Article
Biochemistry & Molecular Biology
Isaac J. Nijman, Benjamin D. Rosen, Philippe Bardou, Thomas Faraut, Tristan Cumer, Kevin G. Daly, Zhuqing Zheng, Yudong Cai, Hojjat Asadollahpour, Bengi Cinar Kul, Wei-Yi Zhang, Guangxin E, A. Ayin, Hayley Baird, Meirat Bakhtin, Valentin A. Balteanu, Diana Barfield, Beate Berger, Thor Blichfeldt, Geert Boink, Sri R. A. Bugiwati, Zexi Cai, Sean Carolan, Emily Clark, Vlatka Cubric-Curik, Muhammad I. A. Dagong, Tashi Dorji, Louise Drew, Jiazhong Guo, Jon Hallsson, Simon Horvat, Juha Kantanen, Fuki Kawaguchi, Polat Kazymbet, Negar Khayatzadeh, Namshin Kim, Manoj Kumar Shah, Yuying Liao, Amparo Martinez, Joseph S. Masangkay, Maho Masaoka, Raffaele Mazza, John McEwan, Marco Milanesi, Faruque Md Omar, Yuto Nomura, Nadjet-Amina Ouchene-Khelifi, Filipe Pereira, Goutam Sahana, Mazdak Salavati, Shinji Sasazaki, Anne Da Silva, Mojca Simcic, Johann Solkner, Alison Sutherland, Johannes Tigchelaar, Hongpin Zhang, Paolo Ajmone-Marsan, Daniel G. Bradley, Licia Colli, Cord Drogemuller, Yu Jiang, Chuzhao Lei, Hideyuki Mannen, Francois Pompanon, Gwenola Tosser-Klopp, Johannes A. Lenstra
Summary: This study analyzed the Y-chromosomal variants in domestic and wild goats, revealing the importance of paternal population history and male-mediated introgression. The findings provide insights into the evolution of goat species and the influence of migrations and crossbreeding on their genetic diversity.
Article
Archaeology
Pierre Zalloua, Nada Elias, Anna Senovska, Catherine Collins, Anna Gosling, Samar Karam, Amine-Jules Iskandar, Elizabeth Matisoo-Smith
Summary: Historic records reveal the exhumation and transfer of 17 Maronite patriarchs' remains from their original burial site to a secondary collective burial. Using various methods, including DNA analysis, the researchers sought to confirm the identity of the patriarchs' remains, particularly that of patriarch Estephan El Douaihy. Through the examination of records, osteological analysis, and genetic testing, it was concluded that the 16 complete skulls discovered in the burial likely belong to the patriarchs exhumed in 1909.
JOURNAL OF CULTURAL HERITAGE
(2023)
Article
Medicine, General & Internal
Rebeca Lorca, Andrea Aparicio, Juan Gomez, Rut Alvarez-Velasco, Isaac Pascual, Pablo Avanzas, Francisco Gonzalez-Urbistondo, Alberto Alen, Daniel Vazquez-Coto, Mar Gonzalez-Fernandez, Claudia Garcia-Lago, Elias Cuesta-Llavona, Cesar Moris, Eliecer Coto
Summary: Mitochondrial DNA (mtDNA) is different from nuclear genome in terms of inheritance patterns, susceptibility to mutations, and heteroplasmy. This study aimed to evaluate mtDNA variants associated with premature cardiovascular disease. Patients with premature myocardial infarction were compared with a control group, and the presence of mtDNA polymorphisms and clinical data were examined. The results showed that certain mtDNA mutations and heteroplasmy were significantly more frequent in premature myocardial infarction patients, particularly in males. These findings suggest that mtDNA mutations and heteroplasmy may be associated with unstable premature atherosclerosis disease in men, emphasizing the importance of protective mitochondrial pathways and preventing exposure to cardiovascular risk factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Legal
Charity A. Holland, Jennifer A. McElhoe, Sidney Gaston-Sanchez, Mitchell M. Holland
Summary: Massively parallel sequencing of mitochondrial DNA can help practitioners fully resolve heteroplasmic sites, especially in forensic DNA analysis. Damage and heteroplasmy can manifest similarly in DNA mixtures, highlighting the importance of differentiating between the two conditions. Controlled experiments involving DNA damage were conducted to evaluate the impact on samples with different template concentrations, aiming to improve mtDNA analysis for low template samples. Damage caused a decrease in mtDNA yield and lower quality sequencing results, especially in samples diluted prior to damage induction, indicating the susceptibility of low template samples to damage. This study's findings will aid forensic laboratories in distinguishing between damage and heteroplasmy, crucial for setting robust mtDNA interpretation guidelines.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Heriberto Santander-Lucio, Armando Totomoch-Serra, Maria de Lourdes Munoz, Normand Garcia-Hernandez, Gerardo Perez-Ramirez, Adan Valladares-Salgado, Ashael Alfredo Perez-Munoz
Summary: This study analyzes the association between 18 mitochondrial DNA variants and type 2 diabetes and related metabolic traits in a Mexican mestizo population. The results show a strong association between the m.315_316insC variant and type 2 diabetes, as well as nominal associations with certain metabolic traits.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Jun Feng, Zhaowei Chen, Wei Liang, Zhongping Wei, Guohua Ding
Summary: The kidney, which is a mitochondria-rich organ, is affected by mitochondria-related pathologies. Damage to mitochondrial DNA (mtDNA) plays a role in kidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD). MtDNA damage is closely associated with loss of kidney function, and the levels of mtDNA in peripheral serum and urine can reflect kidney injury. Alleviating mtDNA damage can promote mitochondrial function recovery and reduce kidney injury. Therefore, mtDNA damage may serve as a novel biomarker for assessing kidney injury and provide a new therapeutic option for kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Cell Biology
Jonathan M. Palozzi, Thomas R. Hurd
Summary: Female germline has evolved a programmed germline mitophagy (PGM) to control the quality of mitochondrial DNA (mtDNA). PGM is induced by the inhibition of mTorC1 and requires the autophagy machinery and the mitophagy adaptor BNIP3, but not Pink1 and park, for germline mtDNA quality control. The study also identified Atx2 as a major regulator of PGM.
Article
Genetics & Heredity
Linying Wang, Guilian Sheng, Michaela Preick, Songmei Hu, Tao Deng, Ulrike H. Taron, Axel Barlow, Jiaming Hu, Bo Xiao, Guojiang Sun, Shiwen Song, Xindong Hou, Xulong Lai, Michael Hofreiter, Junxia Yuan
Summary: Both molecular data and archaeological evidence support an African origin for domestic donkeys, with recent genetic studies suggesting two distinct maternal lineages involved in their initial domestication. The introduction of these lineages into ancient China is dated to at least the opening of the Silk Road in the first century BC. Analysis of mitochondrial genomes indicates population size changes in domestic donkeys over the past 5,000 years.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Lirong Jiang, Jing Liu, Suyu Li, Yufeng Wen, Xinyue Zheng, Liu Qin, Yiping Hou, Zheng Wang
Summary: This study evaluated the performance of four commonly used variant callers in the heterogeneity authentication of human mtDNA and developed a python-based nanopore analytics pipeline, CmVCall. The results showed that CmVCall can accurately identify heterogeneity and reveal significant levels of individual differences. This analysis pipeline lays a solid foundation for comprehensive research on the characteristics of the mitochondrial genome.
FORENSIC SCIENCE INTERNATIONAL-GENETICS
(2023)
Article
Multidisciplinary Sciences
Imam Mustofa, Suherni Susilowati, Wurlina Wurlina, Tatik Hernawati, Yudit Oktanella
Summary: The study found that adding green tea extract (GTE) in extender can improve the quality of post-thawed Kacang buck sperm, with the treatment group containing 0.10 mg GTE/100 mL (T2) showing the best results.
Article
Genetics & Heredity
Nuket Bilgen, Mervenur Guvendi, Efe Sezgin, Huseyin Can, Ahmet Efe Koseoglu, Sedef Erkunt Alak, Mert Doskaya, Cemal Un
Summary: This study investigated the mitochondrial DNA diversity in random bred cats from various regions across Turkey and compared it with the mitochondrial DNA profiles of Turkish Angora and Turkish Van breeds. The analysis identified nine 'universal' mitochondrial DNA profiles and one 'outlier' profile in random bred cats. The haplotype structure in random bred cats showed remarkable diversity compared to Turkish Angora and Van breeds. Overall, this study expands our understanding of the feline genetic landscape in Turkey and lays the foundation for future research on the evolutionary trajectories and genetic legacies of these feline populations.
Article
Biochemistry & Molecular Biology
Alexandros Heraclides, Eva Fernandez-Dominguez
Summary: This study evaluates the use of two tools (ANGSD and schmutzi) for reconstructing high-quality ancient mitogenomes from ancient human genomic data. The results show that filtering improves mtDNA consensus calling and haplogroup prediction accuracy. The study also finds a strong correlation between the number of sequence reads and bases and overall sample quality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Agriculture, Dairy & Animal Science
Alessandra Iannuzzi, Pietro Parma, Leopoldo Iannuzzi
Summary: Numerical autosome abnormalities are rarely reported in domestic bovids, while abnormalities involving sex chromosomes and structural chromosomes are more frequently detected due to their hidden phenotypic effects. Without cytogenetic control, these abnormalities can escape animal selection and negatively impact fertility, especially in female carriers. Chromosome abnormalities can be easily spread through offspring, highlighting the importance of clinical cytogenetics in genetic improvement of livestock.
Review
Agriculture, Dairy & Animal Science
Alessandra Iannuzzi, Leopoldo Iannuzzi, Pietro Parma
Summary: The use of molecular cytogenetics, especially fluorescence in situ hybridization (FISH), has greatly enhanced the understanding of chromosomes in domestic animals. It has been applied to create physical maps of specific DNA sequences, confirm chromosome abnormalities, anchor genetic maps, compare different species, study meiotic segregation, demonstrate conserved or lost DNA sequences, predict chromosome regions, and study genomic stability. This review focuses on the important applications of molecular cytogenetics using FISH mapping in domestic bovids.
Article
Anthropology
Alondra M. Diaz-Lameiro, Jennifer G. L. Kennedy, Stephanie Craig, William H. Isbell, Peter W. Stahl, D. Andrew Merriwether
Summary: The llama and alpaca are important domesticated species native to South America. Research on ancient DNA from pre-conquest South American camelids reveals that the domestic forms have ancestral links to both the guanaco and vicuna, two wild species of camelids. The study also provides insights into the complex ancestry of domestic South American camelids and confirms the occurrence of crossbreeding before the Spanish conquest.
JOURNAL OF ARCHAEOLOGICAL SCIENCE
(2022)
Article
Anthropology
Yong-Bin Zhao, Hong-Jie Li, Sheng-Nan Li, Chang-Chun Yu, Shi-Zhu Gao, Zhi Xu, Li Jin, Hong Zhu, Hui Zhou
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY
(2011)
Article
Pharmacology & Pharmacy
Dayong Si, Juan Wang, Yifan Zhang, Dafang Zhong, Hui Zhou
BIOPHARMACEUTICS & DRUG DISPOSITION
(2012)
Article
Biology
Chunxiang Li, Hongjie Li, Yinqiu Cui, Chengzhi Xie, Dawei Cai, Wenying Li, Victor H. Mair, Zhi Xu, Quanchao Zhang, Idelisi Abuduresule, Li Jin, Hong Zhu, Hui Zhou
Article
Evolutionary Biology
Yinqiu Cui, Hongjie Li, Chao Ning, Ye Zhang, Lu Chen, Xin Zhao, Erika Hagelberg, Hui Zhou
BMC EVOLUTIONARY BIOLOGY
(2013)
Article
Oncology
Chengzhi Xie, Holly Edwards, Xuelian Xu, Hui Zhou, Steven A. Buck, Mark L. Stout, Qun Yu, Jeffrey E. Rubnitz, Larry H. Matherly, Jeffrey W. Taub, Yubin Ge
CLINICAL CANCER RESEARCH
(2010)
Article
Behavioral Sciences
Hongmei Meng, Guimei Guo, Jinyan Ren, Hui Zhou, Yubin Ge, Yingjie Guo
EPILEPSY & BEHAVIOR
(2011)
Article
Anthropology
Haijing Wang, Lu Chen, Binwen Ge, Ye Zhang, Hong Zhu, Hui Zhou
Article
Anthropology
Chunxiang Li, Diane L. Lister, Hongjie Li, Yue Xu, Yinqiu Cui, Mim A. Bower, Martin K. Jones, Hui Zhou
JOURNAL OF ARCHAEOLOGICAL SCIENCE
(2011)
Article
Anthropology
Dawei Cai, Zhuowei Tang, Huixin Yu, Lu Han, Xiaoyan Ren, Xingbo Zhao, Hong Zhu, Hui Zhou
JOURNAL OF ARCHAEOLOGICAL SCIENCE
(2011)
Article
Anthropology
Dawei Cai, Yang Sun, Zhuowei Tang, Songmei Hu, Wenying Li, Xingbo Zhao, Hai Xiang, Hui Zhou
JOURNAL OF ARCHAEOLOGICAL SCIENCE
(2014)
Article
Genetics & Heredity
Yong-Bin Zhao, Hong-Jie Li, Da-Wei Cai, Chun-Xiang Li, Quan-Chao Zhang, Hong Zhu, Hui Zhou
JOURNAL OF HUMAN GENETICS
(2010)
Article
Genetics & Heredity
Hongjie Li, Xin Zhao, Yongbin Zhao, Chunxiang Li, Dayong Si, Hui Zhou, Yinqiu Cui
JOURNAL OF HUMAN GENETICS
(2011)
Article
Multidisciplinary Sciences
Xuelian Xu, Chengzhi Xie, Holly Edwards, Hui Zhou, Steven A. Buck, Yubin Ge
Article
Chemistry, Multidisciplinary
Fu Yu-qin, Li Min, Wang Xu, Zhou Guo-qiang, Zhou Hui, Cui Yin-qiu
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2010)