Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Review
Polymer Science
Olga Luneva, Roman Olekhnovich, Mayya Uspenskaya
Summary: A wide range of skin diseases necessitates the search for alternative and effective treatment options, particularly for various types of wounds. This review examines the advantages and methods of bilayer dressings in wound treatment and skin tissue regeneration, focusing on hydrogel-based materials. The use of such materials can provide unique properties, such as antimicrobial, adhesion, and hemostasis capabilities, as well as drug delivery and self-healing abilities.
Review
Biochemistry & Molecular Biology
Mehdi Farokhi, Fatemeh Mottaghitalab, Mercedeh Babaluei, Yasamin Mojarab, Subhas C. Kundu
Summary: Skin injuries, especially chronic wounds, remain a significant healthcare problem. Recent developments in multifunctional wound dressings aim to improve wound repair.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Chemistry, Applied
Jiawei Lu, Yi Chen, Meng Ding, Xiaokun Fan, Jiawei Hu, Yihua Chen, Jie Li, Zhihan Li, Wenyong Liu
Summary: The novel chitosan hydrogel demonstrated strong toughness, high water absorption rate, antibacterial properties and biocompatibility, showing great potential in the field of wound dressings.
CARBOHYDRATE POLYMERS
(2022)
Article
Multidisciplinary Sciences
Vina R. Aldilla, Renxun Chen, Rajesh Kuppusamy, Sudip Chakraborty, Mark D. P. Willcox, David StC Black, Pall Thordarson, Adam D. Martin, Naresh Kumar
Summary: In this study, antibacterial hydrogels were prepared through the self-assembly of short cationic peptide mimics capped with NaA. The resulting hydrogels exhibited desirable viscoelastic properties and showed potent bactericidal activity against both Gram-positive and Gram-negative bacteria. These hydrogels are non-cytotoxic and have potential applications in areas where bacterial contamination is a problem.
SCIENTIFIC REPORTS
(2022)
Review
Infectious Diseases
Qian Pang, Zilian Jiang, Kaihao Wu, Ruixia Hou, Yabin Zhu
Summary: Nanomaterials have made significant progress in the application of infection control and wound healing. Nanomaterial-based wound dressings with antibacterial properties can effectively prevent and treat bacterial infections. They can kill bacteria and reduce drug resistance. In addition, nanomaterials can act as drug carriers to kill bacteria through photothermal or photodynamic therapy. Intelligent nanomaterial-based wound dressings can detect bacterial infections and provide timely antibacterial therapy for enhanced management of infected wounds.
Article
Nanoscience & Nanotechnology
Xia Qiu, Jiamin Zhang, Lilong Cao, Qin Jiao, Junhao Zhou, Lijun Yang, Hong Zhang, Yuping Wei
Summary: Dextran-based hydrogels with zwitterionic structures showed faster wound healing rates compared to natural dextran hydrogel and commercial dressings, attributed to their protein resistance and ability to scavenge free radicals. These hydrogels also demonstrated excellent cytocompatibility and antibacterial properties, along with self-healing capabilities for irregular wounds, providing a new pathway for multifunctional polysaccharide hydrogels in wound treatment and pain relief during dressing changes.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Wei Peng, Dan Li, Kaili Dai, Yixi Wang, Ping Song, Hairui Li, Pei Tang, Zhenyu Zhang, Zhengyong Li, Yuchi Zhou, Changchun Zhou
Summary: This review summarizes the recent progress in skin repair and wound dressing regeneration biomaterials research, including clinical research, classification, composition, performance, and biological function characteristics of different biomaterials. The future development direction is also discussed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Reihaneh Haghniaz, Hossein Montazerian, Atiya Rabbani, Avijit Baidya, Brent Usui, Yangzhi Zhu, Maryam Tavafoghi, Fazli Wahid, Han-Jun Kim, Amir Sheikhi, Ali Khademhosseini
Summary: In this study, an injectable, photocrosslinkable, and stretchable hydrogel sealant based on GelMA supplemented with antibacterial ZF nanoparticles and hemostatic SNs was developed. The hydrogel reduced the in vitro viability of Staphylococcus aureus by over 90% and improved the burst pressure of perforated ex vivo porcine lungs by more than 40%. It also reduced bleeding by over 50% in rat bleeding models. This nanoengineered hydrogel has great potential for effectively sealing complex wounds that require mechanical flexibility, infection management, and hemostasis.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Rongwei Cui, Luhan Zhang, Rongying Ou, Yunsheng Xu, Lizhou Xu, Xiao-Yong Zhan, Danyang Li
Summary: Wound management is a global challenge and the selection of appropriate wound dressings is crucial for the healing process. Polysaccharide-based hydrogel wound dressings have unique features and flexibilities, allowing for accelerated wound healing and skin regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Irina Popescu, Marieta Constantin, Gheorghe Solcan, Daniela Luminita Ichim, Delia Mihaela Rata, Loredana Horodincu, Carmen Solcan
Summary: In this study, a composite hydrogel based on chitosan (CS) and polyvinyl alcohol (PVA) embedding silver nanoparticles (AgNPs) with antibacterial properties and ibuprofen (Ib) as an anti-inflammatory agent was developed. The hydrogel displayed good mechanical properties, high swelling degree, sustained drug delivery, and showed strong antibacterial activity. In vivo experiments demonstrated that the hydrogel accelerated wound healing process by activating downstream cascades and supporting the healing process of inflammation and promoting cell migration and proliferation.
Article
Chemistry, Applied
Ying Luo, Lei Cui, Lei Zou, Yiping Zhao, Li Chen, Ying Guan, Yongjun Zhang
Summary: Physical hydrogels of pure chitosan with improved mechanical properties and solubility have been developed, which can enhance wound healing and reduce scar formation.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Mengda Xu, Yan Miao, Jiahui Yu, Lidong Zhang
Summary: A hydrogel with cationic moieties introduced into an elastic network is reported, allowing for strong electrostatic interaction with polar groups of skin tissue to promote adhesion. In vivo tests demonstrate significant improvement in wound healing after 12 days of hydrogel dressing treatment.
ADVANCED MATERIALS INTERFACES
(2021)
Article
Engineering, Environmental
Yachao Jiang, Anna Zheng, Yong Guan, Dafu Wei, Xiang Xu, Wuling Gong
Summary: The study successfully synthesized a gene reconstruction spandex spinning solution using polyhexamethylene guanidine hydrochloride as a functional gene, and obtained a composite spandex with superior antimicrobial properties through dry-spinning. The composite spandex showed inhibition rates exceeding 99.99% against E. coli and S. aureus, and maintained excellent antimicrobial performance even after soaking in acetic acid solution at 95 degrees C.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Cristina Chircov, Iuliana Teodora Bejenaru, Adrian Ionut Nicoara, Alexandra Catalina Birca, Ovidiu Cristian Oprea, Bianca Tihauan
Summary: Natural polymers have potential for developing hydrogels with tissue regeneration properties. This study investigated the addition of iron oxide nanoparticles to chitosan-dextran-glycerol hydrogels and found improved antimicrobial properties and cell viability while reducing glycerol's antimicrobial potential.
Review
Biochemistry & Molecular Biology
Yan Xue, Huining Xiao, Yi Zhang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2015)
Article
Engineering, Biomedical
Yan Xue, Huining Xiao
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2016)
Article
Polymer Science
Yan Xue, Huining Xiao
Review
Chemistry, Multidisciplinary
Yan Xue, Zihao Mou, Huining Xiao
Article
Biophysics
Yan Xue, Yong Guan, Anna Zheng, Huining Xiao
COLLOIDS AND SURFACES B-BIOINTERFACES
(2013)
Article
Engineering, Biomedical
Y. Xue, Y. Guan, A. Zheng, H. Wang, H. Xiao
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2012)
Article
Polymer Science
Yan Xue, Dafu Wei, Anna Zheng, Yong Guan, Huining Xiao
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
(2014)
Article
Polymer Science
Yuanfeng Pan, Yan Xue, Jamie Snow, Huining Xiao
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2015)
Article
Materials Science, Biomaterials
Anna Zheng, Yan Xue, Dafu Wei, Yong Guan, Huining Xiao
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2013)
Article
Chemistry, Multidisciplinary
Yan Xue, Yuanfeng Pan, Huining Xiao, Yi Zhao