Article
Endocrinology & Metabolism
Celia L. Gregson, Tafadzwa Madanhire, Andrea Rehman, Rashida A. Ferrand, Anne R. Cappola, Steven Tollman, Tshepiso Mokoena, Lisa K. Micklesfield, Alisha N. Wade, June Fabian
Summary: The study found that osteoporosis is more common than sarcopenia among aging individuals in rural South Africa, with older women living with HIV experiencing greater bone loss. This raises concerns over future fracture risk in Southern Africa, highlighting the importance of routine bone health assessments in HIV clinics, especially for aging women.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Mohsen Farzi, Jose M. Pozo, Eugene McCloskey, Richard Eastell, Nicholas C. Harvey, Alejandro F. Frangi, Jeremy Mark Wilkinson
Summary: The study investigates how the spatial distribution of bone mineral density influences the risk of osteoporotic fracture. Using a large dataset of white European women, the researchers quantified age-related texture variation in bone mineral density maps and developed a reference map of bone aging. They introduced a new index called Densitometric Bone Age (DBA) that predicts fracture risk based on the similarity between an individual's bone mineral density map and the median aging trajectory. The results show that DBA outperforms conventional region-based analysis in predicting hip fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Fabio Vescini, Iacopo Chiodini, Alberto Falchetti, Andrea Palermo, Antonio Stefano Salcuni, Stefania Bonadonna, Vincenzo De Geronimo, Roberto Cesareo, Luca Giovanelli, Martina Brigo, Francesco Bertoldo, Alfredo Scillitani, Luigi Gennari
Summary: Male osteoporosis is often underdiagnosed, leading to undertreatment and higher morbidity and mortality compared to female patients. Understanding the differences in bone health between genders is crucial for effective management and prevention of osteoporotic fractures in men.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
H. R. Sapkota, A. Nune, J. Bateman, S. Venkatachalam
Summary: We propose a simple algorithm to address increased DXA scan waiting lists during the COVID-19 pandemic, helping clinicians prioritize patients in need of urgent treatment and significantly reduce the number of DXA scans.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Chemistry, Inorganic & Nuclear
M. M. Al-Bogami, O. A. Akanle, S. Aldawood, M. Alkhorayef, A. Sulieman, A. S. Jawad, R. A. Mageed
Summary: The goal of this research was to study the impact of individual characteristics and gender on the response of osteoporosis patients to bisphosphonate medication. The results showed that male patients experienced a significant increase in bone mineral density after two years of therapy, while female patients had smaller changes. This difference was attributed to ovarian failure and estrogen loss in male patients.
APPLIED RADIATION AND ISOTOPES
(2023)
Article
Endocrinology & Metabolism
Nicholas C. Harvey, John A. Kanis, Enwu Liu, Cyrus Cooper, Mattias Lorentzon, Jennifer W. Bea, Laura Carbone, Elizabeth M. Cespedes Feliciano, Deepika R. Laddu, Peter F. Schnatz, Aladdin H. Shadyab, Marcia L. Stefanick, Jean Wactawski-Wende, Carolyn J. Crandall, Helena Johansson, Eugene McCloskey
Summary: In the WHI study, associations between baseline appendicular lean mass (ALM) and incident fractures, falls, and mortality in older postmenopausal women were investigated. Higher ALM/height(2) was associated with lower risk of MOF but higher risk of death. These associations were independent of prior falls but attenuated by other factors such as FRAX probability and FN BMD T-score.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Clinical Neurology
Byung-Jou Lee, Hae-Won Koo, Sang Won Yoon, Moon-Jun Sohn
Summary: The study demonstrates that using simple t-ROI computed tomography attenuation values is more accurate in predicting osteoporotic compression fractures compared to DXA, with L4 t-ROI attenuation being particularly effective in independently predicting the number and rate of compression fractures.
Article
Biochemistry & Molecular Biology
Yoichi Sato, Norio Yamamoto, Naoya Inagaki, Yusuke Iesaki, Takamune Asamoto, Tomohiro Suzuki, Shunsuke Takahara
Summary: A deep learning model was developed to predict bone mineral density (BMD) and T-score from chest X-rays, which may have implications for diagnosing osteoporosis.
Article
Orthopedics
Elena Boehm, Eduard Kraft, Johanna Theresia Biebl, Bernd Wegener, Robert Stahl, Isa Feist-Pagenstert
Summary: This study compared the sensitivity and discriminatory power of DXA and QCT in detecting osteoporosis and predicting fractures. The results indicate that QCT is more sensitive than DXA in predicting osteoporosis and fractures.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Review
Endocrinology & Metabolism
Caterina Mosca, Fanney Thorsteinsdottir, Bo Abrahamsen, Juri Johannes Rumessen, Mina Nicole Handel
Summary: Newly diagnosed young adults with celiac disease are at risk of low bone mineral density. A strict gluten-free diet may improve bone density over time, but there is a lack of robust evidence for the effectiveness of nutritional supplements or antiresorptive medications in preventing fragile bones in this age group.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Fabio Massimo Ulivieri, Luca Rinaudo
Summary: Bone Strain Index (BSI) is an innovative index of bone strength that provides crucial information about skeletal resistance to loads, improving the predictability of fragility fractures in osteoporotic patients. It combines clinical, radiographical, and construction-engineering skills to assess bone properties that existing indexes cannot explain.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Environmental Sciences
Jordan R. Kuiper, Ann M. Vuong, Bruce P. Lanphear, Antonia M. Calafat, Maria Ospina, Kim M. Cecil, Yingying Xu, Kimberly Yolton, Heidi J. Kalkwarf, Joseph M. Braun, Aimin Chen, Jessie P. Buckley
Summary: Early life exposure to organophosphate esters (OPEs) may be associated with sex- and exposure period-dependent alterations in early adolescent bone mineral accrual and strength.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biophysics
Dermot O'Rourke, Belinda R. Beck, Amy T. Harding, Steven L. Watson, Peter Pivonka, Saulo Martelli
Summary: Exercise induces spatially heterogeneous bone changes in the proximal femur, with 3D-DXA technology able to assess these changes. However, there were significant differences in bone strength under different loading configurations before and after exercise intervention. The study suggests caution when interpreting the results of 3D-DXA technology in individual cases.
JOURNAL OF BIOMECHANICS
(2021)
Article
Environmental Sciences
Lanxin Gu, Zhongyuan Wang, Yang Pan, Hua Wang, Lian Sun, Luwei Liu, Wei-Jie Zhong, Wei-Bing Zhang
Summary: Phenols and parabens, which are commonly found in personal care and consumer products, have been confirmed to be endocrine disrupting chemicals that can disrupt bone metabolism. Previous studies on the association between phenols and parabens with bone mineral density (BMD) have yielded contradictory conclusions. To address the potential bias caused by not considering mixed exposure, we conducted a cross-sectional study using four different models to investigate the associations of single and mixed metabolites of phenols and parabens with BMD in three populations, based on the US National Health and Nutrition Examination Survey (NHANES) database. Our findings revealed a negative association between the mixtures and total femur BMD in men, with Bisphenol A (BPA) playing a significant role. On the other hand, a positive association was observed between the mixtures and femoral neck and trochanter BMD in postmenopausal women, with Benzophenone-3 (BP-3) being the most significant factor.
Review
Biochemistry & Molecular Biology
Giuseppe Rinonapoli, Carmelinda Ruggiero, Luigi Meccariello, Michele Bisaccia, Paolo Ceccarini, Auro Caraffa
Summary: Osteoporosis, known as the 'silent disease', can lead to fragility fractures and serious consequences, especially in women. However, male osteoporosis is often underestimated by physicians despite high incidence and increased risk of complications, indicating a lack of screening, diagnosis, and treatment for men.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
W. F. Lems, J. Paccou, J. Zhang, N. R. Fuggle, M. Chandran, N. C. Harvey, C. Cooper, K. Javaid, S. Ferrari, K. E. Akesson
Summary: Vertebral fractures are independent risk factors for future fractures, and VFA in FLS plays a crucial role in detecting vertebral fractures for secondary fracture prevention. Additional information from VFA may influence treatment initiation and type by providing baseline vertebral fracture data.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Endocrinology & Metabolism
E. Michael Lewiecki
Summary: Treat-to-target for osteoporosis focuses on individualizing patient treatment decisions to achieve an acceptable level of fracture risk, with bone mineral density being commonly used as a surrogate measure for assessing reduction of fracture risk. Studies have shown a strong correlation between increases in BMD with treatment and reductions in fracture risk. More research is needed to fully validate the use of TTT for osteoporosis in clinical practice.
ENDOCRINOLOGY AND METABOLISM
(2021)
Biographical-Item
Endocrinology & Metabolism
E. Michael Lewiecki, John P. Bilezikian, Neil Binkley, Robin K. Dore, Paul D. Miller, Kelly Krohn, S. Bobo Tanner
JOURNAL OF CLINICAL DENSITOMETRY
(2022)
Article
Endocrinology & Metabolism
E. Michael Lewiecki, Paul A. Anderson, John P. Bilezikian, Neil Binkley, Angela M. Cheung, Erik A. Imel, Diane Krueger, Michael R. McClung, Paul D. Miller, Micol S. Rothman
Summary: The 2021 Virtual Santa Fe Bone Symposium was a conference aimed at improving the care of patients with skeletal disorders. It attracted over 300 attendees from the USA and other countries. The conference covered various aspects of skeletal diseases and provided interactive sessions such as lectures, case presentations, and panel discussions to share the latest research findings and care strategies.
JOURNAL OF CLINICAL DENSITOMETRY
(2022)
Review
Endocrinology & Metabolism
E. Michael Lewiecki
Summary: The evaluation of patients with osteoporosis is crucial for correct diagnosis, identifying correctable factors, and assisting in personalized management decisions.
CURRENT OSTEOPOROSIS REPORTS
(2022)
Article
Endocrinology & Metabolism
Alan Bell, David L. Kendler, Aliya A. Khan, Marla C. M. Shapiro, Anne Morisset, Jean-Pierre Leung, Maureen Reiner, Stephen M. Colgan, Lubomira Slatkovska, Millicent Packalen
Summary: In many countries, primary care physicians are responsible for managing osteoporosis; however, the management after a fragility fracture has not been extensively studied. This study examines the gaps in osteoporosis care in a real-world patient cohort, providing valuable insights to overcome obstacles to effective management of patients after fragility fractures.
ARCHIVES OF OSTEOPOROSIS
(2022)
Review
Endocrinology & Metabolism
E. Michael Lewiecki, Matthew F. Bouchonville
Summary: This article reviews the application of telehealth and teleeducation in the care of osteoporosis and introduces related programs and models. Telemedicine has been widely used during the COVID-19 pandemic and provides opportunities for reducing the burden of osteoporotic fractures globally.
EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Edward Czerwinski, Jose Cardona, Rafal Plebanski, Chris Recknor, Tamara Vokes, Kenneth G. Saag, Neil Binkley, E. Michael Lewiecki, Jonathan Adachi, Dorota Knychas, David Kendler, Eric Orwoll, Yinzhong Chen, Leny Pearman, Y. Heather Li, Bruce Mitlak
Summary: The study shows that Abaloparatide significantly increases bone mineral density in men with osteoporosis and has a safety profile consistent with previous studies. These results suggest that Abaloparatide can be considered as an effective anabolic treatment option for male patients with osteoporosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
E. Michael Lewiecki, John P. Bilezikian, Neil Binkley, Mary L. Bouxsein, Susan V. Bukata, David W. Dempster, Matthew T. Drake, Michael R. McClung, Paul D. Miller, Elisabeth Rosenthal, Laura L. Tosi
Summary: The 22nd Annual Santa Fe Bone Symposium was held in a hybrid format with over 400 attendees. The symposium covered various topics related to skeletal health and featured interactive discussions.
JOURNAL OF CLINICAL DENSITOMETRY
(2022)
Review
Medicine, General & Internal
Yevgeniya Kushchayeva, Iryna Pestun, Sergiy Kushchayev, Nataliia Radzikhovska, E. Michael Lewiecki
Summary: Osteoporosis and osteoarthritis, both age-related disorders, may require surgical treatment. Poor bone quality can negatively impact surgical outcomes. This review summarizes the pathophysiology of osteoporotic bone healing, the effect of fractures on bone turnover markers, the diagnosis of low bone mineral density before surgery, and the effectiveness of anti-osteoporosis treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Fatima Zarzour, Ahmad Didi, Mohammed Almohaya, David Kendler
Summary: Calcium and vitamin D play important roles in mineral homeostasis and skeletal health. The effectiveness and cardiovascular safety of their supplementation have been studied in various trials, yielding inconsistent results. Current guidelines recommend up to 1,200 mg of calcium intake from the diet without concern for cardiovascular risk. Recommendations for vitamin D supplementation vary widely, but well-conducted randomized trials suggest that modest supplementation is safe but does not provide cardiovascular benefits or harms.
ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
E. Michael Lewiecki, Edward Czerwinski, Chris Recknor, Anna Strzelecka, Guillermo Valenzuela, Mary Lawrence, Stuart Silverman, Jose Cardona, Susan M. Nattrass, Neil Binkley, Miriam Annett, Leny Pearman, Bruce Mitlak
Summary: This study evaluated the safety and efficacy of the abaloparatide microstructured transdermal system (abaloparatide-sMTS) as an alternative to subcutaneous injection. The results showed that the abaloparatide-sMTS was not noninferior to the subcutaneous injection in terms of lumbar spine bone density at 12 months, but both treatments significantly increased lumbar spine and total hip bone density.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
E. Michael Lewiecki, Teresita Bellido, John P. Bilezikian, Jacques P. Brown, Azeez Farooki, Christopher S. Kovacs, Brendan Lee, William D. Leslie, Michael R. McClung, Mark L. Prasarn, Deborah E. Sellmeyer
Summary: The 23rd annual Santa Fe Bone Symposium brought together attendees from various states and countries to discuss topics related to osteoporosis and other bone diseases. The event included plenary presentations, panel discussions, workshops, and oral presentations of research abstracts.
JOURNAL OF CLINICAL DENSITOMETRY
(2023)
Review
Endocrinology & Metabolism
Leonardo Bandeira, E. Michael Lewiecki
Summary: Anabolic agents increase bone density, improve bone strength, and reduce fracture risk. They work by increasing osteoblastic bone formation, distinguishing them from antiresorptive drugs. However, the bone forming effects of anabolic therapy are self-limited, necessitating the use of antiresorptive therapy to enhance the benefits achieved.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2022)
Article
Endocrinology & Metabolism
Amber A. Hamilton, Susan Faitos, Gin Jones, Athina Kinsley, Rupal Naik Gupta, E. Michael Lewiecki
Summary: X-linked hypophosphatemia (XLH), a genetic disorder, is often thought to only impact children, leading to insufficient care for adult patients. However, studies have shown that XLH has long-term adverse effects on patients' whole body, whole life, and whole family, necessitating comprehensive lifelong care.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
