Article
Chemistry, Multidisciplinary
Omid Dadras-Toussi, Milad Khorrami, Anto Sam Crosslee Louis Sam Titus, Sheereen Majd, Chandra Mohan, Mohammad Reza Abidian
Summary: By incorporating organic semiconductor materials and utilizing multiphoton lithography technology, three-dimensional OS composite microstructures with high electrical conductivity and biocompatibility were successfully fabricated, providing an efficient platform for sensitive glucose detection in biosensors.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Bowen Ding, Gunwoo Kim, Youngseok Kim, Flurin D. Eisner, Edgar Gutierrez-Fernandez, Jaime Martin, Myung-Han Yoon, Martin Heeney
Summary: Two new glycolated semiconducting polymers, PgBT(F)2gT and PgBT(F)2gTT, with different backbone curvatures were designed and synthesised for application in p-type accumulation mode organic electrochemical transistors (OECTs). While PgBT(F)2gT achieved a higher volumetric capacitance due to its curved backbone geometry, PgBT(F)2gTT exhibited superior OECT performance overall thanks to its enhanced order, resulting in faster charge mobility.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Tommaso Paltrinieri, Luca Bondi, Vedran Derek, Beatrice Fraboni, Eric Daniel Glowacki, Tobias Cramer
Summary: Photoactive organic semiconductor substrates are studied for transducing light into biological signals, with a focus on understanding optoelectronic transduction mechanisms and material science. A model based on a planar p-n junction containing phthalocyanine and PTCDI is developed to predict faradaic or capacitive current transients.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Physical
Aleksandr Markov, Alexander Gerasimenko, Annie-Kermen Boromangnaeva, Sofia Shashova, Elena Iusupovskaia, Ulyana Kurilova, Vita Nikitina, Irina Suetina, Marina Mezentseva, Mikhail Savelyev, Peter Timashev, Dmitry Telyshev, Xing-Jie Liang
Summary: By vertically stacking organic p-n junctions, we have developed highly efficient multilayered organic semiconductor (MOS) photostimulation devices that achieve higher photovoltage and charge density while maintaining a small thickness. These devices demonstrate outstanding stability in in vivo experiments and effectively enhance cell growth density.
Review
Chemistry, Physical
Chenfang Sun, Tie Wang
Summary: The early determination of disease-related biomarkers can improve patient survival rate significantly. Therefore, explorations for new diagnosis technologies, such as optical and electrochemical methods, have been devoted to life and health monitoring. Organic thin-film transistor (OTFT), as a label-free, low-cost, facial, and rapid detection technology, has attracted significant attention. However, the reliability and accuracy of the biosensor need to be improved while ensuring sensitivity, selectivity, and stability.
Article
Chemistry, Multidisciplinary
Jiayao Duan, Genming Zhu, Junxin Chen, Chenyang Zhang, Xiuyuan Zhu, Hailiang Liao, Zhengke Li, Hanlin Hu, Iain McCulloch, Christian B. Nielsen, Wan Yue
Summary: Researchers have reported a new electron-deficient, fused polycyclic aromatic compound, TNR, with excellent n-type mixed conduction properties. By optimizing the side chains, the dominant molecular packing can be changed to support highly efficient mixed conduction properties across the bulk semiconductor film.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Analytical
Si Cheng, Yifan Wang, Ruishi Zhang, Hongjiao Wang, Chenfang Sun, Tie Wang
Summary: This paper provides an exhaustive overview of the production, functionalization strategies, and practical applications of gas sensors incorporating P3HT as the OSC layer. P3HT shows exceptional sensing characteristics and wide-ranging utility, positioning it as a promising candidate for improving PFET-based gas sensors.
Article
Materials Science, Multidisciplinary
Shihui Liu, Debin Xia, Jinghao Wang, Congwu Ge, Sue Hao, Jian Zhang, Ping Wang, Kaifeng Lin, Shaoqiang Dong, Evgeny Tretyakov, Yulin Yang, Xike Gao
Summary: A series of novel p-extended 11-ring-fused linear thienoacenes were synthesized and characterized. The photophysical, electrochemical, and thermal properties of these compounds with different fused lengths and substituent groups were investigated. The stability of these aromatic thienoacenes was found to be better than that of acenes. The single crystal structure of BBDTB-TIPS revealed a molecular length of 22.42 A, making it the longest reported single crystal of a linear thienoacene. The aromaticity of each ring in BBDTB-H was determined using NICS and ACID calculations. Preliminary investigations on thienoacene-based OFETs were also conducted.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Jiuyun Shi, Changxu Sun, Elaine Liang, Bozhi Tian
Summary: This article introduces the potential of semiconductor nanowires in probing biological behaviors, sensing physiology or biochemistry, and modulating biological activity at the cellular level, as well as the progress in drug delivery and bioenergy production.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Oliya S. Abdullaeva, Ihor Sahalianov, Malin Silvera Ejneby, Marie Jakesova, Igor Zozoulenko, Sara I. Liin, Eric Daniel Glowacki
Summary: A microfabricated ROS modulation device based on controlled faradaic reactions was developed in this research. The device can generate tunable gradients of peroxide and oxygen concentrations, enabling controlled H2O2 delivery. The prototype devices were tested by modulating human H2O2-sensitive channels to demonstrate the potential of PEDOT as an H2O2 delivery system.
Article
Materials Science, Multidisciplinary
Giuseppe Ciccone, Jens P. Weber, Ilenia Meloni, Hans Kleemann, Karl Leo, Caroline Murawski
Summary: Optogenetic stimulation allows for precise control of neuronal functions, and using dual-color organic light-emitting diodes (OLEDs) provides high light confinement for targeted cell control.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Tony Schmidt, Marie Jakesova, Vedran Derek, Karin Kornmueller, Oleksandra Tiapko, Helmut Bischof, Sandra Burgstaller, Linda Waldherr, Marta Nowakowska, Christian Baumgartner, Muammer Ucal, Gerd Leitinger, Susanne Scheruebel, Silke Patz, Roland Malli, Eric Daniel Glowacki, Theresa Rienmueller, Rainer Schindl
Summary: This research evaluates the performance of organic electrolytic photocapacitor (OEPC) optoelectronic stimulators on single mammalian cells and neurons, demonstrating the ability to manipulate channel conductivity and trigger action potentials with millisecond precision. This opens up possibilities for novel in vitro electrophysiology protocols and potential in vivo applications.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Review
Chemistry, Multidisciplinary
Lanyi Xiang, Liyao Liu, Fengjiao Zhang, Chong-an Di, Daoben Zhu
Summary: Ion gating engineering offers a new way to connect electronics and ionics, providing unprecedented opportunities for organic semiconductors (OSCs) in bioelectronics and solid-state physics. By manipulating ion-electron coupling, multifunctional organic electronic devices can be designed, accelerating the development of various organic devices. This technology opens up new avenues for exploring the charge transport, thermoelectric, and superconducting properties of organic materials.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Automation & Control Systems
Yunjeong Park, Le Luo, Marco Rolandi
Summary: The precise and regulated flow of biomolecules and ions through cellular networks is crucial for communication and information processing in living systems. Ion channels, with a complexity unmatched in semiconductor devices, play vital roles in regulating this flow. Supported lipid bilayers (SLBs) create a planar cell membrane for integration with bioelectronics to enable biotic-abiotic communication. This review discusses the integration of ion channels in bioelectronic devices for enhanced functionality.
ADVANCED INTELLIGENT SYSTEMS
(2023)
Article
Neurosciences
Grant P. Higerd-Rusli, Matthew Alsaloum, Sidharth Tyagi, Nivedita Sarveswaran, Mark Estacion, Elizabeth J. Akin, Fadia B. Dib-Hajj, Shujun Liu, Daniel Sosniak, Peng Zhao, Sulayman D. Dib-Hajj, Stephen G. Waxman
Summary: Neuronal excitability relies on the coordinated action of functionally distinct channels, specifically voltage-gated sodium (Na-v) and potassium (K-v) channels. Mutations and dysfunction of these channels contribute to disorders of excitability, such as pain and epilepsy. Understanding the trafficking of these channels and other axonal proteins can offer potential therapeutic strategies for these diseases. This study demonstrates that various Na-v and K-v channel isoforms and other axonal membrane proteins are co-transported in specific vesicles, providing new insights into the development and organization of sensory neuron membranes.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Chemistry, Inorganic & Nuclear
Morena Nocchetti, Anna Donnadio, Eleonora Vischini, Tamara Posati, Cristiano Albonetti, Davide Campoccia, Carla Renata Arciola, Stefano Ravaioli, Valentina Mariani, Lucio Montanaro, Riccardo Vivani
Summary: New insoluble layered zirconium phosphate carboxyaminophosphonates (ZPs) were prepared and characterized. By intercalation of short amines, these layered compounds formed colloidal dispersions and Ag nanoparticles were grown in situ on their surface. The compounds showed potential antimicrobial activity against various bacteria.
INORGANIC CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Marta Giannelli, Andrea Guerrini, Marco Ballestri, Annalisa Aluigi, Roberto Zamboni, Giovanna Sotgiu, Tamara Posati
Summary: In recent years, there has been increased interest in the preparation of biocompatible and biodegradable nanocarriers for various biomedical applications. Natural biomolecules, such as proteins, offer advantages over synthetic polymers and inorganic materials due to their biocompatibility, biodegradability, and low immunogenicity. Among these proteins, keratin extracted from wool and feathers, as well as fibroin extracted from Bombyx mori cocoons, show promising potential for biomedical applications. This review provides an overview of the methodologies for obtaining drug-loaded keratin and fibroin nanoparticles, and discusses their potential in the field of biomedicine.
Article
Biochemistry & Molecular Biology
Marianna Barbalinardo, Marta Giannelli, Ludovica Forcini, Barbara Luppi, Anna Donnadio, Maria Luisa Navacchia, Giampiero Ruani, Giovanna Sotgiu, Annalisa Aluigi, Roberto Zamboni, Tamara Posati
Summary: Skin disorders are common globally and oxidative stress is a major cause of skin cell dysfunction. In this study, researchers combined fibroin with antioxidant compounds extracted from pomegranate waste to fabricate bioactive and eco-sustainable films for potential skin repair. The films were visually transparent, flexible, stable and able to release bioactive compounds in a controlled manner. They were also biocompatible with main skin cells and demonstrated a high capacity to reduce oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Emilia Benvenuti, Giuseppe Portale, Marco Brucale, Santiago D. Quiroga, Matteo Baldoni, Roderick C. I. MacKenzie, Francesco Mercuri, Sofia Canola, Fabrizia Negri, Nicolo Lago, Marco Buonomo, Andrea Pollesel, Andrea Cester, Massimo Zambianchi, Manuela Melucci, Michele Muccini, Stefano Toffanin
Summary: A study on organic field-effect transistors (OFETs) reveals that the out-of-plane domain size and crystallite orientation in the vertical direction have a direct correlation with charge mobility and source-drain current. Polycrystalline films with a 3D molecular architecture provide the best electrical and optoelectronic characteristics, highlighting the importance of molecular orientational order in achieving optimum device performance.
ADVANCED ELECTRONIC MATERIALS
(2023)
Article
Engineering, Chemical
Massimo Zambianchi, Sara Khaliha, Antonio Bianchi, Francesca Tunioli, Alessandro Kovtun, Maria Luisa Navacchia, Anastasio Salatino, Zhenyuan Xia, Elena Brinas, Ester Vazquez, Davide Paci, Vincenzo Palermo, Letizia Bocchi, Barbara Casentini, Manuela Melucci
Summary: This study describes polysulfone-graphene oxide hollow fiber membranes (PSU-GO HFs) with simultaneous adsorption and ultrafiltration capabilities for enhanced and simplified Point-of-Use (POU) drinking water purification. The PSU-GO HFs showed competitive removal capabilities for heavy metals and polyfluoroalkyl substances (PFAS) compared to standard industrial sorbents.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Massimiliano Cavallini, Marco Brucale, Denis Gentili, Fabiola Liscio, Lucia Maini, Laura Favaretto, Ilse Manet, Massimo Zambianchi, Manuela Melucci
Summary: In this study, we address the issue of polymorph selection by introducing a general concept based on ordering. We demonstrate the concept by patterning four compounds on surfaces, which are capable of forming different polymorphs. Our approach takes advantage of the confinement of crystalline material growth within small cavities to generate only one polymorph. We verify our method by fabricating micrometric logic patterns using model compounds, where each printed pixel comprises only one polymorph and can be accessed individually.
Article
Engineering, Chemical
Sara Khaliha, Antonio Bianchi, Alessandro Kovtun, Francesca Tunioli, Alex Boschi, Massimo Zambianchi, Davide Paci, Letizia Bocchi, Sara Valsecchi, Stefano Polesello, Andrea Liscio, Michela Bergamini, Maurizia Brunetti, Maria Luisa Navacchia, Vincenzo Palermo, Manuela Melucci
Summary: Graphene nanosheets have great potential for water purification, but their recovery has been a challenge. In this study, graphene oxide and reduced graphene oxide nanosheets were successfully separated and recovered using microfiltration. The recovered nanosheets can be reused, providing an effective solution for water treatment and reducing secondary contamination.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Oncology
Barbara Bortot, Alessandro Mangogna, Ben Peacock, Rebecca Lees, Francesco Valle, Marco Brucale, Sara Tassinari, Federico Romano, Giuseppe Ricci, Stefania Biffi
Summary: The study found that the extent of platelet activation in the ascitic fluid of ovarian cancer patients is correlated with disease status. A method to measure platelet activation in ascites was developed.
Article
Chemistry, Multidisciplinary
Anna Donnadio, Geo Paul, Marianna Barbalinardo, Valeria Ambrogi, Gabriele Pettinacci, Tamara Posati, Chiara Bisio, Riccardo Vivani, Morena Nocchetti
Summary: Different amounts of sodium-alendronate (ALN) were loaded into layered zirconium phosphates of alpha and gamma type by topotactic exchange reactions. To extend the exchange process to the interlayer regions, ALN solutions were in contact with exfoliated single sheets of the layered solids. The ALN loading degree was determined and the compounds were characterized. The effect of ZP derivatives on cell proliferation was assessed and showed no decrease after 7 days of incubation.
Article
Nanoscience & Nanotechnology
Arthur R. J. Barreto, Graziani Candiotto, Harold J. C. Avila, Rafael S. Carvalho, Aline Magalhaes dos Santos, Mario Prosa, Emilia Benvenuti, Salvatore Moschetto, Stefano Toffanin, Rodrigo B. Capaz, Michele Muccini, Marco Cremona
Summary: Organic light-emitting transistors (OLETs) combine the advantages of organic light-emitting diodes (OLEDs) and organic field-effect transistors (OFETs) but face challenges of low charge mobility and high threshold voltage. This study demonstrates that using polyurethane films as a dielectric layer material in OLET devices can significantly reduce traps and improve device parameters. The findings provide a simple solution for low-bias device operation and overcome the limiting factors of OLETs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Franco Dinelli, Michele Modestino, Armando Galluzzi, Tamara Posati, Mirko Seri, Roberto Zamboni, Giovanna Sotgiu, Massimiliano Polichetti
Summary: In this paper, an investigation on HTlcs made of Mg and Fe, recently employed to improve the growth in vitro of osteoblasts within a keratin sponge, is reported. The powders were analyzed, and HTlcs dispersed in keratin and spin-coated on a Si/SiO2 substrate at different temperatures were examined. The magnetic properties of these films were characterized and the local magnetic properties were mapped with a micrometric resolution.
Article
Engineering, Environmental
Sara Khaliha, Derek Jones, Alessandro Kovtun, Maria Luisa Navacchia, Massimo Zambianchi, Manuela Melucci, Vincenzo Palermo
Summary: In this study, we compared different materials in removing organic contaminants from water using Langmuir adsorption isotherms. We found that the removal efficiency reaches a limit at low concentrations and multi-step adsorption processes are more efficient than single-step adsorption with smaller amounts of adsorbent material. The concentration of the adsorbent strongly affects its performance. Furthermore, we emphasized the importance of reporting both Q(m) and K-L parameters for comparing materials tested under different experimental conditions in future work and reviews.
ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY
(2023)
Article
Chemistry, Physical
Jacopo Cardellini, Arianna Balestri, Luca Comparini, Barbara Lonetti, Marco Brucale, Francesco Valle, Debora Berti, Costanza Montis
Summary: The interaction between citrate-coated gold nanoparticles (AuNPs) and hybrid membranes made of lipid and copolymer was investigated. The results showed that the incorporation of copolymer promoted AuNPs clustering, and the size and morphology of AuNPs clusters could be controlled in non-homogeneous membranes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)
Article
Cell Biology
Estefania Lozano-Andres, Agustin Enciso-Martinez, Abril Gijsbers, Andrea Ridolfi, Guillaume Van Niel, Sten F. W. M. Libregts, Claudio Pinheiro, Martijn J. C. van Herwijnen, An Hendrix, Marco Brucale, Francesco Valle, Peter J. Peters, Cees Otto, Ger J. A. Arkesteijn, Marca H. M. Wauben
Summary: Extracellular vesicles (EVs) in blood plasma have potential as biomarkers for disease. However, analyzing EVs at the single particle level is challenging due to the complexity of plasma. This study investigates the presence and formation of EV-lipoproteins particles (LPPs) complexes, and the impact of LPPs on EV analysis and biomarker profiling. The results demonstrate that EV-LPP complexes can form under physiological conditions, and the presence of LPPs can influence the quantitative and qualitative analysis of EVs.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)