Article
Chemistry, Applied
Yang Zhou, Kevin J. Edgar
Summary: The site-specific conjugation of polysaccharides with proteins is challenging, but controlling the reaction between polysaccharides and amino acid derivatives can create useful bioactive natural polymer constructs. By using regioselective bromination, this study successfully synthesized polysaccharide-amino acid ester adducts, providing guidance for designing new pathways to polysaccharide-protein copolymers.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Shunshun Chen, Meimei Wang, Linhua Yu, Jinchao Shi, Yong Zhang, Yao Tian, Li Li, Xiang Zhu, Junkai Li
Summary: A series of rhein-amino acid ester conjugates were synthesized and showed potent inhibitory activity against R. solani and S. sclerotiorum. Conjugate 3c exhibited the highest antifungal activity against R. solani, while conjugate 3m showed the highest antifungal activity against S. sclerotiorum. This research supports the potential of rhein-amino acid ester conjugates as antifungal agents for plant fungal diseases.
Article
Biochemistry & Molecular Biology
Xingliang Lu, Chuan Qin, Jinlong Cai, Min Zhang, Linhua Yu, Junkai Li, Qinglai Wu
Summary: In this study, a series of fenoxaprop-P-ethylamino acid ester conjugates were designed and synthesized, and their biological activity and phloem mobility were tested. The results showed that these compounds exhibited better activity against barnyard grass and less phytotoxicity to rice. Compounds 3i, 3j, and 3k showed excellently herbicidal activities against barnyard grass and low phytotoxicity to rice.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Virology
Lidia A. Baltina, Mann-Jen Hour, Ya-Chi Liu, Young-Sheng Chang, Su-Hua Huang, Hsueh-Chou Lai, Rimma M. Kondratenko, Svetlana F. Petrova, Marat S. Yunusov, Cheng-Wen Lin
Summary: This study investigated the potential of glycyrrhizic acid derivatives as ZIKV inhibitors, and found that some GL conjugates showed activity against ZIKV, with different compounds having varying inhibitory effects at different stages of viral infection. These findings suggest that compounds 13 and 14 are promising candidates for expanded antiviral studies against ZIKV infection.
Article
Biochemistry & Molecular Biology
Dipakkumar Bariya, Vivek Anand, Satyendra Mishra
Summary: Bile acids have unique physicochemical properties and biocompatibility, making them attractive for designing novel hydrogels to deliver biomolecules, drugs, and vaccines. These bile-based hydrogels have the potential to efficiently absorb carbon dioxide and serve as alternative materials for carbon dioxide capture and storage, as well as drug carriers and models for self-assembly in pathological conditions. Efforts have been made to develop molecular hydrogels with a focus on biocompatibility, therapeutic applications, and challenges associated with existing molecular hydrogels.
Article
Medicine, Research & Experimental
Katayun Bahrami, Juulia Järvinen, Tuomo Laitinen, Mika Reinisalo, Paavo Honkakoski, Antti Poso, Kristiina M. Huttunen, Jarkko Rautio
Summary: In this study, a series of LAT1-targeted drug-phenylalanine conjugates were evaluated. Through in vitro studies and induced-fit docking, it was concluded that smaller compounds were preferred for uptake by LAT1. The flexibility of the ligand played a crucial role in determining the transportability and interactions with LAT1. Introducing polar groups enhanced interactions, while compounds with a carbamate bond in the para-position of the aromatic ring displayed efficient transport efficiencies. The findings of this study have implications for designing CNS or antineoplastic drug candidates and discovering LAT1 inhibitors for cancer therapy.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Applied
Motohiko Ukiya, Tomoyuki Sekine, Naoto Shimizu, Hiroyuki Akazawa, Minoru Tanigawa, Yusuke Suzuki, Atsuyoshi Nishina
Summary: The aim of this study was to enhance the cytotoxic activities of terpenoids by conjugating them with amino acids. New ester derivatives (5-15, 19-27, and 29) were prepared by conjugating the hydroxy groups in ent-beyerane-type diterpenoids (4) and oleanane-type triterpenoids (18), and their cytotoxic activity was evaluated against three human cancer cell lines (leukemia, lung, and stomach). The amino acid conjugates of ent-beyerane-type diterpenoids (5-13) showed potent cytotoxic activity, and there were no differences in the cytotoxic activities of l- and d-type amino acid conjugates.
JOURNAL OF OLEO SCIENCE
(2023)
Article
Multidisciplinary Sciences
Ibraheem Alshareedah, Mahdi Muhammad Moosa, Matthew Pham, Davit A. Potoyan, Priya R. Banerjee
Summary: The authors demonstrate that disordered polypeptide-RNA condensates exhibit rheological properties similar to that of a viscoelastic Maxwell fluid, and utilize simple polypeptide design rules to create microcondensates with tunable viscoelasticity.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Liwei Ma, Jinling Zhang, Xuemei Wang, Jifang Yang, Lina Guo, Xiaoli Wang, Bo Song, Wei Dong, Wenbao Wang
Summary: DSG-amino acid ester derivatives showed cytotoxic activities against various human cancer cell lines, with compound 7g exhibiting the most significant cytotoxicity against the K562 cell line. Mechanistic studies revealed that compound 7g induced mitochondrial-related apoptosis in K562 cells, highlighting its potential as a promising scaffold for the development of more potent anticancer agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Kenji Yamaoka, Norifumi L. Yamada, Koichiro Hori, Yoshihisa Fujii, Naoya Torikai
Summary: Understanding the interfacial structure and physical properties of polymer materials is crucial for enhancing their functionality. This study utilized QCM and NR measurements to assess the viscoelasticity and structure of an aqueous methylcellulose solution near the gold interface. QCM provided information about the shear modulus accompanying gelation, while NR revealed interfacial segregation on the gold substrate.
Article
Chemistry, Medicinal
Xiaosu Zou, Chang Liu, Congcong Li, Rong Fu, Wei Xu, Hongzhu Bian, Xun Dong, Xiaozhen Zhao, Zhenye Xu, Jinghua Zhang, Zhengwu Shen
Summary: A series of dihydroartemisinin derivatives with anti-proliferation activity against cancer cells were synthesized, and the dihydroartemisinin-ursodeoxycholic acid conjugate showed the most potent activity. In vivo experiments confirmed its effectiveness in suppressing tumor growth in different cell models.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Chengbin Zhao, Huanhuan Yin, Jiannan Yan, Xi Niu, Baokun Qi, Jingsheng Liu
Summary: The study demonstrated that ultrasonic pretreatment can enhance the glycation reaction of SPI-MD conjugates, resulting in higher storage modulus and gel strength, but prolonged treatment may weaken the gelation properties.
FOOD HYDROCOLLOIDS
(2021)
Article
Biochemical Research Methods
Andrea Mosseri, Mariia Sancho-Albero, Flavia Anna Mercurio, Marilisa Leone, Luisa De Cola, Alessandra Romanelli
Summary: This work explores the self-assembly and generation of complex structures of peptide nucleic acid dimers conjugated to the dipeptide WW. The presence of indole ring in tryptophan promotes the aggregation of the conjugates. Fluorescence is observed upon self-assembly. Molecular modeling studies suggest that fibers are stabilized by stacking interactions between tryptophans and Watson-Crick hydrogen bonds between nucleobases.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Plant Sciences
Bin Zhou, Prabhakar S. Achanta, Gauri Shetye, Shao-Nong Chen, Hyun Lee, Ying-Yu Jin, Jinhua Cheng, Mi-Jin Lee, Joo-Won Suh, Sanghyun Cho, Scott G. Franzblau, Guido F. Pauli, James B. McAlpine
Summary: The paper discusses the structures, naming, and anti-Mycobacterium tuberculosis activity of cyclopeptides such as rufomycin and ilamycin. Through NMR spectroscopy, the configuration and diastereoisomers of these compounds were determined, and semisynthetic derivatives were prepared for validation. Structural differences and conformers were analyzed to understand the biological activity of these compounds, leading to a unified nomenclature for the group.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Chemistry, Multidisciplinary
Xinyu Bian, Chunyan Cui, Ying Qi, Yage Sun, Zhuodan Zhang, Wenguang Liu
Summary: This study proposes a strategy to induce superfast gelation of silk fibroin using the surfactant LAE, creating new possibilities for biomedical applications. LAE can quickly gelate SF and can be applied to prepare injectable antibacterial biodegradable hemostatic hydrogels.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Sourov Chandra, Alice Sciortino, Shruti Shandilya, Lincan Fang, Xi Chen, Nonappa, Hua Jiang, Leena-Sisko Johansson, Marco Cannas, Janne Ruokolainen, Robin H. A. Ras, Fabrizio Messina, Bo Peng, Olli Ikkala
Summary: This study presents a new strategy for in situ site-selective Ag-doping at the central core of AuNCs using sulphated colloidal surfaces as templates. This approach greatly improves the photoluminescence quantum efficiency of AuNCs by eliminating nonradiative losses.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Lauri Happonen, Milla Mattila, Ivan Peshev, Arttu Lehikoinen, Arto Valkonen
Summary: A series of thiourea-based tritopic receptor molecules were synthesized to be used as building blocks for halogen-bonded assemblies. The alkyl substituents in the benzene ring proved to be important for isothiocyanate group formation instead of competing thiocyanate group. The synthesized receptor molecules were used to study their halogen-bond acceptor properties with diiodotetrafluorobenzene donors by single-crystal X-ray diffraction method.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Shreya Mahajan, Antti Marttinen, Samu Forsblom, Manu Lahtinen
Summary: By reacting with acidic solutions, 16 new anion-mediated supramolecular entities with different molecular structures and geometric forms are obtained, which are assembled by hydrogen bonding.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
J. Mikko Rautiainen, Maryna Green, Minna Mahonen, Jani O. Moilane, Manu Lahtinen, Arto Valkonen
Summary: Halogen bonding interactions were studied in 15 crystalline 3-iodopyridinium systems. Experimental results showed that halogen bonding acts as a secondary intermolecular force in these charged systems, while still maintaining high directionality of interaction. Computational studies validated the experimental data and showed that halogen bond strengths were exaggerated in smaller model systems, but improved agreement between experimental and calculated structures was seen in larger systems. The strength of halogen bonds was found to come second to electrostatic interactions in stabilizing structures, but played a major role in directing the packing of solid-state structures.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Inorganic & Nuclear
Jawher Makhlouf, Youness El Bakri, Kandasamy Saravanan, Arto Valkonen, Carlos J. Gomez Garcia, Wajda Smirani Sta
Summary: Two novel methoxyphenyl-based piperazine compounds were studied and their crystal structures were determined by single crystal X-ray crystallography. The compounds exhibited different crystal systems and lattice parameters, and were stabilized by different intermolecular interactions. Comprehensive studies were conducted on the compounds, including infrared spectroscopy, UV-visible analysis, thermal analysis, antibacterial activity testing, and magnetic measurements, revealing their structures, optical behavior, thermal stability, antibacterial activity, and magnetic properties.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Jessy Joseph, Ari Vaisanen, Ajay B. Patil, Manu Lahtinen
Summary: Efficient and environmentally friendly porous hybrid adsorbent beads have been developed for the removal of arsenic from drinking water. The structural tuning of the adsorbents has been shown to have a significant impact on their adsorption performance, with high crystallinity leading to increased adsorption capacity and selectivity towards As5+.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Chemistry, Multidisciplinary
Riikka Kuosmanen, Elina Sievanen, Manu Lahtinen
Summary: As the mining industry expands, there is a growing need for efficient recycling methods for mine chemicals. This study found that potassium ethyl xanthate can coordinate into metal organic frameworks, with HKUST-1 showing the highest effectiveness at low concentrations. The synthesis method of MIL-100(Fe) affects the uptake of potassium ethyl xanthate.
Correction
Chemistry, Multidisciplinary
Korath Shivan Sugi, Amritha P. Sandra, Nonappa, Debasmita Ghosh, Jyoti Sarita Mohanty, Murugesan Paulthangam Kannan, B. S. Sooraj, Pillalamarri Srikrishnarka, Jayoti Roy, Wakeel Ahmed Dar, Thalappil Pradeep
Article
Chemistry, Multidisciplinary
Korath Shivan Sugi, Amritha P. P. Sandra, Nonappa, Debasmita Ghosh, Jyoti Sarita Mohanty, Murugesan Paulthangam Kannan, B. S. Sooraj, Pillalamarri Srikrishnarka, Jayoti Roy, Wakeel Ahmed Dar, Thalappil Pradeep
Summary: Orthogonal self-assembly is used to create complex superstructures from atomically precise silver nanoclusters, and the process is tunable by controlling the molar ratio of the ligand. The resulting nanostructures exhibit enhanced NIR emission due to restricted intramolecular motion.
Article
Chemistry, Multidisciplinary
Jayoti Roy, Biswajit Mondal, Gaurav Vishwakarma, Nonappa, Nishanthi Vasanthi Sridharan, Pattabiraman Krishnamurthi, Thalappil Pradeep
Summary: Reactions between nanoclusters and metal-oxide nanoparticles have been explored for the first time, resulting in the formation of alloy nanoclusters and self-assembled colloidal superstructures. The study demonstrates the possibility of extending interparticle reactions to a wide range of chemical systems.
Review
Chemistry, Multidisciplinary
Burcu Firatligil-Yildirir, Ozden Yalcin-Ozuysal, Nonappa
Summary: Breast cancer is a challenging disease due to its multiple molecular subtypes, heterogeneity, and ability to metastasize. In vitro and in vivo models have limitations in replicating the complex process of metastasis, but lab-on-a-chip (LOC) systems offer valuable insights and preclinical models for personalized treatments. LOC platforms provide cost-effective and scalable solutions for studying breast cancer metastasis and diagnosis, as well as evaluating advanced nanomedicine.
NANOSCALE ADVANCES
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Palica, Fritz Deufel, Susann Skagseth, Gabriela Paula Di Santo Metzler, Johannes Thoma, Anna Andersson Rasmussen, Arto Valkonen, Per Sunnerhagen, Hanna-Kirsti S. Leiros, Hanna Andersson, Mate Erdelyi
Summary: The upswing of antibiotic resistance, particularly resistance mediated by bacterial metallo-ss-lactamases, poses an escalating threat to human health. This study presents a series of novel non-cytotoxic alpha-aminophosphonate-based inhibitor candidates and investigates their inhibitory activities and binding modes. The findings suggest that phosphonate-type inhibitors may be potential therapeutic candidates for combating metallo-ss-lactamase resistant bacteria.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Jawher Makhlouf, Atazaz Ahsin, Youness El Bakri, Arto Valkonen, Rashad Al-Salahi, Wajda Smirani
Summary: A new compound [Co(SCN)(4)]2(C5H14N2)2(CNS) was synthesized from a thiocyanic cobalt precursor and homopiperazinium organic cation under hot and basic conditions. X-ray diffraction data revealed its unique crystal structure with excellent dielectric properties. Fourier Transform Infrared spectroscopy was used to study the different functional groups. Theoretical investigations showed the compound's reactivity and charge transfer, and global reactivity descriptors were calculated. The compound also exhibited remarkable nonlinear optical properties.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Nonappa
Summary: As nanotechnology advances, there is a growing need for engineering nanomaterials with atomic-level precision for self-assembly. This article discusses the potential of virus capsids and atomically precise nanoparticles in designing self-assembly at different length scales.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Ida Mattsson, Johanna Majoinen, Manu Lahtinen, Thomas Sandberg, Anna Fogde, Tiina Saloranta-Simell, Orlando J. Rojas, Olli Ikkala, Reko Leino
Summary: Conformational rigidity plays a crucial role in the self-assembly and liquid crystallinity of block molecules. The stereochemistry of carbohydrate-based assemblies is an important parameter to be considered in material design.
Article
Chemistry, Physical
Yiping Yin, Zhe Wang, Hua Zou
Summary: This study presents a novel method for preparing dimpled polymer-silica nanocomposite particles using interfacial swelling-based seeded polymerization. The optimized conditions allow for a relatively high percentage of dimpled particles to be achieved.
Article
Chemistry, Physical
Brenden D. Hoehn, Elizabeth A. Kellstedt, Marc A. Hillmyer
Summary: Porous materials with nanometer-scale pores have important applications as nanoporous membranes. In this study, ABA triblock copolymers were used as precursors to produce nanoporous polymeric membranes (NPMs) in thin film form by degrading the end blocks. Polycyclooctene (PCOE) NPMs with tunable pore sizes were successfully prepared using solvent casting technique. Oxygen plasma etching was employed to improve the surface porosity and hydrophilicity of the membranes. This study provides a straightforward method to produce tough NPMs with high porosity and hydrophilic surface properties.
Article
Chemistry, Physical
Vladislav S. Petrovskii, Stepan I. Zholudev, Igor I. Potemkin
Summary: This article investigates the behavior of linear and ring polypeptide chains in aqueous solution and explores the properties of the complexes formed by these chains with oppositely charged surfactants. The results demonstrate that the complexes of linear supercharged unfolded polypeptides and the corresponding surfactants exhibit impressive adhesive properties.
Article
Chemistry, Physical
Merve Cevik, Serkan Dikici
Summary: Cardiovascular diseases are a leading cause of death globally, and vascular grafts are a promising treatment option. This study focuses on tissue-engineered vascular grafts (TEVGs) using decellularized parsley stems as a potential biomaterial. The decellularized parsley stems showed suitable properties for TEVGs, providing a suitable environment for human endothelial cells to form a pseudo endothelium. This study showcases the potential of using parsley stems for TEVGs.
Article
Chemistry, Physical
Gustavo A. Vasquez-Montoya, Tadej Emersic, Noe Atzin, Antonio Tavera-Vazquez, Ali Mozaffari, Rui Zhang, Orlando Guzman, Alexey Snezhko, Paul F. Nealey, Juan J. de Pablo
Summary: The optical properties of liquid crystals are typically controlled by electric fields. In this study, we investigate the effects of microfluidic flows and acoustic fields on the molecular orientation and optical response of nematic liquid crystals. We identify several previously unknown structures and explain them through calculations and simulations. These findings hold promise for the development of new systems combining sound, flow, and confinement.
Article
Chemistry, Physical
Xinjun Wu, Xin Guan, Shushu Chen, Jiangpeng Jia, Chongyi Chen, Jiawei Zhang, Chuanzhuang Zhao
Summary: This research presents a novel shape memory hydrogel with a remodelable permanent shape and programmable cold-induced shape recovery behavior. The hydrogel is prepared using specific treatment methods to achieve shape fixation by heating and shape recovery by cooling. Additionally, deformable devices can be obtained by assembling hydrogel blocks with different concentrations.
Article
Chemistry, Physical
Rebecca Hengsbach, Gerhard Fink, Ulrich Simon
Summary: This study examines the properties of DNA functionalized pNipmam microgels and pure pNipmam microgels at different concentrations of sodium chloride and in PBS solutions using temperature dependent H-1-NMR measurements. The results show that DNA modification affects the volume phase transition temperature and the addition of salt and PBS further enhances this effect.
Article
Chemistry, Physical
Ningyi Li, Junhong Li, Lijingting Qing, Shicheng Ma, Yao Li, Baohui Li
Summary: This paper investigates the self-assembly behavior of colloids with competing interactions under spherical confinement and finds that different ordered structures can be formed under different sized spherical confinements. Moreover, more perforated structures are formed in smaller spheres.