期刊
SOCIAL NEUROSCIENCE
卷 5, 期 4, 页码 375-383出版社
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/17470911003589309
关键词
Social behavior; Serotonin; Serotonin 5HT2A receptor; Orbitofrontal cortex; Anterior cingulate cortex; Positron emission tomography
资金
- Canadian Psychiatric Research Foundation
- Schizophrenia Society of Canada
- Stanley Medical Research Institute
- Bristol-Myers Squibb
- AstraZeneca
- Eli Lilly
- EMD-Darmstadt
- GlaxoSmithKlein
- Janssen
- Neuromolecular Inc.
- Pfizer
Social behavior and desire for social relationships have been independently linked to the serotonergic system, the prefrontal cortex, especially the orbitofrontal cortex (OFC), and the anterior cingulate cortex (ACC). The goal of this study was to explore the role of serotonin 5HT2A receptors in these brain regions in forming and maintaining close interpersonal relationships. Twenty-four healthy subjects completed the Temperament and Character Inventory (TCI) prior to undergoing [18F]setoperone brain positron emission tomography (PET) to measure serotonin 5HT2A receptor availability within the OFC (BA 11 and 47) and ACC (BA 32). We explored the relationship between desire for social relationships, as measured by the TCI reward dependence (RD) scale, and 5HT2A receptor non-displaceable binding potential (BPnd) in these regions. Scores of RD were negatively correlated with 5HT2A BPnd in the ACC (BA 32, r = -.528, p = .012) and OFC (BA 11, r = -.489, p = .021; BA 47, r = -.501, p = .017). These correlations were corroborated by a voxel-wise analysis. These results suggest that the serotonergic system may have a regulatory effect on the OFC and ACC for establishing and maintaining social relationships.
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