Review
Food Science & Technology
Patrick Tai, Matt Golding, Harjinder Singh, David Everett
Summary: The milk fat globule membrane (MFGM) has gained attention in nutritional sciences due to recent research on the heterogenous, lateral milk polar lipids assemblies. It has been discovered that these assemblies, enriched with sphingomyelin and cholesterol, can form a liquid-ordered (L-o) phase, challenging previous assumptions about milk fat digestion. This review critically examines the anticholesteremic effect of milk polar lipids, the structure and properties of L-o domains, and hypotheses on the interactions between sphingomyelin and cholesterol in the establishment of L-o structures.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Food Science & Technology
Shuyan Han, Yongjin Wang, Zhongxiang Fang, Yiren Zhang, Wei Zeng, Emad Karrar, Hui Zhang, Qingzhe Jin, Gangcheng Wu, Xingguo Wang
Summary: This study determined the effect of olive oil polyphenols on lipid oxidation of high-fat beef during digestion. The results showed that olive oil with higher polyphenol content could significantly inhibit lipid oxidation, indicating the potential health benefits of consuming olive oil with abundant levels of polyphenols.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Roberta Arena, Simona Bisogno, Lukasz Gasior, Joanna Rudnicka, Laura Bernhardt, Thomas Haaf, Federica Zacchini, Michal Bochenek, Kinga Fic, Ewelina Bik, Malgorzata Baranska, Anna Bodzon-Kulakowska, Piotr Suder, Joanna Depciuch, Artur Gurgul, Zbigniew Polanski, Grazyna E. Ptak
Summary: Embryonic diapause is a temporary arrest of an embryo at the blastocyst stage while waiting for the uterine receptivity signal to implant. Lipid droplets (LDs) play a crucial role in maintaining embryonic diapause and are essential for the survival of diapausing embryos. The presence of LDs in oocytes of various mammals positively correlates with their species-specific length of diapause.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Physical
Andrew J. Clulow, Syaza Y. Binte Abu Bakar, Malinda Salim, Cameron J. Nowell, Adrian Hawley, Ben J. Boyd
Summary: The study investigated the formation of self-assembled lipid structures during the digestion of different milks and milk substitutes, with a focus on the impact of mixing cow milk fat and canola oil on lipid self-assembly. The findings showed that a 1:1 ratio of cow milk fat to canola oil lipids led to the formation of liquid crystalline structures resembling human breast milk during digestion.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Applied
Yandan Wang, Hua Xu, Xiaojing Liu, Wei Wei, Qingzhe Jin, Xingguo Wang
Summary: The study investigates the effects of triglyceride structure on in vitro digestion and bioaccessibility, using a mixture of medium-chain triglycerides and long-chain triglycerides (PM) and medium- and long-chain triglycerides (MLCT). The results show that MLCT releases more free fatty acids (FFAs) than PM (99.88% vs 92.82%, P < 0.05). The first-order rate constant for FFA release from MLCT is lower than that for PM (0.0395 vs 0.0444 s(-1), P < 0.05), indicating that the digestion rates of MLCT are slower than those of PM. The study highlights the important role of triglyceride structure in regulating lipid digestibility and bioaccessibility.
Article
Agriculture, Multidisciplinary
Yue Sun, Shuming Liu, Shuaiyi Ma, Lina Sun, Xiaodong Li, Lu Liu, Chunli Ma, Massounga Bora Awa Fanny, Yang Jiao, Lianji Bi
Summary: This study investigated the use of milk fat globule membrane as an emulsifier to improve the digestibility of fat in infant formula. Results showed that the membrane reduced aggregation during digestion and released higher levels of important long-chain fatty acids compared to other emulsifiers. This makes fat droplets enveloped by milk fat globule membranes more suitable for infant formula.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Review
Immunology
Patricia Elaine de Almeida, Nubia Maria Pereira de Sousa, Pollianne Garbero Rampinelli, Renata Vieira de Sousa Silva, Jose Raimundo Correa, Heloisa D'Avila
Summary: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Lipid metabolism plays a role in the immune response regulation, including lipid droplet formation, association with phagosomes, and synthesis of lipid mediators. Lipid droplets have important functions in host cells and can potentially be targeted for antimicrobial therapies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Chemistry, Applied
Yayuan Xu, Xintian Li, Zhuqing Dai, Zhongyuan Zhang, Lei Feng, Meimei Nie, Chunquan Liu, Dajing Li, Min Zhang
Summary: In this study, lutein nanostructured lipid carriers (Lutein-NLCs) with different interface structures were constructed by combining whey protein isolate with surfactant Tween 80. The kinetics of lipid hydrolysis, mixed micelles formation, and lutein bioaccessibility were analyzed. The results indicated that S-Lutein-NLCs and C-Lutein-NLCs showed better resistance to bile salt displacement compared to D-Lutein-NLCs. S-Lutein-NLCs also had higher lutein bioaccessibility compared to D-Lutein-NLCs and C-Lutein-NLCs. The release of MAGs and FFAs significantly influenced the micellization of lutein and its bioaccessibility. D-LuteinNLCs and C-Lutein-NLCs exhibited a better sustained-release effect. Additionally, C-Lutein-NLCs exhibited a stronger inhibitory effect on lutein degradation with a higher lutein retention rate.
FOOD HYDROCOLLOIDS
(2023)
Article
Agriculture, Multidisciplinary
Lu Liu, Yue Pan, Xiuxiu Zhang, Yu Zhang, Xiaodong Li
Summary: Different particle sizes and sources of droplets covered with milk fat globule membrane phospholipids were studied using an infant digestion model, revealing differences in particle size, aggregation, and free fatty acid release during digestion. The release rate of free fatty acids was significantly higher in MPLs and HM compared to IF, with MPLs and HM also showing higher content of long-chain polyunsaturated fatty acids and lower content of saturated fatty acids compared to IF.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Kyung-A Byun, Seyeon Oh, Myeongjoo Son, Seung Eon Oh, Chul-Hyun Park, Kuk Hui Son, Kyunghee Byun
Summary: An excessive fat diet can lead to intramuscular fat deposition and muscle atrophy, but ECE or dieckol can reduce the size of lipid droplets and attenuate the negative effects of high fat intake on muscle health by decreasing PLIN2 expression.
Article
Cell Biology
Nadav Kislev, Shira Eidelheit, Shaked Perlmutter, Dafna Benayahu
Summary: In this study, a novel machine learning-based method was developed for analyzing lipid droplets (LDs) by segmenting phase-contrast images. This method enables accurate and label-free quantification of LD-related parameters and analysis of LD dynamics. It can be applied in different metabolic conditions to study LD biogenesis and function.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Chemistry, Applied
Mengzhen Ding, Zixin Huang, Zhiying Jin, Chang Zhou, Juqing Wu, Di Zhao, Kai Shan, Weixin Ke, Miao Zhang, Yingqun Nian, Chunbao Li
Summary: A high-fat diet can affect the solubility and secondary structures of proteins, as well as the microstructure of different protein types. Protein digestibility is influenced by protein type and fat content.
FOOD HYDROCOLLOIDS
(2022)
Review
Food Science & Technology
Seonmin Lee, Kyung Jo, Seul-Ki-Chan Jeong, Yun-Sang Choi, Samooel Jung
Summary: The structural changes in emulsion products play a crucial role in controlling the bioavailability of fatty acids and lipophilic compounds. The oil-water interface in the emulsion system modulates the digestive behavior of lipid droplets by affecting the adsorption of lipase and bile salts. The choice of stabilizers can tune the lipid digestibility by altering the accessibility and exposure of lipid substrates to lipase.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Nutrition & Dietetics
Alyssa S. Zembroski, Changting Xiao, Kimberly K. Buhman
Summary: The formation of cytoplasmic lipid droplets in enterocytes is crucial for the absorption of dietary fat, and recent studies have identified various factors that regulate this process, such as compartmentalization of different lipid pools, gut microbiome, liver X receptor, and obesity.
ANNUAL REVIEW OF NUTRITION, VOL 41, 2021
(2021)
Article
Chemistry, Applied
Na Zhang, Xue Han, Rumeng Yu, Xiaomin Tang, Bo Zhang, Yanyan Zhang, Xiaoyu Yin, Wenrui Ni, Mengze Wang, Bolin Zhang, Junfeng Fan
Summary: A stable water/oil interface stabilized by bile salts is essential for the hydrolysis of triacylglycerol by pancreatic lipase. Polysaccharides weakly inhibit the activity of pancreatic lipase, but they also disrupt the stability of bile salt-stabilized emulsions, resulting in the inhibition of free fatty acid release. These findings provide insights into the interface chemistry of polysaccharides in fat digestion and enhance our understanding of their interactions with lipid digestants.
FOOD HYDROCOLLOIDS
(2023)
Article
Nanoscience & Nanotechnology
Serhii Vasylevskyi, Guillaume Raffy, Stefan Salentinig, Andre Del Guerzo, Katharina M. Fromm, Dario M. Bassani
Summary: An anthracene-based Ni-MOF material capable of adsorbing C60 and C70 was reported, with fullerenes showing homogeneous distribution in single crystals under confocal fluorescence and Raman microscopy. Efficient energy transfer from 1 to fullerenes and stronger binding between 1 and C70 than C60 were observed, providing a basis for the selective retention of C70 in liquid chromatography columns packed with 1.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Neda Iranpour Anaraki, Marianne Liebi, Quy Ong, Clement Blanchet, Anjani K. Maurya, Francesco Stellacci, Stefan Salentinig, Peter Wick, Antonia Neels
Summary: This study investigates the influence of nanoparticles properties on colloidal stability in NaCl and protein solutions, revealing that PEG coating provides high stability for nanoparticles. Different mechanisms are observed for citrate-capped nanoparticles, with proteins attaching to the nanoparticle surfaces. Findings pave the way for designing and synthesizing nanoparticles with controlled behaviors in biomedical applications.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Gary G. Scott, Tim Boerner, Martin E. Leser, Tim J. Wooster, Tell Tuttle
Summary: This study demonstrates the potential of using short peptides as emulsifiers in oil-water emulsions. The surface activity of the emulsions can be tuned by designing the peptide sequence, as confirmed by both computational screening and experimental studies.
FRONTIERS IN CHEMISTRY
(2022)
Article
Food Science & Technology
Linda Hong, Stefan Salentinig
Summary: The rational design of advanced food products gives a competitive advantage and understanding the correlation between colloidal structures and their interactions with the digestive system is crucial for the design of novel colloidal food materials. This contribution summarizes the recent progress in examining the structural fate of food materials during digestion, discusses the design and characterization of colloidal food materials, and highlights the dynamic interactions of food materials with components of the digestive tract.
CURRENT OPINION IN FOOD SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Rafael V. M. Freire, Eliane Haenni, Linda Hong, Mark Gontsarik, Stefan Salentinig
Summary: This study reports the pH-responsive colloidal and interfacial properties of nanostructured emulsions and applies this knowledge to sustainable design. It is found that emulsions can be formed under pH conditions that trigger a decrease in interfacial tension. The protonation of oleic acid, influenced by lipid composition, pH, and ionic strength, drives pH-triggered colloidal transformations. These findings can guide the design of novel sustainable functional food emulsions.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Samuel Watts, Bettina Tran, Stefan Salentinig
Summary: Viruses are highly symmetric and monodisperse nanoparticles with well-defined surface chemistry, making them efficient pathogens and fascinating objects for material design. Recent progress has been made in virus self-assembly and virus-based biopolymer composites, with selected applications in food and water purification.
Article
Chemistry, Physical
Marco Manca, Chi Zhang, Frank Scheffold, Stefan Salentinig
Summary: This study demonstrates the analysis of pH-driven structural transformations using a comprehensive approach, revealing the transitions of oleic acid particles from multilamellar structures to nanostructured emulsions and eventually oil droplets. The changes in pH also affect the interfacial tension and induce self-propelled motion of the particles.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Engineering, Biomedical
Lihui Peng, Carlos Matellan, Minerva Bosch-Fortea, Jordi Gonzalez-Molina, Matteo Frigerio, Stefan Salentinig, Armando del Rio Hernandez, Julien E. Gautrot
Summary: Stem cells can sense and respond to the mechanical properties of biomaterials, and their forces exerted on the environment can lead to changes in tissue shape, size, and contraction, potentially causing mechanical disruption and functional failure. This study focuses on the correlation between stem cell phenotype and biomaterials toughness, which has been elusive due to the challenge of uncoupling Youngs' or shear moduli from toughness. The design of polymer nanosheets' macromolecular architecture is found to regulate interfacial toughness, and this control affects the expansion of mesenchymal stem cells at liquid interfaces.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Physical
Marco Manca, Chi Zhang, Rafael Vasconcelos de Melo Freire, Frank Scheffold, Stefan Salentinig
Summary: This study investigates the colloid transformations of triolein droplets triggered by pancreatic lipase and pH through optical micromanipulation, microfluidics, polarized optical video microscopy, and small-angle X-ray scattering (SAXS). The findings show that the droplets undergo surface roughening and overall volume changes during digestion, and multiple structures coexist during the process. The results provide insights into the phase transformations inside emulsion droplets during triglyceride digestion and have implications for the design of advanced food emulsions.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Meron Debas, Rafael V. M. Freire, Stefan Salentinig
Summary: This study hypothesizes the formation of CO2-responsive self-assemblies of oleyl-amidine in water and their integration into glycerol-monooleate-based (GMO) dispersions to form CO2-switchable liquid crystalline nanoparticles. The experiments involve synthesizing and formulating CO2-switchable lipids and characterizing their supramolecular structure and response to CO2. The findings reveal the self-assembly of CO2-responsive lyotropic liquid crystalline structures and the colloid transformations triggered by CO2, providing insights for the design of functional nanomaterials.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Samuel Watts, Mark Gontsarik, Andrea Lassenberger, Jules D. P. Valentin, Aline Wolfensberger, Silvio D. Brugger, Mahsa Zabara, Wouter Pronk, Stefan Salentinig
Summary: This work demonstrates the scalable synthesis and characterization of self-disinfecting nanofilms for the postmodification of hospital-relevant surfaces. The antimicrobial action of the nanofilms is based on charge interactions between a supercharged cationic surface film and the negatively charged bacteria membrane. The coated surfaces show rapid bactericidal activity, reducing bacterial populations in less than 5 minutes.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Infectious Diseases
Youri Cortat, Miroslava Nedyalkova, Kevin Schindler, Parth Kadakia, Gozde Demirci, Sara Nasiri Sovari, Aurelien Crochet, Stefan Salentinig, Marco Lattuada, Olimpia Mamula Steiner, Fabio Zobi
Summary: In the context of the global health issue caused by antimicrobial resistance (AMR), the need for novel antimicrobial agents is urgent. Inorganic and organometallic complexes show potential as untapped sources of antibiotics. This study used a computer-aided drug design approach to synthesize and evaluate fac-Re(I) tricarbonyl complexes as antibacterial agents, with promising results.
Article
Chemistry, Multidisciplinary
Rafael V. M. Freire, Linda Hong, Miroslav Peterek, Stephane Canarelli, Serge Rezzi, Stefan Salentinig
Summary: Functional food emulsions enriched in health-promoting nutrients, such as buriti oil, have been studied for their effects on cardiometabolic health. This study investigates the colloid transformations of whey-stabilized buriti oil-in-water emulsions during simulated digestion. It is found that the oil phase transforms into highly ordered structures during simulated intestinal digestion under compromised bile conditions, and the digestion process can be modulated by adding vitamin E to the oil.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Polymer Science
Subhajit Pal, Linda Hong, Rafael V. M. Freire, Saquib Farooq, Stefan Salentinig, Andreas F. M. Kilbinger
Summary: Polyaromatic amides have been extensively studied for foldamer design. A chlorophosphonium iodide reagent is developed to enable living polymerization of aromatic amino acid monomers and oligomers in solvents that break hydrogen bonds, expanding the application of aramids.
Article
Engineering, Biomedical
Parth Kadakia, Jules D. P. Valentin, Linda Hong, Samuel Watts, Owais Abdul Hameed, Michael Walch, Stefan Salentinig
Summary: This study introduces a pH-responsive antimicrobial nanomaterial made from bacteria-derived rhamnolipids and glycerol monooleate. pH- and composition-triggered colloidal transformations are reported and optimized for antimicrobial performance. The material kills Staphylococcus aureus and methicillin-resistant Staphylococcus aureus at pH 5.0 but not at pH 7.0. Furthermore, it inhibits Staphylococcus aureus biofilm formation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Physical
Yiping Yin, Zhe Wang, Hua Zou
Summary: This study presents a novel method for preparing dimpled polymer-silica nanocomposite particles using interfacial swelling-based seeded polymerization. The optimized conditions allow for a relatively high percentage of dimpled particles to be achieved.
Article
Chemistry, Physical
Brenden D. Hoehn, Elizabeth A. Kellstedt, Marc A. Hillmyer
Summary: Porous materials with nanometer-scale pores have important applications as nanoporous membranes. In this study, ABA triblock copolymers were used as precursors to produce nanoporous polymeric membranes (NPMs) in thin film form by degrading the end blocks. Polycyclooctene (PCOE) NPMs with tunable pore sizes were successfully prepared using solvent casting technique. Oxygen plasma etching was employed to improve the surface porosity and hydrophilicity of the membranes. This study provides a straightforward method to produce tough NPMs with high porosity and hydrophilic surface properties.
Article
Chemistry, Physical
Vladislav S. Petrovskii, Stepan I. Zholudev, Igor I. Potemkin
Summary: This article investigates the behavior of linear and ring polypeptide chains in aqueous solution and explores the properties of the complexes formed by these chains with oppositely charged surfactants. The results demonstrate that the complexes of linear supercharged unfolded polypeptides and the corresponding surfactants exhibit impressive adhesive properties.
Article
Chemistry, Physical
Merve Cevik, Serkan Dikici
Summary: Cardiovascular diseases are a leading cause of death globally, and vascular grafts are a promising treatment option. This study focuses on tissue-engineered vascular grafts (TEVGs) using decellularized parsley stems as a potential biomaterial. The decellularized parsley stems showed suitable properties for TEVGs, providing a suitable environment for human endothelial cells to form a pseudo endothelium. This study showcases the potential of using parsley stems for TEVGs.
Article
Chemistry, Physical
Gustavo A. Vasquez-Montoya, Tadej Emersic, Noe Atzin, Antonio Tavera-Vazquez, Ali Mozaffari, Rui Zhang, Orlando Guzman, Alexey Snezhko, Paul F. Nealey, Juan J. de Pablo
Summary: The optical properties of liquid crystals are typically controlled by electric fields. In this study, we investigate the effects of microfluidic flows and acoustic fields on the molecular orientation and optical response of nematic liquid crystals. We identify several previously unknown structures and explain them through calculations and simulations. These findings hold promise for the development of new systems combining sound, flow, and confinement.
Article
Chemistry, Physical
Xinjun Wu, Xin Guan, Shushu Chen, Jiangpeng Jia, Chongyi Chen, Jiawei Zhang, Chuanzhuang Zhao
Summary: This research presents a novel shape memory hydrogel with a remodelable permanent shape and programmable cold-induced shape recovery behavior. The hydrogel is prepared using specific treatment methods to achieve shape fixation by heating and shape recovery by cooling. Additionally, deformable devices can be obtained by assembling hydrogel blocks with different concentrations.
Article
Chemistry, Physical
Rebecca Hengsbach, Gerhard Fink, Ulrich Simon
Summary: This study examines the properties of DNA functionalized pNipmam microgels and pure pNipmam microgels at different concentrations of sodium chloride and in PBS solutions using temperature dependent H-1-NMR measurements. The results show that DNA modification affects the volume phase transition temperature and the addition of salt and PBS further enhances this effect.
Article
Chemistry, Physical
Ningyi Li, Junhong Li, Lijingting Qing, Shicheng Ma, Yao Li, Baohui Li
Summary: This paper investigates the self-assembly behavior of colloids with competing interactions under spherical confinement and finds that different ordered structures can be formed under different sized spherical confinements. Moreover, more perforated structures are formed in smaller spheres.