期刊
SMALL
卷 14, 期 38, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201801942
关键词
diabetes; insulin delivery; multiresponsiveness; supramolecular assembly; theranostic
类别
资金
- National Basic Research Program of China [2014CB846004]
- National Natural Science Foundation of China [21572101, 21472089]
- Alexander von Humboldt Foundation
A closed-loop smart insulin delivery system with the capability to mimic pancreatic cells will be highly desirable for diabetes treatment. This study reports a multiple stimuli-responsive insulin delivery platform based on an explicit supramolecular strategy. Self-assembled from a well-designed amphiphilic host-guest complex formed by pillar[5]arene and a diphenylboronic acid derivative and loaded with insulin and glucose oxidase, the obtained insulin-GOx-loaded supramolecular vesicles can selectively recognize glucose, accompanied by the structure disruption and efficient release of the entrapped insulin triggered by the high glucose concentration as well as the in situ generated H2O2 and acid microenvironment during the GOx-promoted specific oxidation of glucose into gluconic acid. Moreover, such a smart supramolecular theranostic nanoplatform is able to function as both a glucose sensor and a controlled insulin delivery actuator. In vivo experiments further demonstrate that this smart supramolecular nanocarrier shows fast response to hyperglycemic circumstances and can effectively regulate the glucose levels in a mouse model of type I diabetes.
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