Article
Medicine, General & Internal
Yoon-Hee Choo, Youngbeom Seo, Oh-Lyong Kim
Summary: This study retrospectively analyzed the outcomes of the transsphenoidal approach for nonfunctioning pituitary adenomas treated at a single institute. The study found that the transsphenoidal approach is an effective and safe treatment, improving visual impairment and restoring endocrine function. Diabetes insipidus was the most common complication, and complete resection during surgery helped to lower the risk of recurrence.
ANNALS OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Nasrin Al-Shamkhi, Katarina Berinder, Henrik Borg, Pia Burman, Per Dahlqvist, Charlotte Hoybye, Daniel S. Olsson, Oskar Ragnarsson, Bertil Ekman, Britt Eden Engstrom
Summary: Objective data on pituitary function before and after transsphenoidal surgery in nonfunctioning pituitary adenomas were inconsistent. This study found that adrenocorticotrophic hormone deficiency increased significantly at 1 year postoperatively, while other axis function changes were not significant. Therefore, continuous individual evaluations are needed during longer follow-up of patients operated for NFPA.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Chao Tao, Gang Cheng, Yunxiang Chen, Peiyuan Gu, Weixing Hu
Summary: This study retrospectively reviewed the tumor characteristics and surgical outcomes of a consecutive series of endoscopic endonasal approach pituitary adenomas resection mainly performed by a single author between March 2018 and June 2019. The results demonstrated that EEA is an effective and safe approach for resecting pituitary adenomas with satisfactory gross total resection rate, near-total resection rate, and endocrinological remission rate, while maintaining minimal nasal injury.
Article
Clinical Neurology
Yasuyuki Kinoshita, Akira Taguchi, Atsushi Tominaga, Kazunori Arita, Fumiyuki Yamasaki
Summary: Recovery from AGHD after initial TSS is more likely in younger female patients with higher peak GH levels assessed by preoperative PPT. Patients aged <= 62.2 years and with a peak GH level of >= 0.74 μg/L based on preoperative PPT are likely to recover from AGHD.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Hyung-Chul Lee, Hyun-Kyu Yoon, Jung Hee Kim, Yong Hwy Kim, Hee-Pyoung Park
Summary: The study suggests that preoperative steroid administration may not be necessary for patients without adrenal insufficiency undergoing endoscopic transsphenoidal surgery for nonfunctioning pituitary adenomas, as it does not affect the pituitary hormone levels postoperatively. However, further large-scale studies are needed to determine the impact of preoperative steroid administration on clinically meaningful events such as perioperative AI and postoperative 3-month ACTH deficiency in these patients.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Zhijie Pei, Yi Fang, Shuwen Mu, Jun Li, Tianshun Feng, Kunzhe Lin, Shousen Wang
Summary: Perioperative assessment of adenohypophyseal hormones can improve therapeutic strategies and evaluate the prognosis of pituitary adenomas. Normalization of hormone levels facilitates overall assessment of the adenohypophysis.
NEUROSURGICAL FOCUS
(2022)
Article
Clinical Neurology
Mina M. Gerges, Kavelin Rumalla, Saniya S. Godil, Iyan Younus, Walid Elshamy, Georgiana A. Dobri, Ashutosh Kacker, Abtin Tabaee, Viay K. Anand, Theodore H. Schwartz
Summary: Following gross total resection of nonfunctioning pituitary adenomas, the 10-year chance of recurrence is low and the need for treatment even lower. After subtotal resection, upfront radiation therapy may prevent progression, but even without it, the need for intervention at 10 years is only approximately 20%, warranting a period of observation to prevent unnecessary prophylactic radiation therapy. Tumor volume > 1 cm(3), Knosp score >= 3, and Ki-67 >= 3% may prompt closer follow-up or justify early prophylactic radiation therapy.
JOURNAL OF NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Friso de Vries, Daniel J. Lobatto, Marco J. T. Verstegen, Pieter J. Schutte, Irene C. Notting, Mark C. Kruit, S. Faisal Ahmed, Alberto M. Pereira, Wouter R. van Furth, Nienke R. Biermasz
Summary: This study proposed a novel way to classify and report surgical outcomes, integrating efficacy and safety at the patient level. By presenting results in four outcome groups ranging from good to poor, the study highlights the importance of balancing efficacy and complications in surgical interventions.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Friso de Vries, Daniel J. Lobatto, Marco J. T. Verstegen, Pieter J. Schutte, Irene C. Notting, Mark C. Kruit, S. Faisal Ahmed, Alberto M. Pereira, Wouter R. van Furth, Nienke R. Biermasz
Summary: Transsphenoidal surgery is the standard treatment for hormone-secreting pituitary adenomas. This study proposes a novel way to classify and report surgical outcomes by integrating efficacy and safety at the patient level. The results show that surgical interventions can be presented in four categories, incorporating both efficacy and safety.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Clinical Neurology
Yutaro Fuse, Kazuhito Takeuchi, Noriaki Hashimoto, Yuichi Nagata, Yusuke Takagi, Tetsuya Nagatani, Ichiro Takeuchi, Ryuta Saito
Summary: This study proposes a deep learning approach to discriminate pituitary adenomas using intraoperative endoscopic images. The algorithm showed good performance in identifying tumors and aligning with the diagnoses of medical professionals and histopathological findings.
NEUROSURGICAL REVIEW
(2023)
Article
Clinical Neurology
Georgios Mantziaris, Stylianos Pikis, Tomas Chytka, Roman Liscak, Kimball Sheehan, Darrah Sheehan, Selcuk Peker, Yavuz Samanci, Shray K. Bindal, Ajay Niranjan, L. Dade Lunsford, Rupinder Kaur, Renu Madan, Manjul Tripathi, Dhiraj J. Pangal, Ben A. Strickland, Gabriel Zada, Anne-Marie Langlois, David Mathieu, Ronald E. Warnick, Samir Patel, Zayda Minier, Herwin Speckter, Zhiyuan Xu, Rithika Kormath Anand, Jason P. Sheehan
Summary: This study analyzed 375 patients with residual nonfunctioning pituitary adenomas (NFPAs) who were treated with stereotactic radiosurgery (SRS) and compared the outcomes between early treatment and treatment at progression. The results showed that there was no significant difference in tumor control and preservation of hormonal/visual function between SRS at residual NFPA progression and adjuvant SRS. Deferring radiosurgical management to the time of radiological progression could prolong the onset of radiosurgically induced pituitary dysfunction.
JOURNAL OF NEUROSURGERY
(2023)
Article
Endocrinology & Metabolism
R. Villar-Taibo, C. Diaz-Ortega, M. Sifontes-Dubon, A. Fernandez-Pombo, R. Serramito-Garcia, G. Martinez-Capoccioni, I. Bernabeu
Summary: This study compared surgical outcomes, evolution and postoperative complications between elderly and young patients undergoing transsphenoidal surgery (TSS) for pituitary adenoma. Elderly patients were more likely to have non-functioning PA, macroadenomas, and greater extrasellar extension, as well as more compressive symptoms and hypopituitarism after surgery. However, overall, both groups showed similar surgical and endocrinological outcomes.
Article
Clinical Neurology
Lea M. Alhilali, Andrew S. Little, Kevin C. J. Yuen, Jae Lee, Timothy K. Ho, Saeed Fakhran, William L. White
Summary: In this study of 102 patients undergoing microscopic transsphenoidal resection of a pituitary adenoma, early postoperative MRI showed high sensitivity and specificity for detecting residual tumors, with better reliability than late postoperative MRI. Early MRI identified 4 residual tumors that were missed by intraoperative assessment and late MRI, providing important guidance for reoperation in select patients.
JOURNAL OF NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Alies J. Dekkers, Friso de Vries, Amir H. Zamanipoor Najafabadi, Emmy M. van der Hoeven, Marco J. T. Verstegen, Alberto M. Pereira, Wouter R. van Furth, Nienke R. Biermasz
Summary: This study retrospectively assessed the healthcare costs and cost drivers in perioperative care for pituitary tumour patients. The results showed that length of hospital stay and complications were the main drivers of costs, and certain baseline features were also associated with higher costs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Kihwan Hwang, Yong Hwy Kim, Jung Hee Kim, Jung Hyun Lee, Hee Kyung Yang, Jeong-Min Hwang, Chae-Yong Kim, Jung Ho Han
Summary: The study on the natural history of asymptomatic nonfunctioning pituitary adenomas (NFPAs) with optic nerve compression showed that close follow-up and timely surgical intervention can effectively prevent visual and endocrine issues for cases with optic nerve compression, and conservative management is also acceptable for these tumors. Careful follow-up is necessary for tumors with cavernous sinus invasion.
JOURNAL OF NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Atte Karppinen, Elina Ritvonen, Risto Roine, Harri Sintonen, Satu Vehkavaara, Leena Kivipelto, Ashley B. Grossman, Mika Niemela, Camilla Schalin-Jantti
CLINICAL ENDOCRINOLOGY
(2016)
Article
Endocrinology & Metabolism
Niko Valimaki, Hande Demir, Esa Pitkanen, Eevi Kaasinen, Atte Karppinen, Leena Kivipelto, Camilla Schalin-Jantti, Lauri A. Aaltonen, Auli Karhu
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2015)
Article
Endocrinology & Metabolism
Elina Ritvonen, Esa Pitkanen, Atte Karppinen, Satu Vehkavaara, Hande Demir, Anders Paetau, Camilla Schalin-Jantti, Auli Karhu
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2017)
Article
Oncology
Mikaela Porkholm, Anna Raunio, Reetta Vainionpaa, Tarja Salonen, Juha Hernesniemi, Leena Valanne, Jarno Satopaa, Atte Karppinen, Minna Oinas, Olli Tynninen, Virve Pentikainen, Sanna-Maria Kivivuori
PEDIATRIC BLOOD & CANCER
(2018)
Article
Endocrinology & Metabolism
Anna-Pauliina Iivonen, Johanna Kansakoski, Atte Karppinen, Leena Kivipelto, Camilla Schalin-Jantti, Auli Karhu, Taneli Raivio
ENDOCRINE CONNECTIONS
(2018)
Article
Endocrinology & Metabolism
Elina Ritvonen, Atte Karppinen, Harri Sintonen, Satu Vehkavaara, Leena Kivipelto, Risto P. Roine, Mika Niemela, Camilla Schalin-Jantti
CLINICAL ENDOCRINOLOGY
(2015)
Article
Clinical Neurology
Era D. Mikkonen, Markus B. Skrifvars, Matti Reinikainen, Stepani Bendel, Ruut Laitio, Sanna Hoppu, Tero Ala-Kokko, Atte Karppinen, Rahul Raj
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2019)
Article
Surgery
Anne Saarikko, Eero Mellanen, Linda Kuusela, Junnu Leikola, Atte Karppinen, Taina Autti, Pekka Virtanen, Nina Brandstack
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2020)
Article
Oncology
Niko Valimaki, Camilla Schalin-Jantti, Atte Karppinen, Anders Paetau, Leena Kivipelto, Lauri A. Aaltonen, Auli Karhu
MOLECULAR CANCER RESEARCH
(2019)
Article
Clinical Neurology
Carmen Barba, Judith Helen Cross, Kees Braun, Massimo Cossu, Kerstin Alexandra Klotz, Salvatore De Masi, Maria Angeles Perez Jimenez, Eija Gaily, Nicola Specchio, Pedro Cabral, Joseph Toulouse, Petia Dimova, Domenica Battaglia, Elena Freri, Alessandro Consales, Elisabetta Cesaroni, Oana Tarta-Arsene, Antonio Gil-Nagel, Ioana Mindruta, Giancarlo Di Gennaro, Marco Giulioni, Martin M. Tisdall, Christin Eltze, Muhammad Zubair Tahir, Floor Jansen, Peter van Rijen, Maurits Sanders, Laura Tassi, Stefano Francione, Giorgio Lo Russo, Julia Jacobs, Thomas Bast, Giulia Matta, Marcelo Budke, Concepcion Fournier del Castillo, Eeva-Liisa Metsahonkala, Atte Karppinen, Jose Carlos Ferreira, Krasimir Minkin, Carlo Efisio Marras, Alexis Arzimanoglou, Renzo Guerrini, Tom Jacques, Sophia Varadkar, Albert Colon, Piergiorgio D'Orio, Veronica Pelliccia, Andreas Schulze-Bonhage, Steffen Syrbe, Annamaria Buccoliero, Flavio Giordano, Marta Garcia-Fernandez, Francisco Villarejo, Luca De Palma, Giusy Carfi Pavia, Nuno M. Canas, Alexandra Santos, Alexandra Montavont, Karine Ostrowsky-Coste, Kaloyan Gabrovski, Denitza Stoyanova, Giampiero Tamburrini, Tiziana Granata, Mattia Pacetti, Sara Matricardi, Dana Craiu, Angel Aledo, Irina Popa, Vincenzo Esposito, Ersilia Lucenteforte
Article
Clinical Neurology
Era D. Mikkonen, Markus B. Skrifvars, Matti Reinikainen, Stepani Bendel, Ruut Laitio, Sanna Hoppu, Tero Ala-Kokko, Atte Karppinen, Rahul Raj
Article
Clinical Neurology
Era D. Mikkonen, Markus B. Skrifvars, Matti Reinikainen, Stepani Bendel, Ruut Laitio, Sanna Hoppu, Tero Ala-Kokko, Atte Karppinen, Rahul Raj
PEDIATRIC NEUROLOGY
(2020)
Article
Clinical Neurology
Era D. Mikkonen, Markus B. Skrifvars, Matti Reinikainen, Stepani Bendel, Ruut Laitio, Sanna Hoppu, Tero Ala-Kokko, Atte Karppinen, Rahul Raj
Summary: This study assessed the 1-year costs of pediatric TBI patients in the ICU, finding that greater injury severity was associated with higher costs, with the majority of resources being spent on patients with favorable functional outcomes.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2021)
Article
Oncology
Morten Wibroe, Johan Cappelen, Charlotte Castor, Niels Clausen, Pernilla Grillner, Thora Gudrunardottir, Ramneek Gupta, Bengt Gustavsson, Mats Heyman, Stefan Holm, Atte Karppinen, Camilla Klausen, Tuula Lonnqvist, Rene Mathiasen, Pelle Nilsson, Karsten Nysom, Karin Persson, Olof Rask, Kjeld Schmiegelow, Astrid Sehested, Harald Thomassen, Ingrid Tonning-Olsson, Barbara Zetterqvist, Marianne Juhler
Article
Clinical Neurology
Guilu He, Jianhao Lin, Jing Ye, Fobao Huang, Changzhi Yan, Zesi Liu, Xiuming Zhou, Qiao Li, Liang Zhang
Summary: This article introduces long tunneled external ventricular drain (LTEVD), which effectively avoids multiple surgeries by connecting an external shunt valve. It allows visual control of drainage flow, prolongs catheter indwelling time, and eliminates the need for multiple surgeries.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Vinay Suresh, H. S. Suresh, Bharath Raju, Himanshu Jindal, Ahmad Ozair
Summary: This study investigated the outcomes of postoperative discitis treated with debridement and a novel technique focused on reducing outpatient antibiotic requirement in a low- and middle-income country (LMIC) setting. The results showed that patients with medically refractory postoperative discitis potentially have good outcomes after debridement plus 2-week local antibiotic instillation in LMICs.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Beatrice C. Bono, Davide Milani, Fabio Ferreli, Simone Olei, Luca Raspagliesi, Maria Pia Tropeano, Giovanni B. Lasio, Federico Pessina
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Avi A. Gajjar, Shrey Patel, Raj Swaroop Lavadi, Rida Mitha, Rohit Prem Kumar, Tavis Taylor, Galal A. Elsayed, D. Kojo Hamilton, Nitin Agarwal
Summary: Art in neurosurgery has played a crucial role in the discipline for centuries. Medical illustrations help visualize anatomy and surgical procedures, contributing to education, surgical planning, and navigation.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Joaquin Perez Zabala, Yamila Basilotta Marquez, Romina Arganaraz, Beatriz Mantese
Summary: We present a low-cost and easily accessible adaptation system for stereotactic procedures in infants. By using a headband cast technique, a stereotactic biopsy was successfully performed in a 5-month-old patient, achieving precise targeting, histopathological diagnosis, and no associated complications.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Muhammad Kusdiansah, Arnau Benet, Yosuke Suzuki, Kenichi Haraguchi, Nakao Ota, Kosumo Noda, Rokuya Tanikawa
Summary: Fusiform vertebral artery aneurysms are difficult to treat, and endovascular and open microsurgical treatments are used for different situations. This report presents a case with complex anatomy and branch involvement and describes the treatment strategy used.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Victor M. Lu
Summary: This review emphasizes four essential domains that should be considered when interpreting pediatric neurosurgical SRMAs and provides examples to ensure accurate and effective interpretation of findings in this niche.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Lapo Bonosi, Angelo Torrente, Filippo Brighina, Cateno Concetto Tito Petralia, Pietro Merlino, Chiara Avallone, Vincenzo Gulino, Roberta Costanzo, Lara Brunasso, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Corticocortical evoked potentials (CCEPs) have emerged as a valuable intraoperative monitoring technique in eloquent brain tumor surgery, aiding in preserving critical functional areas. Current research shows the potential of CCEPs in guiding surgical decision making, reducing the risk of postoperative neurological deficits, and mapping functional connectivity, but further research and standardization are needed.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Yuchen Duan, Dagang Feng, Min Zhu, Heng Qiu, Tong Li, Zhen Chen, Leiming Jiang, Yong Huang
Summary: This study aimed to compare the effect of different Modic changes (MC) grades on the cage subsidence rate after spinal interbody fusion surgery. A meta-analysis was conducted on relevant randomized controlled trials and cohort studies. The results showed that MC may be associated with a higher cage subsidence rate. With the increase in MC grades, the incidence of subsidence decreased gradually, but it was always higher than that in the non-Modic changes (NMC). Oblique lumbar interbody fusion may be a better treatment choice for lumbar degenerative disease with MC.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Brian F. Saway, Conor M. Cunningham, Mustafa Ismail, Alejandro M. Spiotta
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Joanna M. Roy, Michael M. Covell, Carmelo Venero Jr, Christian A. Bowers
Summary: Early exposure to neurosurgery during medical school is critical for improving recruitment into the specialty. However, about 30% of medical schools in the U.S. lack a neurosurgery program, limiting students' exposure to the field. Virtual education, facilitated by webinars during the pandemic, has advantages such as global outreach and accessibility for international medical students. This review identifies and describes 16 educational resources, serving as a guide for medical students interested in neurosurgery.
WORLD NEUROSURGERY
(2024)