Article
Pharmacology & Pharmacy
Jiayu Zhou, Yishu Zhai, Jumei Xu, Tian Zhou, Lian Cen
Summary: This study investigated the feasibility of microfluidic preparation of PLGA composite microspheres with mesoporous silica nanoparticles (MSNs) to finely manipulate drug release behaviors. The results showed that PLGA-MSNs achieved sustained release for 4 months without any burst release, while PLGA microspheres encountered a burst release in the mid-term of the studied duration. Incorporating MSNs into PLGA microspheres via microfluidics could be an efficient strategy to finely tune drug release behavior.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Manuel Perez-Garnes, Victoria Morales, Raul Sanz, Rafael A. Garcia-Munoz
Summary: Hollow-shell mesoporous silica nanoparticles encapsulating iron oxide were prepared using a drug-structure-directing agent concept, showing potential for theranostic applications. These nanoparticles can load and release drugs to specific target cells, overcoming limitations of conventional formulations in reaching desired sites.
Article
Biotechnology & Applied Microbiology
Marta Lopez-Ruiz, Francisco Navas, Paloma Fernandez-Garcia, Samuel Martinez-Erro, Ma Victoria Fuentes, Isabel Giraldez, Laura Ceballos, Carmen Ma Ferrer-Luque, Matilde Ruiz-Linares, Victoria Morales, Raul Sanz, Rafael A. Garcia-Munoz
Summary: This study utilized a dental adhesive incorporating L-arginine-containing mesoporous silica nanoparticles to release the amino acid and reduce the number of cariogenic bacteria, without affecting the properties of the adhesive.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Tongfei Shi, Jingtong Zhao, Kongrong Long, Mohan Gao, Fangman Chen, Xuenian Chen, Yue Zhang, Baoding Huang, Dan Shao, Chao Yang, Liang Wang, Ming Zhang, Kam W. Leong, Li Chen, Kan He
Summary: The MSN-PEI nanoparticles prepared in this study have potential therapeutic effects in the treatment of osteoarthritis. By targeting multiple danger mediators, they can attenuate cartilage degradation and inflammation, providing strong joint protection.
Review
Pharmacology & Pharmacy
Eleen Dayana Mohamed Isa, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman, Martin R. Gill
Summary: Mesoporous silica nanoparticles (MSNs) as drug delivery agents show great potential in cancer treatment by enhancing efficacy and reducing side effects. Through the development of smart DDAs and the capability to efficiently trap cargo molecules, MSNs have a bright future in both the diagnosis and treatment of cancer.
Article
Pharmacology & Pharmacy
Jie Zhuang, Yiming Yu, Rui Lu
Summary: Due to abuse of antibiotics, antibiotic resistance has become a global health threat. Many existing antibiotics have lost their effectiveness against drug-resistant bacteria, and the discovery of new antibiotics is becoming increasingly difficult. It is necessary to develop new strategies to combat antibiotic resistance. Nano-drug delivery systems, particularly mesoporous silica nano-particles (MSNs), have been extensively investigated as carriers of antibiotics. MSNs improve the delivery of antibiotics by reducing size, modifying surface, and regulating shapes. Furthermore, MSNs hybridized with metal ions or nanoparticles enhance the antibacterial effect by controlling the release of metal ions or increasing active oxygen species. Metal-capped MSNs can also load antibiotics to exert a synergistic antibacterial effect. This paper reviews the current application of various nanomaterials as antibacterial agents, with a focus on MSNs and approaches for improving their antibacterial effect.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Miguel Gisbert-Garzaran, Daniel Lozano, Kotaro Matsumoto, Aoi Komatsu, Miguel Manzano, Fuyuhiko Tamanoi, Maria Vallet-Regi
Summary: In this study, mesoporous silica nanoparticles were used as a platform to engineer a versatile nanomedicine capable of addressing biological barriers encountered in tumor drug delivery. The nanoparticles demonstrated high biocompatibility and cytotoxic effect in both 2D and 3D in vitro cell cultures and a tumor-bearing chicken embryo model, showing efficient endosomal escape and tumor penetration.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Ozi Adi Saputra, Windy Ayu Lestari, Wahyu Nur Safitriono, Murni Handayani, Witri Wahyu Lestari, Fajar Rakhman Wibowo
Summary: The study successfully prepared surface-modified magnetic mesoporous silica nanoparticles with high loading capacity, which can prevent premature drug release and achieve controlled release under different pH conditions. The nanoparticles also demonstrated good magnetic properties, potentially extending to magnetic hyperthermia for cancer therapy.
Article
Engineering, Environmental
Kaijun Gou, Yumei Wang, Linlin Xie, Xianmou Guo, Yingyu Guo, Jia Ke, Lulu Wu, Sanming Li, Heran Li
Summary: Chiral mesoporous silica nanoparticles (CMSNs) have unique physicochemical properties and advantages in biological behavior, making them valuable in various applications such as chiral catalysis, chiral selectivity, chiral recognition, separation, drug delivery, and medical research. Studies on CMSNs have made significant progress in synthesis, chirality origination mechanisms, structural properties, and practical applications, indicating great potential in the field of pharmaceutical science and beyond.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Applied
Nassira Ferroudj, Patricia Beaunier, Anne Davidson, Sebastien Abramson
Summary: The study explored the relationship between the activity and structure of γ-Fe2O3/SiO2 nanocomposite microspheres as heterogeneous catalysts, revealing that doped Fe3+ and ordered mesoporosity significantly enhance the activity of the materials, demonstrating excellent oxidation and mineralization effects on simulated water pollutants.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Chemistry, Physical
Montserrat Colilla, Maria Vallet-Regi
Summary: Bacterial antimicrobial resistance is a major threat to global health, and the stalled antibiotic research pipeline has worsened the situation. Nanotechnology offers a potential solution by using nanocarriers to transport and deliver antimicrobials to overcome bacterial resistant barriers. Mesoporous silica nanoparticles (MSNs) have attracted attention due to their unique features. This perspective article outlines recent research in the design and development of organically modified MSNs to fight bacterial infections, addressing the current challenges and future perspectives.
CHEMISTRY OF MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Bhagavathi Sundaram Sivamaruthi, Subramanian Thangaleela, Periyanaina Kesika, Natarajan Suganthy, Chaiyavat Chaiyasut
Summary: Complete recovery from infection, sepsis, injury, or trauma requires a vigorous inflammatory response. Nanoparticles have become an efficient medical tool for diagnosing, preventing, and treating diseases due to their unique interactions with biological molecules. Mesoporous silica nanoparticles (MSNs) play a significant role in nano therapy and have several advantages such as easy synthesis, loading, and biocompatibility. MSNs can be used as theranostics in immune-modulatory nano systems to diagnose and treat inflammatory diseases.
Article
Chemistry, Physical
Md Aquib, Hang Zhang, Faisal Raza, Parikshit Banerjee, Rohit Bavi, Samuel Kesse, Kofi Oti Boakye-Yiadom, Mensura Sied Filli, Muhammad Asim Farooq, Bo Wang
Summary: Aminated mesoporous silica nanoparticles (AMPSNPs) were developed as a nanocarrier for disulfiram (DSF) delivery in cancer therapies. The optimized AMPSNPs showed excellent properties and compatibility, providing potential for effective drug delivery.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Engineering, Mechanical
Li Wan, Yi Wang, Xiaolong Tan, Yulong Sun, Jing Luo, Hongyu Zhang
Summary: This study developed biodegradable lubricating drug-loaded nanoparticles for the treatment of osteoarthritis. The nanoparticles showed enhanced lubrication and sustained drug release behavior. The results suggest that these nanoparticles may be a promising approach for osteoarthritis therapy.
Article
Pharmacology & Pharmacy
Khatereh Zarkesh, Reza Heidari, Pooya Iranpour, Negar Azarpira, Fatemeh Ahmadi, Soliman Mohammadi-Samani, Fatemeh Farjadian
Summary: This study successfully synthesized a novel pH-responsive mesoporous silica nanoparticle and achieved targeted drug delivery to cancer cells by coating with hyaluronan. The results showed that the nanoparticles had good biocompatibility and biodegradability, and could improve pharmacokinetic parameters.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Biomedical
Sandra Sanchez-Salcedo, Ana Garcia, Adela Gonzalez-Jimenez, Maria Vallet-Regi
Summary: The development of biomaterials with high bioactivity and antibacterial properties for bone tissue regeneration is investigated. Nanocomposites of mesoporous bioactive glasses doped with silver nanoparticles were synthesized and used to fabricate three-dimensional scaffolds. The presence of silver nanoparticles inhibited bacterial growth and showed potential applications in bone tissue regeneration. The innovative methodology combined the sol-gel method and rapid prototyping technique.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Carla Jimenez-Jimenez, Almudena Moreno-Borrallo, Bianca Dumontel, Miguel Manzano, Maria Vallet-Regi
Summary: Nanotechnology has revolutionized potential disease treatments, but immune clearance and poor biocompatibility limit the use of nanoparticles for drug delivery. Coating nanoparticles with cell membranes is a hypothesis to overcome rejection and enhance biocompatibility. Here, we show that coating mesoporous silica nanoparticles with membranes from preosteoblastic cells can be used for potential bone disease treatments. Our results demonstrate the cellular selectivity and migration capability of camouflaged nanocarriers, which inspire future treatments.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Miguel Gisbert-Garzaran, Maria Natividad Gomez-Cerezo, Maria Vallet-Regi
Summary: Bone diseases have become a global public concern, affecting millions of people. Although current treatments are effective, they come with side effects. To address this, the development of biocompatible nanoparticles and macroscopic scaffolds has shown promise in improving bone regeneration while reducing side effects. This review highlights the emerging trend of materials that specifically recognize agents in the bone microenvironment, showcasing examples of modified nanoparticles and scaffolds. The potential of these bone-targeting agents to revolutionize the treatment of bone-related diseases is discussed, providing a comprehensive overview of the field's state-of-the-art.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Bianca Dumontel, Veronica Conejo-Rodriguez, Maria Vallet-Regi, Miguel Manzano
Summary: In recent years, the functionalization of mesoporous silica nanoparticles (MSNs) with responsive pore gatekeepers has shown potential for drug delivery systems (DDS) with controlled release. The use of natural biopolymers as smart materials in drug delivery applications has been investigated extensively. This review summarizes the coating procedures with natural polysaccharides and protein-based biopolymers, focusing on their application as responsive materials to endogenous stimuli. Biopolymer-coated MSNs have shown promising therapeutic outcomes and potential for selective treatment of various diseases.
Article
Pharmacology & Pharmacy
Ana Arenas-Vivo, Vanessa Celis Arias, Georgiana Amariei, Roberto Rosal, Isabel Izquierdo-Barba, Tania Hidalgo, Maria Vallet-Regi, Hiram I. Beltran, Sandra Loera-Serna, Patricia Horcajada
Summary: Surface microbial colonization and biofilm formation are major problems causing human infectious diseases, and traditional treatments are often ineffective in eliminating biofilms. This study presents a silver-based metal-organic framework (AgBDC) that has antifouling properties and can prevent bacterial adhesion and surface contamination.
Review
Pharmacology & Pharmacy
Maria Vallet-Regi, Montserrat Colilla, Isabel Izquierdo-Barba, Chiara Vitale-Brovarone, Sonia Fiorilli
Summary: Mesoporous bioactive glasses (MBGs) are highly promising candidates in the field of bioceramics for bone tissue regeneration, thanks to their unique chemical composition, structural and surface properties. Recent research has focused on optimizing the texture and structure of MBGs and exploring their potential as multitherapy systems, particularly in the context of local drug delivery. This article provides an overview of the latest developments in MBGs for bone tissue engineering, multifunctionalization, and drug delivery, as well as discussing the current challenges and future directions for clinical translation of MBGs.
Editorial Material
Biochemistry & Molecular Biology
Daniel Arcos
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Guillermo Aragoneses-Cazorla, Maria Vallet-Regi, Ma. Milagros Gomez-Gomez, Blanca Gonzalez, Jose L. Luque-Garcia
Summary: A combination of transcriptomics and metabolomics was used to study the mechanisms behind the antitumor action of a nanosystem called Ag@MSNs-Tf. Transcriptomics analysis was done using gene microarrays and RT-qPCR, while metabolomics analysis was done using high-resolution mass spectrometry. This multiomics approach revealed the impact of the nanosystem on various molecular pathways, including glycolysis, the pentose phosphate pathway, oxidative phosphorylation, and fatty acid synthesis.
Review
Chemistry, Multidisciplinary
Daniel Lozano, Vicente Larraga, Maria Vallet-Regi, Miguel Manzano
Summary: Vaccines are a major advancement in public health, preventing illness and death in millions of people each year. The use of nanotechnology has revolutionized vaccine development, with nanoparticles emerging as promising carriers for future vaccines. Despite significant progress in nanoparticle vaccine research, only a few have advanced to clinical investigation and usage so far.
Article
Pharmacology & Pharmacy
Daniel Lozano, Beatriz Leiva, Ines S. Gomez-Escalonilla, Sergio Portal-Nunez, Arancha R. de Gortazar, Miguel Manzano, Maria Vallet-Regi
Summary: Osteoporosis is commonly treated with antiresorptive drugs and anabolic agents, but these treatments have limitations. Pleiotrophin (PTN), a protein involved in tissue repair, and mesoporous silica nanoparticles (MSNs), a drug-delivery system, have shown potential for improving bone regeneration. In this study, PTN-loaded MSNs significantly enhanced osteogenesis and osteoblast differentiation when tested on MC3T3-E1 cells and human mesenchymal stem cells. This proof of concept suggests that MSNs can effectively deliver PTN and may be a promising treatment for osteoporosis and bone-regeneration scenarios.
Article
Polymer Science
Jesus L. Pablos, Javier Jimenez-Holguin, Sandra Sanchez Salcedo, Antonio J. Salinas, Teresa Corrales, Maria Vallet-Regi
Summary: The production of customized polymeric hydrogels in the form of 3D scaffolds with application in bone tissue engineering is currently a topic of great interest. Based on gelatin methacryloyl (GelMa) as one of the most popular used biomaterials, GelMa with two different methacryloylation degrees (DM) was obtained, to achieve crosslinked polymer networks by photoinitiated radical polymerization.
Article
Chemistry, Physical
Montserrat Colilla, Maria Vallet-Regi
Summary: Bacterial antimicrobial resistance is a major threat to global health, and the stalled antibiotic research pipeline has worsened the situation. Nanotechnology offers a potential solution by using nanocarriers to transport and deliver antimicrobials to overcome bacterial resistant barriers. Mesoporous silica nanoparticles (MSNs) have attracted attention due to their unique features. This perspective article outlines recent research in the design and development of organically modified MSNs to fight bacterial infections, addressing the current challenges and future perspectives.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Laura Casarrubios, Monica Cicuendez, Maria Vallet-Regi, Maria Teresa Portoles, Daniel Arcos, Maria Jose Feito
Summary: Bioactive mesoporous glass nanospheres (nanoMBGs) loaded with ipriflavone can produce positive immune effects, which have great potential for the treatment of osteoporosis and fracture prevention.
Review
Biochemistry & Molecular Biology
Daniel Arcos, Maria Teresa Portoles
Summary: Research on nanomaterials for bone regeneration has made significant progress with the development of bioactive mesoporous nanoparticles (MBNPs). These nanoparticles, consisting of small spherical particles with chemical properties and porous structures, stimulate bone tissue regeneration by mimicking the composition of conventional sol-gel bioactive glasses and possessing high specific surface area and porosity. With their controllable mesoporosity and drug incorporation capabilities, MBNPs have emerged as excellent tools for treating bone defects and related pathologies such as osteoporosis, bone cancer, and infection. The small size of MBNPs allows them to penetrate cells and elicit specific cellular responses that conventional bone grafts cannot. This review comprehensively discusses various aspects of MBNPs, including synthesis strategies, drug delivery behavior, therapeutic ion incorporation, composite formation, specific cellular response, and in vivo studies conducted to date.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Bianca Dumontel, Carla Jimenez-Jimenez, Maria Vallet-Regi, Miguel Manzano
Summary: The integration of artificial nanoplatforms with natural bio-materials has led to the development of more efficient drug delivery systems. In this study, mesoporous silica nanoparticles (MSNs) were combined with tumor derived extracellular vesicles (EVs) to create a hybrid nanosystem that showed selective cellular internalization and enhanced intracellular drug accumulation, making it a promising candidate for targeted treatments.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Inorganic & Nuclear
Mahsa Saberian, Alireza Nezamzadeh-Ejhieh
Summary: CuO was successfully supported on clinoptilolite nanoparticles (NCP) via ion exchange and calcination, forming CuO-NCP photocatalysts. CuO-NCP exhibited enhanced photocatalytic activity towards tetracycline (TC), and the best degradation performance was achieved under optimal conditions (25 ppm TC solution, pH 4.8, and 0.5 g/L catalyst).
SOLID STATE SCIENCES
(2024)
