is crucial for early diagnosis, risk stratification, and potential pharmacological interventions. Genetic approaches, such as genome-wide association studies and Next-Generation Sequencing techniques, have provided valuable insights into the pathogenesis of ARDS and its relationship with severe COVID-19.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Karen E. A. Burns, Deborah J. Cook, Keying Xu, Peter Dodek, Jesus Villar, Andrew Jones, Farhad N. Kapadia, David J. Gattas, Scott K. Epstein, Paolo Pelosi, Kallirroi Kefala, Maureen O. Meade, Leena Rizvi, Canadian Critical Care Trials Grp
Summary: The aim of this study was to compare differences in directives to limit treatments and discontinue IMV between elderly and very elderly ICU patients. The study found that very elderly patients had more orders to withhold treatments after ICU admission and higher hospital mortality, but similar ICU outcomes and IMV discontinuation. Significant regional differences existed in withholding and withdrawal practices.
INTENSIVE CARE MEDICINE
(2023)
Article
Oncology
Javier Perez-Garcia, Maria Pino-Yanes, Elizabeth G. Plender, Jamie L. Everman, Celeste Eng, Nathan D. Jackson, Camille M. Moore, Kenneth B. Beckman, Vivian Medina, Sunita Sharma, Daniel Efrain Winnica, Fernando Holguin, Jose Rodriguez-Santana, Jesus Villar, Elad Ziv, Max A. Seibold, Esteban G. Burchard
Summary: This study provides evidence of epigenetic modifications induced by albuterol in the mucociliary airway epithelium, which might have potential clinical implications for asthma-related biological pathways.
CLINICAL EPIGENETICS
(2023)
Review
Biochemistry & Molecular Biology
Alba Montero-Jodra, Miguel Angel de la Fuente, Dino Gobelli, Marta Martin-Fernandez, Jesus Villar, Eduardo Tamayo, Maria Simarro
Summary: Sepsis is the leading cause of infection-related death worldwide, and there is currently no specific treatment available. This review provides an overview of the important role of endothelial cell activation and dysfunction in sepsis development, as well as the involvement of mitochondria as potential targets in experimental models.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Meeting Abstract
Biochemistry & Molecular Biology
Tamara Hernandez-Beeftink, Megan Paynton, Eva Suarez-Pajes, Beatriz Guillen-Guio, Jose Miguel Lorenzo-Salazar, Almudena Corrales, Miryam Prieto Gonzalez, Aurelio Rodriguez-Perez, Demetrio Carriedo, Jesus Blanco, Alfonso Ambros, Elena Gonzalez Higueras, Elena Espinosa, Arturo Muriel-Bombin, David Dominguez, Abelardo Garcia de Lorenzo, Jose Manuel Anon, Marina Soro, Louise Wain, Jesus Villar, Carlos Flores
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)