One-step radiation-induced construction of multi-responsive self-assemblies using simple cyclic ethers

A general and one-step method was developed as a versatile route to fabricate 'smart' self-assemblies via gamma-irradiation of simple cyclic ethers under air atmosphere. Only by one-step irradiation in water, a series of amphiphilic oligomers containing oligo(ethylene glycol) (oligo-EG) side chains and their supramolecular assemblies with plentiful morphologies could be prepared, including flower-shaped aggregates, microsphere aggregates, well-defined core-shell micelles and nano-sized capsules. The morphology of the supramolecular assemblies could be facilely adjusted based on the different structures of the cyclic ethers. Moreover, the core-shell micelles prepared by irradiating dicyclohexano-18-crown-6 (DCH18C6) aqueous solutions could be easily controlled by simple external stimulations, such as varying temperature, pH and adding metal ions. Based on the results of a series of cyclic ethers, it is expected that this work can provide a novel and general approach to design and construct 'smart' supramolecular assemblies for biomedical and industrial applications.