Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Nutrition & Dietetics
Yan Jiang, Karolin Jarr, Cosima Layton, Christopher D. Gardner, Judith E. Ashouri, Maria T. Abreu, Sidhartha R. Sinha
Summary: Despite being an important issue for patients, the impact of diet on adult inflammatory bowel disease (IBD) is not well explored, with limited guidance. Current evidence on various diets used in the treatment of IBD is summarized, with potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs) to inform providers. Multiple diets, including Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets, have shown positive results in other inflammatory diseases, suggesting potential applicability to IBD, but further well-designed clinical trials are needed for guidance.
Review
Immunology
Susanna Esposito, Giulia Antoniol, Marialuisa Labate, Lucrezia Passadore, Patrizia Alvisi, Valeria Dacco, Chiara Ghizzi, Carla Colombo, Nicola Principi
Summary: The incidence of inflammatory bowel diseases (IBDs) is rising globally, leading to a higher risk of infections in children with dysfunctional immune systems. Vaccines are essential for preventing these infections, and should be administered according to specific immunization guidelines for IBD patients. Compliance with vaccination recommendations is generally low, highlighting the need for multidisciplinary educational programs to improve vaccination coverage and protect children with IBD from vaccine-preventable diseases.
Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Article
Gastroenterology & Hepatology
Salvatori Silvia, Marafini Irene, Venuto Chiara, Laudisi Federica, Neri Benedetto, Lavigna Diletta, Franchin Martina, De Cristofaro Elena, Biancone Livia, Calabrese Emma, Giannarelli Diana, Giovanni Monteleone
Summary: Frailty is common in hospitalized patients with inflammatory bowel disease (IBD) and has been associated with an increased risk of adverse outcomes. This prospective study revealed that nearly one-fifth of IBD patients were frail, with active disease being an independent risk factor for the frail phenotype.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Maria Jose Sanchez-Quintero, Cristina Rodriguez-Diaz, Francisco J. Rodriguez-Gonzalez, Alejandra Fernandez-Castaner, Eduardo Garcia-Fuentes, Carlos Lopez-Gomez
Summary: Mitochondria play a crucial role in maintaining cellular functions and are involved in various cellular processes. Dysfunction of mitochondria has been linked to complex disorders, including inflammatory bowel diseases (IBD). The impact of mitochondrial dysfunction on IBD, including its role in intestinal mucosa, immune cell populations, mucosal repair, microbiota-brain-gut axes, and the development of colitis-associated colorectal cancer, is discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Taotao Han, Xiaomin Hu, Kemin Li, Di Zhang, Yan Zhang, Jingnan Li
Summary: Probiotic strain Bifidobacterium infantis shows efficacy in maintaining remission of ulcerative colitis (UC) by acting as a key predisposing factor for host genome stability. Studies reveal that B. infantis administration can alleviate DSS-induced colitis and decrease DNA double strand breaks (DSBs) levels in both colitis and inflammatory bowel disease models, suggesting its potential in clinical management of UC patients.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Chemistry, Medicinal
Jose Israel Rodrigues Jr, Joice Kelly Gomes de Vasconcelos, Lylian Ellen Militao dos Santos Xavier, Amanda da Silva Gomes, Juliana Celia de Farias Santos, Samara Bomfim Gomes Campos, Amylly Sanuelly da Paz Martins, Marilia Oliveira Fonseca Goulart, Fabiana Andrea Moura
Summary: The objective of this study was to assess the effectiveness of treatment for inflammatory bowel diseases in modulating oxidative stress biomarkers and cytokine levels. A systematic review and meta-analysis were conducted, and it was found that antioxidant capacity and lipid peroxidation levels were not significantly modulated, while superoxide dismutase levels showed significant modulation. However, there is still limited research on oxidative stress biomarkers and cytokines in the context of alternative therapies for IBD treatment. The results highlight the potential of antioxidant supplementation in IBD management and emphasize the need for further investigations into its effects on oxidative stress biomarkers and cytokines.
Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Flavia Baccini, Federica Micheli, Giovanni Di Nardo, Caterina Lombardo
Summary: This study found that patients with inflammatory bowel disease have poorer subjective sleep quality compared to controls, with even worse sleep quality in those with active IBD. However, there were no differences within IBD subtypes. These results highlight the importance of considering sleep quality as a relevant comorbidity in IBD.
SLEEP MEDICINE REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Anna Krystyna Zielinska, Maciej Salaga, Pawel Siwinski, Marcin Wlodarczyk, Adam Dziki, Jakub Fichna
Summary: The study found that IBD patients had significantly decreased SOD activity, GSH and GSSG levels, and GPX activity was significantly diminished only in CD patients. CAT and COX-1 activity was increased, while COX-2 was significantly decreased in IBD patients. TBARS were significantly higher in CD patients compared to the control group. There was no correlation between pain scores, inflammatory status, disease activity, disease duration, or dietary habits and OS markers.
Review
Gastroenterology & Hepatology
Alexa N. Sasson, Ashwin N. Ananthakrishnan, Maitreyi Raman
Summary: The global incidence of inflammatory bowel diseases (IBDs) has increased significantly in the past few decades, with genetic and environmental factors playing a role in the pathogenesis. Diet is a potentially modifiable environmental risk factor for IBD, as it can promote intestinal inflammation through various mechanisms such as dysregulating the immune system and altering intestinal permeability. Dietary changes may be integrated into therapeutic strategies for IBD treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, Research & Experimental
Riham A. El-Shiekh, Dorria Hussein, Attia H. Atta, Samar M. Mounier, Mohamed R. Mousa Shiekh, Essam Abdel-Sattar
Summary: The study highlights the potential therapeutic effects of Jasmine genus for chronic inflammatory conditions, showing anti-inflammatory and antioxidant properties. Results demonstrate that the Jasminum extract improved colon tissues in rats, reduced pro-inflammatory cytokines expression, and maintained intestinal epithelial cell junctions. The study also suggests a potential role of Jasmine in treating immune dysfunction-related chronic inflammatory disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Yinhua Ni, Yi Zhang, Liujie Zheng, Nianke Rong, Yuru Yang, Ping Gong, Yi Yang, Xuerong Siwu, Chenyang Zhang, Linxi Zhu, Zhengwei Fu
Summary: The effects of probiotic strains BL986 and LC122 on intestinal barrier function and gut microbiota in IBD zebrafish were investigated. The results showed that both probiotics improved intestinal mucosal barrier function and altered the composition and function of the microbiota in different IBD models. The impact of probiotics on IBD was influenced by the subtypes of IBD and the age of the zebrafish.
Review
Medicine, General & Internal
Eduard Brunet Mas, Xavier Calvet Calvo
Summary: Combination of two biological therapies (CoT) appears to be a safe and effective treatment option for refractory and severely ill patients with inflammatory bowel disease (IBD). Ustekinumab plus vedolizumab and vedolizumab plus anti-TNF are the most commonly used CoTs for Crohn's disease. For ulcerative colitis, vedolizumab plus anti-TNF and vedolizumab plus tofacitinib are the most commonly used CoTs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Matthias Zilbauer, Robert Heuschkel
Summary: Inflammatory bowel diseases like Crohn's disease and ulcerative colitis are complex conditions that require personalized treatment approaches. Developing biomarkers to predict disease course and treatment response is challenging.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Biotechnology & Applied Microbiology
Spencer S. Santos, Vivian C. Miranda, Luisa M. Trindade, Valbert N. Cardoso, Diego C. Reis, Geovanni D. Cassali, Jacques R. Nicoli, Denise C. Cara, Flaviano S. Martins
Summary: This study evaluated the probiotic effect of Bifidobacterium longum subsp. longum 5(1A) in a murine model of food allergy. The results showed that oral administration of this probiotic prevented weight loss, reduced immune reactions, and improved intestinal permeability. The dose of 10^8 CFU showed the best protective effect, and the use of live bacteria was necessary to achieve these beneficial effects.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Biotechnology & Applied Microbiology
Quesia S. Damaceno, Bruno Gallotti, Isabela M. M. Reis, Yasmim C. P. Totte, Gabriella B. Assis, Henrique C. Figueiredo, Tales F. Silva, Vasco Azevedo, Jacques R. Nicoli, Flaviano S. Martins
Summary: Breast milk contains beneficial bacteria that can positively influence the health of newborns. The study identified 77 bacteria belonging to four genera, including Staphylococcus, Streptococcus, Leuconostoc, and Lacticaseibacillus. Two potential probiotics, Lacticaseibacillus rhamnosus and Leuconostoc mesenteroides, were selected and found to colonize the gastrointestinal tract in germ-free mice and maintain viability after spray-drying.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Microbiology
Michele M. Moraes, Thiago T. Mendes, Leandro Borges, Alice L. Marques, Cristian Nunez-Espinosa, Dawit A. P. Goncalves, Carolina B. Simoes, Tales S. Vieira, Roberto V. P. Ladeira, Talita G. B. Lourenco, Danielle V. Ribeiro, Elaine Hatanaka, Debora Heller, Rosa M. E. Arantes
Summary: Antarctic camps, with their isolated, confined, and extreme (ICE) conditions, can affect the microbiome and inflammatory responses. A 7-week expedition to Nelson Island resulted in fluctuations in the microbiome, a reduction in disease-associated microbes, and changes in inflammation markers. These findings suggest that Antarctic environments and behaviors play a role in modulating oral microbiome and inflammation.
Letter
Dermatology
Maria Cecilia Campos Canesso, Puebla Cassini-Vieira, Camila Francisco Moreira, Suzanne Luong, Milene Alvarenga Rachid, Flaviano Santos Martins, Mauro Martins Teixeira, Angelica Thomas Vieira, Charles Reay Mackay, Luciola Silva Barcelos
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Nutrition & Dietetics
Debora Romualdo Lacerda, Albena Nunes-Silva, Ana Leticia Malheiros Silveira, Katia Anunciacao Costa, Debora Fernandes Rodrigues, Michele Macedo Moraes, Vanessa Pinho, Gustavo Batista Menezes, Mauro Martins Teixeira, Samuel Penna Wanner, Danusa Dias Soares, Adaliene Versiani Matos Ferreira
Summary: This study investigated the effect of acute exercise on the inflammatory response in adipose tissue of lean and obese mice. Acute exercise enhanced the levels of IL-6 and tumor necrosis factor-a in the adipose tissue of lean mice, while no changes were observed in proinflammatory cytokines in obese mice. However, the levels of IL-13, IL-4, and IL-10 were increased in obese mice after exercise. These findings suggest that acute exercise promotes an inflammatory response in adipose tissue of lean mice, but elicits an anti-inflammatory response in adipose tissue of obese mice.
Article
Immunology
Andrew Bacon, Mauro Teixeira, Vivian Costa, Peter Bone, Jennifer Simmons, Jeffrey Drew
Summary: Here we developed a thermally stable, orally administered Zika vaccine using engineered AdHu5. This vaccine, formulated with a mix of sugars and modified amino acids and protected by an enteric coated capsule, induced immune responses and reduced viral counts in mice and non-human primates. It has advantages over current vaccines that require cold storage and parenteral administration.
Review
Virology
Rosangela Santos Pereira, Francoise Camila Pereira Santos, Priscilla Rodrigues Valadares Campana, Vivian Vasconcelos Costa, Rodrigo Maia de Padua, Daniele G. Souza, Mauro Martins Teixeira, Fernao Castro Braga
Summary: This article reviews studies on the anti-ZIKV activity of natural products (NPs) and derivatives from 1997 to 2022. The majority of the studies used NPs from plants (82.4%) or semisynthetic/synthetic derivatives, followed by fungi (3.1%), bacteria (7.6%), animals (1.2%), and marine organisms (1.9%). Different classes of NPs, such as polyphenols, triterpenes, alkaloids, and steroids, have been reported to exhibit anti-ZIKV activity. NPs mainly act at the stages of viral adsorption and internalization, and some compounds show high selectivity index values. However, further research is needed to understand their mechanisms of action and evaluate their safety and efficacy in animal models.
Article
Biotechnology & Applied Microbiology
Vivian C. Miranda, Ramon O. Souza, Monica F. Quintanilha, Bruno Gallotti, Helder C. Assis, Ana Maria C. Faria, Jacques R. Nicoli, Denise C. Cara, Flaviano S. Martins
Summary: This study aimed to evaluate the probiotic and postbiotic potential of Akkermansia muciniphila BAA-835 in an ovalbumin food allergy model. The results showed that treatment with viable A. muciniphila could alleviate weight loss, decrease serum levels of allergy-related antibodies, reduce intestinal injury and inflammation, and modify the gut microbiota composition. Additionally, the administration of inactivated bacteria also had a postbiotic effect by reducing allergy-related immune responses. These findings suggest that A. muciniphila BAA-835 has both probiotic and postbiotic properties in the prevention and treatment of food allergies.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Immunology
Maria Elena Romero-Ibarguengoitia, Diego Rivera-Salinas, Riccardo Sarti, Riccardo Levi, Maximiliano Mollura, Arnulfo Garza-Silva, Andrea Rivera-Cavazos, Yodira Guadalupe Hernandez-Ruiz, Irene Antonieta Barco-Flores, Arnulfo Gonzalez-Cantu, Miguel Angel Sanz-Sanchez, Milton Henriques Guimaraes Junior, Chiara Pozzi, Riccardo Barbieri, Devany Paola Morales-Rodriguez, Mauro Martins Texeira, Maria Rescigno
Summary: This study evaluated the real-life efficacy of six different vaccines against SARS-CoV-2 and found that mRNA vaccines had the highest antibody levels during follow-up. Infection before vaccination and after complete vaccination scheme correlated with higher antibody titers. The CoronaVac vaccine was found to lower the risk of infection in the presence of certain comorbidities.
Editorial Material
Microbiology
Andre Talvani, Mauro Martins Teixeira
Article
Engineering, Biomedical
Joana Lobato Barbosa, Mariane Izabella Abreu de Melo, Pricila da Silva Cunha, Marcelo Coutinho de Miranda, Breno Rocha Barrioni, Cheisy Daiana Freitas Moreira, Andrea da Fonseca Ferreira, Rosa Maria Esteves Arantes, Marcos Augusto de Sa, Marivalda de Magalhaes Pereira, Michele Angela Rodrigues, Silviene Novikoff, Dawidson Assis Gomes, Alfredo Miranda de Goes
Summary: In this study, a new bilayer scaffold composed of a chitosan-gelatin membrane and a chitosan-polyhydroxybutyrate (PHB) porous matrix was synthesized and populated with human adipose-derived mesenchymal stem cells (hASCs) to be potentially used for wound dressing applications. The results demonstrate that this scaffold has the potential to promote tissue regeneration in wound healing studies.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Nutrition & Dietetics
Katia Anunciacao Costa, Marina Chaves de Oliveira, Leticia Maria de Souza Cordeiro, Cynthia Honorato Val, Fabiana Simao Machado, Simone Odilia Antunes Fernandes, Valbert Nascimento Cardoso, Mauro Martins Teixeira, Ana Leticia Malheiros Silveira, Adaliene Versiani Matos Ferreira
Summary: This study aims to evaluate the effects of a high-refined carbohydrate (HC) diet on small intestine changes. Male BALB/c mice were fed an HC diet for 8 weeks, and it was found that although there were no significant differences in body weight gain, mice fed the HC diet exhibited adiposity and metabolic alterations. However, there were no significant changes observed in intestinal integrity, tight junction protein expression, intestinal permeability, and bacterial translocation.