Article
Food Science & Technology
Jing Dong, Tianhui Yan, Qiuhong Yang, Yi Song, Bo Cheng, Shun Zhou, Yongtao Liu, Xiaohui Ai
Summary: Aeromonas hydrophila is a common pathogen in freshwater aquaculture that can also cause health problems in humans. Antibiotic-resistant strains of A. hydrophila are a concern as they limit antibiotic usage and can lead to treatment failure. Additionally, antibiotic residues in aquatic products pose a risk to quality and safety. This study explores alternative strategies to combat infections caused by antibiotic-resistant bacteria, focusing on palmatine, a compound that inhibits the expression of a key virulence factor in A. hydrophila. The findings suggest that palmatine could be a promising treatment for A. hydrophila-associated infections in aquaculture.
Article
Microbiology
Antonio Camilo da Silva Filho, Jeroniza Nunes Marchaukoski, Roberto Tadeu Raittz, Camilla Reginatto De Pierri, Diogo de Jesus Soares Machado, Cyntia Maria Telles Fadel-Picheth, Geraldo Picheth
Summary: This study analyzed 17 complete genomes of A. hydrophila isolates to determine the contribution of genomic islands to this species. Variations in the number and characteristics of predicted genomic islands were found between phylogenetic groups, with some containing virulence, metabolism, and resistance genes. Strains from different phylogenetic groups showed distinctive genomic island features, with potential contributions to host colonization and environmental competitiveness.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Junwei Wang, Ting Qin, Kai Chen, Liangkun Pan, Jun Xie, Bingwen Xi
Summary: The study found that carvacrol has significant antibacterial and antivirulence effects on A. hydrophila, and it does not have an antagonistic effect when used in combination with commonly used antibiotics in aquaculture.
Article
Veterinary Sciences
Jing Dong, Tianhui Yan, Qiuhong Yang, Shun Zhou, Yi Song, Yongtao Liu, Liang Ma, Ning Xu, Yibin Yang, Xiaohui Ai
Summary: The fast-growing demand for aquatic products has led to the rapid development of aquaculture. However, antibiotic resistance caused treatment failure in the control of diseases caused by bacterial pathogens. In this study, researchers identified aerolysin as a target for developing drugs and found that polydatin could decrease the pathogenesis of antibiotic-resistant A. hydrophila infections.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Microbiology
Lushan Zhang, Liang Ma, Qiuhong Yang, Yongtao Liu, Xiaohui Ai, Jing Dong
Summary: The study aimed to find alternative treatments to antibiotics. Through disrupting quorum sensing, sanguinarine was found to inhibit the growth and biofilm formation of A. hydrophila. The results showed that sanguinarine protected A549 cells and reduced mortality in infected channel catfish.
Article
Food Science & Technology
Jing Dong, Lushan Zhang, Yongtao Liu, Shun Zhou, Yibin Yang, Ning Xu, Qiuhong Yang, Xiaohui Ai
Summary: Aeromonas hydrophila is a widely distributed pathogen that has developed antibiotic resistance, necessitating the exploration of novel treatment strategies. The bacterium's pathogenicity is primarily attributed to virulence factors such as aerolysin and biofilm.
Article
Fisheries
Aldo Aparecido Proietti-Junior, Luciana Sampaio Lima, Emily Moraes Roges, Yan Correa Rodrigues, Karla Valeria Batista Lima, Dalia Prazeres Rodrigues, Marcos Tavares-Dias
Summary: This study reported an outbreak of disease in pirarucu caused by Aeromonas, conducted experimental co-infection research, and characterized resistance profile, virulence factors, and phenotypic and molecular differentiation. The findings support the existence of synergism between A. hydrophila and A. jandaei in pirarucu, with implications for occurrences of this co-infection and determinants of virulence.
AQUACULTURE RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Kyoo-Tae Kim, Seung-Hun Lee, Kyoung-Ki Lee, Jee Eun Han, Dongmi Kwak
Summary: The research suggests that stress can increase the virulence of Aeromonas hydrophila and lead to animal mortality, while serial passaging in mice can dramatically enhance the virulence of A. hydrophila.
Article
Immunology
Hongmei Yin, Qiaohua Yan, Guoqiang Cheng, Li Zhang, Meiqing Li, Tingting Hu, Sihui Gao, Yuanhang Chen, Huaqiao Tang, Jie Luo
Summary: This study investigated the effects of EGCG on A. hydrophila and its virulence factors, and its impact on adhesion, invasion, and cytotoxicity in Caco-2 cells. Transcriptomic analysis revealed the potential antibacterial mechanism of EGCG. Results showed that EGCG inhibited the production of biofilm and virulence factors, as well as weakened the chemotaxis and stress response of the bacteria. In addition, animal studies demonstrated the effectiveness of EGCG in improving survival rate and reducing organ damage.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Fisheries
Ping Ouyang, Jiehao Chen, Lizi Yin, Yi Geng, Defang Chen, Kaiyu Wang, Weiming Lai, Hongrui Guo, Jing Fang, Zhengli Chen, Li Tang, Chao Huang, Xiaoli Huang
Summary: Aeromonas hydrophila is a significant pathogen with increasing drug resistance, requiring novel agents and strategies for treatment. Cinnamaldehyde inhibits the production of W-pili through downregulating gene expression, reducing the adhesion ability of A. hydrophila.
AQUACULTURE INTERNATIONAL
(2021)
Article
Microbiology
Gang Xiao, Xiaofeng Zheng, Jiyun Li, Yang Yang, Jie Yang, Ning Xiao, Junqi Liu, Zhiliang Sun
Summary: This study revealed the significant role of the EnvZ/OmpR TCS in the growth, motility, virulence, and stress response of A. hydrophila, providing important insights for the development of novel antibacterial and vaccine therapies targeting EnvZ/OmpR against A. hydrophila.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Jing Dong, Lushan Zhang, Yongtao Liu, Ning Xu, Shun Zhou, Yibin Yang, Qiuhong Yang, Xiaohui Ai
Summary: The study found that luteolin can reduce aerolysin-induced hemolysis by inhibiting aerolysin activity, and hinder the formation of functional heptamer. In addition, luteolin can protect cells from aerolysin-induced cell death and increase the survival rate in A. hydrophila-infected channel catfish.
Article
Pharmacology & Pharmacy
Jing Dong, Defu Zhang, Jianrong Li, Yongtao Liu, Shun Zhou, Yibin Yang, Ning Xu, Qiuhong Yang, Xiaohui Ai
Summary: Genistein can reduce the virulence of A. hydrophila by decreasing the production of aerolysin and biofilm formation, significantly improving aerolysin-mediated cell injury and providing remarkable protection to channel catfish infected with A. hydrophila. Targeting quorum sensing and virulence can be a useful approach developing drugs against A. hydrophila infections in aquaculture, with genistein as a promising candidate.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Ting Qin, Kai Chen, Bingwen Xi, Liangkun Pan, Jun Xie
Summary: The study demonstrates that NE stimulates the growth, biofilm formation, and hemolytic activity of A. hydrophila and enhances the virulence of the pathogen in fish via the QseBC system. Deletion of qseB and qseC inhibits NE-promoted growth, biofilm formation, and hemolytic activity of A. hydrophila. QseBC does not affect the swimming and swarming motility of A. hydrophila.
MICROBIAL PATHOGENESIS
(2023)
Article
Veterinary Sciences
Jihong Li, Zhihao Wu, Changsong Wu, Dan-Dan Chen, Yang Zhou, Yong-An Zhang
Summary: The study identified a virulent strain of Aeromonas hydrophila, GD18, which possesses a functional Type VI secretion system (T6SS) and highlighted the essential role of VasH in T6SS functionality, bacterial cytotoxicity, and resistance. This contributes to the understanding of the regulatory mechanism of VasH and the virulence and bactericidal effects of A. hydrophila mediated by T6SS.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Infectious Diseases
Gianluca Morroni, Andrea Brenciani, Alice Litta-Mulondo, Carla Vignaroli, Gianmarco Mangiaterra, Simona Fioriti, Barbara Citterio, Oscar Cirioni, Eleonora Giovanetti, Francesca Biavasco
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2019)
Article
Multidisciplinary Sciences
Vesna Milanovic, Andrea Osimani, Federica Cardinali, Alice Litta-Mulondo, Carla Vignaroli, Barbara Citterio, Gianmarco Mangiaterra, Lucia Aquilanti, Cristiana Garofalo, Francesca Biavasco, Luca Cocolin, Ilario Ferrocino, Raffaella Di Cagno, Silvia Turroni, Camilla Lazzi, Nicoletta Pellegrini, Francesca Clementi
Article
Chemistry, Medicinal
Paolo Amabili, Francesca Biavasco, Andrea Brenciani, Barbara Citterio, Dario Corbisiero, Lucia Ferrazzano, Simona Fioriti, Giulia Guerra, Mario Orena, Samuele Rinaldi
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Food Science & Technology
Barbara Citterio, Gianmarco Mangiaterra, Maria Assunta Meli, Nicholas Cedraro, Carla Roselli, Carla Vignaroli, Marco Rocchi, Francesca Biavasco
Article
Microbiology
Barbara Citterio, Francesca Andreoni, Serena Simoni, Elisa Carloni, Mauro Magnani, Gianmarco Mangiaterra, Nicholas Cedraro, Francesca Biavasco, Carla Vignaroli
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Infectious Diseases
Gianmarco Mangiaterra, Nicholas Cedraro, Salvatore Vaiasicca, Barbara Citterio, Roberta Galeazzi, Emiliano Laudadio, Giovanna Mobbili, Cristina Minnelli, Davide Bizzaro, Francesca Biavasco
Article
Chemistry, Medicinal
Raffaella Campana, Gianmarco Mangiaterra, Mattia Tiboni, Emanuela Frangipani, Francesca Biavasco, Simone Lucarini, Barbara Citterio
Article
Biotechnology & Applied Microbiology
Simona Fioriti, Sonia Nina Coccitto, Nicholas Cedraro, Serena Simoni, Gianluca Morroni, Andrea Brenciani, Gianmarco Mangiaterra, Carla Vignaroli, Luigi Vezzulli, Francesca Biavasco, Eleonora Giovanetti
Summary: Linezolid is a critical antibiotic for treating severe infections, but the detection of linezolid-resistant enterococci in marine samples raises public health concerns. The study underscores the importance of improving practices to limit the transmission of linezolid-resistant strains to humans.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gianmarco Mangiaterra, Elisa Carotti, Salvatore Vaiasicca, Nicholas Cedraro, Barbara Citterio, Anna La Teana, Francesca Biavasco
Summary: This study investigated the role of subinhibitory concentrations of different anti-pseudomonas antibiotics in maintaining persistent Pseudomonas aeruginosa (PA) cells in vitro biofilms. Tobramycin and bacterial cell wall-targeting antibiotics were found to play a major role in the resilience of VBNC forms, while ciprofloxacin and ceftazidime/avibactam led to their complete loss. The results could provide a deeper understanding of bacterial population dynamics during the treatment of recurrent PA infections within the CF lung.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Gianmarco Mangiaterra, Nicholas Cedraro, Emiliano Laudadio, Cristina Minnelli, Barbara Citterio, Francesca Andreoni, Giovanna Mobbili, Roberta Galeazzi, Francesca Biavasco
Summary: The study found that the alkaloid berberine has an inhibitory effect on the PA MexXY-OprM efflux pump, enhancing the activity of tobramycin against PA and reducing its tolerance. MexY plays a crucial role in the tobramycin tolerance of PA, and the addition of berberine can decrease this tolerance.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Giorgia Giorgini, Gianmarco Mangiaterra, Nicholas Cedraro, Emiliano Laudadio, Giulia Sabbatini, Mattia Cantarini, Cristina Minnelli, Giovanna Mobbili, Emanuela Frangipani, Francesca Biavasco, Roberta Galeazzi
Summary: Berberine and its derivatives show synergistic effects with tobramycin against different strains of Pseudomonas aeruginosa, leading to varying degrees of MIC reduction and killing effect. This suggests their potential as MexXY-OprM inhibitors for the rational design of novel agents.
Article
Engineering, Manufacturing
Chiara Giosue, Alessandra Mobili, Barbara Citterio, Francesca Biavasco, Maria Letizia Ruello, Francesca Tittarelli
MANUFACTURING REVIEW
(2020)
