期刊
ADVANCED HEALTHCARE MATERIALS
卷 4, 期 7, 页码 948-968出版社
WILEY
DOI: 10.1002/adhm.201400773
关键词
cartilage; osteoarthritis; gene therapy; cell therapy; tissue engineering; regenerative medicine
资金
- National Tsing Hua University [103N2051N1, 102N2766E1, 103N2758E1]
- Ministry of Science and Technology, Taiwan [NSC 101-2628-E-007-009-MY3, NSC 101-2923-E-007-002-MY3, MOST 103-2622-E-007-025]
Diseases in articular cartilages affect millions of people. Despite the relatively simple biochemical and cellular composition of articular cartilages, the self-repair ability of cartilage is limited. Successful cartilage tissue engineering requires intricately coordinated interactions between matrerials, cells, biological factors, and phycial/mechanical factors, and still faces a multitude of challenges. This article presents an overview of the cartilage biology, current treatments, recent advances in the materials, biological factors, and cells used in cartilage tissue engineering/regeneration, with strong emphasis on the perspectives of gene regulation (e.g., microRNA) and gene therapy.
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