期刊
SOUTH AFRICAN JOURNAL OF BOTANY
卷 80, 期 -, 页码 57-62出版社
ELSEVIER
DOI: 10.1016/j.sajb.2012.02.005
关键词
Antigenotoxic and antioxidant activities; Comet assay; Kaempferol 3-O-beta-isorhamninoside; Lymphoblastoid cells; rhatnnocitrin 3-O-beta-isorhamninoside
Kaempferol 3-O-beta-isorhamninoside (K30-ir) and rhamnocitrin 3-O-beta-isorhamninoside (R30-ir), were isolated from Rhamnus alaternus L leaves. The genotoxic and antigenotoxic properties of these compounds were investigated by assessing the induction and inhibition of the genotoxicity induced by the direct-acting mutagen, hydrogen peroxide (H2O2), using the comet assay. K30-ir and R30-ir exhibited a preventive effect against H2O2 induced DNA damages in human lymphoblastoid. TK6 cells and its derivative the p53 deficient cell line NH32. These two flavonoids, also investigated for their antioxidant capacities, using different antioxidant tests, such as: Cuprac, Frap and reducing power assays, revealed significant activity through their capacities to transfer electrons. (C) 2012 SAAB. Published by Elsevier By. All rights reserved.
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