Article
Clinical Neurology
Yuan Hou, Jessica Z. K. Caldwell, Justin D. Lathia, James B. Leverenz, Andrew A. Pieper, Jeffrey Cummings, Feixiong Cheng
Summary: This study investigated the cellular metabolism and immune responses in Alzheimer's disease (AD) patients, particularly focusing on sex differences. The results revealed sex-specific metabolites, genes, and pathways associated with AD diagnosis and progression. Female AD patients showed distinct immune metabolite profiles and decreased communication between excitatory neurons and microglia, providing new insights into the molecular basis of female predominance in AD.
ALZHEIMERS & DEMENTIA
(2023)
Review
Neurosciences
Ge Wang, Wenyue Wu, Yuchen Xu, Zhuanyi Yang, Bo Xiao, Lili Long
Summary: This review discusses the relationship between genetic basis and imaging phenotype in epilepsy, particularly focusing on the genetic mechanisms of brain networks in different epilepsy syndromes from a neural developmental perspective. The potential value of endophenotypes is also discussed.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Genetics & Heredity
Lei Du, Jin Zhang, Ying Zhao, Muheng Shang, Lei Guo, Junwei Han
Summary: Identifying genetic risk factors for Alzheimer's disease is an important research topic. This study proposes two integrated multi-task sparse canonical correlation analysis methods, which use multi-omic endophenotypes and their CEP associations to find genetic risk factors. The results show that this approach outperforms other methods.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2023)
Review
Developmental Biology
Judith E. Mank, Elizabeth J. Rideout
Summary: Male-female differences exist in various developmental mechanisms, impacting organ formation, function, and whole-body physiology. Even traits that do not show obvious male-female differences are affected by sex-specific processes. Including both sexes is crucial for a comprehensive understanding of animal development.
Article
Multidisciplinary Sciences
Gergo Ziman, Stepan Aleshin, Zsolt Unoka, Jochen Braun, Ilona Kovacs
Summary: Multistable phenomena in perception are prone to instability, and we investigated a visual example to uncover developmental and maturational trajectories specific to age and sex. Computational modeling allowed us to estimate the development of stability, sensitivity, and exploration over the lifespan. Furthermore, we found atypical function of binocular rivalry in autism spectrum disorder and borderline personality disorder.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Xuelei Xu, Hui Xiang, Yan Qiu, Ziwei Teng, Sujuan Li, Jing Huang, Jindong Chen, Hui Tang, Kun Jin, Lili Jiang, Bolun Wang, Ziru Zhao, Haishan Wu
Summary: The study revealed that male patients with first-diagnosed, drug-naive bipolar disorder had worse cognitive dysfunction compared to female patients, particularly in attention and delayed memory. Additionally, deficits in visuospatial/constructional ability were negatively associated with mania severity only in male patients.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Veronika A. Myasoedova, Antoine Rimbert, Marina Camera, Cedric Le May, Romain Capoulade, Bertrand Cariou, Paolo Poggio
Summary: This study aimed to investigate the sex-differential effect of PCSK9 inhibition on LDL-C levels through pharmacological or genetic methods. The results showed that the reduction in LDL-C under PCSK9 inhibition was significantly greater in men than in women. The study emphasized the need for specific research to develop sex-specific recommendations for the management of ASCVD in women.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Clinical Neurology
Hidenori Yamasue, Masaki Kojima, Hitoshi Kuwabara, Miho Kuroda, Kaori Matsumoto, Chieko Kanai, Naoko Inada, Keiho Owada, Keiko Ochi, Nobutaka Ono, Seico Benner, Tomoyasu Wakuda, Yosuke Kameno, Jun Inoue, Taeko Harada, Kenji Tsuchiya, Kazuo Umemura, Aya Yamauchi, Nanayo Ogawa, Itaru Kushima, Norio Ozaki, Satoshi Suyama, Takuya Saito, Yukari Uemura, Junko Hamada, Yukiko Kano, Nami Honda, Saya Kikuchi, Moe Seto, Hiroaki Tomita, Noriko Miyoshi, Megumi Matsumoto, Yuko Kawaguchi, Koji Kanai, Manabu Ikeda, Itta Nakamura, Shuichi Isomura, Yoji Hirano, Toshiaki Onitsuka, Hirotaka Kosaka, Takashi Okada
Summary: Intranasal oxytocin has the potential to be a novel therapy for autism spectrum disorder, but the efficacy of repeated administrations is inconsistent. This study tested the effect of TTA-121, a new formulation of intranasal oxytocin with improved bioavailability, on the core symptoms of autism spectrum disorder and determined the dose-response relationship. The findings showed that TTA-121 at a dose of 6 U per day significantly improved the reciprocity score, indicating potential benefits for individuals with autism spectrum disorder.
Article
Clinical Neurology
Zhuoliang Hou, Wenhao Jiang, Fan Li, Xiaoyun Liu, Zhenghua Hou, Yingying Yin, Haisan Zhang, Hongxing Zhang, Chunming Xie, Zhijun Zhang, Youyong Kong, Yonggui Yuan
Summary: This study discovered differences in individual functional connectivity variations between patients with major depressive disorder (MDD) and healthy individuals, and genetic risk may affect the clinical manifestations of depression through brain function heterogeneity.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Medicine, General & Internal
Camelia Alkhzouz, Simona Bucerzan, Maria Miclaus, Andreea-Manuela Mirea, Diana Miclea
Summary: Differences in sex development in patients with 46,XX karyotype are mainly caused by congenital adrenal hyperplasia, with enzyme deficiencies in the hormonal synthesis pathway being the primary etiology. Other cases are due to genetic abnormalities affecting the development of the genital system. Recognizing each sign, even the most discreet, is crucial in managing these disorders, especially in the neonatal period, as it can impact long-term evolution, prognosis, and quality of life.
Review
Psychology, Multidisciplinary
Livia Balogh, Attila J. Pulay, Janos M. Rethelyi
Summary: This article provides a brief review of genome-wide and candidate gene association studies on attention-deficit/hyperactivity disorder (ADHD), summarizing findings on disease risk, core symptoms, and other traits associated with ADHD. It also discusses the potential contributions of neuropsychological impairment, neuroimaging, and electrophysiological paradigms as biomarkers for understanding the underlying neurobiological mechanisms and clinical symptom heterogeneity. Additionally, the article highlights the genetic results, including polygenic risk scores, that could potentially predict individual response to different treatment options and offer personalized treatment for ADHD in the future.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Clinical Neurology
Steven C. Cramer, Jill See, Brent Liu, Matthew Edwardson, Ximing Wang, Shlomit Radom-Aizik, Fadia Haddad, Babak Shahbaba, Steven L. Wolf, Alexander W. Dromerick, Carolee J. Winstein
Summary: The study found that BDNF and ApoE gene polymorphisms did not have a significant impact on response to rehabilitation therapy, but the BDNF gene polymorphism was associated with cerebral atrophy, while the ApoE gene polymorphism was linked to a younger age at stroke onset.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
Review
Pediatrics
Agostino Carbone, Asia Dell'Aquila
Summary: This review focuses on the diagnosis of PDD-NOS, a subthreshold diagnosis that was introduced in DSM-IV and later absorbed into the broader autism spectrum disorder in DSM 5. The review uses the Prisma method to select 23 scientific papers and identifies four categories related to diagnosis, differential diagnosis, prognosis, and comorbidity. The review concludes that there are limitations in the consistency, sensitivity, and stability of PDD-NOS and supports its inclusion within the broader autism spectrum disorder category in DSM-5.
Review
Neurosciences
Haizhen You, Junyao Shi, Fangfang Huang, Zhiyun Wei, Gary Jones, Wenchong Du, Jing Hua
Summary: Developmental coordination disorder (DCD) is a developmental disorder characterized by impaired motor coordination, often co-occurring with attention deficit disorder, autism spectrum disorders, and other psychological and behavioural conditions. The genetic basis of DCD is believed to involve brain changes, environmental factors, and certain genetic factors such as deletions, copy number variations, single nucleotide polymorphisms, and epigenetic modifications. Continued research into the genetic mechanisms of DCD is important for understanding its underlying causes and could have implications for diagnosis, treatment, and our overall understanding of the disorder.
Article
Genetics & Heredity
Karlijne Indencleef, Hanne Hoskens, Myoung Keun Lee, Julie D. White, Chenxing Liu, Ryan J. Eller, Sahin Naqvi, George L. Wehby, Lina M. Moreno Uribe, Jacqueline T. Hecht, Ross E. Long, Kaare Christensen, Frederic W. Deleyiannis, Susan Walsh, Mark D. Shriver, Stephen Richmond, Joanna Wysocka, Hilde Peeters, John R. Shaffer, Mary L. Marazita, Greet Hens, Seth M. Weinberg, Peter Claes
Summary: This study identified genetic loci associated with non-syndromic cleft lip with or without cleft palate by comparing distinctive facial features between unaffected relatives of individuals with the condition and controls. The findings suggest a shared genetic architecture between normal facial development and orofacial clefting, supporting the hypothesis of underlying genetic susceptibility to cleft lip in the larger population.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Ryo Morishima, Yousuke Kumakura, Satoshi Usami, Akiko Kanehara, Miho Tanaka, Noriko Okochi, Naomi Nakajima, Junko Hamada, Tomoko Ogawa, Shuntaro Ando, Hidetaka Tamune, Mutsumi Nakahara, Seiichiro Jinde, Yukiko Kano, Kyoko Tanaka, Yoichiro Hirata, Akira Oka, Kiyoto Kasai
Summary: This study found that parental psychological distress in children with 22q11.2 deletion syndrome is associated with challenges such as difficulty in accessing multiple medical institutions, lack of understanding by welfare staff, and inadequate management in educational settings. It highlights the importance of evaluating not only the severity of comorbidities in 22q11DS, but also the medical, welfare, and educational challenges for parental mental health.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2022)
Article
Psychology, Developmental
Masaya Morita, Shuntaro Ando, Tomoki Kiyono, Ryo Morishima, Tomoko Yagi, Sho Kanata, Shinya Fujikawa, Syudo Yamasaki, Atsushi Nishida, Kiyoto Kasai
Summary: The study found bidirectional relationships among problematic Internet use, hyperactivity/inattention, and depressive symptoms in adolescents. Problematic Internet use may be a target for improving hyperactivity/inattention and depressive symptoms in adolescents.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Clinical Neurology
Junya Matsumoto, Kenichiro Miura, Masaki Fukunaga, Kiyotaka Nemoto, Daisuke Koshiyama, Naohiro Okada, Kentaro Morita, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Satsuki Ito, Naomi Hasegawa, Yoshiyuki Watanabe, Kiyoto Kasai, Ryota Hashimoto
Summary: Patients with schizophrenia may experience intelligence decline, and previous studies have suggested that gray matter structures and functional connectivity are more relevant to this decline than white matter microstructures.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Article
Psychiatry
Ai Aoki, Ganchimeg Togoobaatar, Anudari Tseveenjav, Naranbaatar Nyam, Khishigsuren Zuunnast, Gundegmaa Lkhagvasuren, Bat-Erdene Shagdar, Rintaro Mori, Akihito Kikuchi, Hideaki Soya, Kiyoto Kasai, Kenji Takehara
Summary: This study examined the association between socioeconomic and lifestyle factors with mental health problems among school-age children in Mongolia. The results showed that male gender, low maternal education, short sleep, lack of physical activity, and long screen time were associated with a higher risk of mental health problems. The findings suggest the presence of globally common socioeconomic and lifestyle risk factors, and may help in developing targeted preventive interventions for high-risk groups and promoting a healthy lifestyle in Mongolia.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Neurosciences
Miharu Nakanishi, Syudo Yamasaki, Shuntaro Ando, Kaori Endo, Marcus Richards, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida
Summary: This study investigated the association between neighborhood social cohesion and dementia-related stigma and found that greater neighborhood social cohesion was associated with lower personal and perceived public stigma. However, there was no difference in stigma levels between the pre-pandemic and pandemic periods.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Kaori Usui, Kenji Kirihara, Mariko Tada, Mao Fujioka, Daisuke Koshiyama, Motoko Tani, Maiko Tsuchiya, Susumu Morita, Shintaro Kawakami, Akiko Kanehara, Kentaro Morita, Yoshihiro Satomura, Shinsuke Koike, Motomu Suga, Tsuyoshi Araki, Kiyoto Kasai
Summary: This study examines the association between longitudinal changes in clinical symptoms and quality of life in individuals with ultra-high risk for psychosis and patients with recent-onset psychotic disorder. The results indicate that severe anxiety/depression at baseline is associated with poorer quality of life at follow-up. Improvement in anxiety/depression and disorganized thoughts is important for enhancing quality of life. The study also suggests that the diagnosis does not affect the association between clinical symptoms and quality of life.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Psychiatry
Yinghan Zhu, Hironori Nakatani, Walid Yassin, Norihide Maikusa, Naohiro Okada, Akira Kunimatsu, Osamu Abe, Hitoshi Kuwabara, Hidenori Yamasue, Kiyoto Kasai, Kazuo Okanoya, Shinsuke Koike
Summary: The study showed that machine learning approaches using structural MRI can help with disease classification, with a classifier accurately distinguishing patients with chronic schizophrenia from healthy controls. Individuals within the schizophrenia spectrum were more likely to be classified as having chronic schizophrenia, with individuals on the autism spectrum least likely to be classified in the same category.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Medicine, General & Internal
Miharu Nakanishi, Syudo Yamasaki, Junko Niimura, Kaori Endo, Naomi Nakajima, Daniel Stanyon, Kaori Baba, Nao Oikawa, Mariko Hosozawa, Shuntaro Ando, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida
Summary: The study found an association between maternal perceived capacity in finance and mental well-being and the frequency of physical punishment in 14-year-old children. Increasing mothers' perceived capacity in financial management and mental health may help prevent child maltreatment.
Article
Psychiatry
Kaori Endo, Daniel Stanyon, Syudo Yamasaki, Miharu Nakanishi, Junko Niimura, Sho Kanata, Shinya Fujikawa, Yuko Morimoto, Mariko Hosozawa, Kaori Baba, Nao Oikawa, Naomi Nakajima, Kazuhiro Suzuki, Mitsuhiro Miyashita, Shuntaro Ando, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida
Summary: This study investigated the longitudinal association between maternal parenting stress from 1 to 36 months after childbirth and child ADHD symptoms at 12 years old. The results showed that parenting stress at 9-10, 18, and 36 months after childbirth was significantly associated with child ADHD symptoms at 12 years old.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Yuki Suda, Mariko Tada, Takeshi Matsuo, Keisuke Kawasaki, Takeshi Saigusa, Maho Ishida, Tetsuo Mitsui, Hironori Kumano, Kenji Kirihara, Takafumi Suzuki, Kenji Matsumoto, Isao Hasegawa, Kiyoto Kasai, Takanori Uka
Summary: This study investigates the communication between the frontal and temporal cortices in an auditory omission paradigm, finding an increased band synchronization between the higher auditory cortex and the frontal pole at tone onset, but a disappearance of this synchronization when the tone is omitted. An early omission-related neural response was observed, along with stronger low-beta oscillations following tone omission.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Daiki Nagaoka, Nanami Tomoshige, Shuntaro Ando, Masaya Morita, Tomoki Kiyono, Sho Kanata, Shinya Fujikawa, Kaori Endo, Syudo Yamasaki, Masato Fukuda, Atsushi Nishida, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai
Summary: Being praised for prosocial behavior can prevent depression in adolescents. This study investigated the relationship between being praised for prosocial behavior and depressive symptoms in adolescents, and found that being praised for prosocial behavior can lead to lower depressive symptoms.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Kayo Ichihashi, Yoshitaka Kyou, Naomi Hasegawa, Norio Yasui-Furukori, Yoshihito Shimizu, Hikaru Hori, Naoki Hashimoto, Kenta Ide, Yayoi Imamura, Hisashi Yamada, Shinichiro Ochi, Jun-ichi Iga, Yoshikazu Takaesu, Kazutaka Ohi, Takashi Tsuboi, Hitoshi Iida, Hirotaka Yamagata, Akitoyo Hishimoto, Tadasu Horai, Masahide Usami, Manabu Makinodan, Tatsuya Nagasawa, Hiroshi Komatsu, Mikio Kido, Hiroyuki Muraoka, Kiyokazu Atake, Masahiro Takeshima, Chika Kubota, Takahiko Inagaki, Shinichiro Tamai, Taishiro Kishimoto, Ryuji Furihata, Junya Matsumoto, Kenichiro Miura, Ken Inada, Koichiro Watanabe, Kiyoto Kasai, Ryota Hashimoto
Summary: This study aimed to investigate the characteristics of patients with schizophrenia and major depressive disorder who receive psychotropic pro re nata (PRN) prescriptions. The results showed that the proportion of psychotropic PRN prescriptions was lower in elderly patients with schizophrenia and higher in female patients with major depressive disorder. In addition, there was an association between psychotropic PRN prescriptions and regular use of multiple psychotropic medications in schizophrenia.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Psychiatry
Kazuhiro Suzuki, Syudo Yamasaki, Mitsuhiro Miyashita, Shuntaro Ando, Kazuya Toriumi, Akane Yoshikawa, Miharu Nakanishi, Yuko Morimoto, Sho Kanata, Shinya Fujikawa, Kaori Endo, Shinsuke Koike, Satoshi Usami, Masanari Itokawa, Shinsuke Washizuka, Mariko Hiraiwa-Hasegawa, Herbert Y. Meltzer, Kiyoto Kasai, Atsushi Nishida, Makoto Arai
Summary: Muscular strength, assessed by handgrip, is linked to the risk of developing psychiatric disorders, and advanced glycation end products (AGEs) play a role in this association. This study found a negative relationship between handgrip strength and pentosidine levels, a representative AGE, and demonstrated the indirect effect of AGEs on the association between handgrip strength and psychotic symptoms among adolescents.
Article
Clinical Neurology
Kiyoto Kasai, Shin-Ichiro Kumagaya, Yusuke Takahashi, Yutaka Sawai, Akito Uno, Yousuke Kumakura, Mika Yamagishi, Akiko Kanehara, Kentaro Morita, Mariko Tada, Yoshihiro Satomura, Naohiro Okada, Shinsuke Koike, Sho Yagishita
Summary: By nature, humans are participating subjects/player-witnesses who encounter an unpredictable real world. We propose incorporating the interaction loop into cognitive sciences to create world-informed neuroscience (WIN). Based on research with people who do not match the world, we hypothesize that the interaction between individuals and the world occurs in a two-dimensional way of rule-based and story-based. Integrating the humanities and sciences, this approach can contribute to real world issues and diversity and inclusion.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Jordan DeVylder, Kaori Endo, Syudo Yamasaki, Shuntaro Ando, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida
Summary: This study found that migrant status is associated with an increased likelihood of psychotic experiences at age 10 in Tokyo, Japan. This association appears to be primarily driven by visual hallucinations and thought broadcasting, and is specific to children with lower IQ at age 10.
JOURNAL OF MIGRATION AND HEALTH
(2022)