4.8 Article

Effect of Carbon Coating on the Physico-chemical Properties and Toxicity of Copper and Nickel Nanoparticles

期刊

SMALL
卷 8, 期 21, 页码 3289-3299

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201200478

关键词

nanoparticles; toxicity; copper; nickel; carbon coating

资金

  1. SRC/SEMATECH Engineering Research Center for Environmentally Benign Semiconductor Manufacturing [425.035]

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The primary aim of these interdisciplinary studies is to investigate the effect of surface carbon coating on the physico-chemical properties and toxicity of carbon-coated and noncoated copper and nickel nanoparticles (C-Cu, Cu, C-Ni, Ni NPs) in A549 alveolar epithelial cells. Compared to Cu NPs, C-Cu NPs exhibit protection against surface oxidation, tenfold higher cellular uptake, and fourfold lower release of soluble Cu. The toxicity of C-Cu NPs and Cu NPs is associated with pronounced damage to mitochondrial function and plasma membrane integrity, respectively. Compared to Cu and C-Cu NPs, Ni and C-Ni NPs are less toxic. These studies demonstrate that correlations can be drawn between physico-chemical properties and resultant toxicity of NPs as a function of surface carbon coating.

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