期刊
ACS SYNTHETIC BIOLOGY
卷 4, 期 8, 页码 873-879出版社
AMER CHEMICAL SOC
DOI: 10.1021/sb5003289
关键词
SBOL; SBML; standards; modeling genetic design automation
资金
- National Science Foundation [CCF-1218095, DBI-1356041]
In the context of synthetic biology, model generation is the automated process of constructing biochemical models based on genetic designs. This paper discusses the use cases for model generation in genetic design automation (GDA) software tools and introduces the foundational concepts of standards and model annotation that make this process useful. Finally, this paper presents an implementation of model generation in the GDA software tool iBioSim and provides an example of generating a Systems Biology Markup Language (SBML) model from a design of a 4-input AND sensor written in the Synthetic Biology (SBOL).
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