Article
Dentistry, Oral Surgery & Medicine
Berkay Gur, Beral Afacan, Ozge Cevik, Timur Kose, Gulnur Emingil
Summary: This study aimed to evaluate the levels of PLAP-1, sclerostin, and TNF-alpha in gingival crevicular fluid (GCF) of individuals with periodontal disease. The results showed significantly higher levels of PLAP-1, sclerostin, and TNF-alpha in the periodontitis group compared to the gingivitis and periodontally healthy groups. The study suggests that PLAP-1 and sclerostin may be involved in the pathogenesis of periodontal disease.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Bardia Vadiati Saberi, Farouq Yousefi, Tooba Yousefi, Durdi Qujeq
Summary: This study determined the correlation between mucin and alpha-amylase protein levels in gingival crevicular fluid (GCF) with chronic periodontitis. The results showed that the levels of both markers were higher in patients with chronic periodontitis compared to successfully recovered patients, suggesting that they could be used to determine the activity of periodontal disease.
Article
Biology
Hytham N. Fageeh, Hammam Ibrahim Fageeh, Samar Saeed Khan, Prabhadevi C. Maganur, Nishant Vyas, Vikrant R. Patil, A. Thirumal Raj, Hosam Ali Baeshen, Shankargouda Patil
Summary: This study aimed to characterize monocytes isolated from the gingival crevicular fluid (GCF) in patients with periodontitis, evaluating cytokine levels, gene expression, and secreted cytokines and chemokines. CD14+ monocytes from GCF secreted higher levels of CCL2 and expressed genes responsible for monocyte migration, indicating their role in the inflammatory microenvironment of periodontitis.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Beral Afacan, Harika Atmaca Ilhan, Timur Kose, Gulnur Emingil
Summary: This study aims to evaluate the levels of GCF Galectin-3 and IL-1 beta in different grades of stage 3 periodontitis and investigate their efficiency in discriminating periodontal diseases. ELISA was used to measure the total amounts of GCF Galectin-3 and IL-1 beta in 80 individuals. The results showed that GCF Galectin-3 is associated with the pathogenesis of periodontal diseases and has high diagnostic performance.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Pasquale Santamaria, Aysegul Sari, Luigi Nibali
Summary: The aim of this study was to assess the differential molecular profiling of gingival crevicular fluid (GCF) from infrabony and suprabony periodontal defects compared with healthy sites. The results showed that 14 biomarkers levels were elevated in GCF from infrabony and suprabony defects compared with healthy sites, while the difference between infrabony and suprabony defects was not significant in biomarker changes.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Oelisoa M. Andriankaja, Reuben Adatorwovor, Alpdogan Kantarci, Hatice Hasturk, Luciana Shaddox, Michael A. Levine
Summary: This study assessed the association between serum or gingival crevicular fluid endothelial and inflammatory mediators and chronic periodontal disease among Hispanic adults with type 2 diabetes. The findings showed that oral and systemic endothelial and inflammatory mediators are related to periodontal clinical parameters.
Article
Dentistry, Oral Surgery & Medicine
Maria K. Soderlin, Gosta Rutger Persson, Stefan Renvert, Johan Sanmartin Berglund
Summary: In this population-based elderly RA cohort, neither pro-inflammatory nor anti-inflammatory cytokines in GCF were clearly associated with a diagnosis of periodontitis.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Tauqeer Bibi, Zohaib Khurshid, Ambreen Rehman, Eisha Imran, Kumar Chandan Srivastava, Deepti Shrivastava
Summary: Evaluation methods for periodontal diseases have advanced to provide quick, realistic, and scientifically proven results. The use of biomarkers like Gingival crevicular fluid can help differentiate between periodontal health and disease status accurately and quickly.
Article
Dentistry, Oral Surgery & Medicine
Luigi Nibali, Abish Stephen, Eleni Hagi-Pavli, Robert Allaker, Antonino Di Pino, Valentina Terranova, Marcella Pisano, Salvatore Di Marca, Viviana Ferrara, Roberto Scicali, Mauro Giordano, Francesco Purrello, Nikolaos Donos, Lorenzo Malatino
Summary: The study suggests that GCF markers in patients with metabolic syndrome may be associated with concomitant periodontitis, particularly the levels of markers such as Aggrecan, IL-6, and IL-8 are correlated with the severity of the disease.
JOURNAL OF DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Vikender S. Yadav, Riyaz A. Mir, Anu Bhatia, Rakhee Yadav, Mahaiwon Shadang, Shyam S. Chauhan, Kunaal Dhingra, Om P. Kharbanda, Renu Yadav, Rahul Garg
Summary: This study found that smoking and chronic periodontitis may increase the synthesis of metallothionein (MT) due to increased oxidative stress and heavy metal intoxication. Further research with larger sample size and interventional arm is needed to confirm the role of MT as a potential biomarker in periodontitis.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Health Care Sciences & Services
Hammam Ibrahim Fageeh, Hytham N. Fageeh, Shankargouda Patil
Summary: Periodontitis is an inflammatory condition caused by pathogenic bacteria in dental plaque. Macrophages derived from monocytes play a dual role in periodontitis, presenting antigens to lymphocytes while also contributing to periodontal destruction. The study found that GCF samples from periodontitis patients have higher levels of specific cytokines, and that treatment with these samples can induce monocytes to differentiate into destructive macrophages, affecting the phenotype and function of resident cells in the periodontium.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Alejandra Chaparro, Ornella Realini, Marcela Hernandez, Daniela Albers, Laura Weber, Valeria Ramirez, Fernanda Param, Juan Pedro Kusanovic, Timo Sorsa, Gregory Edward Rice, Sebastian E. Illanes
Summary: The study found that concentrations of MMP-8 and -9 in gingival crevicular fluid during early pregnancy are increased in women with severe periodontitis and associated with the development of GDM.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Alina-Ramona Dimofte, Dorin Nicolae Gheorghe, Dora Maria Popescu, Ioana Mitrut, Petre Costin Marasescu, Horia Octavian Manolea, Mihail Virgil Boldeanu, Petra Surlin
Summary: This study evaluated the influence of metal-ceramic crowns on periodontal parameters and inflammatory marker levels. The results showed that metal-ceramic crowns can cause changes in periodontal clinical parameters and are associated with inflammatory marker levels.
APPLIED SCIENCES-BASEL
(2023)
Article
Microbiology
Simran Preet Bhalla, Ann Maria Shaju, Carlos Marcelo da Silva Figueredo, Leticia Algarves Miranda
Summary: C5a levels were significantly increased in both gingival crevicular fluid and saliva of patients with periodontal disease, indicating a potential role of this molecule in the pathogenesis of the disease.
Article
Dentistry, Oral Surgery & Medicine
Zeliha Guney, Sivge Kurgan, Canan Onder, Cavid Mammadov, Muhittin A. Serdar, Meral Gunhan
Summary: This study aimed to evaluate the levels of ADMA, SDMA, and IL-1 beta in GCF from periodontitis patients. The results showed that the levels of IL-1 beta, ADMA, and SDMA in GCF were significantly higher in periodontitis patients compared to the control group, and they were positively correlated with clinical periodontal parameters. It suggests that ADMA and SDMA may be involved in the pathogenesis of periodontal disease.
JOURNAL OF PERIODONTAL RESEARCH
(2023)