Article
Radiology, Nuclear Medicine & Medical Imaging
Feredun Azari, Kevin Zhang, Gregory T. Kennedy, Ashley Chang, Bilal Nadeem, Edward J. Delikatny, Sunil Singhal
Summary: Intraoperative molecular imaging (IMI) is a valuable tool for surgical oncologists, allowing real-time assessment of oncologic resection quality, margin assessment, and occult disease detection. By utilizing the localization characteristics of fluorescent tracers in tumors, the limitations of autofluorescence and depth penetration are being addressed. IMI has been widely used in the treatment of various cancers, with proven benefits in reducing cancer recurrence and improving patient outcomes, without imposing significant burden on clinicians or patients.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Songbai Zhang, Vega Lloveras, Yufei Wu, Juan Tolosa, Joaquin C. Garcia-Martinez, Jose Vidal-Gancedo
Summary: Dual or multimodal imaging probes, such as metal-free organic species based on dendrimers, have been developed as powerful tools for disease diagnosis using magnetic resonance imaging (MRI) and optical fluorescence imaging (OFI). In this study, six radical dendrimers were synthesized and characterized, demonstrating their paramagnetic properties for MRI contrast generation and fluorescence emission. This represents a significant development in the field of macromolecules with bimodal magnetic and fluorescent properties using organic radicals as the magnetic probe.
Article
Chemistry, Analytical
Evin Aysegul Simsir, Serkan Erdemir, Mustafa Tabakci, Begum Tabakci
Summary: A highly selective and sensitive MET detection method based on fluorescence quenching using a fluorescent calix[4]arene derivative has been reported. The probe showed great potential for practical applications, especially in pharmaceutical preparations, with fast and accurate detection of MET. The probe was successfully applied in pharmaceutical samples and as a paper-based sensor for MET detection.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biochemical Research Methods
Jiheun Ryu, Unkyo Kang, Joon Woo Song, Junyoung Kim, Jin Won Kim, Hongki Yoo, Bomi Gweon
Summary: This article introduces a novel high-speed multimodal optical microscope system that can simultaneously observe five different microscopic contrasts, providing complementary optical information that enhances both structural and functional contrasts.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Nanoscience & Nanotechnology
Juan Yue, Qian Mei, Panyong Wang, Peng Miao, Wen-Fei Dong, Li Li
Summary: The yellow fluorescent carbon dots (CDs) for detecting GSSG through a fluorescence off-on process show linear correlation with GSSG concentration and a detection limit of 0.18mu M. Additionally, the CDs can also be used for fluorescence imaging in living cells and zebrafish.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Wenbo Zhang, Luca Bertinetti, Kerstin G. Blank, Rumiana Dimova, Changyou Gao, Emanuel Schneck, Peter Fratzl
Summary: The study introduces a novel osmotic pressure sensor based on liposomes loaded with water-soluble fluorescent dyes exhibiting resonance energy transfer. These sensors show high sensitivity to osmotic pressure in the biologically relevant range and can be used for investigating osmotic pressure dynamics in biology and technology using FRET microscopy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Tuula Penate Medina, Jie Pan, Christabel Damoah, Jana Humbert, Anna-Lena Koepnick, Olga Will, Susanne Sebens, Oula Penate Medina
Summary: Inflammatory bowel disease is a chronic inflammation in the gastrointestinal tract. This study aimed to investigate the use of sphingomyelin-containing liposomes to target areas of inflammation. The results showed that the liposomes were efficiently taken up in intestinal macrophages and preferentially delivered to the inflamed colon.
Article
Optics
Fenghong Chu, Shi Feng, Zhenglan Bian, Chunpeng Zhao, Liang Xue, Anduo Hu
Summary: A hydrogel optical fiber doped with fluorescent indicator was successfully used to detect dissolved oxygen based on fluorescence quenching method. The experiment demonstrated good repeatability and improved sensitivity in detecting dissolved oxygen.
Article
Engineering, Environmental
Hang Li, Garrett McKay
Summary: Fluorescence spectroscopy is widely used to study dissolved organic matter (DOM). This study used fluorescence quenchers to evaluate the chemical and spatial heterogeneity of DOM fluorophores. The study found that multiple emitting species contribute to the observed emission, even at a single excitation wavelength. The results provide insights into the spatial distribution of fluorophores within DOM and their relationship with solvent polarity and pH.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Yuqiong Xia, Chunzhong Xu, Keyun Wu, Jun Wang, Chenhui Cui, Yankun Wu, Cairu Li, Xianghan Zhang
Summary: Near-infrared fluorophores are widely used in tumor imaging due to their superior resolution, sensitivity, penetration depth, and low auto-fluorescence. However, the efficacy of these fluorophores in tumor imaging is often hindered by background signals and delivery efficiency. The self-quenched liposomal probes DiR-LP-C and DiR-LP-B have been developed as tumor-specific imaging probes with a cellular on/off system, showing potential for tumor imaging and phototherapy.
MATERIALS TODAY COMMUNICATIONS
(2022)
Review
Genetics & Heredity
Nian Liu, Xiao Chen, Melanie A. Kimm, Matthias Stechele, Xueli Chen, Zhimin Zhang, Moritz Wildgruber, Xiaopeng Ma
Summary: Optical imaging technology has great potential in detecting inflammation, providing accurate molecular information and offering new insights into the diagnosis and therapeutic evaluation of inflammatory diseases. By using endogenous and exogenous contrast agents, optical imaging technology can accurately visualize sites of inflammation, enabling early disease detection and specific disease characterization.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Chemistry, Multidisciplinary
Florentin R. Nitu, Lorand Savu, Sorin Muraru, Ioan Stoian, Mariana Ionita
Summary: Label-free optical detection of low concentration of oligonucleotides in complex solutions containing proteins using graphene oxide remains challenging. In this study, a colloidal graphene oxide was used as a fluorescent probe quencher to detect microRNA-21 in cell culture medium, overcoming protein interference. The specific quenching-based method successfully detected oligo DNA-microRNA hybridization.
Article
Engineering, Electrical & Electronic
Qin Li, Liyun Ding, Yumei Zhang, Tian Wu
Summary: A novel optical fiber biosensor based on carbon quantum dots fluorescent probe was developed for cholesterol sensing. The sensor showed good biocompatibility and selectivity for cholesterol.
IEEE SENSORS JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Yusheng Wu, Dongmiao Qin, Zhi Luo, Shuo Meng, Guichun Mo, Xiaohua Jiang, Biyang Deng
Summary: The facile hydrothermal method for preparing boron and nitrogen codoped carbon quantum dots (B,N-CQDs) shows excellent properties and potential applications as a ratiometric fluorescent probe for detecting IO4- and in cell imaging.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Jing Ye, Tianxiang Hu, Yanqi Wu, Hui Chen, Qianqian Qiu, Rongqing Geng, Hui Ding, Xiaojuan Zhao
Summary: In this study, a targeted fluorescent imaging probe was successfully constructed using rare earth and gold doped nanoclusters, which showed promising imaging performance and can potentially play an important role in the clinical diagnosis and treatment of tumors.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Felista Tansi, Eric Kallweit, Christoph Kaether, Katarina Kappe, Christina Schumann, Ingrid Hilger, Siegmund Reissmann
JOURNAL OF CELLULAR BIOCHEMISTRY
(2015)
Article
Multidisciplinary Sciences
Felista L. Tansi, Ronny Rueger, Markus Rabenhold, Frank Steiniger, Alfred Fahr, Ingrid Hilger
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2015)
Article
Engineering, Biomedical
Felista L. Tansi, Ronny Rueger, Claudia Boehm, Roland E. Kontermann, Ulf K. Teichgraeber, Alfred Fahr, Ingrid Hilger
Article
Chemistry, Multidisciplinary
Ronny Rueger, Felista L. Tansi, Markus Rabenhold, Frank Steiniger, Roland E. Kontermann, Alfred Fahr, Ingrid Hilger
JOURNAL OF CONTROLLED RELEASE
(2014)
Article
Biochemistry & Molecular Biology
Felista L. Tansi, Margarita P. Filatova, Dmitri O. Koroev, Olga M. Volpina, Steffi Lange, Christina Schumann, Ulf K. Teichgraeber, Siegmund Reissmann, Ingrid Hilger
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Nanoscience & Nanotechnology
Susann Piehler, Lena Wucherpfennig, Felista L. Tansi, Alexander Berndt, Rainer Quaas, Ulf Teichgraeber, Ingrid Hilger
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Felista L. Tansi, Ronny Rueger, Ansgar M. Kollmeier, Markus Rabenhold, Frank Steiniger, Roland E. Kontermann, Ulf K. Teichgraeber, Alfred Fahr, Ingrid Hilger
Article
Pharmacology & Pharmacy
Felista L. Tansi, Ronny Ruger, Claudia Bohm, Frank Steiniger, Martin Raasch, Alexander S. Mosig, Roland E. Kontermann, Ulf K. Teichgraber, Alfred Fahr, Ingrid Hilger
Article
Chemistry, Multidisciplinary
Felista L. Tansi, Filipp Froebel, Wisdom O. Maduabuchi, Frank Steiniger, Martin Westermann, Rainer Quaas, Ulf K. Teichgraeber, Ingrid Hilger
Summary: The study investigated the impact of matrix-modulating enzymes on the uptake of magnetic nanoparticles by pancreatic cancer cells and their overall influence on magnetic heating and cell death. Results showed that hyaluronidase enhanced the uptake of magnetic nanoparticles, leading to improved thermal treatment outcomes.
Review
Pharmacology & Pharmacy
Gary Hannon, Felista L. Tansi, Ingrid Hilger, Adriele Prina-Mello
Summary: Heat has been used for thousands of years to treat tumors, but only recently has it become a more controlled and localized treatment method. The evidence regarding the effects of localized heat on the hallmarks of cancer and the mechanisms behind its efficacy are just starting to emerge.
ADVANCED THERAPEUTICS
(2021)
Article
Oncology
Felista L. Tansi, Wisdom O. Maduabuchi, Melanie Hirsch, Paul Southern, Simon Hattersley, Rainer Quaas, Ulf Teichgraeber, Quentin A. Pankhurst, Ingrid Hilger
Summary: Pulse sequencing of MFH leads to more persistent inhibition of tumor growth and less systemic impact than continuous MFH, even with the same thermal dose. This study provides insights into the influence of pulse sequencing on biological outcomes and validates improved thermal dose localization with lower overall energy expenditure.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Engineering, Biomedical
Felista L. Tansi, Ronny Rueger, Claudia Boehm, Frank Steiniger, Roland E. Kontermann, Ulf K. Teichgraeber, Alfred Fahr, Ingrid Hilger
ACTA BIOMATERIALIA
(2017)
Article
Biotechnology & Applied Microbiology
Felista L. Tansi, Ronny Rueger, Ansgar M. Kollmeier, Claudia Boehm, Roland E. Kontermann, Ulf K. Teichgraeber, Alfred Fahr, Ingrid Hilger
Article
Multidisciplinary Sciences
Felista L. Tansi, Ronny Rueger, Claudia Boehm, Roland E. Kontermann, Ulf K. Teichgraeber, Alfred Fahr, Ingrid Hilger
Proceedings Paper
Engineering, Electrical & Electronic
M. Helbig, J. Sachs, F. Tansi, I. Hilger
2014 8TH EUROPEAN CONFERENCE ON ANTENNAS AND PROPAGATION (EUCAP)
(2014)